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Progress in the chemistry of organic natural products最新文献

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Correction to: Antileishmanial Activity of Lignans, Neolignans, and Other Plant Phenols. 修正:木脂素、新木脂素和其他植物酚类抗利什曼原虫活性。
Progress in the chemistry of organic natural products Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-64853-4_5
Jiří Pospíšil, Daniela Konrádová, Miroslav Strnad
{"title":"Correction to: Antileishmanial Activity of Lignans, Neolignans, and Other Plant Phenols.","authors":"Jiří Pospíšil, Daniela Konrádová, Miroslav Strnad","doi":"10.1007/978-3-030-64853-4_5","DOIUrl":"https://doi.org/10.1007/978-3-030-64853-4_5","url":null,"abstract":"","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"115 ","pages":"C1-C4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38908715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Endogenous Natural Products. 人类内源性天然产物。
Progress in the chemistry of organic natural products Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-59444-2_4
Yingjie Bai, Liyun Zhang, Xiaoguang Lei
{"title":"Human Endogenous Natural Products.","authors":"Yingjie Bai,&nbsp;Liyun Zhang,&nbsp;Xiaoguang Lei","doi":"10.1007/978-3-030-59444-2_4","DOIUrl":"https://doi.org/10.1007/978-3-030-59444-2_4","url":null,"abstract":"<p><p>Natural products are a class of chemical compounds that are biosynthesized by living organisms, including humans. Endogenous natural products are produced by human cells as well as by the human microbiome. This contribution describes the current understanding and recent progress made on endogenous natural products that are produced by human cells, including amines, steroids, and fatty acid-derived natural products. The co-metabolism and natural product produced by the human microbiome will also be described, including the involvement of tryptophan, bile acids, choline, and cysteine. New strategies and technologies have been introduced that can be applied to identify and characterize those natural products produced by the human microbiome in terms of their composition and physiological function.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"114 ","pages":"313-337"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25538003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive Compounds from Medicinal Plants in Myanmar. 缅甸药用植物中的生物活性化合物。
Progress in the chemistry of organic natural products Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-59444-2_2
Nwet Nwet Win, Hiroyuki Morita
{"title":"Bioactive Compounds from Medicinal Plants in Myanmar.","authors":"Nwet Nwet Win,&nbsp;Hiroyuki Morita","doi":"10.1007/978-3-030-59444-2_2","DOIUrl":"https://doi.org/10.1007/978-3-030-59444-2_2","url":null,"abstract":"<p><p>Myanmar is a country with rich natural resources and of these, medicinal plants play a vital role in the primary health care of its population. The people of Myanmar have used their own system of traditional medicine inclusive of the use of medicinal plants for 2000 years. However, systematic and scientific studies have only recently begun to be reported. Researchers from Japan, Germany, and Korea have collaborated with researchers in Myanmar on medicinal plants since 2000. During the past two decades, over 50 publications have been published in peer-reviewed journals. Altogether, 433 phytoconstituents, including 147 new and 286 known compounds from 26 plant species consisting of 29 samples native to Myanmar, have been collated. In this contribution, phytochemical and biological investigations of these plants, including information on traditional knowledge are compiled and discussed.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"114 ","pages":"135-251"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25552734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Progress in the Chemistry of Cytochalasans. 细胞喇喇体化学研究进展。
Progress in the chemistry of organic natural products Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-59444-2_1
Hucheng Zhu, Chunmei Chen, Qingyi Tong, Yuan Zhou, Ying Ye, Lianghu Gu, Yonghui Zhang
{"title":"Progress in the Chemistry of Cytochalasans.","authors":"Hucheng Zhu,&nbsp;Chunmei Chen,&nbsp;Qingyi Tong,&nbsp;Yuan Zhou,&nbsp;Ying Ye,&nbsp;Lianghu Gu,&nbsp;Yonghui Zhang","doi":"10.1007/978-3-030-59444-2_1","DOIUrl":"https://doi.org/10.1007/978-3-030-59444-2_1","url":null,"abstract":"<p><p>Cytochalasans are a group of fungal-derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring, and they exhibit a high structural diversity and a broad spectrum of bioactivities. Cytochalasans have attracted significant attention from the chemical and pharmacological communities and have been reviewed previously from various perspectives in recent years. However, continued interest in the cytochalasans and the number of laboratory investigations on these compounds are both growing rapidly. This contribution provides a general overview of the isolation, structural determination, biological activities, biosynthesis, and total synthesis of cytochalasans. In total, 477 cytochalasans are covered, including \"merocytochalasans\" that arise by the dimerization or polymerization of one or more cytochalasan molecules with one or more other natural product units. This contribution provides a comprehensive treatment of the cytochalasans, and it is hoped that it may stimulate further work on these interesting natural products.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"114 ","pages":"1-134"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25540170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Taccalonolide Microtubule Stabilizers. 他卡洛内酯微管稳定剂。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_3
Samantha S Yee, Lin Du, April L Risinger
{"title":"Taccalonolide Microtubule Stabilizers.","authors":"Samantha S Yee,&nbsp;Lin Du,&nbsp;April L Risinger","doi":"10.1007/978-3-030-52966-6_3","DOIUrl":"https://doi.org/10.1007/978-3-030-52966-6_3","url":null,"abstract":"<p><p>Microtubule stabilizers are a mainstay in the treatment of many solid cancers and continue to find utility in combination therapy with molecularly targeted anticancer agents and immunotherapeutics. However, innate and acquired resistance to microtubule stabilizers can limit their clinical efficacy. The taccalonolides are a unique class of microtubule stabilizers isolated from plants of Tacca that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule-stabilizing activity of the taccalonolides was independent of direct tubulin binding, additional studies have identified that potent C-22, C-23 epoxidized taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule-stabilizing activity. The taccalonolides have distinct properties as compared to other microtubule stabilizers with regard to their biochemical effects on tubulin structure and dynamics that promote distinct cellular phenotypes. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction. This also affords an opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"112 ","pages":"183-206"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800047/pdf/nihms-1657180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38700070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia. 东亚菖蒲属植物的化学成分及其多样性。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-53028-0_1
Motoo Tori, Chiaki Kuroda
{"title":"Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia.","authors":"Motoo Tori,&nbsp;Chiaki Kuroda","doi":"10.1007/978-3-030-53028-0_1","DOIUrl":"https://doi.org/10.1007/978-3-030-53028-0_1","url":null,"abstract":"<p><p>More than 100 Ligularia species and those of several related genera (Cremanthodium, Cacalia, Senecio, and others) in the plant family Senecioneae grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, sterols, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. In this contribution, relevant chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. Terpenoids and aromatic compounds (totaling 1049), both new and known, are listed. Genetic studies and synthesis investigations are also reviewed briefly.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"113 ","pages":"1-247"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25480115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Phytochemistry and Pharmacology of Hypericum. 金丝桃的植物化学和药理研究。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_2
Chuan-Yun Xiao, Qing Mu, Simon Gibbons
{"title":"The Phytochemistry and Pharmacology of Hypericum.","authors":"Chuan-Yun Xiao,&nbsp;Qing Mu,&nbsp;Simon Gibbons","doi":"10.1007/978-3-030-52966-6_2","DOIUrl":"https://doi.org/10.1007/978-3-030-52966-6_2","url":null,"abstract":"<p><p>Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects. A detailed account of the chemical constituents, including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids, is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"112 ","pages":"85-182"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38701475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Allelopathy: The Chemical Language of Plants. 化感作用:植物的化学语言。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-52966-6_1
Francisco A Macías, Alexandra G Durán, José M G Molinillo
{"title":"Allelopathy: The Chemical Language of Plants.","authors":"Francisco A Macías,&nbsp;Alexandra G Durán,&nbsp;José M G Molinillo","doi":"10.1007/978-3-030-52966-6_1","DOIUrl":"https://doi.org/10.1007/978-3-030-52966-6_1","url":null,"abstract":"<p><p>In Nature, the oldest method of communication between living systems is the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process-allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely kind of allelochemicals, have been investigated, as well as their releasing mechanisms and their purpose will be described in this chapter.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"112 ","pages":"1-84"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38701476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Sesterterpenoids. Sester萜烯类。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-37865-3_1
Takaaki Mitsuhashi, Ikuro Abe
{"title":"Sesterterpenoids.","authors":"Takaaki Mitsuhashi,&nbsp;Ikuro Abe","doi":"10.1007/978-3-030-37865-3_1","DOIUrl":"https://doi.org/10.1007/978-3-030-37865-3_1","url":null,"abstract":"<p><p>Sesterterpenoids are known as a relatively small group of natural products. However, they represent a variety of simple to more complex structural types. This contribution focuses on the chemical structures of sesterterpenoids and how their structures are constructed in Nature.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"111 ","pages":"1-79"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37690826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Secondary Metabolites from Marine-Derived Fungi from China. 中国海生真菌次生代谢物研究。
Progress in the chemistry of organic natural products Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-37865-3_2
Zhen Liu, Marian Frank, Xiaoqin Yu, Haiqian Yu, Nam M Tran-Cong, Ying Gao, Peter Proksch
{"title":"Secondary Metabolites from Marine-Derived Fungi from China.","authors":"Zhen Liu,&nbsp;Marian Frank,&nbsp;Xiaoqin Yu,&nbsp;Haiqian Yu,&nbsp;Nam M Tran-Cong,&nbsp;Ying Gao,&nbsp;Peter Proksch","doi":"10.1007/978-3-030-37865-3_2","DOIUrl":"https://doi.org/10.1007/978-3-030-37865-3_2","url":null,"abstract":"<p><p>Marine-derived fungi play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters. The genera Aspergillus (170 new natural products, 28%) and Penicillium (70 new natural products, 11%) were the main fungal producers of new natural products during the time period covered, whereas sponges (184 new natural products, 30%) were the most abundant source of new natural products, followed by corals (154 new natural products, 25%) and algae (130 new natural products, 21%). Close to 40% of all natural products covered in this contribution displayed various bioactivities. The major bioactivities reported were cytotoxicity against different cancer cell lines, antimicrobial (mainly antibacterial) activity, and antiviral activity, which accounted for 13%, 9%, and 3% of all natural products reported. In terms of structural classes, polyketides (188 new natural products, 31%) play a dominant role, and if prenylated polyketides and nitrogen-containing polyketides (included in meroterpenes and alkaloids in this contribution) are taken into account, their total number even exceeds 50%. Nitrogen-containing compounds including peptides (65 new natural products, 10%) and alkaloids (103 new natural products, 17%) are the second largest group.</p>","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"111 ","pages":"81-153"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37690827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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