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[Vitamin K2 reduces the frequency of nocturnal leg cramps in the elderly].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.001
Johann Steurer
{"title":"[Vitamin K2 reduces the frequency of nocturnal leg cramps in the elderly].","authors":"Johann Steurer","doi":"10.23785/PRAXIS.2025.02.001","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fever and Pancytopenia - not Always a Case for Oncology].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.008
Stephanie Kirch, Reto Kühne, Adrian Schibli, Felix Grimm, Corina Ebnöther
{"title":"[Fever and Pancytopenia - not Always a Case for Oncology].","authors":"Stephanie Kirch, Reto Kühne, Adrian Schibli, Felix Grimm, Corina Ebnöther","doi":"10.23785/PRAXIS.2025.02.008","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.008","url":null,"abstract":"<p><strong>Introduction: </strong>The article describes the case of a 68-year-old patient who was admitted to a clinic after returning from southern Italy with fever, night sweats, and pancytopenia. After extensive diagnostic investigations that ruled out bacterial, viral, and parasitic infections as well as other diseases, visceral leishmaniasis (VL) were eventually diagnosed. This diagnosis was confirmed by the detection of Leishmania sp. in the bone marrow and positive serological tests. Additionally, the patient showed signs of macrophage activation syndrome (MAS), a severe inflammatory reaction that often occurs as a complication of infections or rheumatological diseases. The treatment included liposomal amphotericin B for leishmaniasis as well as steroids and etoposide for the treatment of MAS. The patient recovered after treatment and showed an improvement in general condition during follow-up examinations. The article emphasizes the challenge of correctly diagnosing VL and MAS, especially in combination, particularly in patients outside endemic areas. Rapid diagnosis is crucial, as delays can worsen the prognosis in these severe diseases.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"72-74"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in the treatment of ovarian cancer].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.005
Isabell Witzel, E Pierre Samartzis, Ahmed El-Balat
{"title":"[Progress in the treatment of ovarian cancer].","authors":"Isabell Witzel, E Pierre Samartzis, Ahmed El-Balat","doi":"10.23785/PRAXIS.2025.02.005","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.005","url":null,"abstract":"<p><strong>Introduction: </strong>Of all gynaecological tumours, ovarian cancer has the highest mortality rate because it is often not diagnosed until the tumour is at an advanced stage due to the lack of early symptoms and suitable screening tests. The aim of this paper is to examine the current state of diagnosis and therapy.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[VEXAS syndrome - a chameleon of inflammatory syndromes].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.009
Elisa Leggeri, Athina Pangalu, Florence Vallelian
{"title":"[VEXAS syndrome - a chameleon of inflammatory syndromes].","authors":"Elisa Leggeri, Athina Pangalu, Florence Vallelian","doi":"10.23785/PRAXIS.2025.02.009","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.009","url":null,"abstract":"<p><strong>Introduction: </strong>The VEXAS syndrome is a systemic autoinflammatory disease first described in 2020. It primarily affects older men and is caused by a somatic mutation in the UBA1 gene on the X chromosome, leading to dysfunction of the innate immune system. Symptoms include fever, weight loss, various hematological manifestations, and a broad spectrum of clinical symptoms, often including ocular manifestations. Diagnosis is based on the detection of the mutation. There is currently no standardized therapy, and mortality can be as high as 40 %.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"75-79"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia].
Praxis Pub Date : 2025-02-01 DOI: 10.23785//PRAXIS.2025.02.004
Carolin Schäfer, Anne-Kathrin Brill, Marie-Angela Wulf, Markus Schmidt, Claudio L Bassetti
{"title":"[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia].","authors":"Carolin Schäfer, Anne-Kathrin Brill, Marie-Angela Wulf, Markus Schmidt, Claudio L Bassetti","doi":"10.23785//PRAXIS.2025.02.004","DOIUrl":"https://doi.org/10.23785//PRAXIS.2025.02.004","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid-Eye-Movement (REM) sleep is an essential part of sleep dominating the second half of the night. A disturbance of the phy-siological muscle hypotonia of REM sleep can lead to dream enactment: REM sleep behavior disorder (RBD). In the absence of a disease of the central nervous system or provoking factors such as sleep apnea, alcohol consumption or antidepressants, isolated RBD (iRBD) may be present. IRBD is an early stage of alpha-synucleinopathies such as Parkinson's disease, dementia with Lewy bodies and multisystem atrophy. Medical history and polysomnography are the most important diagnostic tools. Clonazepam and melatonin are symptomatic treatments used to prevent injury. New technologies enable long-term monitoring of disease progression in iRBD and thus guide the targeted use of future disease-modifying therapies.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Two Different Courses of a Rare, Potentially Reversible Encephalopathy].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.007
Dominik Imhoff, Rolf Sturzenegger, Philip Went, Georgios Pantazis
{"title":"[Two Different Courses of a Rare, Potentially Reversible Encephalopathy].","authors":"Dominik Imhoff, Rolf Sturzenegger, Philip Went, Georgios Pantazis","doi":"10.23785/PRAXIS.2025.02.007","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.007","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare form of cerebral amyloid angiopathy (CAA). This leads to amyloid deposits and inflammation in the vessel walls with cerebral microbleeds, white matter hyperintensities and edema. Major clinical manifestations vary and are non-specific. They include rapidly progressive dementia, headaches and epileptic seizures. MRI and histology are crucial for further diagnosis, although the definitive diagnosis can only be made in autopsy. Timely therapy, mainly with corticosteroids, is essential for successful healing.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Brucellose as a travel souvenir].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.010
Valentino Monaco, Michael Bodmer, Andrea Christina Frey
{"title":"[Brucellose as a travel souvenir].","authors":"Valentino Monaco, Michael Bodmer, Andrea Christina Frey","doi":"10.23785/PRAXIS.2025.02.010","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.010","url":null,"abstract":"<p><strong>Introduction: </strong>Family with fever, asthenia, arthralgia and headache after travelling back from Kosovo. A precise exposure history led to the suspicion of an underlying zoonosis and allowed a diagnosis to be made. The treatment with doxycycline and gentamicin led to a restitutio ad integrum in all family members.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Statins are not associated with an increased risk of cataracts in patients at risk of cardiovascular disease].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.002
Thomas Rosemann, Andrea Rosemann
{"title":"[Statins are not associated with an increased risk of cataracts in patients at risk of cardiovascular disease].","authors":"Thomas Rosemann, Andrea Rosemann","doi":"10.23785/PRAXIS.2025.02.002","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.002","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Summary of the 2024 ESC-Guidelines for the management of elevated blood pressure and hypertension].
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.003
Miklos Rohla, Emrush Rexhaj
{"title":"[Summary of the 2024 ESC-Guidelines for the management of elevated blood pressure and hypertension].","authors":"Miklos Rohla, Emrush Rexhaj","doi":"10.23785/PRAXIS.2025.02.003","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.003","url":null,"abstract":"<p><strong>Introduction: </strong>This mini-review summarizes the new guideline recommendations of the European Society of Cardiology for the management of elevated blood pressure and hypertension - with particular focus on aspects relevant to daily clinical practice.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute Diverticulitis - Treatment without Antibiotics?]
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.006
Ivana Heinimann, Philipp Busche, Éva Pozder, Gisela Etter, Cordula Gubler, Katia Boggian, Philip Tarr
{"title":"[Acute Diverticulitis - Treatment without Antibiotics?]","authors":"Ivana Heinimann, Philipp Busche, Éva Pozder, Gisela Etter, Cordula Gubler, Katia Boggian, Philip Tarr","doi":"10.23785/PRAXIS.2025.02.006","DOIUrl":"https://doi.org/10.23785/PRAXIS.2025.02.006","url":null,"abstract":"<p><strong>Introduction: </strong>In patients with acute uncomplicated diverticulitis current guidelines recommend that antibiotics should not be used reflexively or routinely, but rather selectively: starting with Hinchey stage 1b, i.e. in the case of localized pericolic abscess. Antibiotic-free diverticulitis therapy is therefore generally possible up to Hinchey stage 1a. We recommend carefully evaluating the patient, taking exclusion criteria into account and re-examining the patient after 48-72 hours. Keywords: Diverticulitis, antibiotics, treatment without antibiotics, complications.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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