Secondary Metabolites from Marine-Derived Fungi from China.

Q1 Medicine
Zhen Liu, Marian Frank, Xiaoqin Yu, Haiqian Yu, Nam M Tran-Cong, Ying Gao, Peter Proksch
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引用次数: 16

Abstract

Marine-derived fungi play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters. The genera Aspergillus (170 new natural products, 28%) and Penicillium (70 new natural products, 11%) were the main fungal producers of new natural products during the time period covered, whereas sponges (184 new natural products, 30%) were the most abundant source of new natural products, followed by corals (154 new natural products, 25%) and algae (130 new natural products, 21%). Close to 40% of all natural products covered in this contribution displayed various bioactivities. The major bioactivities reported were cytotoxicity against different cancer cell lines, antimicrobial (mainly antibacterial) activity, and antiviral activity, which accounted for 13%, 9%, and 3% of all natural products reported. In terms of structural classes, polyketides (188 new natural products, 31%) play a dominant role, and if prenylated polyketides and nitrogen-containing polyketides (included in meroterpenes and alkaloids in this contribution) are taken into account, their total number even exceeds 50%. Nitrogen-containing compounds including peptides (65 new natural products, 10%) and alkaloids (103 new natural products, 17%) are the second largest group.

中国海生真菌次生代谢物研究。
海洋真菌在寻找结构独特的次生代谢物方面发挥着重要作用,其中一些代谢物显示出有希望的药理活性,使它们成为药物发现的有用线索。在过去的二十年中,中国的海洋天然产物研究总体上取得了巨大的进展,本章将介绍真菌代谢物。这一贡献涵盖了2001年至2017年从中国水域的藻类、海绵、珊瑚和其他海洋生物中获得的海洋衍生真菌中报告的613种新的天然产物。在此期间,曲霉属(170种新天然产物,占28%)和青霉属(70种新天然产物,占11%)是新天然产物的主要真菌生产者,而海绵(184种新天然产物,占30%)是最丰富的新天然产物来源,其次是珊瑚(154种新天然产物,占25%)和藻类(130种新天然产物,占21%)。在这一贡献中,近40%的天然产物显示出各种生物活性。报告的主要生物活性是对不同癌细胞系的细胞毒性,抗菌(主要是抗菌)活性和抗病毒活性,分别占报告的所有天然产物的13%,9%和3%。从结构类别上看,聚酮类占据主导地位(新天然产物188种,占31%),如果再加上戊烯化聚酮类和含氮聚酮类(在这一贡献中包含在萜类和生物碱中),其总数甚至超过50%。含氮化合物包括多肽(65个新天然产物,占10%)和生物碱(103个新天然产物,占17%)是第二大类别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
4.40
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