Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第9页

JF1/B6F1 Ngly1^-/- mouse as an isogenic animal model of NGLY1 deficiency. 将 JF1/B6F1 Ngly1-/- 小鼠作为 NGLY1 缺乏症的同源动物模型。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.005

Makoto Asahina, Reiko Fujinawa, Haruhiko Fujihira, Yuki Masahara-Negishi, Tomohiro Andou, Ryuichi Tozawa, Tadashi Suzuki

{"title":"JF1/B6F1 Ngly1-/- mouse as an isogenic animal model of NGLY1 deficiency.","authors":"Makoto Asahina, Reiko Fujinawa, Haruhiko Fujihira, Yuki Masahara-Negishi, Tomohiro Andou, Ryuichi Tozawa, Tadashi Suzuki","doi":"10.2183/pjab.97.005","DOIUrl":"10.2183/pjab.97.005","url":null,"abstract":"N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1-/- mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problematic. In this study, B6-Ngly1-/+ mice were crossed with Japanese wild mice-originated Japanese fancy mouse 1 (JF1) mice to produce viable F2 Ngly1-/- mice from (JF1×B6)F1 Ngly1-/+ mice. Systemic Ngly1-/- mice with a JF1 mouse background were also embryonically lethal. Hybrid F1 Ngly1-/- (JF1/B6F1) mice, however, showed developmental delay and motor dysfunction, similar to that in human patients. JF1/B6F1 Ngly1-/- mice showed increased levels of plasma and urinary aspartylglycosamine, a potential biomarker for NGLY1 deficiency. JF1/B6F1 Ngly1-/- mice are a useful isogenic animal model for the preclinical testing of therapeutic options and understanding the precise pathogenic mechanisms responsible for NGLY1 deficiency.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 2","pages":"89-102"},"PeriodicalIF":4.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25353638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and present status of seismic evaluation and seismic retrofit of existing reinforced concrete buildings in Japan. 日本既有钢筋混凝土建筑抗震评价与抗震改造的发展与现状。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.021

Tsuneo Okada

{"title":"Development and present status of seismic evaluation and seismic retrofit of existing reinforced concrete buildings in Japan.","authors":"Tsuneo Okada","doi":"10.2183/pjab.97.021","DOIUrl":"https://doi.org/10.2183/pjab.97.021","url":null,"abstract":"This paper describes the development and present status of seismic evaluation and seismic retrofit of existing buildings mainly for low-rise and medium-rise reinforced concrete buildings in Japan. First, since the seismic evaluation of existing buildings has close relationships with the seismic design of new buildings, a brief history of the development of seismic design, seismic evaluation, and seismic retrofit is provided in terms of major earthquake disasters mostly in Japan and associated with some major events in the U.S. Then, the development of seismic evaluation and retrofit is reviewed, focusing on the items in which the author has been deeply involved. This provides insight into previous earthquake damage, methodologies for seismic evaluation, the basic concept of the Standard for Seismic Evaluation of Existing Reinforced Concrete Buildings, studies on the demand criteria for seismic safety, and the present status of seismic evaluation and retrofit. Finally, the typical methods of seismic retrofit and some examples of retrofitted buildings in Japan are explained.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 7","pages":"402-422"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39304106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Insight into chemical mechanisms of sepal color development and variation in hydrangea. 洞察绣球花萼片颜色发展和变化的化学机制。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.003

Kumi Yoshida, Kin-Ichi Oyama, Tadao Kondo

引用次数: 0

LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling. LUBAC 介导的线性泛素化：免疫信号转导的关键调节因子。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.007

Kazuhiro Iwai

{"title":"LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling.","authors":"Kazuhiro Iwai","doi":"10.2183/pjab.97.007","DOIUrl":"10.2183/pjab.97.007","url":null,"abstract":"Ubiquitination is a reversible post-translational modification in which ubiquitin chains are conjugated to target proteins to modulate protein function. The type of ubiquitin chain determines the mode of protein regulation. It has been shown that ubiquitin chains are formed via one of seven Lys residues in ubiquitin, and several types of ubiquitin chains are found in cells. We identified a new type of linear ubiquitin chain linked through the N-terminal Met of ubiquitin and assembled by the linear ubiquitin chain assembly complex (LUBAC), which is specific for linear chains. The discovery of linear ubiquitin chains and LUBAC is considered as a paradigm shift in ubiquitin research because linear ubiquitination is exclusive to animals, despite the existence of ubiquitination throughout eukaryotic kingdoms. Linear ubiquitination plays a critical role in immune signaling and cell death regulation. Dysregulation of LUBAC-mediated linear ubiquitination underlies various human diseases, including autoinflammation, autoimmunity, infection, and malignant tumors. This review summarizes the current status of linear ubiquitination research.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 3","pages":"120-133"},"PeriodicalIF":4.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25470365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigenda to "LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling". LUBAC 介导的线性泛素化：免疫信号转导的关键调节器》的更正。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.012

Kazuhiro Iwai

引用次数: 0

Human gastric cancer risk screening: From rat pepsinogen studies to the ABC method. 人类胃癌风险筛查：从大鼠胃蛋白酶原研究到 ABC 法。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.023

Chie Furihata

{"title":"Human gastric cancer risk screening: From rat pepsinogen studies to the ABC method.","authors":"Chie Furihata","doi":"10.2183/pjab.97.023","DOIUrl":"10.2183/pjab.97.023","url":null,"abstract":"We examined the development of gastric cancer risk screening, from rat pepsinogen studies in an experimental rat gastric carcinogenesis model induced with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and human pepsinogen studies in the 1970s and 1980s to the recent \"ABC method\" for human gastric cancer risk screening. First, decreased expression or absence of a major pepsinogen isozyme, PG1, was observed in the rat gastric mucosa from the early stages of gastric carcinogenesis to adenocarcinomas following treatment with MNNG. In the 1980s, decreases in PGI in the human gastric mucosa and serum were identified as markers of atrophic gastritis. In the 1990s, other researchers revealed that chronic infection with Helicobacter pylori (Hp) causes atrophic gastritis and later gastric cancer. In the 2000s, a gastric cancer risk screening method combining assays to detect serum anti-Hp IgG antibody and serum PGI and PGII levels, the \"ABC method\", was established. Eradication of Hp and endoscopic follow-up examination after the ABC method are recommended to prevent gastric cancer.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 8","pages":"462-478"},"PeriodicalIF":4.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39526524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vaccination against COVID-19 spreading. 疫苗接种对COVID-19传播的影响。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.027

Hirotaka Sugawara

引用次数: 2

Transport phenomena in spin caloritronics. 自旋热电子学中的传输现象

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.004

Ken-Ichi Uchida

引用次数: 0

Lipid hydroperoxides in nutrition, health, and diseases. 脂质氢过氧化物在营养、健康和疾病中的作用。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.010

Teruo Miyazawa

引用次数: 0

Genetic variations in medical research in the past, at present and in the future. 遗传变异在过去、现在和将来的医学研究。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.2183/pjab.97.018

Yoichiro Kamatani, Yusuke Nakamura

{"title":"Genetic variations in medical research in the past, at present and in the future.","authors":"Yoichiro Kamatani, Yusuke Nakamura","doi":"10.2183/pjab.97.018","DOIUrl":"https://doi.org/10.2183/pjab.97.018","url":null,"abstract":"As we look so different, our genomic sequences vary enormously. The differences in our genome, genetic variations, have played very significant roles in medical research and have contributed to improvement of medical managements in the last 2-3 decades. Genetic variations include germline variations, somatic mutations, and diversities in receptor genes of rearranged immune cells, T cells and B cells. Germline variants are in some cases causative of genetic diseases, are associated with the risk of various diseases, and also affect drug efficacies or adverse events. Some somatic mutations are causative of tumor development. Recent DNA sequencing technologies allow us to perform single-cell analysis or detailed repertoire analysis of B and T cells. It is critically important to investigate temporal changes in immune environment in various anatomical regions in the next one to two decades. In this review article, we would like to introduce the roles of genetic variations in medical fields in the past, at present and in the future.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"97 6","pages":"324-335"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39089439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2