Progress in Transplantation最新文献

Safety of Concomitant Use of Tacrolimus and High-Intensity Statins in Liver and Kidney Transplant Recipients. 他克莫司和高强度他汀类药物在肝肾移植患者中合用的安全性。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-27 DOI: 10.1177/15269248251349768

Kelsey Klein, Maia Klimatcheva, Reed Hall, Rupal Patel, Kermit V Speeg, Juan Guerrero, Christina Long

{"title":"Safety of Concomitant Use of Tacrolimus and High-Intensity Statins in Liver and Kidney Transplant Recipients.","authors":"Kelsey Klein, Maia Klimatcheva, Reed Hall, Rupal Patel, Kermit V Speeg, Juan Guerrero, Christina Long","doi":"10.1177/15269248251349768","DOIUrl":"https://doi.org/10.1177/15269248251349768","url":null,"abstract":"Due to increased risk of myalgia and rhabdomyolysis associated with the use of simvastatin with cyclosporine, use of high-intensity 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors (statins) is often avoided in transplant recipients. Aim: This program evaluation aimed to determine the safety of high-intensity statins in liver and kidney transplant recipients taking tacrolimus. Design: All liver and kidney transplant recipients who filled prescriptions for tacrolimus and any statin except for simvastatin between June 15, 2020 and July 22, 2022 were screened for inclusion. High-intensity was defined as atorvastatin 40 or 80 mg, or rosuvastatin 20 or 40 mg. The primary outcome was a composite of statin-related myalgia, statin-related rhabdomyolysis, and creatine kinase above the upper limit of normal. Secondary outcomes included liver function tests above 3 times the upper limit of normal, statin discontinuation, and statin dose decrease and associated reason. Results: A total of 178 recipients were included, with 100 receiving low-to-moderate-intensity statins and 78 receiving high-intensity statins. There were no differences between groups for statin-related myalgia, and no reported cases of statin-related rhabdomyolysis in either group. Low to moderate intensity statin use was associated with an increased rate of liver function test elevation (26% vs 11.5%, P = .014) occurring a median of 306 days (interquartile range [IQR] 134-725) post-statin initiation. Conclusion: In liver and kidney transplant recipients receiving tacrolimus, the use of high-intensity statins was not associated with an increased risk of myalgia, rhabdomyolysis, or elevated creatinine kinase when compared with low-to-moderate-intensity statin use.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349768"},"PeriodicalIF":0.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Factors Associated with Sleep Quality After Lung Transplantation. 探讨肺移植术后睡眠质量相关因素。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-24 DOI: 10.1177/15269248251349770

Seol Ju E Moon, Megan Kazakoff, Kristen B Jones, Haydar Abdul, Bryan M Willey, Dianxu Ren, Melissa L Vendetti, Annette DeVito Dabbs, Christopher C Imes

{"title":"Exploring Factors Associated with Sleep Quality After Lung Transplantation.","authors":"Seol Ju E Moon, Megan Kazakoff, Kristen B Jones, Haydar Abdul, Bryan M Willey, Dianxu Ren, Melissa L Vendetti, Annette DeVito Dabbs, Christopher C Imes","doi":"10.1177/15269248251349770","DOIUrl":"https://doi.org/10.1177/15269248251349770","url":null,"abstract":"Introduction: Sleep quality after lung transplant is important for recovery, overall health, and performance of healthy behaviors, such as exercise. Research Aim: The purpose of this study was to explore the associations between sleep quality and factors likely to influence and/or be influenced by sleep. Design: This was a secondary analysis of data from a randomized controlled trial of a tele-rehab exercise intervention for lung transplant recipients. Baseline demographic and clinical characteristics, sleep quality, physical activity, symptom burden, and psychological distress data were collected. Multivariate logistic regression model was used to identify factors associated with poor sleep quality. Results: Participants (N=88) were aged 56.4 (13.0) years and male (54.5%). Seventy-four percent of the patients met the established cut-off for poor sleep quality and the mean Pittsburgh Sleep Quality Index total score was 7.1 (3.7). Recipients reported anxiety (n=21, 23.9%) and depression (n=27, 30.7%). When lung-specific items of the sleep questionnaire were explored, the reported presence of cough or snoring loudly was associated with poor sleep (P = .010). Patients reporting any psychological distress (n=33, 37.5%) had increased odds of experiencing poor sleep (odds ratio [OR]=13.72; 95% confidence interval [CI] =2.33, 264.7.01; P=.017). In a model examining respiratory symptoms concurrently, wheezing increased the odds of reporting poor sleep quality (OR=10.88, 95% CI=1.65, 222.02; P=.037). Conclusion: Clinical attention is needed to detect and manage symptom burden and psychological distress to improve sleep quality and optimize posttransplant recovery among lung recipients. Future studies examining these variables are needed to help guide screening and treatment protocols.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349770"},"PeriodicalIF":0.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Intrapatient Variability of IR-Tacrolimus Versus LCP-Tacrolimus in a Cohort of Lung Transplant Recipients. 在肺移植受者队列中ir -他克莫司与lcp -他克莫司的患者内变异性比较。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-17 DOI: 10.1177/15269248251349773

Hannah Peterson, Jennifer Ferrante, Joelle Nelson, Reed Hall, Lara Jones, Holly Keyt, Elisabeth Kincaide

{"title":"Comparison of Intrapatient Variability of IR-Tacrolimus Versus LCP-Tacrolimus in a Cohort of Lung Transplant Recipients.","authors":"Hannah Peterson, Jennifer Ferrante, Joelle Nelson, Reed Hall, Lara Jones, Holly Keyt, Elisabeth Kincaide","doi":"10.1177/15269248251349773","DOIUrl":"https://doi.org/10.1177/15269248251349773","url":null,"abstract":"IntroductionIntrapatient variability (IPV) of tacrolimus and its predictors post-lung transplant are unclear.Project AimsThis program evaluation aimed to characterize the IPV of immediate-release versus LCP-tacrolimus and predictors of variability ≥30% in lung transplant recipients.DesignAdult lung transplant recipients who received immediate-release- or LCP-tacrolimus from January 2016 through August 2023 were included in this single-center retrospective evaluation. Immediate-release- and LCP-tacrolimus groups were matched 2:1 by time from transplant, presence of azole antifungal, and ethnicity. Three previously published equations calculated IPV. Outcomes to determine clinical impact of tacrolimus variability included de novo donor-specific antibody (DSA) development, rejection, graft loss/mortality, eGFR <60 mL/min, infection. Time in therapeutic range was assessed. Data were analyzed to determine predictors of variability ≥30%.ResultsThere were no significant differences in the variability of immediate-release- versus LCP-tacrolimus among 3 equations used. There was no difference in de novo DSA development, rejection, graft loss, mortality, eGFR <60 mL/min, or infection between groups. Recipients with rejection during follow-up had higher variability compared to those who did not (P = .04). Presence of CYP34A inhibition predicted variability >30% in multivariate analysis. Immediate-release tacrolimus had higher time in therapeutic range versus LCP-tacrolimus, 67% versus 33%, (P = .15).ConclusionThe IPV and associated clinical outcomes of immediate-release versus LCP-tacrolimus in lung transplant recipients did not significantly differ. Development of acute cellular rejection within 1 year follow-up was associated with higher tacrolimus variability regardless of formulation.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349773"},"PeriodicalIF":0.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthening Qualitative Research Manuscript Preparation for Submission to Progress in Transplantation. 加强质性研究稿件准备，投稿《移植进展》。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-17 DOI: 10.1177/15269248251349759

Nicholas R Henry

引用次数: 0

An Exploratory Study of Sleep Quality After Lung Transplantation Using the Pittsburgh Sleep Quality Index. 应用匹兹堡睡眠质量指数对肺移植术后睡眠质量的探索性研究。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-17 DOI: 10.1177/15269248251349752

Jane Simanovski, Jody Ralph, Sherry Morrell

{"title":"An Exploratory Study of Sleep Quality After Lung Transplantation Using the Pittsburgh Sleep Quality Index.","authors":"Jane Simanovski, Jody Ralph, Sherry Morrell","doi":"10.1177/15269248251349752","DOIUrl":"https://doi.org/10.1177/15269248251349752","url":null,"abstract":"Introduction: Sleep is essential for maintaining optimal physical and mental health as it supports crucial functions such as cognition, immune system regulation, and overall well-being. A growing emphasis on the importance of sleep warrants an investigation of sleep quality after lung transplantation. Research Question: What is the overall prevalence, nature, and severity of patient-reported disrupted sleep quality after lung transplantation using the Pittsburgh Sleep Quality Index (PSQI)? Design: This study employed a single-site, exploratory, cross-sectional descriptive design involving lung transplant recipients who completed an anonymous survey. Sleep quality was assessed using the PSQI scale. Additionally, participants provided self-reported data on demographic and transplant-related variables. Results: The response rate was 38.4% (61/158) and 64% of the respondents (39/61) demonstrated PSQI >5 with a mean PSQI score of 8.07 (SD = 4.5), suggestive of poor sleep quality. Lung transplant recipients reported difficulties across all components of sleep quality with more challenges in the categories of sleep duration, sleep latency, sleep efficiency, and the use of sleep medications. Conclusion: The prevalence of poor subjective sleep quality among lung transplant recipients highlighted the importance of continued investigation into this phenomenon. Further research employing standardized measures, larger sample sizes, and longitudinal study designs is warranted to enhance understanding of poor sleep post-lung transplant. Such endeavors are crucial for informing the development of effective assessment strategies and interventions aimed at improving sleep outcomes in patients after lung transplantation.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349752"},"PeriodicalIF":0.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing Perioperative Sleep in Acute Renal Transplants. 急性肾移植围手术期睡眠特征分析。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-17 DOI: 10.1177/15269248251349760

Brandon Stretton, Karthik Venkataraman, Joshua Kovoor, Aashray Gupta, Stephen Bacchi, Danny Liew, Michael Collins, Guy Maddern, Mark Boyd

{"title":"Characterizing Perioperative Sleep in Acute Renal Transplants.","authors":"Brandon Stretton, Karthik Venkataraman, Joshua Kovoor, Aashray Gupta, Stephen Bacchi, Danny Liew, Michael Collins, Guy Maddern, Mark Boyd","doi":"10.1177/15269248251349760","DOIUrl":"https://doi.org/10.1177/15269248251349760","url":null,"abstract":"Introduction: Posttransplant sleep disturbances may influence recovery, immunosuppressive adherence, and graft outcomes. This study examined sleep disruption in acute renal transplant recipients and its relationship with medication comprehension and hospital stressors. Methods/Approach: A mixed-methods, pilot prospective cohort study was conducted at a metropolitan hospital in Australia. Consecutive renal transplant patients were recruited. Perioperative sleep patterns were assessed using the American Academy of Sleep Medicine's sleep diary. The Kidney Transplant Understanding Tool evaluated medication comprehension. Qualitative data from semistructured interviews were analysed using inductive content analysis. Univariate linear regression assessed associations between sleep and perioperative outcomes (P ≤ .05). Findings: Ten recipients were recruited. Recipients averaged 5.2 hours of sleep per night with frequent disruptions. Sleep ranged from 0 to 10 hours per night, with the longest sleepless period being 41 hours. An inverse correlation was observed between sleep duration and medication comprehension scores(β=-8.736, P = .0232), suggesting recipients with less sleep had better medication comprehension. Qualitative analysis identified sleep disruptions due to hospital practices, environmental factors, transplant-related stress, and medication side effects. Conclusion: Perioperative sleep disturbances were multifactorial, influenced by hospital and procedural factors. The paradoxical association between reduced sleep and increased medication comprehension highlights a complex interplay between stress, sleep, and cognitive engagement. This pilot study suggested that addressing sleep disturbances and incorporating culturally sensitive education may enhance perioperative care. However, further research is needed to validate these findings in larger cohorts.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349760"},"PeriodicalIF":0.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrative Review on Exploring Organ Donation After Death by Circulatory Criteria in Canada. 加拿大按循环系统标准探索死后器官捐献的综合综述。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-13 DOI: 10.1177/15269248251349783

Kendra-Lee Dupuis, Amina Silva, Vanessa Silva E Silva

{"title":"An Integrative Review on Exploring Organ Donation After Death by Circulatory Criteria in Canada.","authors":"Kendra-Lee Dupuis, Amina Silva, Vanessa Silva E Silva","doi":"10.1177/15269248251349783","DOIUrl":"https://doi.org/10.1177/15269248251349783","url":null,"abstract":"Introduction: Rising discrepancies between supply and demand of lifesaving organs necessitates considering advancements to improve the health outcomes of Canadians. There is an increased use of organs after death by circulatory criteria, however the evolution of this treatment should be explored to continue to advance practices and save lives. Objective: To summarize the literature on the evolution and use of organ donation after death by circulatory criteria in Canada, to highlight how this donation modality may support future advancements. Methods: A search of electronic databases for any date until June 1st, 2024, was performed. Additional searches of grey literature using Google Scholar and the snowball technique were performed. Applicable documents underwent a multi-phase screening process, and data were extracted, analyzed, and evaluated. Results: There were 793 documents located, and 50 were included in this review. Three main categories emerged among the documents that described the evolution of guidelines for death by circulatory criteria organ donation, experiences with program development and delivery for death by circulatory criteria organ donation and Canadian perspectives of this donation modality. Discussion: Canada has made strides in circulatory criteria organ donation practices through consensus meetings and discussions on key topics, yet variations in practice exist across the country that warrant further investigation when considering future advancements. Conclusion: While national efforts have advanced practices, ongoing variations across programs highlighted the need for continued evaluation, education and harmonization to maximize the life-saving potential of organ donation practices.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349783"},"PeriodicalIF":0.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Concentrated Furosemide Infusions on Postoperative Atrial Fibrillation Rates in Kidney Transplant Recipients. 浓缩速尿输注对肾移植术后房颤发生率的影响。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-12 DOI: 10.1177/15269248251349757

Mark Pulver, Maya Campara, Walaa Dabbas, Jorge Almario Alvarez, Dana Pierce

{"title":"Outcomes of Concentrated Furosemide Infusions on Postoperative Atrial Fibrillation Rates in Kidney Transplant Recipients.","authors":"Mark Pulver, Maya Campara, Walaa Dabbas, Jorge Almario Alvarez, Dana Pierce","doi":"10.1177/15269248251349757","DOIUrl":"https://doi.org/10.1177/15269248251349757","url":null,"abstract":"IntroductionPostoperative atrial fibrillation is an arrhythmia that may complicate postsurgical care in kidney transplant recipients and is associated with longer hospitalizations, postsurgical complications, and increased in-hospital mortality. Pathophysiology is not well understood but is thought to be multifactorial. Iatrogenic hypervolemia may contribute to the incidence of postoperative atrial fibrillation.Project AimsThe program evaluation aim was to evaluate the effects of furosemide concentration on reducing volume overload, and subsequently postoperative atrial fibrillation incidence.DesignThis was a single-center, retrospective, cohort study that analyzed kidney transplant recipients during index hospitalization. Recipients receiving furosemide infusions of 500 mg/50 mL between June 2022 and May 2023 were considered the concentrated group and recipients receiving infusions of 500 mg/250 mL between January 2013 and December 2017 were the dilute group.ResultsThere was no difference identified in atrial fibrillation rates when using concentrated versus dilute furosemide infusions (7.7% vs 12.4%; P = .101). When excluding those with immediate graft function, there was a lower incidence in the concentrated group (9.3% vs 22.0%, P = .031) compared to slow/delayed graft function. Recipients in the concentrated infusion group had higher rates of high (11.7% vs 35.1%) and very high (3.0% vs 14.9%) cardiovascular risk (P < .001). Recipients receiving concentrated infusions had improvement in net fluid balance (0.4 L vs 1.4 L; P < .001) with higher furosemide exposure (2.3 g vs 1.4 g; P < .001).ConclusionsPostoperative atrial fibrillation rates were similar between groups, Recipients with slow/delayed graft function had lower rates of postoperative atrial fibrillation with concentrated furosemide.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"15269248251349757"},"PeriodicalIF":0.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Perspectives and Approaches to Transplant Selection Committee. 移植选择委员会的新观点和新方法。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-10 DOI: 10.1177/15269248251349758

Frank G Lee, Tayyab S Diwan

引用次数: 0

An Integrative Review of Frailty, Patient Mortality and Graft Failure in Solid Organ Transplant. 实体器官移植中虚弱、患者死亡率和移植物衰竭的综合综述。

IF 0.6 4区医学

Progress in Transplantation Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1177/15269248251343387

Theresa M Miller, Cynthia L Russell

{"title":"An Integrative Review of Frailty, Patient Mortality and Graft Failure in Solid Organ Transplant.","authors":"Theresa M Miller, Cynthia L Russell","doi":"10.1177/15269248251343387","DOIUrl":"10.1177/15269248251343387","url":null,"abstract":"IntroductionCharacteristics and the impact of frailty on adult solid organ transplant recipients have not been clearly described. The purpose of this integrative review was to identify characteristics of frailty and associations between frailty and patient mortality and graft failure in adult solid organ transplant recipients.MethodsAn integrative literature review was performed using Cooper's integrative methodology. PubMed, Excerpta Medica, and the Cumulative Index of Nursing and Allied Health Literature databases were searched using the terms frailty and transplant. Inclusion criteria were primary research reports, written in English, focusing on adult solid organ transplant recipients, and including graft or patient survival outcomes.ResultsThe review included 35 articles, were largely retrospective, and published between 2015 and 2023 in 11 different countries. Most studies were single-center studies that were not theory-based, and liver transplant recipients were highly represented. Males outnumbered females in the majority of studies and White race was represented in half of the studies. Most studies used one strategy to measure frailty, and modified versions of the Physical Frailty Phenotype were the measurement used most often. Of the 35 articles that investigated the association of frailty with patient mortality, 44 measures were used, and of those, 32 showed a significant association. For graft failure, of the 10 studies included, half showed a significant association between frailty and graft failure.ConclusionThis integrative review offers insights into the characteristics and the association between frailty, patient mortality, and graft failure.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"97-109"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0