Macromolecular Rapid Communications最新文献_第9页

Porosity Engineering and Functionalization of Hyper-Cross-Linked Polymers for Highly Selective CO₂ Adsorption. 高选择性CO2吸附超交联聚合物的孔隙工程和功能化。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-07 DOI: 10.1002/marc.202500020

Yahya Alemin, Jiarui Hu, Peixuan Xie, Xiaoyan Wang, Hui Gao, Bien Tan

{"title":"Porosity Engineering and Functionalization of Hyper-Cross-Linked Polymers for Highly Selective CO2 Adsorption.","authors":"Yahya Alemin, Jiarui Hu, Peixuan Xie, Xiaoyan Wang, Hui Gao, Bien Tan","doi":"10.1002/marc.202500020","DOIUrl":"https://doi.org/10.1002/marc.202500020","url":null,"abstract":"Selective carbon dioxide (CO₂) capture from industrial processes is vital for reducing emissions associated with fossil fuel combustion. Achieving both high CO₂ adsorption capacity and excellent CO₂/N₂ selectivity, however, remains a significant challenge. In this study, a novel strategy is introduced that integrates porosity engineering using various cross-linkers-dimethoxymethane (F), p-dichloroxylene (D), and dibromomethane (B)-with post-synthetic modifications to incorporate nitro (─NO₂) and amino (─NH₂) functional groups into the polymer matrix. Nitration of hyper-cross-linked polymer based on dimethoxymethane (HCP-F) yields HCP-F-NO₂, which, upon reduction, produces the amine-functionalized framework HCP-F-NH₂. Both HCP-F-NO₂ and HCP-F-NH₂ demonstrate relatively high CO₂ uptake. Despite its lower surface area (784 m2 g⁻¹) compared to HCP-F-NO₂ (1066 m2 g⁻¹), HCP-F-NH₂ exhibits superior CO₂/N₂ selectivity of 100, compared to 70 for HCP-F-NO₂. Furthermore, ideal adsorbed solution theory (IAST) selectivity calculations at 298 K and 1 bar for 15:85 CO2/N2 confirm enhanced CO2/N2 selectivity after post-synthetic modification, with HCP-F-NH2 reaching the highest value (64), breakthrough experiments at 298 K with 3 mL min-1 flow rate validate increased CO2 retention, while regeneration tests confirm structural stability and recyclability, reinforcing the potential of functionalized HCPs for CO2 capture applications.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500020"},"PeriodicalIF":4.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Integrating Proteolysis-Targeting Chimeras (PROTACs) with Delivery Systems for More Efficient and Precise Targeted Protein Degradation. 整合蛋白水解靶向嵌合体（PROTACs）与递送系统更有效和精确的靶向蛋白质降解。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-04 DOI: 10.1002/marc.202401051

Jiachan Lin, Zirui Chen, Dan Zhang, Nan Zhang, Hongzhong Chen, Dong-Sheng Guo

{"title":"Integrating Proteolysis-Targeting Chimeras (PROTACs) with Delivery Systems for More Efficient and Precise Targeted Protein Degradation.","authors":"Jiachan Lin, Zirui Chen, Dan Zhang, Nan Zhang, Hongzhong Chen, Dong-Sheng Guo","doi":"10.1002/marc.202401051","DOIUrl":"https://doi.org/10.1002/marc.202401051","url":null,"abstract":"Targeted protein degradation (TPD) using the proteolysis-targeting chimeras (PROTACs) is emerging as a revolutionary technology, offering a potential strategy for cancer treatment by inducing the degradation of overexpressed oncogenic proteins in tumors. PROTACs function by recruiting E3 ligases and utilizing the ubiquitin-proteasome pathway (UPS) to catalyze the degradation of target oncogenic proteins. Compared to traditional small molecules inhibitors, PROTACs exhibit enhanced selectivity, the ability to overcome drug resistance, and target proteins traditionally deemed \"undruggable\". However, the poor water solubility and low cellular permeability of PROTACs significantly limit their pharmacokinetic properties, while potential systemic toxicity may hinder their clinical application. To address these limitations, strategies that integrate PROTACs with drug delivery systems are gaining attention. This review summarizes the latest advancements in various delivery strategies to enhance the in vivo degradation efficacy and reduce off-target effects of PROTACs, including the prototype delivery of PROTACs using nanoparticles, covalent modification-based prodrug strategies, innovative multi-headed PROTACs designs, and microneedle delivery systems, while discussing their design principles and associated challenges. The combination of potent PROTACs with multifunctional delivery systems holds promise for accelerating clinical translation and improving therapeutic efficacy in cancer treatment.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401051"},"PeriodicalIF":4.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Issue Information: Macromol. Rapid Commun. 7/2025 发布信息：Macromol。快速公报。7/2025

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-04 DOI: 10.1002/marc.202570023

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Functional Polymeric Materials and Interfaces 功能性聚合物材料和界面

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-04 DOI: 10.1002/marc.202500060

Fujian Xu, Liqun Xu

引用次数: 0

Functional Polymeric Materials and Interfaces 功能高分子材料与界面

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-04 DOI: 10.1002/marc.202570022

Fujian Xu, Liqun Xu

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Electroosmotic Flow of Sequence-Defined Polyelectrolyte Solutions in Charged Nanochannels: The Dominant Role of Charge Configuration. 序列定义的多电解质溶液在带电纳米通道中的电渗透流动：电荷结构的主导作用。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-02 DOI: 10.1002/marc.202500209

Xinxi Liu, Zexuan Li, Wenyao Zhang, Qiuwang Wang, Ning Ma, Alaa S Abd-El-Aziz, Cunlu Zhao

{"title":"Electroosmotic Flow of Sequence-Defined Polyelectrolyte Solutions in Charged Nanochannels: The Dominant Role of Charge Configuration.","authors":"Xinxi Liu, Zexuan Li, Wenyao Zhang, Qiuwang Wang, Ning Ma, Alaa S Abd-El-Aziz, Cunlu Zhao","doi":"10.1002/marc.202500209","DOIUrl":"https://doi.org/10.1002/marc.202500209","url":null,"abstract":"Nanoscale electroosmotic flow (EOF) of polyelectrolyte solutions is essential in understanding biological phenomena and developing biotechnologies. However, the lack of understanding of EOF in nanoconfined polyelectrolyte solutions is not conducive to developing these technologies. Here, a charge-configuration sensitive EOF of sequence-defined polyelectrolyte solutions in oppositely charged nanochannels is reported using an advanced dissipative particle dynamics approach, reaching a ≈100% difference in the central velocity between two charge configurations. Specifically, the average EOF velocity vavg of ABA solutions responds linearly to surface charge density, while AB and BAB solutions show nonlinear responses. Even at zero surface charge density, a considerable net EOF is observed due to PE chain conformations. vavg of all solutions exhibits non-monotonic behavior with increasing chain stiffness. vavg decreases consistently with monomer density and chain length but to varying degrees, while increasing with more chain blocks as PE chains get more coiled. As charge fraction rises, vavg of ABA solutions decreases to the fully charged case, while AB and BAB solutions show non-monotonic trends. The differences in vavg are gradually screened by added salt. The findings of this study improve the understanding of EOF of complex fluids and can potentially help develop a new nanofluidic pumping system.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500209"},"PeriodicalIF":4.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Rearrangement in Diamine-Based Polyzwitterion Side Chains for the Modulated pH Responsiveness Regardless of Their Comparable pK_a Values. 二胺基多两性阴离子侧链重排对pH响应性的调节，不管它们的pKa值如何。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-02 DOI: 10.1002/marc.202500156

Sachi Ibuki, Tomohiro Umeno, Makoto Oba, Hiroyasu Takemoto

引用次数: 0

Comprehensive Study of Actuation Mechanisms and Applications in Liquid Crystalline Polymer Networks and Elastomer from Nanometer Precision to Macroscale Functionality. 液晶聚合物网络和弹性体驱动机理及其应用的综合研究——从纳米精度到宏观功能。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-04-02 DOI: 10.1002/marc.202401086

Geunjung Lee, Baekman Kim, Dong Ki Yoon

{"title":"Comprehensive Study of Actuation Mechanisms and Applications in Liquid Crystalline Polymer Networks and Elastomer from Nanometer Precision to Macroscale Functionality.","authors":"Geunjung Lee, Baekman Kim, Dong Ki Yoon","doi":"10.1002/marc.202401086","DOIUrl":"https://doi.org/10.1002/marc.202401086","url":null,"abstract":"Liquid crystalline polymer networks (LCNs) and liquid crystalline elastomers (LCEs) possess unique properties that enable structural deformation in response to external stimuli such as temperature, light, and electric fields. These deformations occur across a wide range of scales, from nanometers to macroscopic scales. This review aims to comprehensively address the actuation mechanisms observed in LCN and LCE-based structures across various scales. First, actuation phenomena are explored at the nanoscale and investigate the potential applications of these mechanisms in nanodevices and nanoscale systems. Next, deformations at the microscale, presenting case studies involving applications in micro-robotics and micro-actuators, are analyzed. Finally, it is examined how structural deformations at the macroscale can be utilized in large systems, such as macro devices and soft robotics. By investigating scale-dependent actuation characteristics, this paper provides an integrated perspective on LCN and LCE research, emphasizing their transformative potential for next-generation applications.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401086"},"PeriodicalIF":4.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in Antimicrobial Peptide-Based Biomaterials for Combating Multidrug-Resistant Bacterial Infections. 抗多药耐药细菌感染的抗菌肽生物材料研究进展。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202401046

Zhe Yuan, Jing Kang, Sachula Wu, Alideertu Dong, Rile Wu

{"title":"Advances in Antimicrobial Peptide-Based Biomaterials for Combating Multidrug-Resistant Bacterial Infections.","authors":"Zhe Yuan, Jing Kang, Sachula Wu, Alideertu Dong, Rile Wu","doi":"10.1002/marc.202401046","DOIUrl":"https://doi.org/10.1002/marc.202401046","url":null,"abstract":"As the clinical prevalence of antibiotic-resistant bacteria rises, the effectiveness of antibacterial drugs has been greatly reduced, hence, it is essential to create novel antibacterial materials for combating bacterial infections. In recent years, antimicrobial peptides (AMPs) have demonstrated significant promise in addressing infections caused by bacteria, but as a natural product, they are limited in terms of activity and stability, and cannot exert their full effect. The conjugation of peptide-based biomaterials makes up for this shortcoming, and the antimicrobial activity is also improved, which also lays the foundation for its clinical application. This review aims to introduce the current progress of AMPs-based biomaterials in the treatment of multidrug-resistant bacterial infections, covering the topics from their sources to the delivery of treatment in combining biomaterial AMPs. In addition, its therapeutic advantages, including synergistic treatment, improved stability and effectiveness, and high biocompatibility, are also discussed. Finally, the current situation and prospects of AMP-based biomaterials for multidrug-resistant bacterial infections are summarized.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401046"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effect of Mechanical Recycling on the Crystallization of PA 11 and PA 11 LDPE Blends. 机械回收对pa11和pa11 LDPE共混结晶的影响。

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202500164

Johanna Morales, Rose Mary Michell, Denis Rodrigue

{"title":"Effect of Mechanical Recycling on the Crystallization of PA 11 and PA 11 LDPE Blends.","authors":"Johanna Morales, Rose Mary Michell, Denis Rodrigue","doi":"10.1002/marc.202500164","DOIUrl":"https://doi.org/10.1002/marc.202500164","url":null,"abstract":"This study investigates the effect of mechanical recycling on the thermal crystallization of virgin polyamide (PA 11) and a post-consumer PA 11 - low-density polyethylene (LDPE) blend (90/10) over ten reprocessing cycles. Isothermal, non-isothermal, and successive self-nucleation and annealing (SSA) methods are used. Isothermal analysis revealed accelerated crystallization kinetics with increasing reprocessing cycles, as shown by an increase in the inverse of the half-crystallization time (1/τ1/2exp) and a decrease in the crystallization energy barrier (Kg), likely due to enhanced chain mobility and molecular weight reduction from thermal degradation. SSA analysis revealed differences in lamellar structures. After three cycles, virgin PA 11 presented a shoulder in the SSA profile, indicating the formation of thinner lamellae. In contrast, post-consumer PA 11 showed a progressive increase in its main melting peak, suggesting the development of thicker lamellae with a more uniform molecular population. Thermogravimetric analysis showed reduced thermal stability, as indicated by lower activation energy (Ea). Despite these changes, their effect is not significant to limit reprocessing, confirming their recyclability for at least ten cycles. To further assess their long-term viability; structural, rheological, and mechanical properties will be presented in a subsequent study.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500164"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0