Macromolecular Rapid Communications最新文献

Advances in Antimicrobial Peptide-Based Biomaterials for Combating Multidrug-Resistant Bacterial Infections.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202401046

Zhe Yuan, Jing Kang, Sachula Wu, Alideertu Dong, Rile Wu

{"title":"Advances in Antimicrobial Peptide-Based Biomaterials for Combating Multidrug-Resistant Bacterial Infections.","authors":"Zhe Yuan, Jing Kang, Sachula Wu, Alideertu Dong, Rile Wu","doi":"10.1002/marc.202401046","DOIUrl":"https://doi.org/10.1002/marc.202401046","url":null,"abstract":"As the clinical prevalence of antibiotic-resistant bacteria rises, the effectiveness of antibacterial drugs has been greatly reduced, hence, it is essential to create novel antibacterial materials for combating bacterial infections. In recent years, antimicrobial peptides (AMPs) have demonstrated significant promise in addressing infections caused by bacteria, but as a natural product, they are limited in terms of activity and stability, and cannot exert their full effect. The conjugation of peptide-based biomaterials makes up for this shortcoming, and the antimicrobial activity is also improved, which also lays the foundation for its clinical application. This review aims to introduce the current progress of AMPs-based biomaterials in the treatment of multidrug-resistant bacterial infections, covering the topics from their sources to the delivery of treatment in combining biomaterial AMPs. In addition, its therapeutic advantages, including synergistic treatment, improved stability and effectiveness, and high biocompatibility, are also discussed. Finally, the current situation and prospects of AMP-based biomaterials for multidrug-resistant bacterial infections are summarized.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401046"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Mechanical Recycling on the Crystallization of PA 11 and PA 11 LDPE Blends.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202500164

Johanna Morales, Rose Mary Michell, Denis Rodrigue

{"title":"Effect of Mechanical Recycling on the Crystallization of PA 11 and PA 11 LDPE Blends.","authors":"Johanna Morales, Rose Mary Michell, Denis Rodrigue","doi":"10.1002/marc.202500164","DOIUrl":"https://doi.org/10.1002/marc.202500164","url":null,"abstract":"This study investigates the effect of mechanical recycling on the thermal crystallization of virgin polyamide (PA 11) and a post-consumer PA 11 - low-density polyethylene (LDPE) blend (90/10) over ten reprocessing cycles. Isothermal, non-isothermal, and successive self-nucleation and annealing (SSA) methods are used. Isothermal analysis revealed accelerated crystallization kinetics with increasing reprocessing cycles, as shown by an increase in the inverse of the half-crystallization time (1/τ1/2exp) and a decrease in the crystallization energy barrier (Kg), likely due to enhanced chain mobility and molecular weight reduction from thermal degradation. SSA analysis revealed differences in lamellar structures. After three cycles, virgin PA 11 presented a shoulder in the SSA profile, indicating the formation of thinner lamellae. In contrast, post-consumer PA 11 showed a progressive increase in its main melting peak, suggesting the development of thicker lamellae with a more uniform molecular population. Thermogravimetric analysis showed reduced thermal stability, as indicated by lower activation energy (Ea). Despite these changes, their effect is not significant to limit reprocessing, confirming their recyclability for at least ten cycles. To further assess their long-term viability; structural, rheological, and mechanical properties will be presented in a subsequent study.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500164"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Hyaluronic Acid-Targeted Supramolecular Delivery Platform With pH and ROS-Responsive Drug Release.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202500201

Kaixuan Jiang, Wenhui Wu, Meiran Xie, Hu He, Ruyi Sun

{"title":"Fabrication of Hyaluronic Acid-Targeted Supramolecular Delivery Platform With pH and ROS-Responsive Drug Release.","authors":"Kaixuan Jiang, Wenhui Wu, Meiran Xie, Hu He, Ruyi Sun","doi":"10.1002/marc.202500201","DOIUrl":"https://doi.org/10.1002/marc.202500201","url":null,"abstract":"A supramolecular drug delivery system is fabricated here based on the assembly of β-cyclodextrin-modified hyaluronic acid (HACD) and ferrocene (Fc) with pH-sensitive polyhistidine (PHIS). The system demonstrates efficient encapsulation of hydrophobic anticancer drugs with high and stable drug loading capacity. The drug-loaded nanoparticles utilize HACD as the hydrophilic corona, enabling active tumor targeting through CD44 receptor-mediated endocytosis and exhibiting dual stimuli-responsive release properties (ROS and pH). In the tumor microenvironment characterized by elevated ROS levels and acidic pH, the nanoparticles undergo structural disassembly, switching from controlled release to rapid drug liberation. Blank nanoparticles exhibit excellent biocompatibility, while drug-loaded formulations demonstrate selective cytotoxicity with significantly reduced toxicity toward normal cells HFF-1 and enhanced therapeutic efficacy against HeLa cancer cells. This nanoplatform significantly improves the aqueous solubility and biocompatibility of hydrophobic drugs, achieving intelligent delivery and double-modal stimulus-responsive release.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500201"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Crosslinking of Tröger Base-Based Membranes with Improved Vanadium Flow Battery Property.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202401129

Jiachen Chu, Xiaokang Yang, Mengtao Wang, Jianxin Li, Yunfei Song, Xiaohua Ma

{"title":"In Situ Crosslinking of Tröger Base-Based Membranes with Improved Vanadium Flow Battery Property.","authors":"Jiachen Chu, Xiaokang Yang, Mengtao Wang, Jianxin Li, Yunfei Song, Xiaohua Ma","doi":"10.1002/marc.202401129","DOIUrl":"https://doi.org/10.1002/marc.202401129","url":null,"abstract":"The high conductivity of anion exchange membrane (AEM) remains a great challenge in achieving high-performance vanadium flow batteries. In this work, this is achieved by designing a series of microporous crosslinked quaternary ammonium membranes (QDTTB-Xs), which is synthesized by in situ reacting of iodomethane with a series of novel crosslinked microporous Tröger base membranes (DTTB-Xs) that prepared by condensation of 2, 6 (7)-diamino-triptycene and 2, 6 (7)-13-triamino-triptycene through in situ crosslinking. Compared with linear microporous QDTTB-0, the crosslinked QDTTB-X membranes showed higher conductivity. The QDTTB-35 membrane displays both higher coulombic efficiency and voltage efficiency, and 80% of energy efficiency is realized at 200 mA cm-2. Outperforming N117 and other reported anion exchange membranes. This is due to the increased triamino-triptycene molar ratio in the membrane resulting in both higher N+ concentration and improved micropores concentration. Moreover, positively charged N+ groups combined with the low swelling ratio also help in restricting the vanadium ions permeation. These results give great perspectives in designing high-performance AEMs for VRFB applications.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401129"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospinning of Well-Aligned P(VDF-TrFE) Fibers Using a Benign Solvent.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-29 DOI: 10.1002/marc.202500099

Shaashwat Saraff, Kalyan Ghosh, Thiyagarajan Natarajan, Giulio Isacco Lampronti, Sohini Kar-Narayan

{"title":"Electrospinning of Well-Aligned P(VDF-TrFE) Fibers Using a Benign Solvent.","authors":"Shaashwat Saraff, Kalyan Ghosh, Thiyagarajan Natarajan, Giulio Isacco Lampronti, Sohini Kar-Narayan","doi":"10.1002/marc.202500099","DOIUrl":"https://doi.org/10.1002/marc.202500099","url":null,"abstract":"Poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) is an important piezoelectric polymer, often electrospun into fibrous membranes for technological applications. Typically, this involves toxic solvents, necessitating a compromise between solvent safety, process stability, and fiber quality. In this study, out of several candidates across different organic families, a safe and effective solvent is identified for electrospinning P(VDF-TrFE). The dual impact of solvent boiling point on process stability and fiber quality is studied, to arrive at a facile, consistent protocol for producing high-quality fibers. The health effects of the solvents are considered, as those posing minimal risks are favored in applications related to biomedicine, for example. Methyl propyl ketone (MPK) is found to be an ideal, non-toxic solvent, with an optimal evaporation rate at typical processing temperatures, to produce uniform, distinct and well-aligned electrospun P(VDF-TrFE) fibers. The impact of electrospinning process parameters is further investigated to optimize results using this solvent. Through the introduction of a benign and effective solvent for electrospinning, this work provides a detailed protocol to produce high-quality P(VDF-TrFE) fibers through a consistent and stable process, without involving toxic solvents, which opens up new possibilities in green electrospinning.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500099"},"PeriodicalIF":4.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Inspired, Zwitterionic Copolymers with Amphiphilic Character.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-27 DOI: 10.1002/marc.202401099

Theresa M Lutz, Cevin P Braksch, Jonas De Breuck, Matthias Hartlieb, Meike N Leiske

{"title":"Bio-Inspired, Zwitterionic Copolymers with Amphiphilic Character.","authors":"Theresa M Lutz, Cevin P Braksch, Jonas De Breuck, Matthias Hartlieb, Meike N Leiske","doi":"10.1002/marc.202401099","DOIUrl":"https://doi.org/10.1002/marc.202401099","url":null,"abstract":"Selectively targeting diseases with therapeutics remains a crucial yet still unsatisfied challenge in (nano)medicine. In recent years, a large body of biologically based drug carrier systems are produced which have proven to be suitable for the efficient transport of active compounds such as biopharmaceuticals and biotechnological drugs. However, those naturally occurring materials often entail risks, for example, due to accessible, functional groups created by uncontrolled protein denaturation processes of enzymes (e.g., proteases) which can lead to unwanted side effects in the body. To deal with this issue, designing bio-inspired synthetic copolymers offers a suitable alternative compared to systems based on materials derived from natural sources. Owing to the variety of electrostatically interacting motifs abundant in nature, synthetic statistical copolymers are developed with different polarity and zwitterionic arginine-derived units. To achieve the required physicochemical demands, a simple one-step synthesis approach is applied, the so-called xanthate-supported photo-iniferter reversible-addition-fragmentation chain-transfer (XPI-RAFT) polymerization. The cellular association of these polymers is compared to a fully non-ionic polymer. The results highlight new findings in the design of zwitterionic macromolecule structures for medical applications and further progress the understanding of the driving forces of the cell specificity of polyzwitterions.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401099"},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rose-Bengal-Tethered Polymer Encapsulant for Carbon-Nanohorn Conjugates: Theranostic Potential for Multimodal Imaging and Phototherapy.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-27 DOI: 10.1002/marc.202500030

Ji Woo Kim, Hea Ji Kim, Thanh Dat Le, Su Woong Yoo, Changho Lee, Hyungwoo Kim

{"title":"Rose-Bengal-Tethered Polymer Encapsulant for Carbon-Nanohorn Conjugates: Theranostic Potential for Multimodal Imaging and Phototherapy.","authors":"Ji Woo Kim, Hea Ji Kim, Thanh Dat Le, Su Woong Yoo, Changho Lee, Hyungwoo Kim","doi":"10.1002/marc.202500030","DOIUrl":"https://doi.org/10.1002/marc.202500030","url":null,"abstract":"This paper presents the molecular design of a rose-bengal-containing functional polymer for the encapsulation of carbon nanohorns (CNHs). The polymer chain consists of hydrophilic monomers and dangling oxirane moieties that tether the rose bengal units. It exhibits high biocompatibility with CNHs and excellent coating ability, resulting in a carbon-based nanoconjugate with a core-shell nanostructure. The dahlia-like CNH core generates photoacoustic signals and heat in response to near-infrared light irradiation, while the polymer shell produces fluorescence signals and reactive oxygen species under visible light irradiation. The multimodal imaging properties of the proposed nanoconjugate are investigated under simulated endoscopic and in vivo imaging conditions and in a photoacoustic microscopy system. In addition, the significant photothermal and photodynamic effects are evaluated in vitro, confirming its potential as a theranostic agent. This design concept can be advanced further by tethering prodrugs, targeting moieties, or enzymes to the backbone, paving the way for the development of a versatile theranostic platform.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500030"},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Synthesis Strategy for Poly(Arylene-Vinylene) Derivatives by Elemental Sulfur-Mediated Polyolefination.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-26 DOI: 10.1002/marc.202500166

Peter Conen, Florian J O Niedermaier, Sophia Abou El Mirate, Michael A R Meier

引用次数: 0

Divanillin Cross-Linked Recyclable Cellulose Networks.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-26 DOI: 10.1002/marc.202401094

Meiling Zhang, Sathiyaraj Subramaniyan, Minna Hakkarainen

{"title":"Divanillin Cross-Linked Recyclable Cellulose Networks.","authors":"Meiling Zhang, Sathiyaraj Subramaniyan, Minna Hakkarainen","doi":"10.1002/marc.202401094","DOIUrl":"https://doi.org/10.1002/marc.202401094","url":null,"abstract":"A series of cellulose networks are designed by reversibly crosslinking amino-functionalized 2-hydroxyethyl cellulose (HEC-NH2) with different amounts of vanillin dimer (VA-CHO). The Schiff base reaction between amino-and aldehyde groups creates networks (SBHEC) bridged with crosslinks containing dynamic imine groups. These SBHEC networks can be hot pressed to flexible films with good thermal stability and solvent resistance, including notable stability in water, opposite to water-soluble HEC and HEC-NH2. Compared to HEC-NH2, the cross-linked SBHEC networks exhibit higher glass transition temperatures, elastic modulus, and tensile stress at break, and slightly reduced tensile strain at break. Reprocessing of the SBHEC networks is achieved through hot pressing under facile conditions, leading to good recovery of mechanical properties. Furthermore, the materials can be chemically recycled in a closed-loop by imine-hydrolysis under acidic conditions at room temperature. This releases the original building blocks HEC-NH2 and VA-CHO, which can be recured to produce new SBHEC. This work highlights the potential of dynamic covalent cellulose networks as mechanically and chemically recyclable materials, contributing to the development of closed-loop recycling systems.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401094"},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplasma-Induced Radical Polymerization for Green Elastic Polymer and Luminescent Nanocomposites.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-26 DOI: 10.1002/marc.202401138

Daniel Muara Sentosa, Livy Laysandra, Darwin Kurniawan, Wei-Hung Chiang, Yu-Cheng Chiu

{"title":"Microplasma-Induced Radical Polymerization for Green Elastic Polymer and Luminescent Nanocomposites.","authors":"Daniel Muara Sentosa, Livy Laysandra, Darwin Kurniawan, Wei-Hung Chiang, Yu-Cheng Chiu","doi":"10.1002/marc.202401138","DOIUrl":"https://doi.org/10.1002/marc.202401138","url":null,"abstract":"Considering the growth and applicability of the polymer industry over the years, alternative polymerization methods can be developed to facilitate simpler, rapid, and efficient polymer synthesis. This can be done via the utilization of radicals from microplasma interactions, proposing a simple initiator-free approach for both polymer and nanocomposite synthesis. In this study, microplasma-assisted synthesis of poly(2-Acrylamido-2-methylpropane sulfonic acid) (PAMPS_M) and poly(2-hydroxyethyl methacrylate) (PHEMA_M) is achieved under ambient conditions through radicals from the plasma interactions. This rapid polymerization method leads to high polymerization yield in short duration (PAMPS_M: 77.57% in 1 h; PHEMA_M 20.74% in 20 min) and long chain polymer formation (Mn: 2.23×106 Da (PAMPS_M); 7.12×104 Da (PHEMA_M)). The remarkable result in microplasma-assisted polymer synthesis is followed by formation of microplasma-synthesized PAMPS/Nitrogen-doped Graphene Quantum Dots (PAMPS/NGQDs_M) and PHEMA/NGQDs_M nanocomposites in one-pot two-step method. NGQDs addition contributes to luminescence properties of both nanocomposites (Photoluminescence emission/excitation: 540/460 nm (PAMPS/NGQDs_M); 505/410 nm (PHEMA/NGQDs_M)) and enhancement in mechanical properties by the formation of the covalent complex structure of polymer-nanomaterial. By unveiling a rapid, facile, and efficient method to radically polymerize water-based polymer and nanocomposite via microplasma, the present study will stimulate and advance further research on the preparation of rubber-based sol-gel via eco-friendly methods.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401138"},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0