细胞喇喇体化学研究进展。

Q1 Medicine
Hucheng Zhu, Chunmei Chen, Qingyi Tong, Yuan Zhou, Ying Ye, Lianghu Gu, Yonghui Zhang
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引用次数: 13

摘要

Cytochalasans是一类真菌衍生的天然产物,其特征是一个过氢异吲哚酮核与一个大环融合,具有高度的结构多样性和广泛的生物活性。近年来,细胞chalasans引起了化学和药理学界的广泛关注,并从不同的角度对其进行了综述。然而,对细胞chalasans的持续兴趣和对这些化合物的实验室研究数量都在迅速增长。该贡献提供了分离,结构测定,生物活性,生物合成和总合成的总体概述。总共涵盖了477种细胞chalasans,包括由一个或多个细胞chalasan分子与一个或多个其他天然产物单位二聚化或聚合而产生的“merocytochalasans”。这一贡献提供了一个全面的治疗细胞chalasans,并希望它可能会刺激这些有趣的天然产物的进一步工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress in the Chemistry of Cytochalasans.

Cytochalasans are a group of fungal-derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring, and they exhibit a high structural diversity and a broad spectrum of bioactivities. Cytochalasans have attracted significant attention from the chemical and pharmacological communities and have been reviewed previously from various perspectives in recent years. However, continued interest in the cytochalasans and the number of laboratory investigations on these compounds are both growing rapidly. This contribution provides a general overview of the isolation, structural determination, biological activities, biosynthesis, and total synthesis of cytochalasans. In total, 477 cytochalasans are covered, including "merocytochalasans" that arise by the dimerization or polymerization of one or more cytochalasan molecules with one or more other natural product units. This contribution provides a comprehensive treatment of the cytochalasans, and it is hoped that it may stimulate further work on these interesting natural products.

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CiteScore
4.40
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