Procedia CIRP最新文献_第5页

A Flexible Digital Twin Framework for ATMP Production – Towards an efficient CAR T Cell Manufacturing 用于 ATMP 生产的灵活数字孪生框架 - 实现高效 CAR T 细胞生产

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.022

Arber Shoshi , Yuchen Xia , Andrea Fieschi , Thomas Ackermann , Peter Reimann , Michael Weyrich , Bernhard Mitschang , Thomas Bauernhansl , Robert Miehe

{"title":"A Flexible Digital Twin Framework for ATMP Production – Towards an efficient CAR T Cell Manufacturing","authors":"Arber Shoshi , Yuchen Xia , Andrea Fieschi , Thomas Ackermann , Peter Reimann , Michael Weyrich , Bernhard Mitschang , Thomas Bauernhansl , Robert Miehe","doi":"10.1016/j.procir.2024.08.022","DOIUrl":"10.1016/j.procir.2024.08.022","url":null,"abstract":"<div><p>This paper presents a flexible digital twin framework tailored for the biomanufacturing of advanced therapeutic medicinal products (ATMPs), particularly focusing on chimeric antigen receptor T cell (CAR T cell) therapy. CAR T cell therapies face significant challenges in the management of their personalized and complex biomanufacturing processes. To tackle these issues, we propose a novel software framework for a digital twin system aimed at digitalizing, monitoring, and managing the physical production processes. The framework has a hierarchical architecture that methodically organizes production into distinct abstraction levels: processes, tasks and skills, and microservices. This layered architecture simplifies the modeling of complex biomanufacturing production and ensures that each component can be individually updated without disrupting the overall system. Furthermore, the digital twin framework integrates both manual and automated operations within a unified system, accommodating varied requirements of diverse tasks in production. The framework’s flexibility enables easier adaptation to dynamic technological advancements and allows for swift modifications in production processes, making it a sustainable and resilient digitalization infrastructure for ATMP manufacturing.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124003767/pdf?md5=d17c98054a5918f5c15d0fde992cb6fa&pid=1-s2.0-S2212827124003767-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical and corrosion behaviour of superelastic additively manufactured Nitinol for biomedical applications 用于生物医学应用的超弹性添加制造镍钛诺的机械性能和腐蚀性能

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.024

A. Guarise , R. Bertolini , M. Franceschi , A. Ghiotti , S. Bruschi

{"title":"Mechanical and corrosion behaviour of superelastic additively manufactured Nitinol for biomedical applications","authors":"A. Guarise , R. Bertolini , M. Franceschi , A. Ghiotti , S. Bruschi","doi":"10.1016/j.procir.2024.08.024","DOIUrl":"10.1016/j.procir.2024.08.024","url":null,"abstract":"<div><p>The interest in Nitinol (NiTi) as biomedical material is growing thanks to its unique properties, particularly shape memory and superelasticity. Recently, additive manufacturing (AM) has emerged as an alternative to fabricate superelastic NiTi biomedical parts. However, when using AM to fabricate NiTi parts, a proper heat treatment must follow, recommended not only to alleviate the AM-induced residual stresses, but also to develop a suitable microstructure to enhance the material superelasticity. This heat treatment is expected to modify also the NiTi corrosion behavior, which must be evaluated since corrosion may lead to the possible harmful release of nickel ions in the human environment.</p><p>In this framework, the objective of the paper is to assess the mechanical and corrosion properties of a Ni-rich NiTi fabricated by laser powder bed fusion before and after heat treatment. To this aim, nano-indentation was used to evaluate superelasticity, whereas electro-chemical tests provided the corrosion potential and current density. The results of the analyses show that both the mechanical and corrosion characteristics were related to the peculiar microstructural features induced by the AM and heat treatment steps, nevertheless ageing at 600°C was the best in terms of superelasticity, while aging at 300°C assured the highest corrosion resistance.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124003780/pdf?md5=18fab1928438a972f7578f99041d7df1&pid=1-s2.0-S2212827124003780-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Concept of Decentralization in Biointelligent Manufacturing 论生物智能制造中的权力下放概念

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.050

Robert Miehe

{"title":"On the Concept of Decentralization in Biointelligent Manufacturing","authors":"Robert Miehe","doi":"10.1016/j.procir.2024.08.050","DOIUrl":"10.1016/j.procir.2024.08.050","url":null,"abstract":"<div><p>Biointelligent manufacturing represents one of the most promising innovation paths towards a sustainable restructuring of industrial production. In doing so, it assumes significantly changing framework conditions for the production of a wide variety of goods. A recurring element is the decentralization of value chain design, i.e. an increasing shift of the focus of value creation to the customer. While the concept of decentralization has been discussed in the context of systems and organization theory, green supply chain and life cycle management for quite some time, recent studies suggest that especially biointelligent manufacturing systems might represent a promising technological opportunity to truly realize this goal. However, up to now the concept appears somewhat vague, as neither the validity of the assumption of increasing decentralization nor the extent to which a reduction of supply chain length results in an improvement of environmental impact is resolved. This paper is intended to provide a foundation for the advancement of the research area by analyzing the state of knowledge and uncovering logical misconceptions. Although the findings indicate a clear technical decentralization potential of biointelligent manufacturing by various examples, a comprehensive dissemination as small-scale production units in industrial practice remains unlikely due to prevailing organizational and socio-political barriers.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124004049/pdf?md5=1253e4ab33f1c9a8644d2ca53e169e58&pid=1-s2.0-S2212827124004049-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing damage with higher precision in drilling bones 以更高的钻孔精度减少对骨骼的损伤

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.038

Raafat Hussein , Anna Carla Araujo , Yann Landon

{"title":"Reducing damage with higher precision in drilling bones","authors":"Raafat Hussein , Anna Carla Araujo , Yann Landon","doi":"10.1016/j.procir.2024.08.038","DOIUrl":"10.1016/j.procir.2024.08.038","url":null,"abstract":"<div><p>Bone drilling poses intricate challenges due to its high hardness, strength, and anisotropic composite structure. In the dynamic field of orthopedics, advancing surgical drilling techniques is imperative for optimizing precision and implant stability. As drilling methods have progressed from conventional to robot-assisted machining, some new possibilities are now appearing. While orbital drilling has been pivotal in aerospace for reduced forces and superior hole quality, its application in bone drilling remains unexplored. This study pioneers the introduction of orbital drilling for bone machining, aiming to unveil its potential to improve processing quality. Experimental investigations were conducted on cortical femur bone to evaluate its mechanical behavior and the geometry of the holes, encompassing parameters such as hole aperture, roundness, cylindricity and delamination. Employing full factorial statistical analysis, the study systematically elucidates the influence of cutting speed and feed rate on hole quality. Results reveal the potential of orbital drilling in mitigating its defaults and could significantly contribute to improving surgical outcomes in orthopedic procedures.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124003925/pdf?md5=6299ddb011ce309d9e26d4008c437c02&pid=1-s2.0-S2212827124003925-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept 药物洗脱支架的超薄聚合物平台：概念验证

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.042

A. Bosch , E. Casanova-Batlle , S. Ausellé-Bosch , E. Polonio-Alcalá , T. Puig , J. Ciurana , A.J. Guerra

{"title":"Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept","authors":"A. Bosch , E. Casanova-Batlle , S. Ausellé-Bosch , E. Polonio-Alcalá , T. Puig , J. Ciurana , A.J. Guerra","doi":"10.1016/j.procir.2024.08.042","DOIUrl":"10.1016/j.procir.2024.08.042","url":null,"abstract":"<div><p>Recent innovations in Drug-Eluting Stents (DES) technology have led to the development of new stents with further reduction in strut width, the ultrathin DES, with struts thinner than 70 µm. Ultrathin DES may further improve the efficacy and safety profile of Percutaneous Coronary Intervention (PCI) by reducing the risk of target-lesion and target-vessel failures compared to the current-generation DES. However, the ultrathin DES metallic platform still presents some associated problems, such as biofilm formation, infection, and migration, all related to the cellular response.</p><p>The present work aims to produce an ultrathin permanent polymeric platform for a new generation of polymeric drug-eluting stents (PDES). In this work, the cellular response was compared with the traditional stainless steel (SS316L) and polycaprolactone (PCL) to determine whether these polymers could address this challenge. An innovative method of tubular 3D micro stereolithography tubular (ST3DT) was used. Different PDES platforms were fabricated with different polymeric materials (based on polyurethane and urethane dimethacrylate). Subsequently, HFL1 fibroblasts were seeded on the PDES, PCL and SS316L for 3 days. The findings from the assays of cell biocompatibility and proliferation (75%PCL), coupled with the successful fabrication of stent struts below 70 µm using the Surgical Guide resin and the ST3DT method, suggest that resin is a promising candidate for a PDES.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124003962/pdf?md5=3d61753a35cad538805626a772a5fad0&pid=1-s2.0-S2212827124003962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired approaches for resource-efficient material flow in production – an innovative actuator concept for peristaltic-based transport 在生产中实现资源节约型物料流的生物启发方法--基于蠕动输送的创新致动器概念

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.043

Henriette Kunze , Marcel Lorenz

{"title":"Bioinspired approaches for resource-efficient material flow in production – an innovative actuator concept for peristaltic-based transport","authors":"Henriette Kunze , Marcel Lorenz","doi":"10.1016/j.procir.2024.08.043","DOIUrl":"10.1016/j.procir.2024.08.043","url":null,"abstract":"<div><p>In automated material flow, in a wide variety of areas, the primary goal is usually to handle a wide spectrum of components as time- and cost-efficiently as possible. In view of the current and future challenges in industrial production, it is becoming apparent that ecological requirements are becoming increasingly important in automation solutions. For example, in form of resource efficiency, transformability and material efficiency. In this context, especially materials handling technology is subject of various optimization approaches, as no value is added to the part handled. The question: \"How does material flow occur in nature?\" thus offers biologically inspired approaches to thinking about transport in the industrial sector. This paper first presents a selection of concepts or existing mechanisms that are adaptable in materials- handling technology and have been developed based on a biological model. In the second part of this paper, a new concept is presented that is modeled on peristalsis as a transport mechanism. The approach presented here uses tensegrity-structures for assembly, which are characterized by their high material efficiency and flexibility. The transport movement is achieved by peristaltic typical contraction or relaxation of the respective structure parts.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124003974/pdf?md5=16d973118c5e4ec33e5312173222e1c5&pid=1-s2.0-S2212827124003974-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of distortion during laser beam welding by applying an in situ alloyed LTT effect and considering influencing factors 通过应用原位合金化 LTT 效应并考虑影响因素，减少激光束焊接过程中的变形

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.143

Maximilian Gamerdinger , Simon Olschok , Uwe Reisgen

{"title":"Reduction of distortion during laser beam welding by applying an in situ alloyed LTT effect and considering influencing factors","authors":"Maximilian Gamerdinger , Simon Olschok , Uwe Reisgen","doi":"10.1016/j.procir.2024.08.143","DOIUrl":"10.1016/j.procir.2024.08.143","url":null,"abstract":"<div><p>In rail vehicle construction, austenitic stainless steels are used to achieve lightweight design concepts, as the higher specific strength of the material allows the thickness of parts to be reduced. However, when these are welded to create complex structures, increased welding distortion occurs even with low-heat joining processes such as laser beam welding.</p><p>In order to reduce distortion, an in situ low transformation temperature (LTT) effect has been achieved using commercially available materials rather than specially manufactured LTT alloys. The LTT effect introduces compressive stresses into the weld seam, which counteract the formation of welding distortion due to tensile stresses. However, in the case of complex structures, several other factors influence the formation of distortion. The influence of the LTT effect and other factors such as tack welding, clamping and cooling conditions were analysed by distortion measurements and a maximum distortion reduction was determined.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124004979/pdf?md5=8c3812b236dad5555f7ddce3205d182f&pid=1-s2.0-S2212827124004979-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized defect frequencies for Laser Metal Deposition processes 激光金属沉积工艺的局部缺陷频率

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.128

Julian Ulrich Weber , Claus Emmelmann

{"title":"Localized defect frequencies for Laser Metal Deposition processes","authors":"Julian Ulrich Weber , Claus Emmelmann","doi":"10.1016/j.procir.2024.08.128","DOIUrl":"10.1016/j.procir.2024.08.128","url":null,"abstract":"<div><p>Laser Metal Deposition (LMD) uses laser energy and powder material to create structures on existing components. It is capable of producing cost-effective multi-material compositions, such as reinforcing metals with ceramic particles for improved wear resistance. However, the use of dissimilar materials often leads to defects, particularly delamination. Previous studies have found a connection between these defects and specific airborne acoustic emissions (AE).</p><p>To mitigate the impact of defects, extensive optimization of process parameters and real-time process monitoring are recommended. For AE, precise localization of defects is crucial besides to time- and frequency-resolved information, especially while producing multiple components on a substrate material.</p><p>This study evaluates multi-sensor arrays for the localization of delamination defects. The research investigates the influence of localization algorithms and array patterns on the accuracy and reliability of defect localization. Experiments were conducted on a test platform with simulated acoustical events to determine the most suitable localization setup.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124004827/pdf?md5=97d382e9e8e7d8625dc9b321451c87d2&pid=1-s2.0-S2212827124004827-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative analysis of spatter formation in Laser Powder Bed Fusion: unraveling the impact of beam shaping and multi-beam processing 激光粉末床融合中飞溅物形成的定量分析：揭示光束整形和多光束加工的影响

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.136

Marvin Kippels , Tim Lantzsch , Constatin Leon Häfner

引用次数: 0

Optical strain measurements during pulsed laser beam welding to improve the understanding of hot crack formation of EN AW-6082 aluminum alloy 脉冲激光束焊接过程中的光学应变测量，以加深对 EN AW-6082 铝合金热裂纹形成的理解

Procedia CIRP Pub Date : 2024-01-01 DOI: 10.1016/j.procir.2024.08.151

Marc Seibold , Jannik Bender , Klaus Schricker , Jean Pierre Bergmann

{"title":"Optical strain measurements during pulsed laser beam welding to improve the understanding of hot crack formation of EN AW-6082 aluminum alloy","authors":"Marc Seibold , Jannik Bender , Klaus Schricker , Jean Pierre Bergmann","doi":"10.1016/j.procir.2024.08.151","DOIUrl":"10.1016/j.procir.2024.08.151","url":null,"abstract":"<div><p>E-mobility turned in the last years to be an emerging market and one solution to fossil fuel free mobility for the future. E-mobility requires, compared to fossil-fueled mobility concepts, a huge amount of welding tasks, which have to guarantee different functionality, as for example high strength, ductility, but also low resistivity and tightness. Last is especially for housing or cases of aluminum in automotive challenging, as pores and cracks can occur. Pulsed laser welding presents, due to the adaptable heat input and the temporal modification of stress state and solidification conditions advantages for this type of applications. EN AW-6xxx group of aluminum alloys is mainly used for such components due to their favorable mechanical properties. However, these alloys are susceptible to hot cracking during solidification from the molten phase. This article aims to present a methodology for demonstrating the resulting strain during pulsed laser beam welding of hot crack susceptible aluminum alloys. It will highlight the influence of factors such as pulse shape, shielding gas, and flow rate on strain and strain rate.</p></div>","PeriodicalId":20535,"journal":{"name":"Procedia CIRP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212827124005055/pdf?md5=6d96b790c667ab1dfa01211dca2ac042&pid=1-s2.0-S2212827124005055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0