Progress in Transplantation最新文献_第2页

Key Associations Found in the Struggle With Sleep in Lung Transplant Recipients. 肺移植受者与睡眠斗争中发现的关键关联。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1177/15269248241289149

Jane Simanovski, Jody Ralph, Sherry Morrell

{"title":"Key Associations Found in the Struggle With Sleep in Lung Transplant Recipients.","authors":"Jane Simanovski, Jody Ralph, Sherry Morrell","doi":"10.1177/15269248241289149","DOIUrl":"10.1177/15269248241289149","url":null,"abstract":"Introduction: Gaps exist in the understanding of the etiology of poor sleep quality after lung transplantation. Research Question: What factors are associated with poor sleep quality in lung transplant recipients?Design: A quantitative, single-site, cross-sectional study used an anonymous survey based on 3 scales. The Pittsburgh Sleep Quality Index scale with scores dichotomized to poor versus good sleepers based on the cutoff score > 8. The Hospital Anxiety and Depression Scale evaluated symptoms of anxiety and depression, and the Short Form-12 measured health-related quality of life using the mental and physical component scores. Additional self-reported data included demographic and transplant-related variables.Results: The response rate was 38.4% (61/158), and 52.5% of the sample (32/61) evidenced a Pittsburgh Sleep Quality Index score > 8, suggestive of poor sleep quality. Bivariate analyses demonstrated that poor sleep was significantly related to symptoms of depression (P < .01), anxiety (P < .01), stressors of hospitalization (P < .05), and treatment of acute rejection (P < .05). Multivariate analysis demonstrated that anxiety was significantly associated with poor sleep (odds ratio = 1.34, P < .05).Conclusion: Poor subjective sleep quality remains prevalent in lung transplant recipients. Individuals with anxiety symptoms were at a greater risk for poor sleep. Guidance for strategies to improve sleep quality requires further in-depth exploration before implementation of interventions.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"183-191"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Age at Liver Transplant on Anxiety, Depression, and Quality of Life Among Adolescents. 肝移植年龄对青少年焦虑、抑郁和生活质量的影响

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1177/15269248241288563

Alison F Marshall, Carmen Mandac, FeiFei Qin, Derek Boothroyd, Annette S Nasr

{"title":"Effect of Age at Liver Transplant on Anxiety, Depression, and Quality of Life Among Adolescents.","authors":"Alison F Marshall, Carmen Mandac, FeiFei Qin, Derek Boothroyd, Annette S Nasr","doi":"10.1177/15269248241288563","DOIUrl":"10.1177/15269248241288563","url":null,"abstract":"Introduction: Life expectancy for pediatric liver transplant patients has increased over the past decade. Different stages of the transplant process can impact patients' quality of life (QOL) and create psychological and physical stressors. This study explored whether age at transplant affected adolescents' feelings of anxiety, depression, and QOL. Design: In this cross-sectional quantitative study, data were collected on 22 adolescent patients aged 13-18 who received a transplant at least 12 months before enrollment. This cohort was divided into 2 groups based on their age at transplant: Group 1 (0-5 years) and Group 2 (6-18 years). To assess transplant-related anxiety, depression, and QOL, participants completed 3 surveys: the Generalized Anxiety Disorder-7 (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the Pediatric Quality of Life Inventory™ Transplant Module (PedsQL TM). Results: Group 1 experienced less anxiety and fewer problems based on GAD-7 scores but reported stronger feelings of depression based on PHQ-9 scores. Based on the PedsQL TM scale, Group 1 had higher mean scores compared to Group 2 across all components (mean difference range: 7.2- 27.3; Cohen's d range: 0.27 - 1.13). The largest difference between the 2 groups was observed on the PedsQL TM scale's How I Look (Group 1 mean 81.1 vs. Group 2 mean 53.8; Cohen's d: 1.13; P = 0.015), Conclusion: In this cohort, age at transplant affected adolescents' feelings of anxiety, depression, and QOL. Awareness of these findings can help clinicians screen for and address mental health issues.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"192-198"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

McArdle Disease Diagnosis After 2 Decades of Kidney Transplantation. 肾移植二十年后的麦卡德尔病诊断。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1177/15269248241288562

Harun Coban, Dilek Barutcu Atas, Asli Karsli Demirsoy, Murat Tugcu, Ebru Asicioglu, Izzet Hakki Arikan, Zübeyde Serhan Tuglular, Arzu Velioglu

引用次数: 0

Transformative Learning Among Organ Procurement Organization Donor Family Volunteers. 器官获取组织捐赠者家庭志愿者的转型学习。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1177/15269248241288558

Nicholas R Henry, Joellen E Coryell

{"title":"Transformative Learning Among Organ Procurement Organization Donor Family Volunteers.","authors":"Nicholas R Henry, Joellen E Coryell","doi":"10.1177/15269248241288558","DOIUrl":"10.1177/15269248241288558","url":null,"abstract":"Introduction: Some family members who previously made the decision to donate a family member's organs support the organ procurement organization (OPO) through volunteer work. Volunteers were asked to describe their family's organ donation story to educate the general and medical communities about organ donation. This study explored the transformative learning experienced by volunteers during and following the organ donation consent process and throughout their volunteer work. Methods/Approach: A narrative inquiry research methodology and transformative learning theoretical framework was used and 6 volunteers were recruited to participate. Two semistructured virtual interviews were conducted. Interviews were transcribed, radically reduced, and subjected to holistic-content and holistic-form narrative analysis. Findings: Participants experienced strong emotional responses during and after the loss of their family member, characterized as a period of disorientation, which lasted for an extended period preventing transformative learning. After the OPO contacted participants regarding the opportunity to volunteer, participants experienced a period of self-examination when they reengaged with the topic of organ donation. Critical reflection occurred through the act of storytelling about their family's organ donation story during their volunteer work. Storytelling to the community facilitated making meaning of their loss and transformations. Conclusion: Volunteering for an OPO played an important role by initiating self-examination and critical reflection of their prior assumptions. Through storytelling, participants reflected on their roles and made meaning of their organ donation experiences. The act of inviting donor families to reengage with the topic of organ donation through volunteer work fostered positive permanent meaningful transformations.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"170-175"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Levels of Vitamins A, C, and E-Alpha in Organ Donors After the Neurologic Determination of Death. 神经系统确定死亡后器官捐献者体内维生素 A、C 和 E-Alpha 的循环水平。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1177/15269248241288561

Robert S Ream, Yi Li, Gary F Marklin

{"title":"Circulating Levels of Vitamins A, C, and E-Alpha in Organ Donors After the Neurologic Determination of Death.","authors":"Robert S Ream, Yi Li, Gary F Marklin","doi":"10.1177/15269248241288561","DOIUrl":"10.1177/15269248241288561","url":null,"abstract":"Introduction: The antioxidant effects of vitamins may attenuate the oxidative stress on organs imposed by ischemia-reperfusion injury during the process of organ transplantation from brain-dead donors. Circulating levels of vitamins A, C, and E-α in donors after brain death and their relationships to donor demographics, management, organ utilization, and recipient outcomes are largely unknown.Methods: An observational, prospective, cohort study of 84 consecutive brain-dead organ donors managed at a single organ procurement recovery center was conducted. Vitamin levels were drawn immediately prior to procurement.Results: Levels of serum vitamins A and E-α and plasma vitamin C were below normal in 80%, 85%, and 92% of donors and deficient in 40%, 62%, and 63%, respectively. Vitamin C deficiency was associated with a longer time between death and specimen collection (P = .004). Death from head trauma and stroke were associated with lower levels of vitamin A than from anoxic causes (P = .003) and smokers had greater vitamin C deficiency (P = .03). During donor management, vitamin C deficiency was associated with longer vasopressor support (P = .03) and normal levels of vitamin E-α were associated with reaching a lower alanine transferase compared to those with subnormal levels (P < .05). Donors deficient in vitamin E-α were less likely to have a liver recovered for transplantation (P = .005). Vitamin levels were not associated with the recipient outcomes examined.Conclusion: Circulating vitamins A, C, and E-α is profoundly low in brain-dead organ donors, associated with relevant demographic features of the donor, and may influence donor management and organ utilization.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"176-182"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Intrapatient Tacrolimus Variability and Increased Cell-Free DNA in Kidney Transplant Recipients. 肾移植受者体内他克莫司的高变异性和游离细胞 DNA 的增加

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1177/15269248241288559

Miranda Kopfman, Marissa Brokhof, Shree Patel, Dennis Fu, Oyedolamu Olaitan

{"title":"High Intrapatient Tacrolimus Variability and Increased Cell-Free DNA in Kidney Transplant Recipients.","authors":"Miranda Kopfman, Marissa Brokhof, Shree Patel, Dennis Fu, Oyedolamu Olaitan","doi":"10.1177/15269248241288559","DOIUrl":"10.1177/15269248241288559","url":null,"abstract":"Introduction: An inverse relationship has been identified between tacrolimus serum concentrations and donor-derived cell-free DNA (dd-cfDNA) levels after lung transplant, but limited data exists on this relationship in the kidney transplant population. Project Aim: The purpose of this evaluation was to examine the relationship between high tacrolimus variability and elevated dd-cfDNA levels in kidney and simultaneous pancreas-kidney transplant recipients at a single center. Design: Single-center, retrospective, descriptive comparative evaluation of kidney and pancreas-kidney transplant recipients who received longitudinal ddcfDNA surveillance. Intrapatient tacrolimus variability was assessed using the coefficient of variation (%CV) measured between 1 and 12 months posttransplant. Pediatrics, retransplant or multiorgan transplant recipients, and pregnant recipients were excluded. Results: One hundred fifteen recipients with 518 dd-cfDNA levels and 3028 tacrolimus troughs were assessed. Pancreas-kidney recipients had significantly higher median dd-cfDNA (0.29% vs. 0.18%, P = .034) and were excluded from analysis. Ninety-nine kidney transplant recipients were included for analysis. Recipients with tacrolimus %CV ≥30 (N = 66) had significantly higher median dd-cfDNA than %CV <30 (0.22% vs. 0.17%, P = .031). Tacrolimus %CV ≥30 demonstrated higher median peak dd-cfDNA than %CV <30, though this was not statistically significant (0.36% vs. 0.28%, P = .058). Conclusion: These data demonstrated that high intrapatient tacrolimus variability may be associated with elevated dd-cfDNA in the first year after kidney transplant.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"204-210"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinician Prediction of Early Readmission Among Kidney and Liver Transplant Recipients. 临床医生对肾脏和肝脏移植受者早期再入院的预测。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1177/15269248241288556

Yi-Ting Hana Lee, Julien Hogan, Kieran Maroney, Andrew Adams, Ray J Lynch, Rachel E Patzer

{"title":"Clinician Prediction of Early Readmission Among Kidney and Liver Transplant Recipients.","authors":"Yi-Ting Hana Lee, Julien Hogan, Kieran Maroney, Andrew Adams, Ray J Lynch, Rachel E Patzer","doi":"10.1177/15269248241288556","DOIUrl":"10.1177/15269248241288556","url":null,"abstract":"Introduction: Patients are at risk of hospital readmission after kidney and liver transplantation due to the complexity of posttransplant care. Currently, clinical practice relies on providers' prediction since there is a lack of specific strategies. However, the accuracy of clinicians' ability to predict readmissions using clinical judgment alone is unknown. Research Question: What is the accuracy of clinicians' ability to predict readmissions after transplantation using clinical judgment alone? Design: In 2019, clinical providers at a large, urban transplant center were electronically surveyed. Primary surgeons, nephrologists, transplant pharmacists, hepatologists, and nurses were asked, within 24 h of any kidney or liver transplant recipient discharge, to predict whether a patient would be readmitted within 30 days, and the suspected causes of readmission. Prediction accuracy was assessed by sensitivity, specificity, positive and negative predictive value, and F-score. Kappa scores were calculated to assess agreement between transplant surgeons and other providers. Results: Overall, N = 34 unique providers were surveyed about 148 kidney and 63 liver transplant recipients, and 27.0% of kidney recipients and 25.4% of liver recipients were readmitted within 30 days. The positive predictive values were low among clinical providers, ranging from 0.25 to 0.55. Agreements between providers were weak, but higher among kidney transplant providers (range: 0.42-0.44) than for liver transplant providers (range: -0.02-0.26). Conclusion: Clinical judgment alone to predict readmission among transplant recipients may not be sufficient and a combination of clinicians' predictions, multitiered discharge surveillance strategies and data-based predictive models may better identify high-risk patients and guide interventions to reduce readmission.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"157-164"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Should Patients With Less Than 6 Months Sobriety Be Transplanted? 戒酒不足 6 个月的患者何时应该接受移植？

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1177/15269248241268684

Nicky Keller, Allison Lewis, Carol Zogran, Sheila Bullock, Maureen Flattery

引用次数: 0

Highly Sensitized Kidney Transplant Outcomes After the 2014 Kidney Allocation System Change. 2014 年肾脏分配制度改革后的高度敏感肾移植结果。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.1177/15269248241268697

Jae-Hyung Chang, Kristen L King, S Ali Husain, Geoffrey K Dube, E Rodica Vasilescu, Shefali Patel, David J Cohen, Lloyd E Ratner, Sumit Mohan, R John Crew

{"title":"Highly Sensitized Kidney Transplant Outcomes After the 2014 Kidney Allocation System Change.","authors":"Jae-Hyung Chang, Kristen L King, S Ali Husain, Geoffrey K Dube, E Rodica Vasilescu, Shefali Patel, David J Cohen, Lloyd E Ratner, Sumit Mohan, R John Crew","doi":"10.1177/15269248241268697","DOIUrl":"10.1177/15269248241268697","url":null,"abstract":"Introduction: Kidney Allocation System (KAS) was implemented by United Network for Organ Sharing in 2014 to reduce allocation disparities. Research Questions: Outcomes of highly sensitized patients (calculated panel reactive antibody (cPRA) ≥ 97%) before and after KAS were compared to low-risk recipients (cPRA <10%) in the post-KAS era were examined. The impact on racial disparities was determined. Design: This was a retrospective study of national registry data. Two cohorts of adult candidates waitlisted for deceased donor transplantation during 3-year periods before and after KAS were identified. Results: Highly sensitized patients (N = 1238 and 4687) received a deceased donor kidney transplant between January 1, 2011 and December 31, 2013 and between January 1, 2015 and December, 31, 2017. Racial disparity for highly sensitized patients improved, yet remained significant (P < 0.001), with Black patients comprising 40% and 41% of the highly sensitized candidates and 28% and 34% of the recipients pre- and post-KAS. While posttransplant death-censored graft failure for highly sensitized recipients was similar overall, post-KAS was associated with improved graft survival in the first year after transplant (HR 0.56, 95% CI 0.40-0.78). When compared to contemporaneous lowrisk recipients, both death-censored and all-cause graft failure were similar for highly sensitized recipients and was associated with increased risk for death-censored graft failure beyond the first year (HR 1.39, 95% CI 1.11-1.73). Conclusion: The allocation system led to an increase in transplantation in highly sensitized candidates without compromising outcomes. Although KAS has led to more balanced transplant rates between highly sensitized Black and White patients, racial inequalities persist.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"70-80"},"PeriodicalIF":0.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Cognitive and Motor Performance in Liver Recipients. 肝脏受体认知和运动能力比较研究

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1177/15269248241268716

Tuba Yüksel Ergene, Ümit Akay, Didem Karadibak, İsmail Özsoy

{"title":"A Comparative Study of Cognitive and Motor Performance in Liver Recipients.","authors":"Tuba Yüksel Ergene, Ümit Akay, Didem Karadibak, İsmail Özsoy","doi":"10.1177/15269248241268716","DOIUrl":"10.1177/15269248241268716","url":null,"abstract":"Introduction: Neurocognitive and motor impairments are often observed both before and after liver transplantation, resulting in inefficiencies in dual-task performance. Specific aim: The aim of this study was to evaluate the motor-cognitive dual-task performance in liver recipients, with a particular emphasis on cognition, performance status, and the impact of the COVID-19 pandemic. Design: A prospective, cross-sectional, web-based design with a control group was used. The study included 22 liver transplant recipients and 23 controls. Participants completed a motor-cognitive dual-task test (timed up and go test, TUG), a cognitive assessment (mini mental state examination), and a physical performance test (5-repetition sit-to-stand test). The study also used a functional performance status scale (The Karnofsky performance status) and assessed fear of coronavirus disease (fear of COVID-19 scale). Dual-task interference was assessed and the rate of correct responses per second was calculated to assess cognitive performance. Results: The results indicated no statistically significant difference in TUG time and TUG correct responses per second between the groups (group × condition interactions; P > 0.05). There was no significant difference in cognitive and motor dual-task interference during the TUG test between the two groups (P > 0.05). The Karnofsky Performance Status score was significantly correlated with TUG motor dual-task interference (r = -0.424 and P = 0.049). Conclusion: This study suggests that dual-task performance does not differ in cognitive or motor performance between liver recipients and healthy controls under the same dual-task condition. However, further controlled studies are needed to improve the generalizability of these findings.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"103-110"},"PeriodicalIF":0.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0