Progress in Transplantation最新文献_第2页

A Journey From Patient and Physician to Entrepreneur and Advocate in Transplantation. 从病人和医生到企业家和移植倡导者的旅程。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1177/15269248241304804

Karin Hehenberger, Souha Farhat, Amy D Waterman

引用次数: 0

Racial Variation of Donor-Derived Cell-Free DNA in Kidney Transplant Recipients. 肾移植受者供体来源的无细胞DNA的种族差异。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1177/15269248241304787

Oliver G Ralph, Michael D Williams, Edie Y Chan, Oyedolamu Olaitan

{"title":"Racial Variation of Donor-Derived Cell-Free DNA in Kidney Transplant Recipients.","authors":"Oliver G Ralph, Michael D Williams, Edie Y Chan, Oyedolamu Olaitan","doi":"10.1177/15269248241304787","DOIUrl":"10.1177/15269248241304787","url":null,"abstract":"Introduction: There is a need for a noninvasive, affordable, sensitive, and specific biomarker to diagnose early acute rejection, to negate the need for frequent biopsies. Dd-cfDNA is a powerful adjunct yet there is limited data on the ethnic differences in its values. There is anecdotal evidence that dd-cfDNA values at rejection may be higher in Black as compared to non-Black recipients. This study aims to add to this literature while defining such variability and comparing it to previously validated cutoffs for dd-cfDNA of 0.5% or 1%.Design: This was a single-center retrospective observational study of patients who underwent graft biopsies with a preceding, paired, dd-cfDNA value. Recipients were separated into White, Black, and Hispanic racial and ethnic groups, and dd-cfDNA values at rejection versus nonrejection were compared.Results: With 0.5% and 1% cutoffs, false negative rates for rejection were 13% and 22%, respectively. The false positive rate was 38.4%. 12.2% of Black recipients, 11.8% of Hispanic recipients, and 44% of White recipients had rejection with a negative AlloSure®. Values >0.5% corresponded to histologic rejection in 61.5% of Black, 66.7% of White, and 56.3% of Hispanic recipients. Antibody-mediated rejection occurred in 65.5% of rejection cases in Black recipients, while exhibiting the lowest rate of T-cell-mediated rejection. Dd-cfDNA values gave an accurate diagnosis of rejection in 52.8% of recipients with AMR versus 19.3% in TCMR.Conclusion: This study demonstrated that dd-cfDNA was applicable to Black recipients with a robust ability to detect antibody-mediated rejection, as compared to White and Hispanic recipients.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"14-21"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Postintervention Outcomes from a Randomized Trial that Sought to Enhance Access to Live Donor Kidney Transplant for Black and African Americans. 一项旨在提高黑人和非裔美国人获得活体肾脏移植的随机试验的干预后即时结果。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI: 10.1177/15269248241304794

Kimberly Jacob Arriola, D'Jata Barrett, Stephen Pastan, Jennie Perryman, Derek DuBay, Courtney Tresslar, Sara Useche De Abreu, Mengyu Di, Larissa Teunis, Miranda Montoya, Tatenda Mangurenje, Rachel E Patzer

{"title":"Immediate Postintervention Outcomes from a Randomized Trial that Sought to Enhance Access to Live Donor Kidney Transplant for Black and African Americans.","authors":"Kimberly Jacob Arriola, D'Jata Barrett, Stephen Pastan, Jennie Perryman, Derek DuBay, Courtney Tresslar, Sara Useche De Abreu, Mengyu Di, Larissa Teunis, Miranda Montoya, Tatenda Mangurenje, Rachel E Patzer","doi":"10.1177/15269248241304794","DOIUrl":"10.1177/15269248241304794","url":null,"abstract":"Introduction: Eliminating racial inequities in access to kidney transplantation requires multilevel interventions that target both patients and health systems.Research question: The aim of this study was to determine whether adding culturally sensitive, web-based patient education to a transplant center-level intervention was associated with increased knowledge, motivation to pursue living donor kidney transplant, and confidence in the behavioral skills to discuss living donation among Black/African American patients with end-stage kidney disease.Design: A total of 411 transplant candidates were randomized to intervention (N = 222) or control groups (N = 189) and completed measures at baseline and immediate follow-up during the transplant evaluation visit.Results: Results indicated no significant change in knowledge across time or study condition. At immediate follow-up, participants of both study conditions exhibited a significantly higher motivation to pursue living donation (t = 3.066, P < .01) versus at baseline. Both study conditions demonstrated increased confidence in the behavioral skills to discuss living donation over time (t = 3.580, P < .001). Process evaluation findings demonstrated limited engagement with the online video content across both conditions.Conclusion: Results suggest that the intervention did not perform better than control but raised important considerations for the delivery of transplant education targeting Black/African American patients in a busy clinical setting.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"5-12"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Robotic-Assisted Ectopic Pelvic Kidney Donation for Living Donor Transplant. 机器人辅助异位盆腔肾移植活体移植成功。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1177/15269248241304795

Badi Rawashdeh, Emily McCracken, Paola Vargas, Yazan Al-Adwan, Jose Oberholzer

引用次数: 0

Organ Donation Changed My Life. 器官捐献改变了我的生活

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1177/15269248241304793

Samantha Facer

引用次数: 0

Empowering the Voice of Patients, Families, and Caregivers Through Participation in Organ Donation and Transplantation Conferences. 通过参加器官捐献和移植会议，增强患者、家属和护理人员的话语权。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-16 DOI: 10.1177/15269248241307160

Macey L Levan, Alin Gragossian

引用次数: 0

The Impact of Engaging Transplant Recipients in Health Care Policy Deliberations. 移植受者参与医疗保健政策审议的影响。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1177/15269248241304792

Earnest Davis, Jennifer Jones, Molly McCarthy, Katie McKee, Morgan Reid, Dale Rogers, Rolanda Schmidt, Ameen Tabatabai, Allyson Hart

引用次数: 0

Reconsidering Public Attitudes Toward Deceased Organ Donation Registration. 重新考虑公众对死者器官捐献登记的态度。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1177/15269248241288566

Thomas H Feeley, Stephanie J Gillis

引用次数: 0

Evaluating Predictive Factors for Lymphocele Formation Following Kidney Transplantation. 评估肾移植术后淋巴囊形成的预测因素

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-13 DOI: 10.1177/15269248241288568

Oleksandr Boiko, Ignacio Garcia-Alonso, Adela Navarro, Asier Maldonado, Sergio Prieto, Ana Llorente, Florina Iliuta, Joel Sanz, Ivan Olano, Beatriz Martinez, Oskar Estrade, Jesus Padilla

{"title":"Evaluating Predictive Factors for Lymphocele Formation Following Kidney Transplantation.","authors":"Oleksandr Boiko, Ignacio Garcia-Alonso, Adela Navarro, Asier Maldonado, Sergio Prieto, Ana Llorente, Florina Iliuta, Joel Sanz, Ivan Olano, Beatriz Martinez, Oskar Estrade, Jesus Padilla","doi":"10.1177/15269248241288568","DOIUrl":"10.1177/15269248241288568","url":null,"abstract":"Introduction: Lymphocele is a common complication post-kidney transplantation, influenced by various factors including surgical technique, graft vessel count, operator experience, body mass index, ischemia time, and immunotherapy regimens.Project aims: The purpose of this study was to evaluate lymphocele risk factors, particularly focusing on the role of end-stage kidney disease.Design: A retrospective study was conducted on renal transplant recipients from a single center (March 2020 to December 2022). Patients were categorized into those developing lymphocele and those without during the postoperative period. Data, including sociodemographic, personal history, graft-related variables, intervention, and postoperative outcomes, were collected from electronic medical records.Results: Out of 291 renal transplant recipients, 57 (19.6%) developed postoperative lymphocele, with 15 (5.1%) being symptomatic. Patients with body mass index <24.9 kg/m2 have lower risk of developing lymphocele with an Odds Ratio of 0.538 (P=0.046). Higher lymphocele prevalence was noted in patients with chronic tubulointerstitial nephritis (46.2%; OR 3.815; P=0.024). Focal segmental glomerulosclerosis patients showed no lymphocele (0.0%; OR 0.123; P=0.048). Other factors, including autosomal dominant polycystic kidney disease, did not exhibit significant differences in lymphocele prevalence.Conclusion: The etiology of end-stage kidney disease can serve as a significant predictor of lymphocele development during the postoperative period following renal transplantation. Further larger prospective studies are required to comprehensively assess risk factors and explore end-stage kidney disease potential role in predicting lymphocele formation.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"199-203"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key Associations Found in the Struggle With Sleep in Lung Transplant Recipients. 肺移植受者与睡眠斗争中发现的关键关联。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1177/15269248241289149

Jane Simanovski, Jody Ralph, Sherry Morrell

{"title":"Key Associations Found in the Struggle With Sleep in Lung Transplant Recipients.","authors":"Jane Simanovski, Jody Ralph, Sherry Morrell","doi":"10.1177/15269248241289149","DOIUrl":"10.1177/15269248241289149","url":null,"abstract":"Introduction: Gaps exist in the understanding of the etiology of poor sleep quality after lung transplantation. Research Question: What factors are associated with poor sleep quality in lung transplant recipients?Design: A quantitative, single-site, cross-sectional study used an anonymous survey based on 3 scales. The Pittsburgh Sleep Quality Index scale with scores dichotomized to poor versus good sleepers based on the cutoff score > 8. The Hospital Anxiety and Depression Scale evaluated symptoms of anxiety and depression, and the Short Form-12 measured health-related quality of life using the mental and physical component scores. Additional self-reported data included demographic and transplant-related variables.Results: The response rate was 38.4% (61/158), and 52.5% of the sample (32/61) evidenced a Pittsburgh Sleep Quality Index score > 8, suggestive of poor sleep quality. Bivariate analyses demonstrated that poor sleep was significantly related to symptoms of depression (P < .01), anxiety (P < .01), stressors of hospitalization (P < .05), and treatment of acute rejection (P < .05). Multivariate analysis demonstrated that anxiety was significantly associated with poor sleep (odds ratio = 1.34, P < .05).Conclusion: Poor subjective sleep quality remains prevalent in lung transplant recipients. Individuals with anxiety symptoms were at a greater risk for poor sleep. Guidance for strategies to improve sleep quality requires further in-depth exploration before implementation of interventions.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"183-191"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0