Proceedings of the Nutrition Society最新文献

筛选
英文 中文
Nutrition in cancer survivorship: bridging the evidence-practice gap. 癌症生存中的营养-弥合证据与实践的差距。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-09 DOI: 10.1017/S0029665125102152
Laura Keaver, Niamh O'Callaghan, Katie E Johnston, Samantha J Cushen
{"title":"Nutrition in cancer survivorship: bridging the evidence-practice gap.","authors":"Laura Keaver, Niamh O'Callaghan, Katie E Johnston, Samantha J Cushen","doi":"10.1017/S0029665125102152","DOIUrl":"10.1017/S0029665125102152","url":null,"abstract":"<p><p>Nutrition plays a pivotal role in cancer survivorship, influencing not only long-term health outcomes but also quality of life and risk of recurrence. As advances in early detection and treatment have led to a growing global population of cancer survivors, attention has increasingly shifted from acute care to the promotion of sustained well-being and prevention of secondary health challenges. Despite growing evidence linking dietary patterns, body composition and metabolic health with survivorship outcomes, there remains significant variability in nutritional guidance, access to evidence-based interventions and integration of nutrition into oncology care. This review explores the current state of knowledge on nutrition in cancer survivorship, highlights key challenges faced by healthcare systems and patients and presents a new proposed model of care to optimise nutrition within survivorship care, bridging the evidence-practice gap.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-12"},"PeriodicalIF":4.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iodine deficiency in the UK - should we take it with a pinch of salt? 英国的碘缺乏症——我们应该对此持保留态度吗?
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-08 DOI: 10.1017/S0029665125102164
Sarah C Bath
{"title":"Iodine deficiency in the UK - should we take it with a pinch of salt?","authors":"Sarah C Bath","doi":"10.1017/S0029665125102164","DOIUrl":"10.1017/S0029665125102164","url":null,"abstract":"<p><p>Iodine deficiency is now a significant public-health concern in the UK. Data from the National Diet and Nutrition Survey (NDNS; 2019-2023) shows that several population groups are now classified as mildly iodine deficient, including women of childbearing age. This is a change from previous NDNS data where these groups were iodine sufficient. As iodine is needed for thyroid-hormone production, which are essential for brain development, iodine deficiency prior to, and during, pregnancy may have implications for child cognition - including lower IQ. However, the evidence base for the health effects of mild deficiency is not as strong as in severe deficiency. The WHO recommends salt iodisation to control iodine deficiency in a population, but such a policy was never introduced in the UK and iodised salt is not widely available. While UK milk is rich in iodine and is the principal source, the rise in popularity of plant-based milk alternatives may increase the risk of iodine deficiency. It may be necessary to give personalised advice to those with low iodine intake, but identify those at risk is challenging owing to a lack of a biomarker for iodine in an individual. Population-wide approaches may be required in the UK - for example, fortification of bread with iodised salt or mandatory iodine fortification of plant-based dairy alternatives. This review will critically discuss (i) the data on iodine deficiency in the UK (ii) the evidence base for the health implications of mild deficiency and (iii) the potential public-health solutions.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-8"},"PeriodicalIF":4.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medium-chain triglyceride supplementation in infants with biliary atresia: a review of the evidence for impacts on fat absorption, growth, nutritional status and clinical outcomes. 胆道闭锁婴儿补充中链甘油三酯:对脂肪吸收、生长、营养状况和临床结果影响的证据综述
IF 7.1 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-08 DOI: 10.1017/S0029665125102140
Sara Mancell, Anil Dhawan, Salma Ayis, Kevin Whelan
{"title":"Medium-chain triglyceride supplementation in infants with biliary atresia: a review of the evidence for impacts on fat absorption, growth, nutritional status and clinical outcomes.","authors":"Sara Mancell, Anil Dhawan, Salma Ayis, Kevin Whelan","doi":"10.1017/S0029665125102140","DOIUrl":"10.1017/S0029665125102140","url":null,"abstract":"<p><p>Biliary atresia is a rare bile duct disease resulting in intestinal bile salt depletion due to poor bile flow. Medium-chain triglyceride (MCT) supplementation is widely recommended and used as the main dietary management in infants, however evidence for its use is limited and there is uncertainty regarding the optimal percentage (proportion of total fat that is MCT) and dose (grams/kilogram/day, g/kg/d). The aim was to review the evidence for the impact of MCT on fat absorption, growth, nutritional status and clinical outcomes in infants with biliary atresia and the optimal nutrition profile of MCT supplementation. A scoping review found that the mostly observational, historic evidence for MCT supplementation pointed to greater fat absorption during MCT supplementation compared to no supplementation, but also some evidence of a risk of essential fatty acid deficiency with very high MCT percentage. Only six studies have investigated MCT percentages and only three reported MCT dose. One analysis of MCT in the largest cohort of biliary atresia patients ever presented (<i>n</i> = 200), found no association between MCT percentage with growth, nutritional status or clinical outcomes. Counterintuitively, there was an unexpected inverse association between MCT dose and growth. A possible interpretation was that increased MCT was a consequence of poor growth rather than a cause, as infants either drank more or dietitians prescribed more MCT as fat malabsorption worsened. In conclusion, MCT is widely recommended, however, the evidence for its use is lacking and there remains uncertainty about the optimum percentage and dose for infants with biliary atresia.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-8"},"PeriodicalIF":7.1,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary restriction in people living with an ileostomy: impacts on nutrition, hydration and quality of life. 回肠造口患者的饮食限制:对营养、水合作用和生活质量的影响
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-08 DOI: 10.1017/S0029665125102103
Niamh Magee, Erika Rosbotham, L Kirsty Pourshahidi, Pauline Douglas, Victoria Gilpin, Ellen Elizabeth Anne Simpson, James Davis, Chris I R Gill
{"title":"Dietary restriction in people living with an ileostomy: impacts on nutrition, hydration and quality of life.","authors":"Niamh Magee, Erika Rosbotham, L Kirsty Pourshahidi, Pauline Douglas, Victoria Gilpin, Ellen Elizabeth Anne Simpson, James Davis, Chris I R Gill","doi":"10.1017/S0029665125102103","DOIUrl":"10.1017/S0029665125102103","url":null,"abstract":"<p><p>In the UK, approximately 64,000 individuals are living with an ileostomy. This surgery creates an opening in the abdominal wall (stoma), allowing for diversion of egesta into a disposable pouch. This procedure impacts nutrient absorption meaning people living with an ileostomy may be subject to sub-optimal nutrition, often compounded by the low-fibre diet - which is frequently encouraged post-operatively. This review explores the restrictive dietary patterns of this population and their effects on nutrition and quality of life, alongside current approaches to improve dietary management and health outcomes. Dietary restriction beyond the post-operative period is frequently reported, with avoidance of high-fibre foods (e.g., fruits and vegetables) being most prevalent. These long-term dietary changes are presumed to impact nutritional status, with current evidence suggesting diminished bone mineral density and vitamin B12. High-output stoma (HOS) and dehydration are significant issues for people living with an ileostomy, and dietary management of stoma output and other ileostomy-related symptoms is a major contributor to food avoidance. The efficacy of oral rehydration solutions (ORS) in management of HOS is well-established; however, due to high concentrations of glucose and sodium, the palatability of such treatments is poor, impacting patient adherence. Encouragingly, personalised dietary advice has shown some positive effects on both quality of life and nutritional outcomes for people living with an ileostomy. However, a greater understanding of dietary management is needed, and there remains scope to improve current dietary advice and enable people living with an ileostomy to benefit from a more complete and unrestricted diet.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-14"},"PeriodicalIF":4.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of technology and machine learning to monitor diet in older adults; learning lessons to develop a new prototype. 技术和机器学习在监测老年人饮食中的作用;吸取教训,开发新的原型。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-07 DOI: 10.1017/S0029665125102097
Jenni Connelly, Anna C Whittaker
{"title":"The role of technology and machine learning to monitor diet in older adults; learning lessons to develop a new prototype.","authors":"Jenni Connelly, Anna C Whittaker","doi":"10.1017/S0029665125102097","DOIUrl":"10.1017/S0029665125102097","url":null,"abstract":"<p><p>Positive food consumption remains one of the most common challenges among older adults in the UK with at least 10% in community settings and up to 45% in care homes affected by malnutrition. It is strongly associated with frailty, functional and health decline. Tracking and understanding the impact of diet is not easy. There are problems with monitoring diet and malnutrition screening such as difficulty remembering, lack of time, or needing a dietician to interpret the results. Computerised tailored education may be a positive solution to these issues. Due to the rise in smartphone ownership the use of technology to monitor diet is becoming more popular. This review paper will aim to look at the issues with current methods of dietary monitoring particularly in older adults, it will present the benefits and barriers of using to monitor food intake. It will discuss how a photo food monitoring app was developed to address the current issues with technology and how it was tested with older adults living in community and care settings. The prototype was co-developed and incorporated automated food classification to monitor dietary intake and food preferences and tested with older adults. The prototype was usable to both older adults and care workers and feedback on how to improve its use was collected. Key design improvements to make it quicker and more accurate were suggested for future testing in this population. With adaptions this prototype could be beneficial to older adults living in both community and care settings.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-7"},"PeriodicalIF":4.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food-based strategies to mitigate protein-energy undernutrition in later life. 以食物为基础的策略以减轻晚年的蛋白质能量营养不良。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-07 DOI: 10.1017/S0029665125102127
Taibat Ibitoye, Lisa Methven, Miriam E Clegg
{"title":"Food-based strategies to mitigate protein-energy undernutrition in later life.","authors":"Taibat Ibitoye, Lisa Methven, Miriam E Clegg","doi":"10.1017/S0029665125102127","DOIUrl":"10.1017/S0029665125102127","url":null,"abstract":"<p><p>Ensuring adequate food intake among older people is essential for maintaining health and preventing malnutrition. This review explores strategies to enhance dietary intake in this population group. Several key interventions are highlighted, including offering high-energy and protein-fortified meals and snacks, optimising the visual appeal and presentation of foods, enhancing flavours, and providing finger foods or modified textures to support consumption. Familiarity with fortified foods may encourage acceptance and increase intake, while improving food aesthetics and incorporating varied flavours can enhance enjoyment and promote consumption. Flavour enhancement may help compensate for decline in smell and taste sensitivity often experienced by older people, helping to sustain interest in food and promote greater intake. Finger foods present a practical solution for older adults with physical impairments, allowing for easier handling and self-feeding. Additionally, for individuals with dysphagia or chewing difficulties, texture-modified diets tailored to their needs support safe food intake. Research suggests that refining food presentation through techniques such as moulding and 3D printing may improve palatability and appeal, potentially boosting consumption among older adults. Addressing sensory preferences and physical challenges associated with eating is critical to ensuring adequate nutrition and promoting overall wellbeing in the elderly population. This review underscores the importance of multifaceted dietary strategies, advocating for personalised interventions that align with older individuals' needs and preferences to enhance food intake and nutritional status.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-7"},"PeriodicalIF":4.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaborating with 'blue food' system stakeholders to achieve optimal nutritional health and wellbeing in less affluent communities. 与“蓝色食品”系统利益相关者合作,在不太富裕的社区实现最佳营养健康和福祉。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2026-01-07 DOI: 10.1017/S0029665125102139
Clare Pettinger, Louise Hunt, Carol Wagstaff
{"title":"Collaborating with 'blue food' system stakeholders to achieve optimal nutritional health and wellbeing in less affluent communities.","authors":"Clare Pettinger, Louise Hunt, Carol Wagstaff","doi":"10.1017/S0029665125102139","DOIUrl":"10.1017/S0029665125102139","url":null,"abstract":"<p><p>UK food system transformation is urgently needed, but to date, minimal research has investigated 'blue foods' probably because they are ethically nuanced. There exists a paradox whereby materially deprived communities should be eating more fish to meet nutritional requirements, yet there is a global 'red flag' around global overfishing. New collaborative and creative solutions are, therefore, needed to tackle such food system inequities. By working together, all voices can be equally heard when decisions are being made to improve the system. Similarly, innovation and disruption of established supply chains will enable better access to healthy, affordable and tasty food that will support better nutrition, health and wellbeing. This review paper will present a critique of the 'The Plymouth Fish Finger' as a collaborative social innovation case study. Part of the FoodSEqual research project, this exploratory pilot project championed 'co-production' approaches to achieve multiple (potential) impacts. This review will critically explore how this social innovation case study has exemplified the complex interplay between factors driving distortions in access to and availability of fish within the local food system. Through collaborative multi-stakeholder (transdisciplinary) processes, using participatory creative methods, new strategies and recommendations for research, practice, action and policy are informed, all of which offer great potential for progressive and transformative systemic (blue) food system change.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-10"},"PeriodicalIF":4.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focussing on appetite decline to optimise management of undernutrition in later life: a geriatric medicine perspective. 关注食欲下降以优化晚年营养不良的管理-老年医学观点。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2025-12-29 DOI: 10.1017/S0029665125102115
Natalie J Cox, Liam Jones, Stephen E R Lim
{"title":"Focussing on appetite decline to optimise management of undernutrition in later life: a geriatric medicine perspective.","authors":"Natalie J Cox, Liam Jones, Stephen E R Lim","doi":"10.1017/S0029665125102115","DOIUrl":"10.1017/S0029665125102115","url":null,"abstract":"<p><p>Undernutrition is common amongst older people and can lead to adverse health outcomes and increased dependence. This review focuses on an aspect of undernutrition that is often overlooked, namely loss of appetite, and will discuss the challenges in this under-researched field from the perspective of geriatric medicine. Appetite decline is common in later life and predicts undernutrition in older populations. As such, timely identification and intervention on poor appetite could delay onset or progression of undernutrition to optimise healthy ageing and maintain independence. In addition, management of undernutrition ultimately requires the individual to meet their nutritional requirements. However, unless attention is paid to mitigating appetite decline, strategies to improve intake are likely to be ineffective. Treatment for appetite decline is challenging due to the multiple and complex underlying mechanisms. Current evidence is limited to a few trials targeting older people including flavour enhancement and fortification or supplementation, lifestyle measures such as increasing physical activity and social interaction, and medications, all with mixed results. Progress on treatments for appetite decline has been hampered by a lack of distinction from undernutrition but also perhaps the approach to it as a concept. Categorising appetite decline in ageing as a geriatric syndrome could aid progress in the unification of approaches to mechanistic research, assessment and management strategies, which are likely to be most effective when in multi-component form and underpinned by the principles of Comprehensive Geriatric Assessment (CGA).</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-6"},"PeriodicalIF":4.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a more nuanced understanding of policies that lead to food reformulation for a food system change. 朝着更细致入微地理解导致粮食系统变化的粮食重新配方的政策。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2025-12-26 DOI: 10.1017/S002966512510205X
Kawther Hashem
{"title":"Towards a more nuanced understanding of policies that lead to food reformulation for a food system change.","authors":"Kawther Hashem","doi":"10.1017/S002966512510205X","DOIUrl":"https://doi.org/10.1017/S002966512510205X","url":null,"abstract":"<p><p>The aim of this paper is to review the latest evidence on food reformulation as a public health policy to improve our understanding of how different policy designs can drive reformulation and influence food system change. The focus is on three key nutrients of concern-trans fatty acids, salt and sugar.In recent times, food reformulation has been categorised as either mandatory or voluntary, a distinction that can help assess policy effectiveness. However, this binary classification oversimplifies a far more complex landscape. Some policies-whether mandated by government or voluntarily suggested to industry-are explicitly intended to trigger reformulation. Others, by contrast, may have never been designed with the intention to encourage reformulation but have nonetheless prompted significant changes in product composition, intake and potential health outcomes.Within what is commonly described as mandatory reformulation, for example, we find a broad mix of policy tools that operate very differently. Some, such as the UK's Soft Drinks Industry Levy, were deliberately created to incentivise reformulation by applying financial pressure. Others, including front of pack nutrition labelling systems (particularly warning labels) and school food standards have encouraged reformulation only as a positive unintended consequence. These indirect drivers are not always evaluated for their impact on reformulation, which may lead to an incomplete understanding of their contribution to reducing intake nutrients of concern and health outcomes.Nevertheless, emerging evidence suggests no single policy encourages reformulation alone, instead a combination of approaches are likely to drive it and contribute to meaningful and sustained food system change.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-23"},"PeriodicalIF":4.5,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies. 生命早期营养、表观遗传学和终身健康——来自队列和干预研究的证据。
IF 4.5 2区 医学
Proceedings of the Nutrition Society Pub Date : 2025-12-26 DOI: 10.1017/S0029665125102061
Keith M Godfrey, Paula Costello, Sarah El-Heis
{"title":"Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies.","authors":"Keith M Godfrey, Paula Costello, Sarah El-Heis","doi":"10.1017/S0029665125102061","DOIUrl":"10.1017/S0029665125102061","url":null,"abstract":"<p><p>This review summarises evidence from cohort and intervention studies on the relationships between nutrition in early life, epigenetics and lifelong health. Established links include maternal diet quality with conception rates, micronutrient sufficiency before and during pregnancy with preterm birth prevention, gestational vitamin D intake with offspring bone health, preconception iodine status with child IQ, adiposity with offspring obesity and maternal stress with childhood atopic eczema. Animal studies demonstrate that early-life environmental exposures induce lasting phenotypic changes via epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA, with DNA methylation of non-imprinted genes most extensively studied. Human data show that nutrition during pregnancy induces epigenetic changes associated with childhood obesity risk, such as Antisense long Non-coding RNA in the INK4 Locus (ANRIL, a long non-coding RNA) methylation variations linked to obesity and replicated across multiple populations. Emerging insights reveal that paternal nutrition and lifestyle also modify sperm epigenomics and influence offspring development. Although nutritional-randomised trials in pregnancy remain limited, findings from the NiPPeR trial showed widespread preconception micronutrient deficiencies and indicated that maternal preconception and pregnancy nutritional supplementation can reduce preterm birth and early childhood obesity. The randomised trials UPBEAT and MAVIDOS have shown that nutritional intervention can impact offspring epigenetics. Postnatal nutritional exposures further influence offspring epigenetic profiles, exemplified by ALSPAC cohort findings linking rapid infant weight gain to later methylation changes and increased obesity risk. Together, these studies support a persistent impact of maternal and early-life nutrition on child health and development, underpinned by modifiable epigenetic processes.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-6"},"PeriodicalIF":4.5,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书