Mass Spectrometry Reviews最新文献_第3页

Exploring the dynamic landscape of immunopeptidomics: Unravelling posttranslational modifications and navigating bioinformatics terrain. 探索免疫肽组学的动态景观：揭开翻译后修饰的神秘面纱，驾驭生物信息学领域。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-08-16 DOI: 10.1002/mas.21905

Daniel Flender, Frédérique Vilenne, Charlotte Adams, Kurt Boonen, Dirk Valkenborg, Geert Baggerman

{"title":"Exploring the dynamic landscape of immunopeptidomics: Unravelling posttranslational modifications and navigating bioinformatics terrain.","authors":"Daniel Flender, Frédérique Vilenne, Charlotte Adams, Kurt Boonen, Dirk Valkenborg, Geert Baggerman","doi":"10.1002/mas.21905","DOIUrl":"https://doi.org/10.1002/mas.21905","url":null,"abstract":"Immunopeptidomics is becoming an increasingly important field of study. The capability to identify immunopeptides with pivotal roles in the human immune system is essential to shift the current curative medicine towards personalized medicine. Throughout the years, the field has matured, giving insight into the current pitfalls. Nowadays, it is commonly accepted that generalizing shotgun proteomics workflows is malpractice because immunopeptidomics faces numerous challenges. While many of these difficulties have been addressed, the road towards the ideal workflow remains complicated. Although the presence of Posttranslational modifications (PTMs) in the immunopeptidome has been demonstrated, their identification remains highly challenging despite their significance for immunotherapies. The large number of unpredictable modifications in the immunopeptidome plays a pivotal role in the functionality and these challenges. This review provides a comprehensive overview of the current advancements in immunopeptidomics. We delve into the challenges associated with identifying PTMs within the immunopeptidome, aiming to address the current state of the field.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reminiscences of a career in mass spectrometry in the US and in Spain 在美国和西班牙从事质谱分析工作的回忆。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-08-06 DOI: 10.1002/mas.21803

Emilio Gelpí

引用次数: 0

Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry. 利用质谱分析不溶性合成聚合物结构特征的降解策略。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-08-02 DOI: 10.1002/mas.21903

Thierry N J Fouquet, Robert B Cody, Laurence Charles

{"title":"Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry.","authors":"Thierry N J Fouquet, Robert B Cody, Laurence Charles","doi":"10.1002/mas.21903","DOIUrl":"https://doi.org/10.1002/mas.21903","url":null,"abstract":"With the advent of soft ionization techniques such as electrospray (ESI) and matrix-assisted laser desorption/ionization (MALDI) to produce intact gas-phase ions from nonvolatile macromolecules, mass spectrometry has become an essential technique in the field of polymeric materials. However, (co)polymers of very high molecular weight or with reticulated architectures still escape ESI or MALDI, mainly due to solubility issues. Strategies developed to tackle such an analytical challenge all rely on sample degradation to produce low-mass species amenable to existing ionization methods. Yet, chain degradation needs to be partial and controlled to generate sufficiently large species that still contain topological or architectural information. The present article reviews the different analytical degradation strategies implemented to perform mass spectrometry of these challenging synthetic polymers, covering thermal degradation approaches in sources developed in the 2000s, off-line sample pre-treatments for controlled chemical degradation of polymeric substrates, and most recent achievements employing reactive ionization modes to perform chemolysis on-line with MS.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in high-resolution traveling wave-based ion mobility separations coupled to mass spectrometry. 基于行波的高分辨率离子迁移率分离与质谱联用技术的最新进展。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-08-01 DOI: 10.1002/mas.21902

Cameron N Naylor, Gabe Nagy

引用次数: 0

Protein analysis by desorption electrospray ionization mass spectrometry. 利用解吸电喷雾离子质谱仪分析蛋白质。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-07-26 DOI: 10.1002/mas.21900

Andre R Venter

{"title":"Protein analysis by desorption electrospray ionization mass spectrometry.","authors":"Andre R Venter","doi":"10.1002/mas.21900","DOIUrl":"https://doi.org/10.1002/mas.21900","url":null,"abstract":"This review presents progress made in the ambient analysis of proteins, in particular by desorption electrospray ionization-mass spectrometry (DESI-MS). Related ambient ionization techniques are discussed in comparison to DESI-MS only to illustrate the larger context of protein analysis by ambient ionization mass spectrometry. The review describes early and current approaches for the analysis of undigested proteins, native proteins, tryptic digests, and indirect protein determination through reporter molecules. Applications to mass spectrometry imaging for protein spatial distributions, the identification of posttranslational modifications, determination of binding stoichiometries, and enzymatic transformations are discussed. The analytical capabilities of other ambient ionization techniques such as LESA and nano-DESI currently exceed those of DESI-MS for in situ surface sampling of intact proteins from tissues. This review shows, however, that despite its many limitations, DESI-MS is making valuable contributions to protein analysis. The challenges in sensitivity, spatial resolution, and mass range are surmountable obstacles and further development and improvements to DESI-MS is justified.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry-based metabolomics for the investigation of antibiotic-bacterial interactions. 基于质谱的代谢组学研究抗生素与细菌之间的相互作用。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-07-14 DOI: 10.1002/mas.21899

Xiaoyuan Lv, Zhenye Gao, Bingjie Li, Wenxiu Zhou, Shengman Zhang, Xin Wang

引用次数: 0

Advances in targeted liquid chromatography-tandem mass spectrometry methods for endocannabinoid and N-acylethanolamine quantification in biological matrices: A systematic review. 用于生物基质中内大麻素和 N-酰乙醇胺定量的定向液相色谱-串联质谱方法的进展：系统综述。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-07-03 DOI: 10.1002/mas.21897

Khalisa Amir Hamzah, Natalie Turner, David Nichols, Luke J Ney

引用次数: 0

Hyphenation of microflow chromatography with electrospray ionization mass spectrometry for bioanalytical applications focusing on low molecular weight compounds: A tutorial review. 将微流色谱与电喷雾质谱联用，用于生物分析应用（侧重于低分子量化合物）：教程综述。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-07-01 DOI: 10.1002/mas.21898

Sergey Girel, Isabel Meister, Gaetan Glauser, Serge Rudaz

{"title":"Hyphenation of microflow chromatography with electrospray ionization mass spectrometry for bioanalytical applications focusing on low molecular weight compounds: A tutorial review.","authors":"Sergey Girel, Isabel Meister, Gaetan Glauser, Serge Rudaz","doi":"10.1002/mas.21898","DOIUrl":"https://doi.org/10.1002/mas.21898","url":null,"abstract":"Benefits of miniaturized chromatography with various detection modes, such as increased sensitivity, chromatographic efficiency, and speed, were recognized nearly 50 years ago. Over the past two decades, this approach has experienced rapid growth, driven by the emergence of mass spectrometry applications serving -omics sciences and the need for analyzing minute volumes of precious samples with ever higher sensitivity. While nanoscale liquid chromatography (flow rates <1 μL/min) has gained widespread recognition in proteomics, the adoption of microscale setups (flow rates ranging from 1 to 100 μL/min) for low molecular weight compound applications, including metabolomics, has been surprisingly slow, despite the inherent advantages of the approach. Highly heterogeneous matrices and chemical structures accompanied by a relative lack of options for both selective sample preparation and user-friendly equipment are usually reported as major hindrances. To facilitate the wider implementation of microscale analyses, we present here a comprehensive tutorial encompassing important theoretical and practical considerations. We provide fundamental principles in micro-chromatography and guide the reader through the main elements of a microflow workflow, from LC pumps to ionization devices. Finally, based on both our literature overview and experience, illustrated by some in-house data, we highlight the critical importance of the ionization source design and its careful optimization to achieve significant sensitivity improvement.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics for dental caries diagnosis: Past, present, and future. 用于龋齿诊断的代谢组学：过去、现在和未来。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-06-28 DOI: 10.1002/mas.21896

Paras Ahmad, Dina G Moussa, Walter L Siqueira

{"title":"Metabolomics for dental caries diagnosis: Past, present, and future.","authors":"Paras Ahmad, Dina G Moussa, Walter L Siqueira","doi":"10.1002/mas.21896","DOIUrl":"https://doi.org/10.1002/mas.21896","url":null,"abstract":"Dental caries, a prevalent global infectious condition affecting over 95% of adults, remains elusive in its precise etiology. Addressing the complex dynamics of caries demands a thorough exploration of taxonomic, potential, active, and encoded functions within the oral ecosystem. Metabolomic profiling emerges as a crucial tool, offering immediate insights into microecosystem physiology and linking directly to the phenotype. Identified metabolites, indicative of caries status, play a pivotal role in unraveling the metabolic processes underlying the disease. Despite challenges in metabolite variability, the use of metabolomics, particularly via mass spectrometry and nuclear magnetic resonance spectroscopy, holds promise in caries research. This review comprehensively examines metabolomics in caries prevention, diagnosis, and treatment, highlighting distinct metabolite expression patterns and their associations with disease-related bacterial communities. Pioneering in approach, it integrates singular and combinatory metabolomics methodologies, diverse biofluids, and study designs, critically evaluating prior limitations while offering expert insights for future investigations. By synthesizing existing knowledge, this review significantly advances our comprehension of caries, providing a foundation for improved prevention and treatment strategies.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141464635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry imaging of N-linked glycans: Fundamentals and recent advances. N-连接糖的质谱成像：基本原理和最新进展。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-06-27 DOI: 10.1002/mas.21895

Tana V Palomino, David C Muddiman

引用次数: 0