猫自我给药甲基苯丙胺。

R L Balster, M M Kilbey, E H Ellinwood
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引用次数: 19

摘要

本文描述了一种研究猫体内静脉药物自我给药的方法。10只猫被给予24小时甲基苯丙胺强化(0.04 mg/kg/注射)。受试者对药物强化的反应率明显高于生理盐水。几天内自我给药的模式在高剂量和低剂量期间交替进行。另外还使用了6只猫来研究在有限接触条件下每次注射剂量对甲基苯丙胺自我给药的影响。当每次输注不同剂量的甲基苯丙胺替代可卡因强化维持的动物时,反应率显示为剂量的倒u型函数。这些研究表明,甲基苯丙胺在猫体内是一种强化物,其在24小时和有限获取条件下的摄入模式与其他物种相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Methamphetamine self-administration in the cat.

A procedure for studing intravenous drug self-administration in the cat is described. Ten cats were given 24-h access to methamphetamine reinforcement (0.04 mg/kg/inj). The subjects maintained a significantly higher response rate for drug reinforcement than for saline. The pattern of self-administration over days alternated between periods of high and low drug intake. Six additional cats were used to study the effect of dose per injection on methamphetamine self-administration under conditions of limited access. When methamphetamine was subtituted at various doses per infusion in animals maintained on cocaine reinforcement, response rate was shown to be an inverted U-shaped function of dose. These studies demonstrate that methamphetamine is a reinforcer in the cat and its patterns of intake under conditions of 24-h and limited access resemble other species.

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