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An image processing application for liver tumour segmentation 肝脏肿瘤分割的图像处理应用
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026097
P. Rodrigues, J. Vilaça, J. Fonseca
{"title":"An image processing application for liver tumour segmentation","authors":"P. Rodrigues, J. Vilaça, J. Fonseca","doi":"10.1109/ENBENG.2011.6026097","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026097","url":null,"abstract":"Liver cancer is one of the leading causes of death worldwide. Consequently, the development of accurate and reliable segmentation techniques is indispensable for tumour volume measurement and staging analysis. An interactive algorithm for liver tumour segmentation was developed, allowing the user to quickly paint the object of interest in the image using an intelligent paintbrush. This technique was based on an image partitioning into homogeneous primitives regions by applying a pseudo-watershed algorithm on an image gradient magnitude. Outcome of this initial segmentation was the input of an efficient region merging process to find the best image partitioning, based on the minimum description length principle. The algorithm was evaluated on Computed Tomography (CT) and Magnetic Resonance (MR) data using the dice similarity coefficient (DSC) as a statistical validation metric. This led to a DCS mean scores of 87% and 84% on the CT and MR studies, respectively.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128079997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
ArthroNav: Computer assisted navigation system for orthopedic surgery using endoscopic images ArthroNav:利用内窥镜图像进行骨科手术的计算机辅助导航系统
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026050
J. Barreto, R. Melo, M. Antunes, M. Lourenço, F. Vasconcelos
{"title":"ArthroNav: Computer assisted navigation system for orthopedic surgery using endoscopic images","authors":"J. Barreto, R. Melo, M. Antunes, M. Lourenço, F. Vasconcelos","doi":"10.1109/ENBENG.2011.6026050","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026050","url":null,"abstract":"In the future, medicine will increasingly rely in Computer Aided Surgery and Diagnosis, hence techniques to extract information from endoscopic images of human-body cavities will be crucial. The ArthroNav project main goal is to process the endoscopic video in order to improve practioner's perception and navigation skill inside the knee joint. Some navigation systems for CAS (Computer Aided Surgery) based on image processing techniques have been already proposed in the literature. However, most of them employ methods designed for conventional cameras and do not account with the special optical arrangement of the endoscopic lens. We intend to adapt/design new computer vision techniques invariant to the numerous challenges that endoscopic video places. The usefulness of developing algorithms for endoscopic images is not limited to Computer Assisted Orthopedic Surgery. Many other medical fields can benefit from the research herein proposed. The processing of endoscopic video can be equally used in other minimally invasive procedures like nose surgery, neurosurgery, and cardiac surgery.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134334797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Microreactors and microdevices for analytical and biosensors applications 用于分析和生物传感器的微反应器和微装置
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026064
L. Fonseca, V. Martins, P. Freitas
{"title":"Microreactors and microdevices for analytical and biosensors applications","authors":"L. Fonseca, V. Martins, P. Freitas","doi":"10.1109/ENBENG.2011.6026064","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026064","url":null,"abstract":"It is thought that worldwide more than 109 analyses are now performed every day with a double-digit growth rate. Microreactors and analytical microdevices and biosensors can provide important role on the control of environment, bioprocesses, processed food, biomedical analysis, among others due to rapid analysis and high sensitivity. This work envisages showing the potential of microreactors and biosensors on two mainly applications: i) The development of enzyme-base analytical microreactors for detection of multi-analyte compounds (e.g. sugars, alcohols, aminoacids, organic acids, among others) based on enzyme immobilization carried out on CPG beads integrated in FIA/SIA systems and sol-gel matrix integrated in glass capillary and microchannels. ii) The manipulation of individual microbial cells and single strand DNA molecules with functional paramagnetic nano-and micro-beads and their detection with magneto-resistive sensors demonstrates the applicability of these biosensors for the detection of pathogen microorganisms (e.g. Salmonella) through two different strategies: hybridization of DNA molecules (DNA-chips) and antibody-antigen biorecognition (immuno-chips).","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133377306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Legionella: Bioactive nano-filters for air purification systems 军团菌:用于空气净化系统的生物活性纳米过滤器
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026057
P. Rodrigues, M. J. Geraldes, N. Belino
{"title":"Legionella: Bioactive nano-filters for air purification systems","authors":"P. Rodrigues, M. J. Geraldes, N. Belino","doi":"10.1109/ENBENG.2011.6026057","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026057","url":null,"abstract":"Legionnaires disease or legionellosis arose due to human alteration of the environment, Legionella species can be found in aquatic environments, water warm and hot, and humid places, such as cooling towers, spas, among others. This is an infectious disease caused by bacteria belonging to the genus Legionella. To reduce the multiplication of Legionella pneumophila and the associated risk of Legionnaires' disease should be taken measures to prevent and control physical, chemical and microbiological, in order to promote and maintain clean surfaces of water systems and air. One of the systems used for purification of air filtration consists in the separation and capture of particles of any kind. The filters need technical requirements that are a balance between three key parameters: the filter efficiency, pressure drop and the durability of the filter.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115119517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Laser Doppler flowmeters for microcirculation measurements 微循环测量用激光多普勒流量计
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026037
Ricardo Oliveira, S. Semedo, E. Figueiras, L. R. Ferreira, A. Humeau
{"title":"Laser Doppler flowmeters for microcirculation measurements","authors":"Ricardo Oliveira, S. Semedo, E. Figueiras, L. R. Ferreira, A. Humeau","doi":"10.1109/ENBENG.2011.6026037","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026037","url":null,"abstract":"Laser Doppler flowmetry (LDF) is a technique for real-time assessment of microcirculation blood flow. LDF can be used for non-invasive perfusion monitoring (for example skin perfusion monitoring), or for invasive microcirculation evaluations (for example perfusion brain evaluations). Using a multi-wavelength laser Doppler flowmeter prototype with different spaced detection fibers, we propose to add depth discrimination capabilities to LDF skin monitoring. We also propose to build a self-mixing based laser Doppler flowmeter prototype for brain perfusion estimation. These two prototypes will solve two drawbacks prevailing in the laser Doppler flowmeters commercially available: one dealing with the absence of depth information in skin perfusion monitoring; and the other dealing with the fact that laser Doppler probes for invasive evaluations are too large for perfusion brain measurements causing damage to the tissues.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115596316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Elucidation of the drug resistance mechanisms of osteosarcoma cancer stem cells with PET tracers PET示踪剂对骨肉瘤肿瘤干细胞耐药机制的研究
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026060
S. C. Neves, Vitor Eb Oliveira, Anália do Carmo, A. Abrunhosa, M. Botelho, Célia M Gomes
{"title":"Elucidation of the drug resistance mechanisms of osteosarcoma cancer stem cells with PET tracers","authors":"S. C. Neves, Vitor Eb Oliveira, Anália do Carmo, A. Abrunhosa, M. Botelho, Célia M Gomes","doi":"10.1109/ENBENG.2011.6026060","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026060","url":null,"abstract":"Cells stem cells (CSCs) have been identified in several types of malignancies and referred as the responsible for driving tumor growth and resistance to chemotherapy. Previous studies have identified CSCs in a human osteosarcoma cell line that is relatively resistant to doxorubicin. We aimed to identify the mechanisms underlying this resistant phenotype and to assess the functional alterations occurring during differentiation of CSCs using PET-radiotracers. CSCs were isolated using the sphere-formation assay and incubated with different concentrations of DOX during 48h, with and without verapamil. Cells' viability was measured using the MTT-colorimetric assay. Metabolic and osteoblastic activity was assessed with [18F]FDG and [18F]NaF, respectively during differentiation of CSCs. The half-maximal inhibitory concentrations of DOX was higher in CSCs (IC50=0.90±0.10μM) than in the MNNG/HOS (IC50=0.61±0.05μM) and decreased to 0.29μM with verapamil. Cellular uptake of [18F]FDG was lower in CSCs and increased progressively during differentiation, whereas [18F]NaF accumulation was higher in undifferentiated CSCs.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128571830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrosion and tribocorrosion behavior of CoCrMo alloys used as hip joint implant materials under simulated body fluids: Effect of proteins and normal load 模拟体液下用作髋关节植入材料的CoCrMo合金的腐蚀和摩擦腐蚀行为:蛋白质和正常负荷的影响
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026086
M. Runa, L. A. Rocha, M. Mathew
{"title":"Corrosion and tribocorrosion behavior of CoCrMo alloys used as hip joint implant materials under simulated body fluids: Effect of proteins and normal load","authors":"M. Runa, L. A. Rocha, M. Mathew","doi":"10.1109/ENBENG.2011.6026086","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026086","url":null,"abstract":"The release of metal ions and wear debris are raising serious concerns on metal-on-metal (MoM) hip prosthesis. The purpose of this work was to evaluate the corrosion and tribocorrosion behavior, of a low-carbon CoCrMo alloy, as a function of proteins content in the biological fluid and normal applied load. Electrochemical tests were performed to study the corrosion behavior of the alloy, under two simulated body fluids: phosphate buffer solution (PBS) and bovine calf serum (BCS). The tribocorrosion tests were performed using the same solutions, under different loading conditions and tribometer configuration. An attempt was made to evaluate the synergistic interactions between corrosion and wear. The surface characterization of the sample was also studied. The presence of proteins was found to improve the corrosion resistance and passive behavior due to their protective boundary lubricant effect. Normal applied load showed to increase the passive film destruction.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126142228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Bioelectromagnetic wound dressings as tool for the prophylaxis of pressure ulcers 生物电磁创面敷料作为预防压疮的工具
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026059
S. M. S. Farropas, N. Belino, C. Cabrita, M. Geraldes
{"title":"Bioelectromagnetic wound dressings as tool for the prophylaxis of pressure ulcers","authors":"S. M. S. Farropas, N. Belino, C. Cabrita, M. Geraldes","doi":"10.1109/ENBENG.2011.6026059","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026059","url":null,"abstract":"This study aims to develop bioelectromanetic wound dressings to accelerate the healing of chronic wounds such as pressure ulcers. For this purpose the authors will carry out three different methods: nanolayered structures with metallic oxide elements, coated nanofiber bandages with metallic oxide elements and finally, bandages produced with knit structures integrating metallic yarns. The key concept of this project entails around the formation of the Foucault currents derived from the electromagnetic radiation incident on the metallic elements of the bandages. These Eddy currents are the rationale for heating up the bandages, which are in deep contact with the skin, promoting the blood flow into the wound area (capillary perfusion), and consequently, the in taking of oxygen, nutrients, etc. accelerating the healing of the wound.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126344044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An appraisal of genetic stability in human mesenchymal stem cells 人间充质干细胞遗传稳定性的评价
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026040
P. Oliveira, Joana S. Boura, M. Abecasis, C. L. da Silva, J. Cabral
{"title":"An appraisal of genetic stability in human mesenchymal stem cells","authors":"P. Oliveira, Joana S. Boura, M. Abecasis, C. L. da Silva, J. Cabral","doi":"10.1109/ENBENG.2011.6026040","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026040","url":null,"abstract":"Human bone-marrow mesenchymal stem cells (BM MSCs) and adipose derived stem cells (ADSCs) were evaluated for evidence of senescence during exposure to hypoxic conditions and protracted ex vivo expansion. Under hypoxia we have observed microsatellite instability and down-regulation of genes involved in DNA repair. Simultaneously, a decrease in ATP content and in the number of mitochondrial genomes was observed. Irrespective of O2 tension or cell passage, we observed several heteroplasmic point mutations, some of which have been reported in a wide range of tumors. These results alert for a careful analysis of cell integrity during the development and application of regenerative therapies.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116839427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification of cancer stem-like cells in osteosarcoma: Implications in radioresistance 骨肉瘤中癌症干细胞样细胞的鉴定:放射耐药的意义
1st Portuguese Biomedical Engineering Meeting Pub Date : 2011-03-01 DOI: 10.1109/ENBENG.2011.6026095
S. Neves, C. Gomes
{"title":"Identification of cancer stem-like cells in osteosarcoma: Implications in radioresistance","authors":"S. Neves, C. Gomes","doi":"10.1109/ENBENG.2011.6026095","DOIUrl":"https://doi.org/10.1109/ENBENG.2011.6026095","url":null,"abstract":"Recent studies suggest that many tumors contain a small subset of cells with stem-like properties that are responsible for tumor initiation and progression and resistance to conventional treatments. We aimed to identify the presence of putative cancer stem-like cells in a human osteosarcoma cell line and to evaluate their responsiveness to ionizing radiation. The isolated cells formed sphere-clusters, were positive for mesenchymal stem cell markers, differentiated into osteoblasts and developed tumors in immunocompromised mice. [18F]fluoro-2-deoxyglucose uptake in cancer stem-like cells was significantly lower than that in the original parental cell line and the median lethal dose was significantly higher. Production of reactive oxygen species was higher in the parental cell line. The cell-cycle progression in isolated cancer stem-like cells remained almost unaltered with irradiation, while parental cells arrested in G2/M phase.","PeriodicalId":206538,"journal":{"name":"1st Portuguese Biomedical Engineering Meeting","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129781239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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