Progress in Transplantation最新文献

{"title":"A Scoping Review and Practical Approach to Measuring Health Literacy in Solid Organ Transplantation.","authors":"Vanessa Phommavong, Breanna Morrison, Nicola Rosaasen, Kathryn Haubrich, Irène Pandraud-Riguet, Holly Mansell","doi":"10.1177/15269248261432238","DOIUrl":"https://doi.org/10.1177/15269248261432238","url":null,"abstract":"<p><p><b>Introduction:</b> Solid organ transplant recipients have extensive self-care responsibilities. Limited health literacy (HL) can hinder effective self-management and long-term outcomes. <b>Objective:</b> A scoping review of HL instruments is needed to summarize their use in solid organ transplant. <b>Methods:</b> A systematic search was conducted using Medline, Embase, and CINAHL databases to identify studies that measured HL in the context of solid organ transplant. Search results were uploaded into Mendeley, and duplicates were removed. Two reviewers screened the abstracts and full texts for eligibility and discrepancies were resolved by the research team. Data extraction included publication details, study features, and HL instruments. <b>Results:</b> Of 721 articles identified for title and abstract assessment, 94 articles were further reviewed for full-text eligibility, and 50 were included in the review. HL instruments included: the Brief HL Screen (BHLS) and iterations (with 16 studies), Newest Vital Sign (NVS) (15 studies), Rapid Estimate of Adult Literacy in Medicine (REALM) (8 studies), Test of Functional HL in Adults (TOFHLA) (7 studies), HL Questionnaire (HLQ) (6 studies), eHL Scale (eHEALS) (4 studies), Brief Medical Numbers Test (BMNT) (3 studies), Decision-Making Capacity Assessment Tool (DMCAT) (2 studies), Short Assessment of HL (SAHL) (1 study). <b>Discussion:</b> Seven studies used multiple HL instruments in their analysis. Some instruments had multiple versions, such as the original TOFHLA and its shortened form (S-TOFHLA), and the original REALM and its transplant-specific version (REALMT). <b>Conclusion:</b> This review provides an overview of HL instruments for transplant healthcare providers who may want to incorporate HL measurement into practice.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":"36 1","pages":"25-50"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Türkiye.","authors":"Yaprak Sarigol Ordin, Eda Ayten Kankaya, Buket Celik","doi":"10.1177/15269248261430365","DOIUrl":"10.1177/15269248261430365","url":null,"abstract":"<p><p>IntroductionGender disparity remains a global issue in access to renal replacement therapy and kidney transplantation among patients with end-stage kidney disease.AimThis study examined trends in donor type, recipient age, and dialysis modality in kidney transplantation in Türkiye from 2013 to 2022. A secondary aim was to explore gender disparities in kidney transplantation and treatment modalities for end-stage kidney disease using registry data.MethodsThis descriptive and cross-sectional study analyzed the distribution and trends of kidney transplants in Türkiye between 2013 and 2022. The data were obtained from the publicly accessible Registry of Nephrology, Dialysis, and Transplantation reports in Türkiye. Per million population increase/decrease rate, χ² linear trend, and χ² R by C were used.ResultsOver time, transplants from living donors increased, while deceased donor transplants decreased. The highest rates of living donor transplants were in 2022, 2021, and 2019. Transplants in high-risk age groups increased significantly. There were differences in donor type among patients receiving hemodialysis, peritoneal dialysis, or preemptive transplantation (<i>p</i> < .001). Preemptive transplants showed the most significant increase, especially from living donors in 2022. Between 2013 and 2022, kidney transplantation increased by 24.67% in men and 19.94% in women. Female transplant rates were lowest in 2016, 2020, and 2021, indicating a persistent gender gap. There was no significant gender difference in the incidence of hemodialysis or peritoneal dialysis.ConclusionLiving donor transplants, especially preemptive ones, increased markedly over the past decade. Gender disparities persist, and efforts should focus on improving access for women and promoting deceased donor programs to ensure equity.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"3-11"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Social and Psychological Factors on Cognition Among Liver Transplant Recipients.","authors":"Dami Ko, Priyadarshani Bajracharya, Neha Singh, Charles H Hillman, Alan Bonder","doi":"10.1177/15269248261426835","DOIUrl":"10.1177/15269248261426835","url":null,"abstract":"<p><p>IntroductionCognitive impairment in liver transplant recipients can lead to poor health outcomes, and identifying at-risk individuals is important to provide timely support. Poor social conditions, including poor socioeconomic status and lack of social support, have been suggested as potential contributors to cognitive impairment. Further, individuals with poor social conditions may experience psychological symptoms, such as depression and anxiety, which can further affect cognition.AimThis preliminary study explored longitudinal associations between social conditions, depression and anxiety symptoms, and cognition in liver transplant recipients.DesignA total of 23 adult liver transplant candidates were enrolled, with 9 receiving liver transplantation, who were followed for up to 1-year post-transplant. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. Social conditions and psychological symptoms were assessed through surveys. Linear mixed-effects models adjusted for age and education were used to examine the relationships between social conditions, psychological symptoms, and cognition. Moderation analysis was also conducted to explore interactions between social conditions and psychological symptoms.ResultsCognitive scores remained stable over time. Social conditions were not associated with cognition, whereas higher levels of depression and anxiety symptoms were associated with worse cognitive performance. No significant interaction was found between social conditions and psychological symptoms on cognition.ConclusionDepression and anxiety symptoms, but not social conditions, showed associations with cognition in liver transplant recipients. These findings suggest the importance of assessing psychological symptoms in this population to identify those at risk for cognitive impairment.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"17-24"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partnering with Living Donors in the Development of Long-Term Follow-Up Data Collection Instruments.","authors":"Allyson Hart, Katie Siegert, Heather Hunt, Jill Brown, Glenna Frey, Trysha L Galloway, Becky Gustamante, Matt Harmody, Kelley Hitchman, McKenzie Hull, Sophia Jackson, Katie McKee, Michael Murphy, Jennifer Roberts, Aubrey Sepko, Sue Venteicher, Francis Wheeler, Krista L Lentine, Amy D Waterman","doi":"10.1177/15269248261430491","DOIUrl":"10.1177/15269248261430491","url":null,"abstract":"<p><p>Patient-centered outcomes are increasingly recognized by the transplant community as a key component to improving knowledge and patient counseling, and long-term outcomes after living kidney or liver donation are not well understood. With efforts underway to follow living donors and donor candidates long term, it is critical that living donors and candidates drive the process of patient-centered data collection. Living donors on the Scientific Registry of Transplant Recipients' Living Donor Steering Committee were engaged to brainstorm and prioritize which data elements should be captured. Committee members identified long-term lab values, difficulty with normal activities, and diagnosis of chronic kidney or liver disease as critical long-term outcomes. Additional high-priority elements included short-term lab values, deaths related to donation, mortality among donors compared to nondonors, hospital readmissions, costs and physical limitations related to donation, and whether a donor would donate again. Finally, living donors wanted to know the risk of organ failure among donors compared to nondonors. This prioritization exercise provided valuable insights from living donors to help determine key themes and discrete data elements that should be prioritized for long-term collection and reporting to living donors and living donor candidates.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"12-16"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Study of Discrepancy in Hospital Versus Home Device Readings of CardioMEMs Monitoring.","authors":"Ibrahim Zaky, Audrey Cohen, Edward Betterton","doi":"10.1177/15269248251383953","DOIUrl":"10.1177/15269248251383953","url":null,"abstract":"","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"229-231"},"PeriodicalIF":1.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey Study of Liver Donors' Information Needs on Recipient Outcomes in High-Risk Donation Scenarios.","authors":"Adrienne Chen, Allison Carroll, Elisa J Gordon, Josh Levitsky","doi":"10.1177/15269248251383952","DOIUrl":"10.1177/15269248251383952","url":null,"abstract":"<p><p>IntroductionLiving donor liver transplantation is expanding worldwide as a treatment for end-stage liver disease, especially in high-risk recipients. No standardized information is provided to donors during the informed consent process. Consequently, variable information may be provided to the donor about the recipient, which may undermine donor-informed consent.Research QuestionsIn high-risk donation scenarios, it is uncertain whether information disclosed about the recipient is sufficient for donor-informed decision-making. Would information about the recipient's potential adverse and beneficial short- and long-term outcomes help donors make a decision about donating?DesignAn online survey was conducted of previous living liver donors' likelihood of donating and information needs regarding their recipients in 3 hypothetical high-risk clinical scenarios: alcoholic liver disease (ALD) with high relapse risk, acute liver failure (ALF), and hepatocellular carcinoma (HCC) with high recurrence risk.ResultsA total of 98 living liver donors participated in this study. Most living liver donors expressed willingness to donate to a patient in each scenario: ALD (51%), ALF (56%), and HCC (85%). Most living liver donors (56% to 93%) reported desiring information about the recipient's diagnosis, clinical condition, and projected outcomes in their donation decision-making process. Most living liver donors (82%) considered an acute consultation service to be useful in deciding whether to donate to a patient with ALF.ConclusionsThe findings suggested that transplant programs should incorporate recipient health information with recipient consent into the informed consent process and offer consultation services to support living liver donors' decision-making.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"206-213"},"PeriodicalIF":1.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Physical Activity Levels and Performance Among High-Intensity Transplant Athletes at the World Transplant Games.","authors":"Bart Rienties, Leigh Martin, Fereshte Goshtasbpour","doi":"10.1177/15269248251383949","DOIUrl":"10.1177/15269248251383949","url":null,"abstract":"<p><p>IntroductionWhile most transplant recipients remain sedentary posttransplant, some transplant recipients are able to meet and even exceed recommended physical activity levels.Research QuestionThe objective of this study was (1) to explore what physical activity levels 25 recipient athletes could sustain over a 7-month period while preparing for and participating in the World Transplant Games in cycling and/or triathlon, and (2) what intensity levels recipients sustained in competitive conditions.DesignThe study adopted an observational descriptive research design and used physical activity self-reported data of 25 recipient athletes and self-tracked data from online social fitness network apps such as Strava. It also examined World Transplant Games performance metrics to evaluate transplant athletes' capabilities in competitive settings.ResultsFindings revealed that transplant athletes exceeded the current physical activity level guidelines by 300% over a 7-month period, with an average of 8.33 h per week of self-reported activities and 4.67 h per week of self-tracked moderate to intense physical activity.ConclusionThe findings highlighted the need to consider the capabilities of transplant athletes in reassessing the current physical activity guidelines since the results demonstrated that enhanced performance in competition settings was attainable through physical activity and support. There is a need for more personalised physical activity metrics and recommendations for transplant recipients.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"214-220"},"PeriodicalIF":1.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus Disease 2019 (COVID-19) Vaccination Coverage and Effectiveness Among Pediatric Transplant Recipients.","authors":"Elizabeth Cohen, Sarah Hinderstein, Eve Carciofi, Kayla Hopkins, Hillary Kuzaro, Inci Yildirim","doi":"10.1177/15269248251383951","DOIUrl":"10.1177/15269248251383951","url":null,"abstract":"<p><p>IntroductionIn pediatric solid organ transplant and bone marrow transplant recipients, there is minimal data describing coronavirus disease 2019 (COVID-19) vaccine uptake and effectiveness.Research QuestionsWhat is the real-world experience of COVID-19 vaccination, subsequent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and vaccine efficacy in pediatric heart, liver, kidney and bone marrow transplant recipients?DesignThis observational cohort study assessed COVID-19 vaccination rates and outcomes between March 2020 and January 2024 among pediatric heart, liver, kidney, and bone marrow transplant recipients. This study was approved by the local institutional review board as exempt.ResultsOne hundred and thirty-three pediatric solid organ transplant or bone marrow recipients were included; 33 of 133 (24.8%) were unvaccinated, 100 and 133 (75.2%) had at least 1 dose, and 72 of 133 (54.1%) completed at least 3 doses of COVID-19 vaccination. Ninety-two SARS-CoV-2 infection episodes in 74 of 133 (55.6%) patients. Fifty-eight (63%) episodes were in those who were never vaccinated or before completion of 3 doses and 34 (36.9%) episodes were after completion of the primary series (<i>P</i> = 0.09). Hospitalization was required in 2 of 34 (5.9%) and 7 of 59 (11.9%) of the infections among vaccinated and unvaccinated patients. No severe cases occurred among vaccinated patients while severe infection was seen among those unvaccinated. Adjusted COVID-19 vaccine effectiveness against SARS-CoV-2 infection was estimated as 52.6% (95% CI 7.0% -72%).ConclusionCOVID-19 vaccine uptake remains suboptimal among pediatric transplant recipients and completion of primary series is low. Further studies to understand dynamics of vaccine acceptance and vaccine effectiveness among pediatric transplant patients are needed.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"221-228"},"PeriodicalIF":1.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Willingness to Be Evaluated for Living Kidney Donation.","authors":"Ritah R Chumdermpadetsuk, Cayley Ryan-Claytor, Mary K Roberts, Zarmeen Salim, Jennifer M Kirk, Ashton Verdery, Selena Ortiz, Stalin Canizares, Belen Rivera, Devin E Eckhoff, Jonathan Daw","doi":"10.1177/15269248251383950","DOIUrl":"10.1177/15269248251383950","url":null,"abstract":"<p><p>IntroductionWomen comprise 55% to 65% of living kidney donors. Most studies focus on individuals who underwent donor nephrectomies, rather than potential living donors prior to engagement with the healthcare system. Therefore, the underlying reasons for gender discrepancy are unclear.Research questionAmong relatives of patients with renal disease, do men and women differ in willingness to be evaluated for living kidney donation, regardless of prior donation behavior?DesignAn online survey administered in 2019 to US adult members of the Qualtrics Survey Panel whose relatives had weak or failing kidneys. The survey was designed to examine perspectives of living kidney donation from realistic potential donors. Self-reported willingness was compared between men and women for statistically significant differences. Average marginal effects of male gender on willingness and interaction effects estimated with multivariable logistic regression, adjusted for respondent/patient demographics and relationship.ResultsA total of 1647 responses showed 7.1% higher willingness among men (<i>P</i> = .016). Among those whose relatives (<i>N</i> = 808) were seeking transplants [subgroup], men had 13.1% higher willingness (<i>P</i> = .002). Interaction effect analysis showed men aged 70 to 79 years, with insurance, self-reported very good health, and self-reported medical contraindications, had significantly higher willingness than corresponding women. In the transplant subgroup, men aged 18 to 39 years and with full-time employment also had higher willingness.ConclusionMen showed 7.1% higher willingness to be evaluated for living kidney donation. Rather than reflecting a fixed difference, the existence and degree of gender difference were context-dependent. Identifying strategic interventions to facilitate male donation in contexts where they reported high willingness could improve access to transplantation.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":"35 4","pages":"195-205"},"PeriodicalIF":1.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Intrapatient Variability of IR-Tacrolimus Versus LCP-Tacrolimus in a Cohort of Lung Transplant Recipients.","authors":"Hannah Peterson, Jennifer Ferrante, Joelle Nelson, Reed Hall, Lara Jones, Holly Keyt, Elisabeth Kincaide","doi":"10.1177/15269248251349773","DOIUrl":"10.1177/15269248251349773","url":null,"abstract":"<p><p>IntroductionIntrapatient variability (IPV) of tacrolimus and its predictors post-lung transplant are unclear. Project AimsThis program evaluation aimed to characterize the IPV of immediate-release versus LCP-tacrolimus and predictors of variability ≥30% in lung transplant recipients. DesignAdult lung transplant recipients who received immediate-release- or LCP-tacrolimus from January 2016 through August 2023 were included in this single-center retrospective evaluation. Immediate-release- and LCP-tacrolimus groups were matched 2:1 by time from transplant, presence of azole antifungal, and ethnicity. Three previously published equations calculated IPV. Outcomes to determine clinical impact of tacrolimus variability included de novo donor-specific antibody (DSA) development, rejection, graft loss/mortality, eGFR <60 mL/min, infection. Time in therapeutic range was assessed. Data were analyzed to determine predictors of variability ≥30%. ResultsThere were no significant differences in the variability of immediate-release- versus LCP-tacrolimus among 3 equations used. There was no difference in de novo DSA development, rejection, graft loss, mortality, eGFR <60 mL/min, or infection between groups. Recipients with rejection during follow-up had higher variability compared to those who did not (<i>P</i> = .04). Presence of CYP34A inhibition predicted variability >30% in multivariate analysis. Immediate-release tacrolimus had higher time in therapeutic range versus LCP-tacrolimus, 67% versus 33%, (<i>P</i> = .15). ConclusionThe IPV and associated clinical outcomes of immediate-release versus LCP-tacrolimus in lung transplant recipients did not significantly differ. Development of acute cellular rejection within 1 year follow-up was associated with higher tacrolimus variability regardless of formulation.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"183-189"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}