The effect of pyrithioxine and pyridoxine on individual behavior, social interactions, and learning in rats malnourished in early postnatal life.

K Tikal, O Benesová, S Franková
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引用次数: 13

Abstract

Low protein (LP) or low calorie (LC) dietary regimens were applied in early postnatal life(1st-40th day of life) in male rats. After nutritional rehabilitation, open-field behavior in larger more illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), and smaller, less illuminated boxes (HI, high intensity stimulus), dyadic interactions, and learning ability were investigated in these animals as adults (between the 200th to 300th day of life). LP malnutrition induced an increase of open-field activity with features of sterotypy both in LI and HI situations, an increase number of intersignal reactions during learning procedures without changes in other registered criteria of learning ability (latency, number of correct responses), and an increase of aggressive behavior in pair interaction. LC rats revealed only significant inhibition in LI--open-field activity and a slightly increased number in intersignal reactions during avoidance learning. With the aim of preventing previously described long-term deviations in early malnourished rats, some groups of animals with the above-mentioned early calorie or protein deficits were treated with pyrithioxine (Encephabol Merck) or pyridoxine in 10 doses of 40 mg/kg i.p. administered in the period when nutritional rehabilitation was carried out (between the 40th--50th day of life). The treatment with pyrithioxine reduced significantly behavioral disturbances in adult LP rats except the increase of intersignal reactions which was even potentiated. Pyridoxine was less effective but normalized the increase number of intersignal reactions both in LP and LC rats. The effect of pyridoxine of adult LC rats was interesting. There was significant improvement in all registered parameters of avoidance learning and a significant increase of sexual acts was recorded.

pyrithioxine和pyridoxine对产后早期营养不良大鼠个体行为、社会互动和学习的影响。
在雄性大鼠出生后早期(出生后第1 ~ 40天)采用低蛋白(LP)或低热量(LC)饮食方案。在营养康复后,研究了这些动物成年后(在第200至300天)在较大的照明箱(HI,高强度刺激)、较小的照明箱(HI,高强度刺激)、较小的照明箱(HI,高强度刺激)和较小的照明箱(HI,高强度刺激)中的开场行为、双元相互作用和学习能力。LP营养不良导致LI和HI情境下具有刻板印象特征的开放领域活动增加,学习过程中信号间反应数量增加,而其他学习能力标准(延迟,正确反应数量)没有改变,并且在配对互动中攻击性行为增加。LC大鼠在回避学习过程中仅表现出LI- open-field活性的显著抑制和信号间反应的轻微增加。为了防止先前描述的早期营养不良大鼠的长期偏差,在进行营养康复期间(在生命的第40 -50天之间),对一些具有上述早期卡路里或蛋白质缺陷的动物组进行了10次吡硫辛(Encephabol Merck)或吡哆醇治疗,每次剂量为40 mg/kg。pyrithioxine治疗显著减少了成年LP大鼠的行为障碍,但信号间反应增加甚至增强。吡哆醇效果较差,但使LP和LC大鼠的信号间反应数量增加正常化。吡哆醇对成年LC大鼠的作用令人感兴趣。回避学习的各项指标均有显著改善,性行为显著增加。
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