Chinese medicine and natural products最新文献

{"title":"The Relationship between Golgi Protein 73, Alpha-Fetoprotein, Liver Function Indicators, and Traditional Chinese Medicine Syndrome Types of Primary Liver Cancer","authors":"Baoping Lu, Jinxia Rong, Huaimin Liu","doi":"10.1055/s-0043-1777333","DOIUrl":"https://doi.org/10.1055/s-0043-1777333","url":null,"abstract":"Objective Our objective was to analyze the correlation between Golgi protein 73 (GP73), alpha-fetoprotein (AFP), liver function indicators, and traditional Chinese medicine (TCM) syndrome types of primary liver cancer (hereinafter referred to as “liver cancer”). Methods In total, 156 liver cancer patients (liver cancer group) and 52 healthy individuals (health group) were selected as the research subjects to detect their GP73, AFP expression, and liver function-related indicators. The obtained data were statistically analyzed using SPSS 21.0 software. Results (1) The positive expression rate of GP73 in the liver cancer group was 50%; the positive expression rates of qi stagnation and blood stasis syndrome, heat toxin in liver and gallbladder syndrome, and yin deficiency of liver and kidney syndrome were 37.9, 54.3, and 59.6%, respectively. There was no statistically significant difference between the groups (p > 0.05). The positive expression rate of AFP was 50%. The positive expression rates of qi stagnation and blood stasis syndrome, heat-toxin in liver and gallbladder syndrome, and yin deficiency of liver and kidney syndrome were 41.7, 54.3, and 59.6%, respectively. There was a statistically significant difference between the groups (p < 0.05). (2) The GP73 levels of patients with different syndrome types in the liver cancer group were ranked from high to low as yin deficiency of liver and kidney syndrome, heat toxin in liver and gallbladder syndrome, and qi stagnation and blood stasis syndrome. The differences between the groups were statistically significant (p < 0.05). The AFP levels of patients with different syndrome types in the liver cancer group were ranked from high to low as heat toxin in liver and gallbladder syndrome, yin deficiency of liver and kidney syndrome, and qi stagnation and blood stasis syndrome. There was no statistically significant difference between the groups (p > 0.05). (3) Analysis of liver function indicators in the liver cancer group: the alanine transaminase (ALT) levels of patients with different syndrome types were in descending order from high to low, including yin deficiency of liver and kidney syndrome, heat toxin in liver and gallbladder syndrome, and qi stagnation and blood stasis syndrome. The differences between groups were statistically significant (p < 0.05). The aspartate aminotransferase (AST) levels of patients with different syndrome types were ranked from high to low as follows: heat toxin in liver and gallbladder syndrome, yin deficiency of liver and kidney syndrome, and qi stagnation and blood stasis syndrome. The difference between groups was statistically significant (p < 0.05). The levels of albumin (ALB) in patients with different syndrome types were ranked from high to low, including heat toxin in liver and gallbladder syndrome, qi stagnation and blood stasis syndrome, and yin deficiency of liver and kidney syndrome. The differences between groups were statistically significant (p < 0.05","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"33 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Formononetin on Lipopolysaccharide-Induced Depressive-Like Behaviors and Neuroinflammation in Mice","authors":"Mengyuan Li, Hui Liu, Shuaijun Peng, Pan Su, Erping Xu, Ming Bai, Yucheng Li","doi":"10.1055/s-0043-1773797","DOIUrl":"https://doi.org/10.1055/s-0043-1773797","url":null,"abstract":"Abstract Objective The objective of this article is to explore the effect of formononetin (FMN) on depressive-like behaviors and neuroinflammation in lipopolysaccharide (LPS)-induced mice. Methods After acclimatization, male Institute of Cancer Research mice were randomly divided into normal group, LPS group, paroxetine group (20 mg/kg), FMN low-dose group (20 mg/kg, FMN20), and FMN high-dose group (40 mg/kg, FMN40), with eight mice in each group. The depressive-like behaviors were observed by sucrose preference test, tail suspension test (TST), and open field test. The protein and mRNA levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the hippocampus were determined by enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction. The expression level of ionized calcium-binding adapter molecule 1 (Iba-1) in the hippocampus was observed by immunofluorescence staining to evaluate the activation level of microglia. Results Compared with the control group, the sucrose preference rate, the activity time of the central area, the distance of the central area, and the number of times of entering the central area were significantly decreased in the LPS group (p < 0.01), and the immobility time of TST was significantly prolonged (p < 0.05), the expression levels of IL-6, IL-1β, and TNF-α protein and mRNA in hippocampus were significantly increased (p < 0.01), and the fluorescence intensity of Iba-1 in CA1, CA3, and DG regions of hippocampus was significantly increased (p < 0.01). Compared with the LPS group, the sucrose preference rate, central area activity time, central area activity distance, and the number of times of entering the central area were significantly increased (p < 0.05 or p <0.01) in the FMN group, and TST immobility time was significantly shortened (p < 0.01), the expression levels of IL-6, IL-1β, and TNF-α protein and mRNA in the hippocampus were significantly decreased (p < 0.05 or p < 0.01), and the fluorescence intensity of Iba-1 in CA1, CA3, and DG regions of hippocampus was significantly decreased (p < 0.01). Conclusion FMN could inhibit LPS-induced activation of microglia, reduce hippocampal neuroinflammation, and improve depressive-like behaviors in mice.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Granulomatous Mastitis with Half-Yin and Half-Yang Syndrome","authors":"Zhikun Li, Xufeng Cheng, Wenke Zhang, Huiduo Zhao","doi":"10.1055/s-0043-1773795","DOIUrl":"https://doi.org/10.1055/s-0043-1773795","url":null,"abstract":"Abstract Granulomatous mastitis (GM) is a refractory chronic mastitis, which belongs to the category of “acne mammary abscess” and “ulcer” in Traditional Chinese External Medicine. According to yin-yang syndrome differentiation, the disease can be divided into yin syndrome, yang syndrome, and half-yin and half-yang syndrome. Among them, the theories and treatment of yin syndrome and yang syndrome are relatively comprehensive in Traditional Chinese External Medicine. However, the half-yin and half-yang syndrome lacks a specific theoretical elaboration and treatment system, which is a special and complex syndrome of the disease, limiting the improvement of the clinical efficacy of the disease. The core pathogenesis of GM with half-yin and half-yang syndrome is “obstruction of nutritive and defensive phases, and yin-yang obstruction.” The clinical features are local yin syndrome complicated with yang syndrome, and the disease is lingering and difficult to cure. For syndrome differentiation, it is advisable to “attach more importance to the local while less importance to the whole body.” The treatment should be based on the general principle of “eliminating yin and transforming yang.” For the use of herbs, it is recommended to adopt the methods of “the combination of the herbs in cold and warm nature, mainly with herbs in warm nature, attaching more importance to use the herbs with the function of ascending and less to descending.” Finally, restore the normal circulation of qi and blood as well as the balance of yin and yang to achieve the purpose of treatment.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Potential of Acupuncture in Chronic Prostatitis/Chronic Pelvic Pain Syndrome","authors":"Yang Yu, Xunchao Peng, Chenglin Tang","doi":"10.1055/s-0043-1774412","DOIUrl":"https://doi.org/10.1055/s-0043-1774412","url":null,"abstract":"Abstract Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents the most common type of CP, characterized by complex pathogenesis and a wide array of symptoms, making diagnosis and treatment challenging. Acupuncture, a widely used treatment for chronic and painful conditions, has demonstrated clinical efficacy in restoring prostate function and enhancing the quality of life for affected patients. This article critically examines the intricate pathogenesis of CP/CPPS and explores the related therapeutic mechanisms of acupuncture. Additionally, it summarizes the advancements made in the last decades regarding the use of acupuncture for treating CP/CPPS and elucidates potential effect pathways, laying the groundwork for further fundamental research.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Effects of Neuroglobin on Ferroptosis in the Nerve Cells","authors":"Wenjin Gao, Chen Mo, Wei Feng, Xinmin Pan, Haojie Qin","doi":"10.1055/s-0043-1773796","DOIUrl":"https://doi.org/10.1055/s-0043-1773796","url":null,"abstract":"Abstract Objectives The objective of this article was to explore the effects of neuroglobin (NGB) on ferroptosis in the nerve cells. Methods The NGB knockdown model of HT22 cells was constructed, and the ferroptosis-related indexes of cell proliferation activity, contents of iron ion, malondialdehyde (MDA), superoxide and reactive oxygen, and the changes of nuclear factor E2-related factor 2 (Nrf2) expression were examined in the normal group, erastin group, NGB siRNA group, and NGB siRNA + Erastin group, respectively. Results Compared with the normal group, cell proliferation activity and Nrf2 expression were significantly lower in the erastin group, NGB siRNA group, and NGB siRNA + erastin group, and ferroptosis-related indexes such as iron ion content, MDA content, superoxide content, and reactive oxygen species content were significantly reduced, and the difference between NGB siRNA + erastin group, erastin group, and NGB siRNA group was statistically significant (p < 0.05). Conclusion Knockdown of NGB in cells enhances the action of the ferroptosis inducer erastin, and NGB may regulate the cellular ferroptosis process through Nrf2. This research may provide references for the clinical treatment of nervous system disease with Chinese medicine.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Intestinal Flora and Related Diseases","authors":"Yaping Sun, Xindi Zhang, Yanli Zhang, Yanpo Si, Bing Cao, Zengfu Shan","doi":"10.1055/s-0043-1774414","DOIUrl":"https://doi.org/10.1055/s-0043-1774414","url":null,"abstract":"Abstract The intestinal tract is an important digestive organ and detoxification organ of the human body, and its circling structure is vividly called the “second brain” of the human body. There are hundreds of millions of bacterium in the intestinal tract. These bacteria live in mutual benefit with the body, provide energy and nutrients for the host and themselves through fermented food, participate in the metabolism of the body, and form a metabolic mode of cometabolism between the host and the symbiotic flora. In addition, intestinal flora can also help the body resist the invasion of pathogens, promote human health, and resist diseases. More and more studies have shown that when the body is subjected to exogenous or endogenous stimuli, the microbial flora in the intestinal will change, and the disturbance of intestinal flora is closely related to the occurrence and development of inflammatory bowel diseases, metabolic diseases, immune system diseases, mental system diseases, and tumors. This article reviews the research progress of the intestinal flora affecting the pathogenesis of various diseases, aiming to provide new references and ideas for the clinical treatment of diseases.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Migraine Knowledge Graph Based on Diagnosis and Treatment Guidelines of Integrative Medicine","authors":"Yanhua Jiang, Shiqing Qiu, Zhuang Guo, Huiling Ren, Xiaoying Li, Dongping Gao, Zhiwei Jing, Junwen Wang","doi":"10.1055/s-0043-1774413","DOIUrl":"https://doi.org/10.1055/s-0043-1774413","url":null,"abstract":"Abstract Our objective was to transform the text data in migraine diagnosis and treatment guidelines into a visualized knowledge graph by using knowledge graph technology, visually display the clinical diagnosis and treatment process, and provide assistance for the standardization of diagnosis and treatment of migraine with integrative medicine. Manual extraction, knowledge fusion, and standardization were performed on the text data in the migraine diagnosis and treatment guidelines. Combined with the clinical diagnosis and treatment process, the data of Chinese and Western medicine diagnosis and treatment of migraine were visualized and stored through the Neo4j graph database. A knowledge graph of Chinese and Western medicine diagnosis and treatment of migraine including 616 entities and 615 entity relationships was constructed, which realized the visual display of the diagnosis and treatment process of integrative medicine for migraine including examination, diagnosis, and treatment. Based on the guidelines for the diagnosis and treatment of migraine, this study visualized the diagnosis and treatment process of integrative medicine for migraine through knowledge graph technology, which is of great significance for the clinical implementation of relevant guidelines for the diagnosis and treatment and the standardization of integrative medicine diagnosis and treatment for the dominant diseases in Chinese medicine.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Method of Combining Internal and External Treatment of Ulcerative Colitis in Chinese Medicine","authors":"Qian Dai, Chunyan Dai, Jie Han","doi":"10.1055/s-0043-1777310","DOIUrl":"https://doi.org/10.1055/s-0043-1777310","url":null,"abstract":"Abstract Traditional Chinese medicine (TCM) believes that the main pathogenesis of ulcerative colitis is spleen deficiency; damp heat in the large intestine as the symptom, the treatment must be warming, clearing, eliminating, tonifying, astringing concurrently. From the concept of combining holism and the local treatment in TCM, idea of combining internal and external treatment is adopted. That is, the external treatment follows the therapeutic principle of using herbs with a bitter and cold nature to eliminate stagnation, and the seven carbon decoction, which can clear heat and dampness, cool the blood, and stop dysentery, is used as a rectal drip to retain the enema. Internal treatment follows the therapeutic principle of warmly tonifying and cultivating vital qi, with oral Chinese herbal medicine named Maodie Tang to strengthen the spleen and tonify the kidney, clearing heat and inducing dampness.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"25 1","pages":"e158 - e164"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Professor Diangui Li's Medication Experience in Treating Atrophic Gastritis Concomitant with Helicobacter Pylori Infection Based on Data Mining","authors":"Huijie Zhang, Diangui Li, Yulei Tao, Jiaxin Wu, Zhongqiang Sun, Fuping Zhai, Xiaofa Liu","doi":"10.1055/s-0043-1777300","DOIUrl":"https://doi.org/10.1055/s-0043-1777300","url":null,"abstract":"Abstract Objective  Our objective was to explore the national traditional Chinese medicine by studying master Diangui Li's medication experience in treating atrophic gastritis (AG) concomitant with Helicobacter pylori (Hp) infection based on data mining, and to provide the reference for the clinical treatment of relevant diseases. Methods  The Chinese medicine prescriptions of the patients' first visits to the Famous Doctors' Consultation Room in Hebei Provincial Hospital of Chinese Medicine from May 2019 to December 2022 were collected and frequency analysis of the Chinese herbs, association rules analysis of the Chinese herbs, and cluster analysis were conducted using the Famous Doctor Inheritance Assistance Platform. Results  A total of 188 prescriptions were collected, with 136 kinds of Chinese herbs. The highest use frequency of Chinese herbs was 185 and the lowest was 1. There were 28 kinds of Chinese herbs with high use frequency. The top 10 herbs with the high use frequency include Baihuasheshecao (Hedyotis Diffusae Herba), Huanglian (Coptidis Rhizoma), Yinchen (Artemisiae Scopariae Herba), Jigucao (Abriherba), Baishao (Paeoniae Radix Alba), Danggui (Angelicae Sinensis Radix), Banzhilian (Scutellariae Barbatae Herba), Baihe (Lilii Bulbus), Zhishi (Aurantii Immaturus Fructus), Chuanxiong (Chuanxiong Rhizoma). Chinese herbs with high frequency use are mostly heat-clearing herbs and qi-regulating herbs; the flavors of the herbs are mainly pungent, bitter, and sweet; the properties are mainly warm, cold, and neutral; the meridian tropism is mainly the spleen, liver, and stomach meridians. The core herbal medicines are Huanglian (Coptidis Rhizoma), Yinchen (Artemisiae Scopariae Herba), Baishao (Paeoniae Radix Alba), Danggui (Angelicae Sinensis Radix), etc.; the results of association rules: Jigucao (Abriherba)-Kushen (Sophorae Flavescentis Radix), Jiaogulan (Gynostemmatis Pentaphylli Rhizoma seu Herba)-Banlangen (Isatidis Radix), Huangqin (Scutellariae Radix)-Banlangen (Isatidis Radix), etc.; the results of cluster analysis showed that there were 10 clusters: (1) Yinchen (Artemisiae Scopariae Herba), Huanglian (Coptidis Rhizoma), Baihuasheshecao (Hedyotis Diffusae Herba), Banzhilian (Scutellariae Barbatae Herba), Jigucao (Abriherba); (2) Baishao (Paeoniae Radix Alba), Danggui (Angelicae Sinensis Radix), Chuanxiong (Chuanxiong Rhizoma), Wuyao (Linderae Radix); (3) Yuanhu (Corydalis Rhizoma), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Baizhi (Angelicae Dahuricae Radix). Conclusions  For the treatment of AG concomitant with Hp infection, Professor Diangui Li mainly adopts the method of clearing heat and removing the toxin, regulating qi and resolving phlegm, combining disease differentiation with syndrome differentiation, performing reinforcing method, and reducing method simultaneously to regulate the mechanism of the human body.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"13 1","pages":"e172 - e182"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139356997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-analysis of Randomized Controlled Trials on Manual Therapy for the Treatment of Gastroesophageal Reflux Disease","authors":"Mengdie Yan, Yunzhou Shi, Yanqin Liu, Yue Shi, Mengzhu Zhang, Dongnan Chen, Senlin Ye, Shiyin Li, Yue Feng","doi":"10.1055/s-0043-1777296","DOIUrl":"https://doi.org/10.1055/s-0043-1777296","url":null,"abstract":"Abstract Objective  The objective of our study was to systematically evaluate the clinical efficacy and safety of manual therapy in the treatment of gastroesophageal reflux disease (GERD), providing a reference value for clinical decision-making. Method  Studies of randomized controlled trials (RCTs) evaluating the efficacy of manual therapy in patients with GERD were searched through Chinese National Knowledge Infrastructure, Wanfang, VIP China Science and Technology Journal Database, China Biology Medicine Database, PubMed, The Cochrane Library, OVID Medline, and Embase. Two researchers independently reviewed the literature, extracted data, and performed a risk of bias analysis using the Cochrane risk of bias assessment tool, and conducted meta-analysis analysis and publication bias evaluation, the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool 26 was used to rate the caliber of the data in this meta-analysis. Results  This study included 11 RCTs. Meta-analysis showed that the manual therapy group had a higher total effective rate (odds ratio [OR] = 4.63, 95% confidence interval [CI; 3.01, 7.14], p  < 0.00001) and better Reflux Disease Questionnaire scores {weighted mean difference (WMD) = −1.59, 95% CI [−2.85, −0.33], p  = 0.01} than the control group. The subgroup analysis showed significant differences in improving the total effective rate in manual therapy versus Western medicine, manual therapy versus Chinese medicine decoction, manual therapy + Western medicine versus Western medicine, and manual therapy + conventional treatment versus conventional treatment groups. Among the 11 trials, 5 reported adverse events, and all RCTs had the possibility of publication bias. Subgroup analysis shows that the differences in age could significantly influence heterogeneity; The GRADE analysis revealed that the overall quality of evidence for all outcome indicators was low and did not support our recommendation for the outcome. Conclusion  Manual therapy is more effective than medication therapy alone in relieving GERD symptoms. Furthermore, conventional therapy combined with manual therapy was found to be even more effective. Hence, it is crucial to consider these findings when applying manual therapy to GERD patients to enhance treatment outcomes. Future studies must address issues such as study quality, treatment duration, and generalizability.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"17 1","pages":"e143 - e157"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}