Psychopharmacology最新文献

{"title":"A single intake of flavanol-rich cocoa improves inhibitory executive process under cognitive fatigue during aerobic exercise in men: a randomized, double-blind, placebo-controlled crossover trial.","authors":"Hayato Tsukamoto, Sota Yoneya, Takahiro Koyama, Asuka Suzuki, I Wayan Yuuki, Kento Dora, Takeshi Hashimoto","doi":"10.1007/s00213-025-06826-7","DOIUrl":"https://doi.org/10.1007/s00213-025-06826-7","url":null,"abstract":"<p><strong>Rationale: </strong>Although cognitive fatigue commonly occurs during sports, effective strategies to improve it during exercise have not been established.</p><p><strong>Objectives: </strong>This study determined whether high-cocoa flavanol (HCF) consumption improves reaction time and inhibitory executive function impairments during prolonged cognitive load combined with aerobic exercise.</p><p><strong>Methods: </strong>In this randomized crossover study, 18 healthy males (22 ± 2 years) participated in both low-cocoa flavanol (LCF) and HCF trials. Double-blinded capsules (LCF 50 mg and HCF 500 mg) were consumed 1 h before a 50-min cognitive exercise dual-tasking protocol, which included a color-word Stroop task (CWST) and moderate-intensity cycling. The CWST assessed reaction time and reverse-Stroop interference score as indicators of inhibitory executive process.</p><p><strong>Results: </strong>Reaction time (LCF 774 ± 146 ms vs. HCF 731 ± 101 ms, P < 0.01) and reverse-Stroop interference score (LCF 6.2 [3.2-15.5] vs. HCF 4.6 [1.2-11.4], P < 0.01) were significantly better 1 h after HCF consumption than after LCF consumption, indicating that HCF improved both reaction time and the inhibitory executive process at rest. During the 50-min cognitive-exercise dual-tasking protocol, HCF consumption resulted in faster reaction time (LCF 712 ± 122 ms vs. HCF 685 ± 111 ms, P < 0.05) and better inhibitory executive process (LCF 8.4 ± 5.0 vs. HCF 6.6 ± 3.5, P < 0.05) compared to those following LCF consumption.</p><p><strong>Conclusions: </strong>These findings suggest that flavanol-rich cocoa may improve reaction time and inhibitory executive process impaired by cognitive fatigue during aerobic exercise.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nicotine-alcohol co-use on alcohol-induced blackouts and other alcohol-related consequences in college students.","authors":"Veronica L Richards, Kimberly A Mallett, Robert J Turrisi, Jason A Oliver, Julie M Croff, Michael A Russell","doi":"10.1007/s00213-025-06830-x","DOIUrl":"https://doi.org/10.1007/s00213-025-06830-x","url":null,"abstract":"<p><strong>Rationale: </strong>Alcohol-induced blackouts (AIBs) are common in college students and are associated with other alcohol-related consequences. Alcohol-nicotine co-use is also common in this population. Nicotine has cognitive-enhancing properties impacting multiple cognitive domains, including those impaired by alcohol (e.g., attention), but it is unclear whether nicotine affects AIB risk or the relationship between AIBs and other alcohol-related consequences.</p><p><strong>Objectives: </strong>We examined the moderating effects of nicotine use on the associations between (a) alcohol and AIBs and (b) AIBs and other consequences (total and serious: sexual, legal, or those with potential to cause great harm).</p><p><strong>Methods: </strong>College students who reported past semester heavy drinking and at least 1 AIB (N = 79, 55.7% female, 86.1% White) wore alcohol sensors and completed daily diaries over four consecutive weekends (89.9% completion). Multilevel models were conducted to test for moderating effects of nicotine (yes/no) on the alcohol-AIB relationship and the AIB-consequence relationship, adjusting for sex, race/ethnicity, and baseline nicotine use.</p><p><strong>Results: </strong>Concurrent alcohol and nicotine use did not moderate the alcohol-AIB relationship, but weakened the associations between AIBs and both (1) total consequences and (2) serious consequences. On days with nicotine use, AIBs were associated with approximately 30% fewer total consequences and 50% fewer serious consequences than days without nicotine use.</p><p><strong>Conclusions: </strong>College students experienced fewer total and serious consequences on AIB nights when nicotine was used compared to AIB nights when nicotine was not used. Future research should explore potential mechanisms underlying the observed effects.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 pathway in mice.","authors":"Jingyi Li, Xiufeng Wang, Yu Zhang, Min Wei, Jianqiang Qi, Dan Liu, Runhua Wu, Qin Chen, Junshan Huang","doi":"10.1007/s00213-025-06828-5","DOIUrl":"https://doi.org/10.1007/s00213-025-06828-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the neuroprotective effects of Ginsenoside Rg1 in alleviating P-chlorophenylalanine (PCPA)-induced insomnia and explore its underlying mechanisms involving the inhibition of NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation and pyroptosis through the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) pathway in mice.</p><p><strong>Methods: </strong>Sprague-Dawley rats were randomly divided into five groups: control, sleep deprivation (SD, PCPA-induced insomnia), and three treatment groups receiving different doses of Ginsenoside Rg1 (low, medium, and high). Behavioral assessments included the Pentobarbital Sodium-Induced Sleep Test (PIST), Sucrose Preference Test (SPT), and Morris Water Maze (MWM). Histopathological and immunofluorescence evaluations of hippocampal tissues were performed. Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure neurotransmitter levels (5-Hydroxytryptamine [5-HT], 5-Hydroxytryptophan [5-HTP], Gamma-aminobutyric acid [GABA], glutamate [GLU]) and pro-inflammatory cytokines (Tumor Necrosis Factor Alpha [TNF-α], Interleukin-6 [IL-6], Interleukin-1 beta [IL-1β], Interleukin-8 [IL-8]). In vitro, corticosterone-induced neurotoxicity in HT22 hippocampal cells was assessed, and the role of the Nrf2/HO-1 pathway was examined through molecular docking, gene silencing, and Western blot.</p><p><strong>Results: </strong>Ginsenoside Rg1 treatment significantly improved PCPA-induced insomnia symptoms in a dose-dependent manner, as evidenced by reduced sleep latency, increased sleep duration, restored sucrose preference, and improved spatial memory. Histopathological analysis revealed that Ginsenoside Rg1 mitigated neuronal damage and astrocytic activation. Neurotransmitter imbalances were corrected, and inflammation was alleviated, as reflected by reductions in pro-inflammatory cytokines and increased interleukin-10 (IL-10) levels. Mechanistically, Ginsenoside Rg1 inhibited NLRP3 inflammasome activation, pyroptosis, and reduced IL-1β and IL-8 levels in both in vivo and in vitro models. The activation of the Nrf2/HO-1 pathway was further confirmed by molecular docking, immunofluorescence, and Western blot, demonstrating that Nrf2 activation was critical for the anti-inflammatory effects of Ginsenoside Rg1.</p><p><strong>Conclusion: </strong>Ginsenoside Rg1 effectively alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis, with its neuroprotective effects mediated through the activation of the Nrf2/HO-1 pathway. These findings suggest Ginsenoside Rg1 as a potential therapeutic agent for insomnia and related neuroinflammatory conditions.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternating self-administration sessions of cocaine and heroin impact drug-related motivation and vocalisations in rats.","authors":"Kristian Adamatzky, Angharad C Collins, Aldo Badiani, Bryan F Singer","doi":"10.1007/s00213-025-06821-y","DOIUrl":"https://doi.org/10.1007/s00213-025-06821-y","url":null,"abstract":"<p><strong>Rationale: </strong>Animal models of addiction often study changes in motivation after repeated self-administration of a single drug. However, human users frequently consume multiple drugs, potentially altering their motivation and affective response.</p><p><strong>Objectives: </strong>This study investigated how individual rats differentially self-administer cocaine and heroin, and whether motivation to take each drug was associated with affective states, as indicated by ultrasonic vocalisations (USVs). We also determined whether opioid antagonism (via naltrexone), which is known to decrease heroin-taking and associated USVs, also altered motivation and vocalisations for cocaine.</p><p><strong>Methods: </strong>Male Lister Hooded rats, with surgically implanted catheters, self-administered cocaine and heroin on alternating days. Motivation was evaluated via drug intake escalation (fixed-ratio schedule), behavioural adaptation to dose reductions (behavioural economics), and progressive ratio breakpoints (with or without naltrexone). USVs were recorded and analysed using machine learning software (DeepSqueak).</p><p><strong>Results: </strong>Rats escalated intake of both drugs during training. At the start of each session, rats rapidly self-administered cocaine or heroin; this drug-loading behaviour was associated with an increase in 50 kHz vocalisations. Rats altered their cocaine and heroin intake when drug doses decreased, and this was accompanied by reduced 50 kHz USVs. Lastly, naltrexone reduced progressive ratio breakpoints for heroin but not cocaine; naltrexone also decreased 50 kHz USVs for heroin (an effect which persisted).</p><p><strong>Conclusions: </strong>Distinct patterns emerged in motivation and USVs between cocaine and heroin self-administration. Notably, USV frequency did not consistently align with motivation, especially when drug dosage changed. Future research may clarify this divergence.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Zabik et al. (2024): timing and dosage effects of THC in fear extinction: challenges and feasibility in a clinical setting.","authors":"Ellen Barner, Alex Corbett, Luke J Ney","doi":"10.1007/s00213-025-06829-4","DOIUrl":"https://doi.org/10.1007/s00213-025-06829-4","url":null,"abstract":"","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggression is not blind: dominance and social history modulate murine responses to social instigation.","authors":"Tomoya Nagai, Aki Takahashi","doi":"10.1007/s00213-025-06824-9","DOIUrl":"https://doi.org/10.1007/s00213-025-06824-9","url":null,"abstract":"","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radixin in the nucleus accumbens core modulates amphetamine-induced locomotor activity based on context association.","authors":"Wen Ting Cai, Myung Ji Kwak, Joonyeup Han, Haeun Rim, Lars Björn Riecken, Helen Morrison, Wha Young Kim, Jeong-Hoon Kim","doi":"10.1007/s00213-025-06823-w","DOIUrl":"https://doi.org/10.1007/s00213-025-06823-w","url":null,"abstract":"<p><strong>Rationale: </strong>The expression of addictive behaviors is linked to the structural plasticity of dendritic spines in the nucleus accumbens (NAcc). While radixin is known to contribute to morphological changes in dendritic spines, its role in the NAcc, specifically in the structural plasticity of dendritic spines and related drug-induced behavioral changes, is not well understood.</p><p><strong>Objective: </strong>In the present study, we investigated the effects of radixin manipulation in the NAcc core on amphetamine (AMPH)-induced locomotor activity, both in association with and independent of a specific environment. Additionally, we examined the accompanying changes in dendritic spine density in this region.</p><p><strong>Methods: </strong>We used a phosphomimetic pseudo-active mutant form (Rdx-T564D) and wild-type (Rdx-WT) radixin in conditioning and context-independent sensitization models induced by AMPH (1 mg/kg).</p><p><strong>Results: </strong>We observed that Rdx-T564D in the NAcc core selectively inhibited the expression of non-associative locomotor sensitization induced by AMPH. Conversely, overexpression of Rdx-WT in this region inhibited both conditioned locomotor activity and context-specific locomotor sensitization. Spine analysis revealed that the increase in mature thin spine density observed in the context-paired group was specifically suppressed by Rdx-WT, but not by GFP or Rdx-T564D.</p><p><strong>Conclusions: </strong>This study revealed that associative and non-associative forms of AMPH-induced reward memory are differentially regulated by radixin manipulation in the NAcc core, suggesting a critical role of radixin in psychomotor stimulant addiction.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine differentially affects implicit and explicit memory processes in rats.","authors":"Bahar Yuksel, Zeynep Sen, Gunes Unal","doi":"10.1007/s00213-024-06720-8","DOIUrl":"10.1007/s00213-024-06720-8","url":null,"abstract":"<p><strong>Rationale: </strong>Ketamine, a non-competitive NMDA receptor antagonist, produces antidepressant effects at subanesthetic doses. The therapeutic effect, however, is often accompanied by cognitive side effects, including memory impairments. Yet, the specific effects of ketamine on different processes of implicit and explicit memory remain to be elucidated.</p><p><strong>Objectives: </strong>We examined the effect of an antidepressant dose of ketamine (10 mg/kg, IP) on the encoding, retrieval, and modulation processes of fear memory and spatial memory in adult Wistar rats.</p><p><strong>Methods: </strong>Ketamine was administered before the fear acquisition, retrieval, or extinction procedures in a Pavlovian fear conditioning task. In another set of experiments, it was administered before the training, probe trial, or reversal training phases of the Morris Water Maze (MWM).</p><p><strong>Results: </strong>The antidepressant dose of ketamine partially impaired fear extinction when administered before the acquisition or retrieval. In contrast, it facilitated memory modulation and decreased the escape latency in the first day of reversal training in the MWM when administered before the training or reversal training sessions. Encoding or retrieval performance in either type of memory was not affected.</p><p><strong>Conclusions: </strong>These findings show that ketamine does not impair the acquisition or retrieval processes of cued fear or spatial memory; but exerts differential effects on memory modulation of these implicit and explicit memory paradigms, by disrupting fear extinction and facilitating reversal spatial learning.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1245-1258"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans.","authors":"Elisabeth Prevete, Eef L Theunissen, Kim P C Kuypers, Riccardo Paci, Johannes T Reckweg, Mauro Cavarra, Stefan W Toennes, Sabrina Ritscher, Giuseppe Bersani, Ornella Corazza, Massimo Pasquini, Johannes G Ramaekers","doi":"10.1007/s00213-024-06734-2","DOIUrl":"10.1007/s00213-024-06734-2","url":null,"abstract":"<p><strong>Rationale: </strong>Despite the growing scientific interest on mitragynine, the primary alkaloid in kratom (Mitragyna Speciosa), there is a lack of clinical trials in humans.</p><p><strong>Objectives: </strong>This phase 1 study aimed to evaluate mitragynine's safety profile and acute effects on subjective drug experience, neurocognition, and pain tolerance.</p><p><strong>Methods: </strong>A placebo-controlled, single-blind, within-subjects study was conducted in two parts. In part A, eight healthy human volunteers received placebo and three doses of mitragynine (5, 10, and 20 mg) in a sequential dosing scheme, on separate days. In part B, a second group of seven volunteers received placebo and 40 mg of mitragynine. Vital signs, subjective drug experience, neurocognitive function, and pain tolerance were measured at regular intervals for 7 h after administration.</p><p><strong>Results: </strong>Overall, mitragynine did not affect most of the outcome measures at any dose. Yet, the lowest dose (5 mg) of mitragynine increased subjective ratings of arousal and attention, accuracy in a sustained attention task, and motor inhibition. The highest dose (40 mg) of mitragynine increased subjective ratings of amnesia and produced mild psychopathological symptoms. Mitragynine did not significantly affect vital signs, and only mild, transient side effects were reported.</p><p><strong>Conclusion: </strong>The present study suggests that low doses (5-10 mg) of mitragynine may cause subjective feelings of stimulation and enhance attention, while the highest dose (40 mg) may cause inhibitory feelings of amnesia and distress. Mitragynine doses up to 40 mg were well tolerated in this group.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1363-1376"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of GPR39 in treatment of stress-induced depression and anxiety.","authors":"Dominika Siodłak, Urszula Doboszewska, Gabriel Nowak, Piotr Wlaź, Katarzyna Mlyniec","doi":"10.1007/s00213-024-06736-0","DOIUrl":"10.1007/s00213-024-06736-0","url":null,"abstract":"<p><strong>Rationale: </strong>Chronic stress is one of the leading causes of depression. Yet, knowledge of the pathomechanism of this process still eludes us. Chronic unpredictable mild stress (CUMS) model of depression enables researchers to look for a root cause of the disease in mice by mimicking a stressful human environment.</p><p><strong>Objective: </strong>Since zinc has already been shown to impact the treatment of depression, in our study we aimed to shed light on the role of the zinc receptor GPR39 in stress-induced depression. We also aimed to highlight the role of GPR39 activation in monoamine-based antidepressant treatment.</p><p><strong>Methods: </strong>Using large battery of behavioural tests, we provided a detailed description of CUMS-induced phenotype in both - CD-1 and GPR39 knock-out mice.</p><p><strong>Results: </strong>Our experiments showed that combined treatment with TC-G 1008 (GPR39 agonist) and antidepressants produces stronger antidepressant-like effect of classic antidepressants. We also demonstrated the inter-strain differences in stress response and the greater stress susceptibility of GPR39 knock-out mice. The lack of GPR39 expression also either diminished or completely abolished the response to treatment with different antidepressants combined with TC-G 1008.</p><p><strong>Conclusions: </strong>The results show that GPR39 KO mice are more susceptible to chronic stress and that they are non-responsive to SSRI treatment. Utilizing various behavioural tests gave us much broader understanding not only of the role of GPR39 in depression treatment, but also of the importance of detailed behavioural description in a proper interpretation of the results. Further research with known selective agonists and antagonists of GPR39 will be necessary to understand the full potential of this receptor as a pharmacological target.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1377-1406"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}