Effect of cortisone, aldosterone and nialamide on "amphetamine stereotypies" and brain methamphetamine levels of adrenalectomized rats.

M Kobayashi, E Arai
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引用次数: 1

Abstract

Cortisone, aldosterone or nialamide was administered to adrenalectomized or sham-operated rats for 7 days, and methamphetamine was injected 24 hrs after the last injection of these compounds. Stereotyped head movement and licking activity were scored 5 min, 30 min and 60 min after methamphetamine injection and, in parallel brain methamphetamine levels in similarly treated rats were measured 5 min, 30 min and 60 min after the methamphetamine injection. Adrenalectomy depressed stereotyped head movements but enhanced the brain amphetamine accumulation. Nialamide but not the hormones further increased the amphetamine accumulation in adrenalectomized rats. No drugs had any effect on the amphetamine-induced head movement suppressed by adrenalectomy.

可的松、醛固酮和烟酰胺对去肾上腺大鼠“安非他命刻板印象”和脑甲基苯丙胺水平的影响。
肾上腺切除或假手术大鼠连续7天给予可的松、醛固酮或烟酰胺,最后一次注射后24小时注射甲基苯丙胺。在注射甲基苯丙胺后5分钟、30分钟和60分钟对刻板的头部运动和舔舐活动进行评分,同时在注射甲基苯丙胺后5分钟、30分钟和60分钟测量同样处理的大鼠的脑甲基苯丙胺水平。肾上腺切除术抑制了刻板的头部运动,但增加了大脑安非他明的积累。烟酰胺而非激素进一步增加了去肾上腺大鼠的安非他明蓄积。没有药物对安非他明引起的肾上腺切除术抑制的头部运动有任何影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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