Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第8页

Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition. 卵母细胞向胚胎转变过程中，胞内吞噬和自噬在细胞内重塑中的多重作用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.013

Ken Sato

{"title":"Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition.","authors":"Ken Sato","doi":"10.2183/pjab.98.013","DOIUrl":"https://doi.org/10.2183/pjab.98.013","url":null,"abstract":"Fertilization is the starting point for creating new progeny. At this time, the highly differentiated oocyte and sperm fuse to form one zygote, which is then converted into a pluripotent early embryo. Recent studies have shown that the lysosomal degradation system via autophagy and endocytosis plays important roles in the remodeling of intracellular components during oocyte-to-embryo transition. For example, in Caenorhabditis elegans, zygotes show high endocytic activity, and some populations of maternal membrane proteins are selectively internalized and delivered to lysosomes for degradation. Furthermore, fertilization triggers selective autophagy of sperm-derived paternal mitochondria, which establishes maternal inheritance of mitochondrial DNA. In addition, it has been shown that autophagy via liquid-liquid phase separation results in the selective degradation of some germ granule components, which are distributed to somatic cells of early embryos. This review outlines the physiological functions of the lysosomal degradation system and its molecular mechanisms in C. elegans and mouse embryos.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 5","pages":"207-221"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/02/pjab-98-207.PMC9130481.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10251416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

From Nobeyama Radio Observatory to the international project ALMA -Evolution of millimeter and submillimeter wave astronomy in Japan. 从野山射电天文台到国际项目ALMA -日本毫米波和亚毫米波天文学的发展。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.023

Masato Ishiguro, Kurazo Chiba, Seiichi Sakamoto

{"title":"From Nobeyama Radio Observatory to the international project ALMA -Evolution of millimeter and submillimeter wave astronomy in Japan.","authors":"Masato Ishiguro, Kurazo Chiba, Seiichi Sakamoto","doi":"10.2183/pjab.98.023","DOIUrl":"https://doi.org/10.2183/pjab.98.023","url":null,"abstract":"The establishment of the Nobeyama Radio Observatory (NRO) in 1982 was an important event that greatly influenced the subsequent development of Japanese astronomy. The 45 m radio telescope and the Nobeyama Millimeter Array (NMA) pushed Japanese radio astronomy to the forefront of the world. As a plan beyond the Nobeyama telescopes, the Japanese radio astronomy community considered a large array to achieve unprecedented resolution at millimeter and submillimeter wavelengths under the project name of the Large Millimeter and Submillimeter Array (LMSA). After long and patient discussions and negotiations with the United States and Europe, the LMSA plan eventually led to the ALMA (Atacama Large Millimeter/submillimeter Array) as an international joint project, and the ALMA was inaugurated in 2013. This paper reviews the process from the establishment of the NRO to the realization of the ALMA, including planning of the LMSA, international negotiations, site survey, instrumental developments, and initial science results.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 8","pages":"439-469"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/f6/pjab-98-439.PMC9614208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33519994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bacteria with a mouth: Discovery and new insights into cell surface structure and macromolecule transport. 有嘴的细菌:对细胞表面结构和大分子运输的发现和新见解。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.027

Kousaku Murata, Shigeyuki Kawai, Wataru Hashimoto

{"title":"Bacteria with a mouth: Discovery and new insights into cell surface structure and macromolecule transport.","authors":"Kousaku Murata, Shigeyuki Kawai, Wataru Hashimoto","doi":"10.2183/pjab.98.027","DOIUrl":"https://doi.org/10.2183/pjab.98.027","url":null,"abstract":"A bacterium with a \"mouth\"-like pit structure isolated for the first time in the history of microbiology was a Gram-negative rod, containing glycosphingolipids in the cell envelope, and named Sphingomonas sp. strain A1. The pit was dynamic, with repetitive opening and closing during growth on alginate, and directly included alginate concentrated around the pit, particularly by flagellins, an alginate-binding protein localized on the cell surface. Alginate incorporated into the periplasm was subsequently transferred to the cytoplasm by cooperative interactions of periplasmic solute-binding proteins and an ATP-binding cassette transporter in the cytoplasmic membrane. The mechanisms of assembly, functions, and interactions between the above-mentioned molecules were clarified using structural biology. The pit was transplanted into other strains of sphingomonads, and the pitted recombinant cells were effectively applied to the production of bioethanol, bioremediation for dioxin removal, and other tasks. Studies of the function of the pit shed light on the biological significance of cell surface structures and macromolecule transport in bacteria.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 10","pages":"529-552"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/d7/pjab-98-529.PMC9751261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10723739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural studies of functional nucleosome complexes with transacting factors. 具有交易因子的功能性核小体复合物的结构研究。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.001

Hitoshi Kurumizaka

引用次数: 1

Mannose-binding analysis and biological application of pradimicins. pradimicins的甘露糖结合分析及生物学应用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.002

Yu Nakagawa, Yukishige Ito

引用次数: 0

Central regulation of body fluid homeostasis. 体液平衡的中枢调节。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.016

Masaharu Noda, Takashi Matsuda

{"title":"Central regulation of body fluid homeostasis.","authors":"Masaharu Noda, Takashi Matsuda","doi":"10.2183/pjab.98.016","DOIUrl":"https://doi.org/10.2183/pjab.98.016","url":null,"abstract":"Extracellular fluids, including blood, lymphatic fluid, and cerebrospinal fluid, are collectively called body fluids. The Na+ concentration ([Na+]) in body fluids is maintained at 135-145 mM and is broadly conserved among terrestrial animals. Homeostatic osmoregulation by Na+ is vital for life because severe hyper- or hypotonicity elicits irreversible organ damage and lethal neurological trauma. To achieve \"body fluid homeostasis\" or \"Na homeostasis\", the brain continuously monitors [Na+] in body fluids and controls water/salt intake and water/salt excretion by the kidneys. These physiological functions are primarily regulated based on information on [Na+] and relevant circulating hormones, such as angiotensin II, aldosterone, and vasopressin. In this review, we discuss sensing mechanisms for [Na+] and hormones in the brain that control water/salt intake behaviors, together with the responsible sensors (receptors) and relevant neural pathways. We also describe mechanisms in the brain by which [Na+] increases in body fluids activate the sympathetic neural activity leading to hypertension.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 7","pages":"283-324"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/0f/pjab-98-283.PMC9363595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Developments of GNSS buoy for a synthetic geohazard monitoring system. 地质灾害综合监测系统GNSS浮标研制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.004

Teruyuki Kato, Yukihiro Terada, Keiichi Tadokoro, Akira Futamura

引用次数: 2

Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14. 靶向癌细胞干性调节因子PRDI-BF1和RIZ结构域锌指蛋白14的治疗性siRNA。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.017

Kohzoh Imai, Hiroaki Taniguchi

{"title":"Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14.","authors":"Kohzoh Imai, Hiroaki Taniguchi","doi":"10.2183/pjab.98.017","DOIUrl":"https://doi.org/10.2183/pjab.98.017","url":null,"abstract":"PRDI-BF1 and RIZ (PR) domain zinc finger protein 14 (PRDM14), first reported in 2007 to be overexpressed in breast cancer, plays an important role in breast cancer proliferation. Subsequent studies reported that PRDM14 is expressed in embryonic stem cells, primordial germ cells, and various cancers. PRDM14 was reported to confer stemness properties to cancer cells. These properties induce cancer initiation, cancer progression, therapeutic resistance, distant metastasis, and recurrence in refractory tumors. Therefore, PRDM14 may be an ideal therapeutic target for various types of tumors. Silencing PRDM14 expression using PRDM14-specific siRNA delivered through an innovative intravenous drug delivery system reduced the size of inoculated tumors, incidence of distant metastases, and increased overall survival in nude mice without causing adverse effects. Therapeutic siRNA targeting PRDM14 is now being evaluated in a human phase I clinical trial for patients with refractory breast cancer, including triple-negative breast cancer.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 7","pages":"325-335"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/04/pjab-98-325.PMC9363597.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An interpretation of COVID-19 in Tokyo using a combination of SIR models. 结合SIR模型对东京COVID-19的解读。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.006

Koichiro Maki

引用次数: 5

Phenine design for nanocarbon molecules. 纳米碳分子的苯设计。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.020

Koki Ikemoto, Toshiya M Fukunaga, Hiroyuki Isobe

引用次数: 0