Chinese medicine and natural products最新文献

{"title":"Research Progress on Molecular Mechanism of Moxibustion in the Treatment of Ankylosing Spondylitis","authors":"Min Yan, Jiang Huali, Linyun Wu, Xiao Zhou, Qing Yang, Qinfeng Wu, Xi Liu, Hong-yuan Wang, Xiao Xu","doi":"10.1055/s-0042-1747914","DOIUrl":"https://doi.org/10.1055/s-0042-1747914","url":null,"abstract":"As an important part of traditional Chinese medicine (TCM) nursing technology, moxibustion plays a unique role in improving the symptoms of ankylosing spondylitis (AS). The research on the mechanism of moxibustion intervention in AS mainly focuses on anti-inflammatory effects, immune regulation, bone metabolism regulation, intestinal flora regulation, and so on. Molecular medicine is of great significance to further clarify the mechanism of moxibustion intervention in AS. However, there are still some problems in the research on the molecular mechanism of moxibustion intervention in AS: the existing biomedical research methods only explore from a specific field and lack the exploration of moxibustion-targeted molecules based on biomedical network. In the future, the molecular network effect of moxibustion on AS can be discussed comprehensively and systematically with the help of omics technology and the construction of biological information interaction network between omics. The effect of moxibustion on upstream osteogenic transcription factors and related signaling pathways such as WNT, β-catenin, and BMP/Smads is not yet clear. Future research can focus on the relevant signal targets of bone reconstruction and clarify the mechanism of moxibustion against the new bone formation. In addition, there is a lack of research on the molecular mechanism of moxibustion in the treatment of AS from the perspective of metabolites. It is necessary to further explore the mechanism of moxibustion in the treatment of AS with the help of metabonomics technology.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116788929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Resulting in Potential Hearing Damage of Rodents","authors":"Jinxin Miao, Hongen Xu, Yongan Tian, Jianyao Wang, Wenxue Tang, Yaohe Wang, Mingsan Miao, Jianbo Liu, Xia Xue, Yongjun Guo","doi":"10.1055/s-0042-1747915","DOIUrl":"https://doi.org/10.1055/s-0042-1747915","url":null,"abstract":"\u0000 Objectives To find out the association between the sensorineural hearing loss and coronavirus disease 2019 (COVID-19), the expression of ACE2 and TMPRSS2 in hamsters and mice was detected.\u0000 Design Using the public data from the National Center for Biotechnology Information and the Global Initiative on Sharing All Influenza Data, the expression of ACE2 and TMPRSS2 at the transcriptomic, DNA, and protein levels of ACE2 in the brain, inner ear, and muscle from the golden Syrian hamsters (Mesocricetus auratus) and mice (Mus musculus) was assessed.\u0000 Results We identified ACE2 and TMPRSS2 expressed at different levels in the inner ear and brain at DNA and transcriptomic levels of both mice and hamsters. The protein expression from the brain and inner ear showed a similar pattern, while the expression of ACE2 from the inner ear was relatively higher than that from the muscle.\u0000 Conclusion Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shows genetic potential to infect the hearing system of rodents and lead to sudden sensorineural hearing loss that can be used as a characteristic to detect asymptomatic patients of COVID-19.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124399814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Gancao Nourish-Yin Decoction on Liver Metabolic Profiles in hTNF-α Transgenic Arthritic Model Mice","authors":"Rongbin Pan, K. S. Cheng, Yanjuan Chen, Xin-yi Zhu, Wenting Zhao, C. Xiao, Yong Chen","doi":"10.1055/s-0042-1747916","DOIUrl":"https://doi.org/10.1055/s-0042-1747916","url":null,"abstract":"\u0000 Objective Gancao Nourish-Yin Decoction (GNYD) has been applied to clinical rheumatoid arthritis (RA) patients, and it had shown effectiveness not only in disease activity controlling but also in improving patients' physical status. However, its mechanism of function has not been investigated. Metabolic perturbations have been associated with RA, and targeting the metabolic profile is one of the ways to manage the disease. The aim of this study is to observe the effect of GNYD on metabolic changes of human tumor necrosis factor α (hTNF-α) transgenic arthritic model mice.\u0000 Methods hTNF-α transgenic arthritic model mice were divided into the control group and the GNYD group with six mice in each group. After 8 weeks of treatment, liver tissues of mice in both groups were obtained for liquid chromatography-mass spectrometry analysis. Significantly regulated metabolites by GNYD treatment were first identified, followed by Kyoto Encyclopedia of Genes and Genomes pathway and network analysis.\u0000 Results A total of 126 metabolites were detected in the liver. Compared with the control group, 17 metabolites in the GNYD group were significantly altered. Specifically, thiamine, gamma-L-glutamyl-L-valine, pantothenic acid, pyridoxal (vitamin B6), succinic acid, uridine 5′-diphospho-glucuronic acid, uridine, allantoic acid, N-acetyl-D-glucosamine, nicotinamide ribotide, and N2, N2-dimethylguanosine were down-regulated by GNYD treatment, whereas isobutyrylglycine, N-acetylcadaverine, N-carbamoyl-L-aspartic acid, L-anserine, creatinine, and cis-4-hydroxy-D-proline were up-regulated. Six metabolic pathways were significantly altered including the alanine, aspartate, and glutamate metabolism; pyrimidine metabolism; thiamine metabolism; amino sugar and nucleotide sugar metabolism; pantothenate and CoA biosynthesis; and citrate cycle. Integrative metabolic network analysis suggested the possibility of GNYD having both positive and negative effects on RA through the suppression of angiogenesis and the promotion of leukocyte extravasation into the synovium, respectively.\u0000 Conclusions GNYD can modulate the hepatic metabolism of hTNF-α transgenic arthritic model mice. Further optimization of this decoction may lead to better therapeutic effects on RA patients.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114958577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis","authors":"Lingling Li, Hailiang Huang","doi":"10.1055/s-0042-1747918","DOIUrl":"https://doi.org/10.1055/s-0042-1747918","url":null,"abstract":"\u0000 Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis (KOA) based on network pharmacology and molecular docking.\u0000 Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases, and the targets of KOA were obtained by DisGeNET, OMIM, and GeneCards databases. Then, the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA. The protein–protein interaction network was constructed through the STRING database, and the core targets were screened. Gene ontology (GO) functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using DAVID database. The drug–target–pathway–disease network was constructed by Cytoscape software, and the molecular docking verification was performed by Vina.\u0000 Results There were 49 potential targets for quercetin against KOA, including 10 core targets. GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process, collagen catabolic process, and extracellular matrix disassembly. KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway, Rap 1 signaling pathway, FoxO signaling pathway, Ras signaling pathway, TNF signaling pathway, and ErbB signaling pathway. The results of molecular docking showed that the binding energies between ligand and receptors were less than −5 kcal • mol−1.\u0000 Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways, which can regulate the proliferation and apoptosis of chondrocytes, degradation of extracellular matrix, and inflammatory reaction. Quercetin can stably bind to the active pockets of core target proteins, thereby exerting the effect against KOA.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132265206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of Clinical Application of Yufeng Ningxin Preparations and the Meta-Analysis of Its Efficacy and Safety in the Treatment of Cardiovascular and Cerebrovascular Diseases","authors":"Lishuang Zhang, Y. Ma, Ying Wang, Feng Jiang","doi":"10.1055/s-0042-1750324","DOIUrl":"https://doi.org/10.1055/s-0042-1750324","url":null,"abstract":"Abstract Objective  The objective of this study was to analyze the status of the clinical application of Yufeng Ningxin (YFNX) preparations and systematically evaluate their efficacy and safety in the treatment of cardiovascular and cerebrovascular diseases. Methods  Through searching databases of China National Knowledge Infrastructure, Wanfang, SinoMed, VIP, PubMed, Embase, and the Cochrane Library, the literature of clinical research on YFNX preparations in treating malignant tumors of cardiovascular and cerebrovascular diseases from the establishment of the databases to February 2021 was collected. The clinical randomized controlled trials and case–control studies of cardiovascular and cerebrovascular diseases treated with these preparations were analyzed. Two reviewers independently screened literature, extracted data, and assessed the risk of bias in the included studies, and meta-analysis was performed by using ReMan 5.3 software to analyze the efficacy and safety of YFNX preparations in the treatment of cardiovascular and cerebrovascular diseases. Results  A total of 29 clinical studies were finally included. The dosage forms were dropping pills, tablets, capsules, and granules. The preparations were used for the treatment of coronary heart disease, hypertension, neuropathic headache, etc. This study systematically evaluated the efficacy and safety of YFNX preparations in the treatment of coronary heart disease, hypertension, and nervous headache. A total of 1,162 cases were included in 13 studies, 582 cases of the YFNX preparation group and 580 cases of the Western medicine group. The results of meta-analysis showed that the clinical efficacy of YFNX preparations combined with the Western medicine group in the treatment of coronary heart disease and hypertension, improving electrocardiogram and reducing the frequency and duration of angina attacks, was better than that of the simple Western medicine group, and the difference was statistically significant. Conclusion  YFNX preparations are effective for coronary heart disease, hypertension, and neuropathic headache, and the adverse reactions are few.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"298 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120967777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Huangqi Guizhi Wuwu Decoction in Orthopaedics and Traumatology","authors":"Peng Xu, M. Tan, Mingming Wang, Yong Cheng","doi":"10.1055/s-0042-1750321","DOIUrl":"https://doi.org/10.1055/s-0042-1750321","url":null,"abstract":"Abstract The Huangqi Guizhi Wuwu Decoction(HQGZWWT) is composed of Huangqi (Astragali Radix), Shaoyao (Paeoniae Radix Alba), Guizhi (Cinnamomi Ramulus), Shengjiang (Zingiberis Rhizoma Recens), and Dazao (Jujubae Fructus) which has various pharmacological anti-inflammatory, analgesic, antioxidant, antitumor, lipid-lowering, and immunity-regulating activities. It has certain advantages in the treatment of orthopaedic diseases, such as cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, knee osteoarthritis, rheumatoid arthritis, myofascial pain syndrome, etc., with outstanding clinical efficacy, few adverse reactions, and high patient compliance. However, modern pharmacological researches on the whole prescription of HQGZWWT are insufficient and the therapeutic targets are not clear which needs further exploration. Besides, this prescription cannot treat all orthopaedic diseases, so we should adhere to the thinking of four diagnostics in traditional Chinese medicine (TCM), select prescriptions based on syndrome differentiation, closely follow the pathogenesis, innovate and expand its scope of application, reflect the application advantages of this prescription in orthopaedics and traumatology and improve the total clinical efficiency.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127582938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ancient Respected and Modern Absorbed, Chinese Essence and Western Utility—Thoughts of the Integrated Chinese Medicine and Western Medicine","authors":"Xiaofa Liu, D. Li, Shengda Lu","doi":"10.1055/s-0042-1750320","DOIUrl":"https://doi.org/10.1055/s-0042-1750320","url":null,"abstract":"Abstract Traditional Chinese medicine (TCM) and Western medicine are two medical systems formed in different cultural backgrounds. The differences between them are that TCM focuses on the study of the invisible state while Western medicine focuses more on the study of the visible state of the human body; TCM pays attention to systematicity and integrity, while Western medicine pays attention to local evidence; TCM attaches importance to dialectical thinking, while Western medicine attaches importance to materialistic thinking. For the development of TCM, it is necessary to take the initiative to learn from and absorb all the advanced scientific and technological achievements in the world today. To innovate TCM, it is necessary to need to adhere to (1) the integration of “research on TCM with the thought of TCM ” and “research on TCM based on the thought of Western medicine”; (2) the integration of scientization of TCM and scientization for TCM; (3) the integration of mobilization therapy and allopathic therapy; (4) the integration of treating patients and treating diseases; (5) the integration of preventive treatment and existent disease treatment; (6) the integration of individuality and commonality; and (7) the integration of the macro and the micro.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130819984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Action Mechanism of Yadanzi ( Brucea javanica ) in the Treatment of Glioblastoma Based on Bioinformatics and Network Pharmacology","authors":"Wenyu Zhao, Fuchun Si","doi":"10.1055/s-0042-1750326","DOIUrl":"https://doi.org/10.1055/s-0042-1750326","url":null,"abstract":"Abstract Objective  The aim of the study is to explore the molecular mechanism of Yadanzi ( Brucea javanica ) in the treatment of glioblastoma (GBM) by using the methods of bioinformatics and network pharmacology. Methods  The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and literature retrieval method were applied to obtain the active ingredients of Yadanzi ( Brucea javanica ), and to predict the relevant targets of the active ingredients. The GBM-related targets were retrieved and screened through the Gene Expression Profiling Interactive Analysis (GEPIA) database, and mapped to each other with the targets of the components of Yadanzi ( Brucea javanica ) to obtain the intersection targets. The GBM differentially expressed gene targets were imported into the String database to obtain the protein interaction relationship, the Cytoscape software was used to draw the protein interaction network, the Cytobba and MCODE plug-ins were used to screen the core genes and important protein interaction modules, and the GEPIA database was applied to make survival analysis of the core genes. The network map of “active ingredients-targets” was constructed through the Cytoscape 3.6.1 software. Gene Ontology (GO) biological function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis for GBM differentially expressed genes were performed through the DAVID database. Results  Through TCMSP and literature retrieval, 23 potential active ingredients and 129 related targets were obtained from Yadanzi ( Brucea javanica ). In the GEPIA database, 247 GBM differentially expressed genes were screened, including 113 up-regulated genes and 134 downregulated genes. After mapping with the targets related to the active ingredients of Yadanzi ( Brucea javanica ), six intersection targets were obtained, that is, the potential action targets of Yadanzi ( Brucea javanica ) in treating GBM, including MMP2, HMOX1, BIRC5, EGFR, CCNB2 , and TOP2A . Cytoscape software was applied to build an “active ingredient-action target” network. Two active ingredients and five action targets of β-sitosterol (BS) and luteolin were found, and the targets were mainly concentrated in BS. It was found by KEGG pathway enrichment analysis that GBM differentially expressed genes were mainly involved in signaling pathways related to Staphylococcus aureus infection, phagosome formation, tuberculosis and systemic lupus erythematosus and other infectious and autoimmune diseases. It was found by GO enrichment analysis that the GBM differentially expressed genes mainly involved such biological processes (BP) as the processing and presentation of exogenous antigenic peptides and polysaccharide antigens through MHC II molecules, γ-interferon-mediated signaling pathways, extracellular matrix composition, and chemical synapses transmission; it involved cellular components such as cell junctions, axon terminal buttons,","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114942297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Mechanisms of Yanghe Decoction in the Treatment of Soft Tissue Sarcoma and Arteriosclerosis Obliterans Based on Network Pharmacology","authors":"Yiran Zhai, Shiqing Jiang, Binyi Li, Li-na Miao, Jie Wang, Shan Li","doi":"10.1055/s-0042-1755401","DOIUrl":"https://doi.org/10.1055/s-0042-1755401","url":null,"abstract":"Abstract Objective  The objective of this study was to investigate potential mechanisms of Yanghe Decoction ( , YHD) in treating soft tissue sarcoma (STS) and arteriosclerosis obliterans (ASO) based on the use of network pharmacology. Methods  Candidate compounds and potential targets were identified through the TCM Systems Pharmacology database and a comprehensive literature search. Related targets of STS and ASO were collected in the GeneCards database, DisGeNET database, and Drugbank database. Furthermore, The STRING 11.0 database was used to determine protein–protein interaction (PPI) networks; common targets were obtained and imported into Cytoscape 3.7.2. Then, a PPI network comprising common targets was drawn, and network topology analysis was performed to screen for key shared targets. Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software. Subsequently, a compound–target–pathway network was constructed via Cytoscape 3.7.2. Results  The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO: AGE-RAGE signaling pathway, IL-17 signaling pathway; HIF-1 signaling pathway, TNF signaling pathway, interactions between cytokines and cytokine receptors, Th17 cell differentiation, and NOD-like receptor signaling pathway. Among the compounds and targets involved in these pathways, quercetin, luteolin, and kaempferol were found to be core compounds, and TNF, IL-6, and MAPK1 were found to be core targets. Conclusion  Taken together, our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation, angiogenesis, inflammation, immune responses, oxidative stress, and other related signaling pathways.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"25 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115962186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}