Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第9页

Mannose-binding analysis and biological application of pradimicins. pradimicins的甘露糖结合分析及生物学应用。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.002

Yu Nakagawa, Yukishige Ito

引用次数: 0

Central regulation of body fluid homeostasis. 体液平衡的中枢调节。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.016

Masaharu Noda, Takashi Matsuda

{"title":"Central regulation of body fluid homeostasis.","authors":"Masaharu Noda, Takashi Matsuda","doi":"10.2183/pjab.98.016","DOIUrl":"https://doi.org/10.2183/pjab.98.016","url":null,"abstract":"Extracellular fluids, including blood, lymphatic fluid, and cerebrospinal fluid, are collectively called body fluids. The Na+ concentration ([Na+]) in body fluids is maintained at 135-145 mM and is broadly conserved among terrestrial animals. Homeostatic osmoregulation by Na+ is vital for life because severe hyper- or hypotonicity elicits irreversible organ damage and lethal neurological trauma. To achieve \"body fluid homeostasis\" or \"Na homeostasis\", the brain continuously monitors [Na+] in body fluids and controls water/salt intake and water/salt excretion by the kidneys. These physiological functions are primarily regulated based on information on [Na+] and relevant circulating hormones, such as angiotensin II, aldosterone, and vasopressin. In this review, we discuss sensing mechanisms for [Na+] and hormones in the brain that control water/salt intake behaviors, together with the responsible sensors (receptors) and relevant neural pathways. We also describe mechanisms in the brain by which [Na+] increases in body fluids activate the sympathetic neural activity leading to hypertension.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 7","pages":"283-324"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/0f/pjab-98-283.PMC9363595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Developments of GNSS buoy for a synthetic geohazard monitoring system. 地质灾害综合监测系统GNSS浮标研制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.004

Teruyuki Kato, Yukihiro Terada, Keiichi Tadokoro, Akira Futamura

引用次数: 2

Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14. 靶向癌细胞干性调节因子PRDI-BF1和RIZ结构域锌指蛋白14的治疗性siRNA。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.017

Kohzoh Imai, Hiroaki Taniguchi

{"title":"Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14.","authors":"Kohzoh Imai, Hiroaki Taniguchi","doi":"10.2183/pjab.98.017","DOIUrl":"https://doi.org/10.2183/pjab.98.017","url":null,"abstract":"PRDI-BF1 and RIZ (PR) domain zinc finger protein 14 (PRDM14), first reported in 2007 to be overexpressed in breast cancer, plays an important role in breast cancer proliferation. Subsequent studies reported that PRDM14 is expressed in embryonic stem cells, primordial germ cells, and various cancers. PRDM14 was reported to confer stemness properties to cancer cells. These properties induce cancer initiation, cancer progression, therapeutic resistance, distant metastasis, and recurrence in refractory tumors. Therefore, PRDM14 may be an ideal therapeutic target for various types of tumors. Silencing PRDM14 expression using PRDM14-specific siRNA delivered through an innovative intravenous drug delivery system reduced the size of inoculated tumors, incidence of distant metastases, and increased overall survival in nude mice without causing adverse effects. Therapeutic siRNA targeting PRDM14 is now being evaluated in a human phase I clinical trial for patients with refractory breast cancer, including triple-negative breast cancer.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"98 7","pages":"325-335"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/04/pjab-98-325.PMC9363597.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An interpretation of COVID-19 in Tokyo using a combination of SIR models. 结合SIR模型对东京COVID-19的解读。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.006

Koichiro Maki

引用次数: 5

Phenine design for nanocarbon molecules. 纳米碳分子的苯设计。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI: 10.2183/pjab.98.020

Koki Ikemoto, Toshiya M Fukunaga, Hiroyuki Isobe

引用次数: 0

JF1/B6F1 Ngly1^-/- mouse as an isogenic animal model of NGLY1 deficiency. 将 JF1/B6F1 Ngly1-/- 小鼠作为 NGLY1 缺乏症的同源动物模型。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.005

Makoto Asahina, Reiko Fujinawa, Haruhiko Fujihira, Yuki Masahara-Negishi, Tomohiro Andou, Ryuichi Tozawa, Tadashi Suzuki

{"title":"JF1/B6F1 Ngly1-/- mouse as an isogenic animal model of NGLY1 deficiency.","authors":"Makoto Asahina, Reiko Fujinawa, Haruhiko Fujihira, Yuki Masahara-Negishi, Tomohiro Andou, Ryuichi Tozawa, Tadashi Suzuki","doi":"10.2183/pjab.97.005","DOIUrl":"10.2183/pjab.97.005","url":null,"abstract":"N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1-/- mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problematic. In this study, B6-Ngly1-/+ mice were crossed with Japanese wild mice-originated Japanese fancy mouse 1 (JF1) mice to produce viable F2 Ngly1-/- mice from (JF1×B6)F1 Ngly1-/+ mice. Systemic Ngly1-/- mice with a JF1 mouse background were also embryonically lethal. Hybrid F1 Ngly1-/- (JF1/B6F1) mice, however, showed developmental delay and motor dysfunction, similar to that in human patients. JF1/B6F1 Ngly1-/- mice showed increased levels of plasma and urinary aspartylglycosamine, a potential biomarker for NGLY1 deficiency. JF1/B6F1 Ngly1-/- mice are a useful isogenic animal model for the preclinical testing of therapeutic options and understanding the precise pathogenic mechanisms responsible for NGLY1 deficiency.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 2","pages":"89-102"},"PeriodicalIF":4.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25353638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and present status of seismic evaluation and seismic retrofit of existing reinforced concrete buildings in Japan. 日本既有钢筋混凝土建筑抗震评价与抗震改造的发展与现状。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.021

Tsuneo Okada

{"title":"Development and present status of seismic evaluation and seismic retrofit of existing reinforced concrete buildings in Japan.","authors":"Tsuneo Okada","doi":"10.2183/pjab.97.021","DOIUrl":"https://doi.org/10.2183/pjab.97.021","url":null,"abstract":"This paper describes the development and present status of seismic evaluation and seismic retrofit of existing buildings mainly for low-rise and medium-rise reinforced concrete buildings in Japan. First, since the seismic evaluation of existing buildings has close relationships with the seismic design of new buildings, a brief history of the development of seismic design, seismic evaluation, and seismic retrofit is provided in terms of major earthquake disasters mostly in Japan and associated with some major events in the U.S. Then, the development of seismic evaluation and retrofit is reviewed, focusing on the items in which the author has been deeply involved. This provides insight into previous earthquake damage, methodologies for seismic evaluation, the basic concept of the Standard for Seismic Evaluation of Existing Reinforced Concrete Buildings, studies on the demand criteria for seismic safety, and the present status of seismic evaluation and retrofit. Finally, the typical methods of seismic retrofit and some examples of retrofitted buildings in Japan are explained.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 7","pages":"402-422"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39304106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Insight into chemical mechanisms of sepal color development and variation in hydrangea. 洞察绣球花萼片颜色发展和变化的化学机制。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.003

Kumi Yoshida, Kin-Ichi Oyama, Tadao Kondo

引用次数: 0

LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling. LUBAC 介导的线性泛素化：免疫信号转导的关键调节因子。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.007

Kazuhiro Iwai

{"title":"LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling.","authors":"Kazuhiro Iwai","doi":"10.2183/pjab.97.007","DOIUrl":"10.2183/pjab.97.007","url":null,"abstract":"Ubiquitination is a reversible post-translational modification in which ubiquitin chains are conjugated to target proteins to modulate protein function. The type of ubiquitin chain determines the mode of protein regulation. It has been shown that ubiquitin chains are formed via one of seven Lys residues in ubiquitin, and several types of ubiquitin chains are found in cells. We identified a new type of linear ubiquitin chain linked through the N-terminal Met of ubiquitin and assembled by the linear ubiquitin chain assembly complex (LUBAC), which is specific for linear chains. The discovery of linear ubiquitin chains and LUBAC is considered as a paradigm shift in ubiquitin research because linear ubiquitination is exclusive to animals, despite the existence of ubiquitination throughout eukaryotic kingdoms. Linear ubiquitination plays a critical role in immune signaling and cell death regulation. Dysregulation of LUBAC-mediated linear ubiquitination underlies various human diseases, including autoinflammation, autoimmunity, infection, and malignant tumors. This review summarizes the current status of linear ubiquitination research.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 3","pages":"120-133"},"PeriodicalIF":4.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25470365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0