Progress in the chemistry of organic natural products最新文献_第4页

Progress in the Chemistry of Cytochalasans. 细胞喇喇体化学研究进展。

Progress in the chemistry of organic natural products Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-59444-2_1

Hucheng Zhu, Chunmei Chen, Qingyi Tong, Yuan Zhou, Ying Ye, Lianghu Gu, Yonghui Zhang

引用次数: 13

Taccalonolide Microtubule Stabilizers. 他卡洛内酯微管稳定剂。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_3

Samantha S Yee, Lin Du, April L Risinger

{"title":"Taccalonolide Microtubule Stabilizers.","authors":"Samantha S Yee, Lin Du, April L Risinger","doi":"10.1007/978-3-030-52966-6_3","DOIUrl":"https://doi.org/10.1007/978-3-030-52966-6_3","url":null,"abstract":"Microtubule stabilizers are a mainstay in the treatment of many solid cancers and continue to find utility in combination therapy with molecularly targeted anticancer agents and immunotherapeutics. However, innate and acquired resistance to microtubule stabilizers can limit their clinical efficacy. The taccalonolides are a unique class of microtubule stabilizers isolated from plants of Tacca that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule-stabilizing activity of the taccalonolides was independent of direct tubulin binding, additional studies have identified that potent C-22, C-23 epoxidized taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule-stabilizing activity. The taccalonolides have distinct properties as compared to other microtubule stabilizers with regard to their biochemical effects on tubulin structure and dynamics that promote distinct cellular phenotypes. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction. This also affords an opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800047/pdf/nihms-1657180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38700070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia. 东亚菖蒲属植物的化学成分及其多样性。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-53028-0_1

Motoo Tori, Chiaki Kuroda

引用次数: 0

The Phytochemistry and Pharmacology of Hypericum. 金丝桃的植物化学和药理研究。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_2

Chuan-Yun Xiao, Qing Mu, Simon Gibbons

引用次数: 9

Allelopathy: The Chemical Language of Plants. 化感作用:植物的化学语言。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_1

Francisco A Macías, Alexandra G Durán, José M G Molinillo

引用次数: 11

Sesterterpenoids. Sester萜烯类。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-37865-3_1

Takaaki Mitsuhashi, Ikuro Abe

引用次数: 54

Secondary Metabolites from Marine-Derived Fungi from China. 中国海生真菌次生代谢物研究。

Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-37865-3_2

Zhen Liu, Marian Frank, Xiaoqin Yu, Haiqian Yu, Nam M Tran-Cong, Ying Gao, Peter Proksch

{"title":"Secondary Metabolites from Marine-Derived Fungi from China.","authors":"Zhen Liu, Marian Frank, Xiaoqin Yu, Haiqian Yu, Nam M Tran-Cong, Ying Gao, Peter Proksch","doi":"10.1007/978-3-030-37865-3_2","DOIUrl":"https://doi.org/10.1007/978-3-030-37865-3_2","url":null,"abstract":"Marine-derived fungi play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters. The genera Aspergillus (170 new natural products, 28%) and Penicillium (70 new natural products, 11%) were the main fungal producers of new natural products during the time period covered, whereas sponges (184 new natural products, 30%) were the most abundant source of new natural products, followed by corals (154 new natural products, 25%) and algae (130 new natural products, 21%). Close to 40% of all natural products covered in this contribution displayed various bioactivities. The major bioactivities reported were cytotoxicity against different cancer cell lines, antimicrobial (mainly antibacterial) activity, and antiviral activity, which accounted for 13%, 9%, and 3% of all natural products reported. In terms of structural classes, polyketides (188 new natural products, 31%) play a dominant role, and if prenylated polyketides and nitrogen-containing polyketides (included in meroterpenes and alkaloids in this contribution) are taken into account, their total number even exceeds 50%. Nitrogen-containing compounds including peptides (65 new natural products, 10%) and alkaloids (103 new natural products, 17%) are the second largest group.","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37690827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Chemical Diversity and Biological Activity of African Propolis. 非洲蜂胶的化学多样性和生物活性。

Progress in the chemistry of organic natural products Pub Date : 2019-10-22 DOI: 10.1007/978-3-030-12858-6_3

N. Blicharska, V. Seidel

引用次数: 8

Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities. 内生放线菌的次生代谢产物:分离、合成、生物合成和生物活性。

Progress in the chemistry of organic natural products Pub Date : 2019-01-01 DOI: 10.1007/978-3-030-01099-7_3

Darlon Irineu Bernardi, Fernanda Oliveira das Chagas, Afif Felix Monteiro, Gabriel Franco Dos Santos, Roberto Gomes de Souza Berlinck

引用次数: 10

Bioactive Compounds Involved in the Life Cycle of Higher Plants. 高等植物生命周期中的生物活性化合物。

Progress in the chemistry of organic natural products Pub Date : 2019-01-01 DOI: 10.1007/978-3-030-12858-6_2

H. Shigemori

引用次数: 2