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EEG-fMRI measures of functional brain connectivity in epilepsy 癫痫患者脑功能连通性的EEG-fMRI测量
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026094
Teresa Murta, P. Figueiredo, A. Leal
{"title":"EEG-fMRI measures of functional brain connectivity in epilepsy","authors":"Teresa Murta, P. Figueiredo, A. Leal","doi":"10.1109/ENBENG.2011.6026094","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026094","url":null,"abstract":"A study of the epileptic seizure dynamics using simultaneous recording of electroencephalography correlated functional magnetic resonance imaging (EEG-fMRI) data from 5 focal epilepsy patients undergoing pre-surgical evaluation was realised with the aim of identifying the focus and propagation network seizure-involved. A method based on the General Linear Model (GLM) at different neurophysiology regressor lags (LasgM), a connectivity model-based method, Dynamic Causal Modelling (DCM), and a data-driven method, Granger Causality (GC) were investigated. DCM analysis provided meaningful and significant results when a sufficient number of seizure events was recorded, but suffered from the generally poor data signal-to-noise ratio (SNR). The concordance between the LagsM results and the clinical expectation suggests that LagsM can be useful as a complementary approach. Intending to establish the validity of a GC approach for the problem addressed, a simulation study was performed and the results showed that it is not appropriated.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123301664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Biomaterials research at NanoLab(IST): Seeding seeds for the future 纳米实验室的生物材料研究:为未来播下种子
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026062
A. P. Serro, Maria de Fátima Montemor, B. Saramago, A. P. D. de Matos, E. A. Pires, P. Carvalho, R. Colaço
{"title":"Biomaterials research at NanoLab(IST): Seeding seeds for the future","authors":"A. P. Serro, Maria de Fátima Montemor, B. Saramago, A. P. D. de Matos, E. A. Pires, P. Carvalho, R. Colaço","doi":"10.1109/ENBENG.2011.6026062","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026062","url":null,"abstract":"The NanoLab research laboratory based in Instituto Superior Técnico is strongly involved in the development, processing and characterization of biomaterials. The associated BioMater teaching laboratory will enable undergraduate and graduate students to acquire a hands-on experience in the field. Research lines in biomaterials development and biological materials characterization are described.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131489124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivariate pattern analysis of brain structure: A diagnostic tool for Neurofibromatosis type 1 脑结构的多变量模式分析:1型神经纤维瘤病的诊断工具
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026061
J. Duarte, M. Ribeiro, I. Violante, Gil Cunha, Mohammed Al-Rawi, João Paulo Silva Cunha, M. Castelo‐Branco
{"title":"Multivariate pattern analysis of brain structure: A diagnostic tool for Neurofibromatosis type 1","authors":"J. Duarte, M. Ribeiro, I. Violante, Gil Cunha, Mohammed Al-Rawi, João Paulo Silva Cunha, M. Castelo‐Branco","doi":"10.1109/ENBENG.2011.6026061","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026061","url":null,"abstract":"Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by increased predisposition for tumor development and cognitive deficits. In this work, we used maps of grey matter density obtained from Magnetic Resonance (MR) brain structural scans to distinguish between NF1 patients and healthy controls with a multivariate pattern analysis technique, Support Vector Machines. Up to 83% of all participants were correctly classified (mean sensitivity of 82%; mean specificity of 84%; significance level p < 0.01). This high level of classification accuracy of NF1 patients suggests this technique as a potential diagnostic tool. In addition, we determined the brain regions that the algorithm used to distinguish between NF1 patients and healthy controls. These regions were not identified as abnormal using univariate voxel-by-voxel comparison indicating that multivariate techniques are a useful powerful tool with which to identify potential structural defects in the NF1 brain.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130728943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel strategies for the purification of monoclonal antibodies 单克隆抗体纯化的新策略
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026067
A. Azevedo, M. Aires-Barros
{"title":"Novel strategies for the purification of monoclonal antibodies","authors":"A. Azevedo, M. Aires-Barros","doi":"10.1109/ENBENG.2011.6026067","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026067","url":null,"abstract":"Following the success of therapeutic recombinant proteins, monoclonal antibodies (mAbs) represent the second outbreak of innovation created by the biotechnology industry. With more than 25 products in clinical use worldwide, including eight blockbuster drugs, mAbs remain one of the most exciting and promising areas within the world pharmaceutical market, with a global share worth $55 billion in 2010. The greatest capacity constraints in current manufacturing platforms are no longer found in the upstream production processes, where cell culture productivity has dramatically increased over the past decade, but in the downstream purification area. Challenges in the purification of mAbs include reducing production costs, developing robust purification processes and integrating upstream and downstream processes. Although packed-bed chromatography is the workhorse in the downstream processing of therapeutic mAbs, limitations are observed at the very large-scale and therefore additional options are needed to increase the manufacturing capacity and decrease the cost of goods.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133651510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers 细菌蛋白azurin作为治疗无法治愈的乳腺癌的新候选药物
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026047
N. Bernardes, A. Ribeiro, R. Seruca, J. Paredes, A. Fialho
{"title":"Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers","authors":"N. Bernardes, A. Ribeiro, R. Seruca, J. Paredes, A. Fialho","doi":"10.1109/ENBENG.2011.6026047","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026047","url":null,"abstract":"Azurin is a blue copper protein produced by Pseudomonas aeruginosa. Azurin enters preferentially into cancer cells and forms a complex with p53, stabilizing it and inducing apoptosis. Azurin allows in vivo regression of human melanoma and breast cancer without toxic effects to the animal. Its immunoglobulin-like fold and a large exposed hydrophobic patch confer on it the property of a natural scaffold. This has already been proven for the receptor tyrosine kinase EphB2, since azurin prevents its binding to the ligand ephrinB2. We intend to extend the azurin interaction to cell adhesion molecules (CAMs), particularly P-cadherin. P-cadherin is frequently overexpressed in invasive breast carcinomas and it is a poor prognosis marker. Protein-protein docking results have validated this approach confirming an interaction between both proteins. Thus, natural azurin or derived proteins or peptides could be scaffolds against these proteins in breast cancer cells models, being an interesting new therapeutic tool.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116816735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The use of bacteriophages for P. aeruginosa biofilm control 噬菌体在铜绿假单胞菌生物膜控制中的应用
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026045
D. Pires, S. Sillankorva, J. Azeredo
{"title":"The use of bacteriophages for P. aeruginosa biofilm control","authors":"D. Pires, S. Sillankorva, J. Azeredo","doi":"10.1109/ENBENG.2011.6026045","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026045","url":null,"abstract":"Pseudomonas aeruginosa is a relevant opportunistic pathogen frequently associated with several nosocomial infections and, worryingly, this bacterium shows a low antibiotic susceptibility. One of its virulence factors is related with the ability to adhere to surfaces and also human epithelium and form virulent biofilms. This work describes the isolation and characterization of lytic phages capable to infect antibiotic resistant P. aeruginosa strains. It is also described herein the potential of the new isolated phages for planktonic cells and biofilm control. According to the results of this work, the isolated phages showed different spectra of activity and most of them were efficient even against P. aeruginosa multidrug resistant strains. Furthermore, the biofilm infection assays revealed that phages can be a good strategy to combat virulent biofilms achieving significant reductions in the number of biofilm cells.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121123089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Biodegradable nanoparticles of alginate and chitosan as non-viral DNA oral delivery system 可生物降解的海藻酸盐和壳聚糖纳米颗粒作为非病毒DNA口服递送系统
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026051
Lídia M D Gonçalves, A. Cadete, L. Figueiredo, C. Calado, A. Almeida
{"title":"Biodegradable nanoparticles of alginate and chitosan as non-viral DNA oral delivery system","authors":"Lídia M D Gonçalves, A. Cadete, L. Figueiredo, C. Calado, A. Almeida","doi":"10.1109/ENBENG.2011.6026051","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026051","url":null,"abstract":"The delivery of nucleic acids via the oral route involves overcoming barriers such as degradation of nucleic acids by low pH in the stomach, enzymatic degradation by DNases in the gut, crossing the physical barrier imposed by the mucus layer, cellular uptake, intracellular trafficking and nuclear uptake. As an oral drug carrier system chitosan nanoparticles are ideal, being mucoadhesive, interacting with the anionic sialic acid residues in mucin. In this study, plasmid DNA expressing a “humanized” secreted Gaussia Luciferase as reporter gene was encapsulated in alginate and chitosan nanoparticles, via a mild ionotropic gelation procedure with sodium tripolyphosphate as a counterion. The nanoparticle system here developed shows effective transfection of different human gastric epithelial cell lines with distinct cell differention. That was confirmed by the expression of luciferase in the different tested conditions, particularly the amount of encapsulated pGLuc.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117163543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Towards detailed whole body group analysis in nuclear medicine 迈向核医学中详细的全身群分析
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026069
N. Ferreira, F. Caramelo, A. Liborio, M. Botelho, S. Carvalho, L. Mendes, R. Faustino, M. Ribeiro, A. Rodrigues
{"title":"Towards detailed whole body group analysis in nuclear medicine","authors":"N. Ferreira, F. Caramelo, A. Liborio, M. Botelho, S. Carvalho, L. Mendes, R. Faustino, M. Ribeiro, A. Rodrigues","doi":"10.1109/ENBENG.2011.6026069","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026069","url":null,"abstract":"In this work we describe a project that is currently in progress. We point out the key ideas of the project explaining the pros and cons of the chosen approach. A clinic with image facilities produces a huge amount of information per year that, most of the times, is underused since exams are analyzed individually without the comparison between individuals or the exploration of features of a certain population. Data mining would be recommendable in these cases, however image databases are difficult to analyze because they depend on robust and automatic methods of segmentation and classification. We propose a method for segmenting nuclear medicine images (whole body PET scans) based on a classification method. The segmented regions are also labeled and used as additional features for a structured database.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128444050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Evaluation of Ion Jelly biopolymer on glucose biosensing 离子果冻生物聚合物对葡萄糖生物传感的评价
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026055
N. Lourenço, J. Osterreicher, J. Cabral, L. Fonseca, P. Vidinha, S. Barreiros
{"title":"Evaluation of Ion Jelly biopolymer on glucose biosensing","authors":"N. Lourenço, J. Osterreicher, J. Cabral, L. Fonseca, P. Vidinha, S. Barreiros","doi":"10.1109/ENBENG.2011.6026055","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026055","url":null,"abstract":"The kinetics of Glucose oxidase (GOD) and Horseradish peroxidase (HRP) on a transparent Ion Jelly biopolymer has been investigated using a colorimetric assay of H2O2 with phenol-4-sulfonic acid and 4-aminoantipyrine, as color-generating precursors. The activity of GOD and HRP on the Ion Jelly biopolymer solid disk formed in the bottom of the well ELISA plate showed to be respectively 16 times and 13 times lower than in free sodium phosphate buffer. The storage stability at 4°C of the both immobilized enzymes showed that GOD can retain up to 70% of the initial activity after two weeks, where HRP retained 91% of its initial activity. The drop cast deposition of the transparent Ion Jelly biopolymer containing the two enzymes (GOD, HRP) and the color-generating precursors on filter paper allowed to demonstrate their applicability on colorimetric glucose detection.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116870749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Temporal correlation compensation (whitening) of the fMRI data using Akaike Information Criterion 基于Akaike信息准则的fMRI数据时间相关补偿(白化)
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026085
R. Maximiano, J. Sanches
{"title":"Temporal correlation compensation (whitening) of the fMRI data using Akaike Information Criterion","authors":"R. Maximiano, J. Sanches","doi":"10.1109/ENBENG.2011.6026085","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026085","url":null,"abstract":"This work concerns the noise present in BOLD-fMRI (Blood-Oxygen-Level-Dependent: functional Magnetic Resonance Imaging, a technique that evaluates the levels of oxygen in the blood vessels of the brain. It is known that there is a temporal correlation present in the BOLD-fMRI's noise signal, complicating the estimation of the active regions of the brain due to an external stimulus. Using SPM-GLM methods (Statistical Parametric Mapping — General Linear Methods), denoised signal and response coefficients from all voxels (Volume Element) are estimated. The comparison between both signals gives an approximation of its noise signal. Using Akaike Information Criterion, this technique estimates the best model's order to decorrelate the noise and pre-whiten. Moreover, this algorithm recalculates new unknown parameters until a minimum threshold is achieved. Final results obtained were analyzed and concluded to have less false-positives, allowing a better definition of the real active regions.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122064364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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