Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第8页

Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases. 小分子有机化合物治疗重复性疾病的可能性和挑战。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.003

Kazuhiko Nakatani

引用次数: 4

Functional genomics in plant abiotic stress responses and tolerance: From gene discovery to complex regulatory networks and their application in breeding. 植物非生物胁迫响应和耐受性的功能基因组学:从基因发现到复杂调控网络及其在育种中的应用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.024

Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki

{"title":"Functional genomics in plant abiotic stress responses and tolerance: From gene discovery to complex regulatory networks and their application in breeding.","authors":"Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki","doi":"10.2183/pjab.98.024","DOIUrl":"https://doi.org/10.2183/pjab.98.024","url":null,"abstract":"Land plants have developed sophisticated systems to cope with severe stressful environmental conditions during evolution. Plants have complex molecular systems to respond and adapt to abiotic stress, including drought, cold, and heat stress. Since 1989, we have been working to understand the complex molecular mechanisms of plant responses to severe environmental stress conditions based on functional genomics approaches with Arabidopsis thaliana as a model plant. We focused on the function of drought-inducible genes and the regulation of their stress-inducible transcription, perception and cellular signal transduction of stress signals to describe plant stress responses and adaptation at the molecular and cellular levels. We have identified key genes and factors in the regulation of complex responses and tolerance of plants in response to dehydration and temperature stresses. In this review article, we describe our 30-year experience in research and development based on functional genomics to understand sophisticated systems in plant response and adaptation to environmental stress conditions.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 8","pages":"470-492"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/0e/pjab-98-470.PMC9614206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33519997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Metabolomics of clinical samples reveal the treatment mechanism of lanthanum hydroxide on vascular calcification in chronic kidney disease. 临床样品的代谢组学研究揭示了氢氧化镧对慢性肾病血管钙化的治疗机制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.019

Chao Gu, Yuan Gao, Ruilan Han, Min Guo, Hong Liu, Jie Gao, Yang Liu, Bing Li, Lijun Sun, Ren Bu, Yang Liu, Jian Hao, Yan Meng, Ming An, Xiaodong Cao, Changhai Su, Gang Li

{"title":"Metabolomics of clinical samples reveal the treatment mechanism of lanthanum hydroxide on vascular calcification in chronic kidney disease.","authors":"Chao Gu, Yuan Gao, Ruilan Han, Min Guo, Hong Liu, Jie Gao, Yang Liu, Bing Li, Lijun Sun, Ren Bu, Yang Liu, Jian Hao, Yan Meng, Ming An, Xiaodong Cao, Changhai Su, Gang Li","doi":"10.2183/pjab.98.019","DOIUrl":"https://doi.org/10.2183/pjab.98.019","url":null,"abstract":"Previous studies showed that lanthanum hydroxide (LH) has a therapeutic effect on chronic kidney disease (CKD) and vascular calcification, which suggests that it might have clinical value. However, the target and mechanism of action of LH are unclear. Metabolomics of clinical samples can be used to predict the mechanism of drug action. In this study, metabolomic profiles in patients with end-stage renal disease (ESRD) were used to screen related signaling pathways, and we verified the influence of LH on the ROS-PI3K-AKT-mTOR-HIF-1α signaling pathway by western blotting and quantitative real-time RT-qPCR in vivo and in vitro. We found that ROS and SLC16A10 genes were activated in patients with ESRD. The SLC16A10 gene is associated with six significant metabolites (L-cysteine, L-cystine, L-isoleucine, L-arginine, L-aspartic acid, and L-phenylalanine) and the PI3K-AKT signaling pathway. The results showed that LH inhibits the ESRD process and its cardiovascular complications by inhibiting the ROS-PI3K-AKT-mTOR-HIF-1α signaling pathway. Collectively, LH may be a candidate phosphorus binder for the treatment of vascular calcification in ESRD.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 7","pages":"361-377"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/b3/pjab-98-361.PMC9363596.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones. 生物活性糖基胺的设计与合成:从糖苷酶抑制剂到药理学伴侣。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.018

Seiichiro Ogawa, Shinichi Kuno, Tatsushi Toyokuni

引用次数: 0

The UHRF protein family in epigenetics, development, and carcinogenesis. UHRF蛋白家族在表观遗传学、发育和癌变中的作用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.021

Motoko Unoki, Hiroyuki Sasaki

引用次数: 5

Recent volcanic activity at the Asama volcano and long-period seismic signals. 浅间火山最近的火山活动和长周期地震信号。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.022

Minoru Takeo, Yosuke Aoki, Takao Koyama

引用次数: 1

Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition. 卵母细胞向胚胎转变过程中，胞内吞噬和自噬在细胞内重塑中的多重作用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.013

Ken Sato

{"title":"Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition.","authors":"Ken Sato","doi":"10.2183/pjab.98.013","DOIUrl":"https://doi.org/10.2183/pjab.98.013","url":null,"abstract":"Fertilization is the starting point for creating new progeny. At this time, the highly differentiated oocyte and sperm fuse to form one zygote, which is then converted into a pluripotent early embryo. Recent studies have shown that the lysosomal degradation system via autophagy and endocytosis plays important roles in the remodeling of intracellular components during oocyte-to-embryo transition. For example, in Caenorhabditis elegans, zygotes show high endocytic activity, and some populations of maternal membrane proteins are selectively internalized and delivered to lysosomes for degradation. Furthermore, fertilization triggers selective autophagy of sperm-derived paternal mitochondria, which establishes maternal inheritance of mitochondrial DNA. In addition, it has been shown that autophagy via liquid-liquid phase separation results in the selective degradation of some germ granule components, which are distributed to somatic cells of early embryos. This review outlines the physiological functions of the lysosomal degradation system and its molecular mechanisms in C. elegans and mouse embryos.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 5","pages":"207-221"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/02/pjab-98-207.PMC9130481.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10251416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

From Nobeyama Radio Observatory to the international project ALMA -Evolution of millimeter and submillimeter wave astronomy in Japan. 从野山射电天文台到国际项目ALMA -日本毫米波和亚毫米波天文学的发展。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.023

Masato Ishiguro, Kurazo Chiba, Seiichi Sakamoto

{"title":"From Nobeyama Radio Observatory to the international project ALMA -Evolution of millimeter and submillimeter wave astronomy in Japan.","authors":"Masato Ishiguro, Kurazo Chiba, Seiichi Sakamoto","doi":"10.2183/pjab.98.023","DOIUrl":"https://doi.org/10.2183/pjab.98.023","url":null,"abstract":"The establishment of the Nobeyama Radio Observatory (NRO) in 1982 was an important event that greatly influenced the subsequent development of Japanese astronomy. The 45 m radio telescope and the Nobeyama Millimeter Array (NMA) pushed Japanese radio astronomy to the forefront of the world. As a plan beyond the Nobeyama telescopes, the Japanese radio astronomy community considered a large array to achieve unprecedented resolution at millimeter and submillimeter wavelengths under the project name of the Large Millimeter and Submillimeter Array (LMSA). After long and patient discussions and negotiations with the United States and Europe, the LMSA plan eventually led to the ALMA (Atacama Large Millimeter/submillimeter Array) as an international joint project, and the ALMA was inaugurated in 2013. This paper reviews the process from the establishment of the NRO to the realization of the ALMA, including planning of the LMSA, international negotiations, site survey, instrumental developments, and initial science results.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 8","pages":"439-469"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/f6/pjab-98-439.PMC9614208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33519994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bacteria with a mouth: Discovery and new insights into cell surface structure and macromolecule transport. 有嘴的细菌:对细胞表面结构和大分子运输的发现和新见解。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.027

Kousaku Murata, Shigeyuki Kawai, Wataru Hashimoto

{"title":"Bacteria with a mouth: Discovery and new insights into cell surface structure and macromolecule transport.","authors":"Kousaku Murata, Shigeyuki Kawai, Wataru Hashimoto","doi":"10.2183/pjab.98.027","DOIUrl":"https://doi.org/10.2183/pjab.98.027","url":null,"abstract":"A bacterium with a \"mouth\"-like pit structure isolated for the first time in the history of microbiology was a Gram-negative rod, containing glycosphingolipids in the cell envelope, and named Sphingomonas sp. strain A1. The pit was dynamic, with repetitive opening and closing during growth on alginate, and directly included alginate concentrated around the pit, particularly by flagellins, an alginate-binding protein localized on the cell surface. Alginate incorporated into the periplasm was subsequently transferred to the cytoplasm by cooperative interactions of periplasmic solute-binding proteins and an ATP-binding cassette transporter in the cytoplasmic membrane. The mechanisms of assembly, functions, and interactions between the above-mentioned molecules were clarified using structural biology. The pit was transplanted into other strains of sphingomonads, and the pitted recombinant cells were effectively applied to the production of bioethanol, bioremediation for dioxin removal, and other tasks. Studies of the function of the pit shed light on the biological significance of cell surface structures and macromolecule transport in bacteria.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 10","pages":"529-552"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/d7/pjab-98-529.PMC9751261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10723739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural studies of functional nucleosome complexes with transacting factors. 具有交易因子的功能性核小体复合物的结构研究。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.001

Hitoshi Kurumizaka

引用次数: 1