Psychopharmacologia最新文献_第9页

Effect of cortisone, aldosterone and nialamide on "amphetamine stereotypies" and brain methamphetamine levels of adrenalectomized rats. 可的松、醛固酮和烟酰胺对去肾上腺大鼠“安非他命刻板印象”和脑甲基苯丙胺水平的影响。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421121

M Kobayashi, E Arai

引用次数: 1

The effect of pyrithioxine and pyridoxine on individual behavior, social interactions, and learning in rats malnourished in early postnatal life. pyrithioxine和pyridoxine对产后早期营养不良大鼠个体行为、社会互动和学习的影响。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421122

K Tikal, O Benesová, S Franková

{"title":"The effect of pyrithioxine and pyridoxine on individual behavior, social interactions, and learning in rats malnourished in early postnatal life.","authors":"K Tikal, O Benesová, S Franková","doi":"10.1007/BF00421122","DOIUrl":"https://doi.org/10.1007/BF00421122","url":null,"abstract":"Low protein (LP) or low calorie (LC) dietary regimens were applied in early postnatal life(1st-40th day of life) in male rats. After nutritional rehabilitation, open-field behavior in larger more illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), dyadic interactions, and learning ability were investigated in these animals as adults (between the 200th to 300th day of life). LP malnutrition induced an increase of open-field activity with features of sterotypy both in LI and HI situations, an increase number of intersignal reactions during learning procedures without changes in other registered criteria of learning ability (latency, number of correct responses), and an increase of aggressive behavior in pair interaction. LC rats revealed only significant inhibition in LI--open-field activity and a slightly increased number in intersignal reactions during avoidance learning. With the aim of preventing previously described long-term deviations in early malnourished rats, some groups of animals with the above-mentioned early calorie or protein deficits were treated with pyrithioxine (Encephabol Merck) or pyridoxine in 10 doses of 40 mg/kg i.p. administered in the period when nutritional rehabilitation was carried out (between the 40th--50th day of life). The treatment with pyrithioxine reduced significantly behavioral disturbances in adult LP rats except the increase of intersignal reactions which was even potentiated. Pyridoxine was less effective but normalized the increase number of intersignal reactions both in LP and LC rats. The effect of pyridoxine of adult LC rats was interesting. There was significant improvement in all registered parameters of avoidance learning and a significant increase of sexual acts was recorded.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00421122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12167844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Methamphetamine self-administration in the cat. 猫自我给药甲基苯丙胺。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421107

R L Balster, M M Kilbey, E H Ellinwood

引用次数: 19

The effect of delta 9-tetrahydrocannabinol and LSD on the acquisition of an active avoidance response in the rat. 9-四氢大麻酚和LSD对大鼠获得主动回避反应的影响。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421110

P G Waser, A Martin, L Heer-Carcano

{"title":"The effect of delta 9-tetrahydrocannabinol and LSD on the acquisition of an active avoidance response in the rat.","authors":"P G Waser, A Martin, L Heer-Carcano","doi":"10.1007/BF00421110","DOIUrl":"https://doi.org/10.1007/BF00421110","url":null,"abstract":"The course of active avoidance learning of rats in a symmetrical Y-maze under the influence of 1, 3, and 9 mg/kg of delta 9-THC i.p., and 5, 20, and mug/kg of LSD was investigated. Delta-THC in a dosage of 1 mg/kg had no effect on avoidance learning. Three to a lesser extent 9 mg/kg produced more rapid learning with a significantly better performance. Learning under delta 9-THC proved to be state-dependent. The withdrawal of delta 9-THC caused a decrease in the avoidance rate, which was dependent on the dosage. Upon renewal of the THC doses, the animals reattained their earlier preformance. In the course of the experiment there was rapid tolerance development, especially of the sedative properties of THC. LSD retarded the rate of acquisition of the active avoidance response. Whereas the control animals displayed over 80% successful active avoidance from the 14th session onwards, this was achieved by the LSD groups only after the 20th session. However, in contrast to the control group the LSD animals were able to increase their avoidance rate to over 90%, and this was maintained to the end of the experiment (a total of 24 sessions with LSD). The sudden withdrawal of LSD produced a fall in avoidance rate, which was dependent on the pervious training dosage; as with delta 9-THC state-dependent learning can also be assumed for LSD.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00421110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12134451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Electrophysiological effects of triiodothyronine and propranolol. 三碘甲状腺原氨酸和心得安的电生理效应。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421115

J J Straumanis, C Shagass

引用次数: 3

Rate-dependent effect of amphetamine in rats: extension to between-subjects effect. 安非他明对大鼠的速率依赖效应:扩展到受试者间效应。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421119

M D Beecher, D E Jackson

引用次数: 4

The effects of high doses of oxprenolol and of propranolol on pursuit rotor performance, reaction time and critical flicker frequency. 大剂量奥普萘洛尔和心得安对跟踪转子性能、反应时间和临界闪烁频率的影响。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421117

C W Ogle, P Turner, H Markomihelakis

{"title":"The effects of high doses of oxprenolol and of propranolol on pursuit rotor performance, reaction time and critical flicker frequency.","authors":"C W Ogle, P Turner, H Markomihelakis","doi":"10.1007/BF00421117","DOIUrl":"https://doi.org/10.1007/BF00421117","url":null,"abstract":"The effects of oral oxprenolol (320 mg) or propranolol (240 or 320 mg) and of diazepam (5 mg) or lorazepam (2 mg) on pursuit rotor performance, reaction time and critical flicker frequency were investigated in healthy subjects in 3 separate studies. A 240-mg dose of propranolol significantly impaired pursuit rotor performance but not 320 mg of propranolol or oxprenolol. Both beta-adrenoceptor blockers did not affect reaction time or critical flicker frequency. Diazepam impaired pursuit rotor performance and reaction time, but not critical flicker frequency. Lorazepam generally impaired all three parameters. The findings suggest that it is possible for beta-adrenoceptor blockers to depress skeletal muscle activity without having a central effect, as shown by impairment of CNS function tests which rely also on muscle coordination but not of those relying only on central activity. These results also show that single oral doses of oxprenolol or propranolol, as high as 320 mg, do not have central effects, and support the belief that small anxiolytic doses of these blockers exert their actions through peripheral blockade of beta-adrenoceptors.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00421117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12134456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Hormonal influences of the extinction of conditioned taste aversion. 条件性味觉厌恶消退的激素影响。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421111

H Rigter, A Popping

引用次数: 17

Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs. δ 9-四氢大麻酚、乙醇和安非他明与其他药物的区别性刺激推广试验。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421108

O F Bueno, E A Carlini, E Finkelfarb, J S Suzuki

引用次数: 18

Differential potency of taste and audiovisual stimuli in the conditioning of morphine withdrawal in rats. 味觉和视听刺激在吗啡戒断大鼠条件反射中的不同效力。

Psychopharmacologia Pub Date : 1976-04-15 DOI: 10.1007/BF00421109

K Frumkin

引用次数: 12