Progress in Transplantation最新文献

筛选
英文 中文
Challenges in Meeting UNOS Personnel Requirements for Pancreas Transplant Programs Amid Declining National Case Volumes. 在全国病例量下降的情况下,满足美国联合医院胰腺移植项目人员需求的挑战。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-09-01 Epub Date: 2026-07-13 DOI: 10.1177/15269248261469205
Matin Moallem Shahri, Reza F Saidi
{"title":"Challenges in Meeting UNOS Personnel Requirements for Pancreas Transplant Programs Amid Declining National Case Volumes.","authors":"Matin Moallem Shahri, Reza F Saidi","doi":"10.1177/15269248261469205","DOIUrl":"10.1177/15269248261469205","url":null,"abstract":"<p><p>Pancreas transplantation remains a highly specialized and life-enhancing procedure for selected patients with insulin-dependent diabetes mellitus. As national transplant volumes have declined over the past decade, many U.S. transplant centers are finding it increasingly difficult to satisfy the personnel credentialing standards established by the Organ Procurement and Transplantation Network (OPTN). These standards, designed to ensure safety and competency, require documented case volumes and training experience that are difficult to achieve in today's landscape, where most programs perform fewer than 10 pancreas transplants annually, and training opportunities are limited. This growing mismatch between regulatory expectations and real-world practice highlights the need to reassess current personnel criteria and consider more flexible, competency-based approaches that maintain quality while supporting program viability and patient access.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"132-134"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-Savings Realized Using Rabbit Anti-Thymocyte Globulin Ideal Body Weight Dosing for Kidney Transplantation Induction Immunosuppression. 兔抗胸腺细胞球蛋白理想体重剂量用于肾移植诱导免疫抑制的成本节约。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1177/15269248261456512
Christy Ilia, Ciara Walshe, Linh Nguyen, Chelsea Sammons, Maxwell Norris, Abigail Forte, Jennifer Trofe, Gregory Malat
{"title":"Cost-Savings Realized Using Rabbit Anti-Thymocyte Globulin Ideal Body Weight Dosing for Kidney Transplantation Induction Immunosuppression.","authors":"Christy Ilia, Ciara Walshe, Linh Nguyen, Chelsea Sammons, Maxwell Norris, Abigail Forte, Jennifer Trofe, Gregory Malat","doi":"10.1177/15269248261456512","DOIUrl":"10.1177/15269248261456512","url":null,"abstract":"<p><p>IntroductionRabbit anti-thymocyte globulin (rATG) induction ideal dosing strategies in kidney transplant recipients have not been fully elucidated.Project AimsThis study compares the impact of ideal body weight-based versus actual body weight-based rATG dosing on drug purchasing costs and kidney transplant outcomes.DesignRetrospective, single-center chart review of kidney transplant recipients receiving rATG induction using (1) actual body weight-based dosing between May 17, 2019, and Mar 13, 2020, versus (2) ideal body weight-based dosing between May 17, 2022, and Mar 13, 2023. The primary endpoint is the rATG drug cost/kidney transplant recipient [measured by average wholesale price] compared between cohorts. Secondary endpoints are rates of biopsy-proven acute rejection, readmissions secondary to infection, myelosuppression (leukopenia or neutropenia), and viremia (Epstein-Barr virus, cytomegalovirus, and BK virus) measured for 6 months. Study design adhered to EQUATOR STROBE guidelines for reporting cohort studies.ResultsOverall, rATG ideal body weight-based dosing resulted in a median $3838 saved per kidney transplant recipients, based on average wholesale price, and a statistically significant reduction in cost versus actual body weight-based dosing (<i>P</i> = .02). Secondary outcomes were generally similar between groups, with a difference in Epstein-Barr viremia (<i>P</i> = .017) not translating to a significant difference in readmissions for infection (<i>P</i> = .226).ConclusionOur institution conducts around 250 kidney transplants annually, and considering the majority will receive rATG induction, this dosing protocol estimates average wholesale price drug purchasing cost-savings of about $900 000/year without compromising early clinical outcomes.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"74-80"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
End-of-Life Care of Young Adult Solid Organ Transplant Recipients Compared to Nontransplant Recipients. 年轻成人实体器官移植受者与非移植受者的临终关怀。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1177/15269248261456464
Carolina M Gustafson, Jeannie P Cimiotti, Gerard Vong, Vicki Hertzberg, Mi-Kyung Song
{"title":"End-of-Life Care of Young Adult Solid Organ Transplant Recipients Compared to Nontransplant Recipients.","authors":"Carolina M Gustafson, Jeannie P Cimiotti, Gerard Vong, Vicki Hertzberg, Mi-Kyung Song","doi":"10.1177/15269248261456464","DOIUrl":"10.1177/15269248261456464","url":null,"abstract":"<p><p>IntroductionLittle is known about end-of-life care of young adult solid organ transplant-recipients and how it compares to care received by nontransplant-recipient young adults with chronic illness.Research Questions(1) What aggressive and palliative care methods are used among young adults by solid organ transplant status (ie, recipient vs nonrecipient), and (2) what factors, including transplant recipient status, predict receiving a palliative care consult in the last 90 days of life.DesignData on young adults (18-39 years) with a history of solid organ transplant (recipient cohort) or cancer, heart disease, and/or HIV (nonrecipient cohort) were obtained from the clinical data warehouse of a large academic medical center/primary transplant center. The nonrecipient cohort (n = 412) was propensity score matched to the recipient cohort (n = 412) on gender, race, and age at death. Aggressive care was the use of cardiopulmonary resuscitation (CPR), dialysis, tube feedings, emergent intubation, extracorporeal membrane oxygenation, and mechanical ventilation. Data on receipt of and reason for palliative care consult were also extracted, and logistic regression was used to identify factors associated with receiving a palliative care consult.ResultsA larger percentage of nonrecipients received CPR (36.0% vs 20.0%, <i>P</i> < .01) and emergent intubation (16.8% vs 6.1%, <i>P</i> < .01), whereas a larger percentage of recipients received dialysis (31.7% vs 19.9%, <i>P</i> < .01). A larger percentage of palliative care consults for symptom management were noted in the recipient cohort (49.2% vs 22.2%, <i>P</i> = .04).ConclusionsSimilarities in care between the cohorts may indicate transplant recipient status does not impact end-of-life care in young adults.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"55-64"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Study on the Experiences Related to Immunosuppressive Therapy in Liver Transplant Recipients. 肝移植受者免疫抑制治疗相关经验的定性研究。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-06-01 Epub Date: 2026-06-03 DOI: 10.1177/15269248261456868
Adile Savsar, Hatice Ayhan, Gülay Aksu Kul, Murat Kilic
{"title":"A Qualitative Study on the Experiences Related to Immunosuppressive Therapy in Liver Transplant Recipients.","authors":"Adile Savsar, Hatice Ayhan, Gülay Aksu Kul, Murat Kilic","doi":"10.1177/15269248261456868","DOIUrl":"10.1177/15269248261456868","url":null,"abstract":"<p><p>IntroductionWhile lifelong immunosuppressive therapy is pivotal for liver transplant recipients, nonadherence driven by complex biological, psychological, and social challenges remains a significant clinical problem. This study explored recipients' experiences with immunosuppressive therapy within the framework of the biopsychosocial model.MethodsThis descriptive qualitative study included 16 liver transplant recipients recruited via purposive sampling at a hospital in the Aegean region of Türkiye. Data were collected through in-depth interviews and analyzed using qualitative content analysis. Following an inductive identification of themes, a deductive mapping approach was employed to integrate the findings within the biological, psychological, and social dimensions of the biopsychosocial model.ResultsRecipients' mean age was 54.56 ± 13.47 years. The analysis revealed 2 main themes and 7 subthemes. In the biological dimension, recipients viewed medications as a \"way to survive,\" though physical quality of life was compromised by persistent \"side effects.\" The psychological dimension was characterized by \"doubts\" and \"psychological effects,\" where recipients developed hypervigilance toward bodily sensations and experienced anxiety regarding missed doses. Within the social dimension, the theme \"a difficult situation\" highlighted how rigid medication schedules and fear of infection led to restricted social participation. Recipients described the development of \"improving health and coping behaviors,\" utilizing individualized strategies and social supports to maintain adherence.ConclusionsThis study demonstrates the complex interplay between the biological, psychological, and social dimensions of medication experiences. Although participants view medications as a vital necessity, they experience adherence challenges due to psychological difficulties and social limitations, highlighting the need for holistic support strategies.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"81-88"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Failed Deceased Donor Kidney Graft Longevity on Mortality. 死亡供体肾脏移植失败寿命对死亡率的影响。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-06-01 Epub Date: 2026-06-02 DOI: 10.1177/15269248261456508
William A Preston, Scott H Koeneman, Mia N Brownfield, Devon J Pace, Haley Kittle, Khaled Noueihed, Peter Altshuler, Adam M Frank, Jaime M Glorioso, Carlo Ramirez, Kenneth Andreoni, Warren R Maley, Adam S Bodzin, Ashesh P Shah
{"title":"The Impact of Failed Deceased Donor Kidney Graft Longevity on Mortality.","authors":"William A Preston, Scott H Koeneman, Mia N Brownfield, Devon J Pace, Haley Kittle, Khaled Noueihed, Peter Altshuler, Adam M Frank, Jaime M Glorioso, Carlo Ramirez, Kenneth Andreoni, Warren R Maley, Adam S Bodzin, Ashesh P Shah","doi":"10.1177/15269248261456508","DOIUrl":"10.1177/15269248261456508","url":null,"abstract":"<p><p>IntroductionWhile the benefits of deceased donor kidney transplant versus dialysis are clear, the impact of graft longevity remains unclear.Research QuestionsThis study assessed survival between patients with failed grafts and patients who remained on dialysis alone.DesignUtilizing the Organ Procurement and Transplant Network database, adults on dialysis listed for deceased donor kidney transplant between 1/2005 and 12/2017 were identified (<i>n</i> = 265 280; <i>n</i> = 129 062 [48.7%] transplant; <i>n</i> = 136 218 [51.3%] dialysis alone, not transplanted). A multivariable Cox proportional hazards model incorporating confounding covariates and utilizing transplant status (dialysis alone, functioning graft, failed graft) as a time-varying covariate was constructed. Representative patients were then fit to this model to assess survival probability.ResultsPatients who underwent transplant experienced a 65% reduction in mortality compared to those remaining on dialysis. However, graft failure (<i>n</i> = 19 389, 15.0% of transplants) was associated with a 47% increase in hazard rate compared to dialysis. When an average-risk patient was fit to this model, with transplant 4 years after dialysis initiation, a graft required longevity of 3 years to convey a survival probability benefit at 5 years postoperatively (9 years from waitlisting, 35%) over remaining on dialysis through the same time point (9 years from waitlisting, 32%).ConclusionsThese results argue for scrutiny of anticipated graft longevity and its expected impact on individual outcomes and advocate for 3-year graft survival as a critical clinical measure for transplant programs.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"89-96"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Inhaled Anesthetic Administration on Deceased Organ Donors and Transplant Recipients. 吸入麻醉对已故器官供体和移植受者的影响。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-06-01 DOI: 10.1177/15269248261456454
Elodie Vertefeuille, Alexis Martin, Marc-Antoine Bolduc, Frederick D'Aragon
{"title":"The Effect of Inhaled Anesthetic Administration on Deceased Organ Donors and Transplant Recipients.","authors":"Elodie Vertefeuille, Alexis Martin, Marc-Antoine Bolduc, Frederick D'Aragon","doi":"10.1177/15269248261456454","DOIUrl":"10.1177/15269248261456454","url":null,"abstract":"<p><p>IntroductionDue to the organ shortage, effective treatments for early graft dysfunction are critically needed. Early graft dysfunction is associated with a prolonged hospital stay, acute rejection, and mortality. Ischemia-reperfusion injury is a major contributor to early graft dysfunction. Inhaled anesthetics may reduce ischemia-reperfusion injury and improve donation and transplant outcomes.ObjectiveThis review aimed to summarize clinical studies of inhaled anesthetics administration to deceased donors, investigating downstream effects on transplant outcomes.MethodsWe searched MEDLINE, EMBASE, Cochrane Library, and conference proceedings for clinical studies comparing deceased donors' treatment with inhaled anesthetics to either placebo or no intervention and evaluating outcomes for any organ transplantation. Reviewers independently screened and selected studies, extracted data, and assessed the risk of bias. We assessed the overall quality of evidence using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.ResultsThree studies with different inhaled anesthetics regimens were included. Most studies have assessed the effects of sevoflurane. Conflicting results were reported on early graft dysfunction since 1 study showed a reduced incidence, while the other 2 did not report any difference. Two studies evaluated graft function, with peak serum alanine transaminase and aspartate aminotransferase improvements in the intervention groups. No difference in graft survival was reported between the 2 studies. The quality of evidence was very low for all outcomes.DiscussionCurrent studies offer limited evidence to support the use of inhaled anesthetics preconditioning in deceased donors. Since there is physiological plausibility of their use, rigorous randomized clinical trials are needed to establish clear conclusions on their benefits.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"66-73"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Scoping Review and Practical Approach to Measuring Health Literacy in Solid Organ Transplantation. 测量实体器官移植健康素养的范围综述和实用方法。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-03-01 Epub Date: 2026-04-17 DOI: 10.1177/15269248261432238
Vanessa Phommavong, Breanna Morrison, Nicola Rosaasen, Kathryn Haubrich, Irène Pandraud-Riguet, Holly Mansell
{"title":"A Scoping Review and Practical Approach to Measuring Health Literacy in Solid Organ Transplantation.","authors":"Vanessa Phommavong, Breanna Morrison, Nicola Rosaasen, Kathryn Haubrich, Irène Pandraud-Riguet, Holly Mansell","doi":"10.1177/15269248261432238","DOIUrl":"10.1177/15269248261432238","url":null,"abstract":"<p><p><b>Introduction:</b> Solid organ transplant recipients have extensive self-care responsibilities. Limited health literacy (HL) can hinder effective self-management and long-term outcomes. <b>Objective:</b> A scoping review of HL instruments is needed to summarize their use in solid organ transplant. <b>Methods:</b> A systematic search was conducted using Medline, Embase, and CINAHL databases to identify studies that measured HL in the context of solid organ transplant. Search results were uploaded into Mendeley, and duplicates were removed. Two reviewers screened the abstracts and full texts for eligibility and discrepancies were resolved by the research team. Data extraction included publication details, study features, and HL instruments. <b>Results:</b> Of 721 articles identified for title and abstract assessment, 94 articles were further reviewed for full-text eligibility, and 50 were included in the review. HL instruments included: the Brief HL Screen (BHLS) and iterations (with 16 studies), Newest Vital Sign (NVS) (15 studies), Rapid Estimate of Adult Literacy in Medicine (REALM) (8 studies), Test of Functional HL in Adults (TOFHLA) (7 studies), HL Questionnaire (HLQ) (6 studies), eHL Scale (eHEALS) (4 studies), Brief Medical Numbers Test (BMNT) (3 studies), Decision-Making Capacity Assessment Tool (DMCAT) (2 studies), Short Assessment of HL (SAHL) (1 study). <b>Discussion:</b> Seven studies used multiple HL instruments in their analysis. Some instruments had multiple versions, such as the original TOFHLA and its shortened form (S-TOFHLA), and the original REALM and its transplant-specific version (REALMT). <b>Conclusion:</b> This review provides an overview of HL instruments for transplant healthcare providers who may want to incorporate HL measurement into practice.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":"36 1","pages":"25-50"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Türkiye. 肾移植的十年趋势,按供体类型、年龄、透析和性别/性别不平等划分。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-03-01 Epub Date: 2026-03-27 DOI: 10.1177/15269248261430365
Yaprak Sarigol Ordin, Eda Ayten Kankaya, Buket Celik
{"title":"Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Türkiye.","authors":"Yaprak Sarigol Ordin, Eda Ayten Kankaya, Buket Celik","doi":"10.1177/15269248261430365","DOIUrl":"10.1177/15269248261430365","url":null,"abstract":"<p><p>IntroductionGender disparity remains a global issue in access to renal replacement therapy and kidney transplantation among patients with end-stage kidney disease.AimThis study examined trends in donor type, recipient age, and dialysis modality in kidney transplantation in Türkiye from 2013 to 2022. A secondary aim was to explore gender disparities in kidney transplantation and treatment modalities for end-stage kidney disease using registry data.MethodsThis descriptive and cross-sectional study analyzed the distribution and trends of kidney transplants in Türkiye between 2013 and 2022. The data were obtained from the publicly accessible Registry of Nephrology, Dialysis, and Transplantation reports in Türkiye. Per million population increase/decrease rate, χ<sup>2</sup> linear trend, and χ<sup>2</sup> R by C were used.ResultsOver time, transplants from living donors increased, while deceased donor transplants decreased. The highest rates of living donor transplants were in 2022, 2021, and 2019. Transplants in high-risk age groups increased significantly. There were differences in donor type among patients receiving hemodialysis, peritoneal dialysis, or preemptive transplantation (<i>p</i> < .001). Preemptive transplants showed the most significant increase, especially from living donors in 2022. Between 2013 and 2022, kidney transplantation increased by 24.67% in men and 19.94% in women. Female transplant rates were lowest in 2016, 2020, and 2021, indicating a persistent gender gap. There was no significant gender difference in the incidence of hemodialysis or peritoneal dialysis.ConclusionLiving donor transplants, especially preemptive ones, increased markedly over the past decade. Gender disparities persist, and efforts should focus on improving access for women and promoting deceased donor programs to ensure equity.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"3-11"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Social and Psychological Factors on Cognition Among Liver Transplant Recipients. 社会心理因素对肝移植受者认知的影响。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-03-01 Epub Date: 2026-02-26 DOI: 10.1177/15269248261426835
Dami Ko, Priyadarshani Bajracharya, Neha Singh, Charles H Hillman, Alan Bonder
{"title":"The Influence of Social and Psychological Factors on Cognition Among Liver Transplant Recipients.","authors":"Dami Ko, Priyadarshani Bajracharya, Neha Singh, Charles H Hillman, Alan Bonder","doi":"10.1177/15269248261426835","DOIUrl":"10.1177/15269248261426835","url":null,"abstract":"<p><p>IntroductionCognitive impairment in liver transplant recipients can lead to poor health outcomes, and identifying at-risk individuals is important to provide timely support. Poor social conditions, including poor socioeconomic status and lack of social support, have been suggested as potential contributors to cognitive impairment. Further, individuals with poor social conditions may experience psychological symptoms, such as depression and anxiety, which can further affect cognition.AimThis preliminary study explored longitudinal associations between social conditions, depression and anxiety symptoms, and cognition in liver transplant recipients.DesignA total of 23 adult liver transplant candidates were enrolled, with 9 receiving liver transplantation, who were followed for up to 1-year post-transplant. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. Social conditions and psychological symptoms were assessed through surveys. Linear mixed-effects models adjusted for age and education were used to examine the relationships between social conditions, psychological symptoms, and cognition. Moderation analysis was also conducted to explore interactions between social conditions and psychological symptoms.ResultsCognitive scores remained stable over time. Social conditions were not associated with cognition, whereas higher levels of depression and anxiety symptoms were associated with worse cognitive performance. No significant interaction was found between social conditions and psychological symptoms on cognition.ConclusionDepression and anxiety symptoms, but not social conditions, showed associations with cognition in liver transplant recipients. These findings suggest the importance of assessing psychological symptoms in this population to identify those at risk for cognitive impairment.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"17-24"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partnering with Living Donors in the Development of Long-Term Follow-Up Data Collection Instruments. 与活体捐赠者合作开发长期随访数据收集工具。
IF 1.1 4区 医学
Progress in Transplantation Pub Date : 2026-03-01 Epub Date: 2026-03-13 DOI: 10.1177/15269248261430491
Allyson Hart, Katie Siegert, Heather Hunt, Jill Brown, Glenna Frey, Trysha L Galloway, Becky Gustamante, Matt Harmody, Kelley Hitchman, McKenzie Hull, Sophia Jackson, Katie McKee, Michael Murphy, Jennifer Roberts, Aubrey Sepko, Sue Venteicher, Francis Wheeler, Krista L Lentine, Amy D Waterman
{"title":"Partnering with Living Donors in the Development of Long-Term Follow-Up Data Collection Instruments.","authors":"Allyson Hart, Katie Siegert, Heather Hunt, Jill Brown, Glenna Frey, Trysha L Galloway, Becky Gustamante, Matt Harmody, Kelley Hitchman, McKenzie Hull, Sophia Jackson, Katie McKee, Michael Murphy, Jennifer Roberts, Aubrey Sepko, Sue Venteicher, Francis Wheeler, Krista L Lentine, Amy D Waterman","doi":"10.1177/15269248261430491","DOIUrl":"10.1177/15269248261430491","url":null,"abstract":"<p><p>Patient-centered outcomes are increasingly recognized by the transplant community as a key component to improving knowledge and patient counseling, and long-term outcomes after living kidney or liver donation are not well understood. With efforts underway to follow living donors and donor candidates long term, it is critical that living donors and candidates drive the process of patient-centered data collection. Living donors on the Scientific Registry of Transplant Recipients' Living Donor Steering Committee were engaged to brainstorm and prioritize which data elements should be captured. Committee members identified long-term lab values, difficulty with normal activities, and diagnosis of chronic kidney or liver disease as critical long-term outcomes. Additional high-priority elements included short-term lab values, deaths related to donation, mortality among donors compared to nondonors, hospital readmissions, costs and physical limitations related to donation, and whether a donor would donate again. Finally, living donors wanted to know the risk of organ failure among donors compared to nondonors. This prioritization exercise provided valuable insights from living donors to help determine key themes and discrete data elements that should be prioritized for long-term collection and reporting to living donors and living donor candidates.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"12-16"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书