Chinese medicine and natural products最新文献

{"title":"Senkyunolide A Attenuates OGD/R-Induced HT22 Cell Injury by Inhibiting Oxidative Stress and Apoptosis","authors":"Roujia Guo, Yufang Zhao, Zhouli Yue, Yan Li","doi":"10.1055/s-0045-1814092","DOIUrl":"https://doi.org/10.1055/s-0045-1814092","url":null,"abstract":"Abstract This study aimed to investigate the protective effect and mechanism of Senkyunolide A (SenA) on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in mouse hippocampal neuronal HT22 cells, providing experimental evidence for elucidating the application of SenA in the prevention and treatment of cerebral ischemia–reperfusion injury. An HT22 cell injury model was established using the OGD/R method and divided into the Control group, Model (OGD/R) group, Edaravone (EDA) group (OGD/R + EDA), and SenA group (OGD/R + SenA). Cell viability was detected by Cell counting kit-8 (CCK-8) assay; live and dead cells were observed by Calcein AM/PI cell viability assay kit (Calcein-AM/PI) double staining; intracellular reactive oxygen species (ROS) levels were measured using the H2DCFDA (DCFH-DA) fluorescent probe; levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined by biochemical kits; apoptosis rate was detected by flow cytometry; protein expression levels of Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), and Cysteine-dependent aspartate-specific protease-3 (Caspase-3) were measured by Western blot. Compared with the Control group, the OGD/R group showed significantly reduced cell viability (p < 0.001), increased proportions of dead cells, ROS and MDA levels, and apoptosis rate (p < 0.001), decreased SOD activity and GSH levels (p < 0.05; p < 0.001), significantly upregulated protein expression of Bax and Caspase-3 (p < 0.01; p < 0.001), and downregulated Bcl-2 expression (p < 0.001). Compared with the OGD/R group, both SenA and EDA significantly increased cell viability (p < 0.001), reduced the proportion of dead cells, ROS and MDA levels, and apoptosis rate (p < 0.001), upregulated SOD activity and GSH levels (p < 0.01; p < 0.001), downregulated protein expression of Bax and Caspase-3 (p < 0.01; p < 0.001), and upregulated Bcl-2 expression (p < 0.001). SenA can alleviate OGD/R-induced neuronal injury by mitigating oxidative stress and inhibiting cell apoptosis. This study provides modern experimental evidence for the traditional theory of Chuanxiong in “promoting blood circulation, removing blood stasis, and unblocking brain collaterals,” and offers new insights for the prevention and treatment of ischemia–reperfusion brain injury with traditional Chinese medicine.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"05 04","pages":"e235-e241"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1814092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-1 Promotes Apoptosis and Aggravates Myocardial Ischemia–Reperfusion Injury by Downregulating Insulin-Like Growth Factor-1","authors":"Zhen Lei, Fei Yan, Yan Shu, Tengyun Liang, Mengwen Zhang, Xinzhou Wang, Haixia Gao, Hong Wu","doi":"10.1055/s-0045-1811947","DOIUrl":"https://doi.org/10.1055/s-0045-1811947","url":null,"abstract":"Abstract MicroRNA-1 (miR-1) aggravates myocardial ischemia–reperfusion (I/R) injury, whereas insulin-like growth factor-1 (IGF-1) maintains cardiomyocyte homeostasis. In this study, the aim is to investigate whether miR-1 can exacerbate I/R injury through the regulation of IGF-1. The infarct area, lactate dehydrogenase, miR-1 level, and apoptosis level were examined in the Langendorff isolated rat I/R model. The hypoxia–reoxygenation model of rat cardiac myocytes and H9c2 cells were developed to determine the levels of miR-1, IGF-1 mRNA, and IGF-1 protein. Furthermore, the dual-luciferase assay was used to verify the relationship between miR-1 and IGF-1. Overexpression of miR-1 increased the level of apoptosis and decreased the IGF-1 expression. However, inhibition of miR-1 expression decreased the level of apoptosis, alleviated the degree of injury, and increased the IGF-1 expression. Overexpression of IGF-1 also reduced the degree of cellular damage and level of apoptosis caused by the overexpression of miR-1. When IGF-1 was knocked down, myocardial cells displayed more severe damage and a higher apoptosis level, even with decreased levels of miR-1. miR-1 promotes apoptosis and aggravates I/R injury by downregulating IGF-1.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"05 03","pages":"e162-e171"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1811947.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147894383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Scientific Connotation of Gypsum in Baihu Decoction Compatibility with Heat-clearing Effect Based on Phase Composition","authors":"Yunyun Wang, Zhengxian Zhang, Haotian Peng, Huahui Zeng, Xiangxiang Wu","doi":"10.1055/s-0045-1807263","DOIUrl":"https://doi.org/10.1055/s-0045-1807263","url":null,"abstract":"Abstract This study aimed to study the effects of different crystalline states of Sheng Shigao (raw gypsum, RG) and its inorganic elements on the antipyretic efficacy of Baihu Decoction (BHT). RG samples calcined at different temperatures were prepared. The phase composition of RG and Duan Shigao (calcination of gypsum, CG) as well as the changes in phase composition before and after adding water to RG calcined at specific temperatures, were determined using X-ray diffraction (XRD). A fever model was established by subcutaneously injecting 20% yeast suspension (10 mL·kg−1) into the backs of rats. The effects of BHT containing RG in different crystalline states on rat body temperature were measured. Serum levels of IL-1β, IL-6, and hypothalamic prostaglandin E2 (PGE2) were detected using ELISA. Serum Ca2+ levels were measured using a microplate method. The content of trace elements in RG and CG and the corresponding freeze-dried BHT powder was determined using inductively coupled plasma mass spectrometry (ICP-MS). The complexation of representative inorganic elements with mangiferin, a major active component in BHT, was investigated using UV-Vis spectroscopy and fluorescence spectroscopy. A validation model was established using RAW264.7 mouse macrophages. Drug-containing serum of BHT with different inorganic elements was prepared, and the nitric oxide (NO) levels in the cell supernatant of different treatment groups were measured using the Griess method. The mRNA levels of IL-6, TNF-α, and PGE2 in each group were detected using qPCR (real-time fluorescent quantitative PCR). After calcination, the phase composition of RG changed, and the content of inorganic elements in RG, CG170 (RG calcined at 170 °C), and CG350 (RG calcined at 350 °C) showed similar trends. Compared with RG, the content of Ca, Sr, Al, and Na in CG changed significantly. Compared with BHT, the content of Ca, Sr, Si, and Na in CG changed significantly when incorporated into the formula. Intermolecular interactions confirmed strong binding between mangiferin and Cu2+ and Al3+. Cu2+ and Fe3+ exhibited fluorescence quenching effects on mangiferin solution, while Al3+ and Zn2+ showed strong fluorescence enhancement, with fluorescence intensity increasing by 120-fold and 30-fold, respectively. In vitro evaluation of synergistic anti-inflammatory effects confirmed that Ca, Fe, Cr, Al, and Si exhibited synergistic anti-inflammatory effects. The crystalline state of RG has little effect on its antipyretic properties, while Ca, Sr, Na, Fe, and Al are likely the key material bases influencing its efficacy.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"05 01","pages":"e35-e46"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1807263.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Action of the Traditional Chinese Medicine Formula Weichang'an in the Treatment of Gastric Cancer Based on TMT Proteomics Analysis","authors":"Yaofei Niu, Weixia Chen, Yajie Ding, Yan Xu, Aiguang Zhao","doi":"10.1055/s-0044-1801293","DOIUrl":"https://doi.org/10.1055/s-0044-1801293","url":null,"abstract":"Abstract Objective The aim of the study was to screen key proteins involved in the treatment of human gastric cancer subcutaneous xenografts in nude mice by the traditional Chinese medicine formula Weichang'an and to explore its mechanism of action in treating gastric cancer. Methods Sixteen 7- to 8-week-old female BALB/C nude mice were used to establish a human gastric cancer subcutaneous xenograft model by bilateral axillary injection of MKN45 cells. Mice with successfully established tumors were randomly divided into the Weichang'an group and the model group, with eight mice in each group. Mice in the Weichang'an group were orally administered 0.5 mL of Weichang'an decoction, while mice in the model group were given 0.5 mL of normal saline by gavage once a day for 21 consecutive days. On day 28, the animals were sacrificed by cervical dislocation, and tumors were excised to measure tumor weight and assess the tumor suppression rate. Tandem mass tags (TMT) quantitative proteomics was used to analyze the tumor samples, identify differentially expressed proteins, and perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results Compared with the model group, the tumor weight in the Weichang'an group was significantly reduced (p < 0.001), and the tumor suppression rate was 41.40%, indicating that Weichang'an can inhibit the growth of human gastric cancer subcutaneous xenografts in nude mice. TMT quantitative proteomics identified a total of 2,856 proteins, with 13 proteins showing downregulated expression and 25 proteins showing upregulated expression in the Weichang'an group. GO enrichment analysis revealed that differentially expressed proteins were mainly enriched in cellular components such as the cell membrane, extracellular matrix, and envelope, and participated in biological processes like negative regulation of cell adhesion, hematopoiesis, and skeletal system development, with functions in cell adhesion molecule binding and molecular sensor activity. The KEGG pathway enrichment analysis identified the autophagy-lysosome pathway. Conclusion Weichang'an may exert its therapeutic effect on gastric cancer by regulating the expression of various proteins and modulating the autophagy-lysosome pathway.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"04 04","pages":"e173-e181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0044-1801293.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Protective Effects of Different Chinese Medicine Compounds on Gefitinib-Induced Hepatotoxicity","authors":"Xiaoting Yin, Min Li, Yucheng Li","doi":"10.1055/s-0044-1787120","DOIUrl":"https://doi.org/10.1055/s-0044-1787120","url":null,"abstract":"Abstract Objective Our objective was to screen drugs with good protective effects on gefitinib-induced hepatotoxicity. Methods Fifty-four specific pathogen-free-grade male mice of the Institute of Cancer Research were randomly divided into a normal group, gefitinib group, glutathione group, ligustrazine group, silymarin group, glycyrrhizic acid group, baicalin group, paeoniflorin group, and matrine group, with six mice in each group. Except for the normal group, the remaining groups of mice were intragastrically administered 400 mg·kg−1 of gefitinib for 16 days to induce liver injury. Mice in each treatment group were intragastrically administered 100 mg·kg−1 of the corresponding drug 30 minutes after gefitinib administration each day. The normal group and model group mice were intragastrically administered with an equal volume of 0.5% carboxymethylcellulose sodium (CMC-Na), and the administration volume was 10 mg·kg−1. Then, 30 minutes after the last administration, blood was collected from the retro-orbital venous plexus, and the mice were killed by cervical dislocation to obtain liver weight and calculate the liver index. Liver pathological changes were observed by hematoxylin–eosin (HE) staining; the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were detected using biochemical kits. AML12 cells were cultured in a medium containing drugs for 30 minutes. Except for the normal group, the remaining groups were induced cell damage with 20 μmoL·L−1 gefitinib for 24 hours. Cell viability was detected using a cell counting kit-8, and the levels of ALT, AST, and lactate dehydrogenase (LDH) in the cell culture supernatant were measured using biochemical kits. Results Animal experiments showed that compared with the gefitinib group, glycyrrhizic acid and baicalin significantly increased the body weight of mice (p < 0.01) and decreased the liver index and levels of ALT and AST (p < 0.05); ligustrazine and silymarin significantly increased the body weight of mice (p < 0.01) and decreased the level of AST (p < 0.05); paeoniflorin and matrine significantly decreased the levels of ALT and AST (p < 0.01). HE staining showed that the liver tissue of mice in the gefitinib group presented a large number of inflammatory cell infiltrations and disordered arrangement of hepatic cords; glutathione, glycyrrhizic acid, baicalin, paeoniflorin, and matrine significantly alleviated pathological damage to mouse liver tissue. Cell experiments showed that all drugs could alleviate gefitinib-induced damage to AML12 cells to varying degrees, among which glycyrrhizic acid, baicalin, and paeoniflorin had better protective effects, with cell survival rates increased to 96.4, 81.1, and 78.2%, respectively. Compared with the gefitinib group, glycyrrhizic acid significantly reduced the levels of ALT, AST, and LDH (p < 0.05); silymarin, baicalin, and paeoniflorin significantly reduced the levels of ALT and LDH (p < 0.05).","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"04 02","pages":"e76-e84"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0044-1787120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Golgi Protein 73, Alpha-Fetoprotein, Liver Function Indicators, and Traditional Chinese Medicine Syndrome Types of Primary Liver Cancer","authors":"Baoping Lu, Jinxia Rong, Huaimin Liu","doi":"10.1055/s-0043-1777333","DOIUrl":"https://doi.org/10.1055/s-0043-1777333","url":null,"abstract":"Objective Our objective was to analyze the correlation between Golgi protein 73 (GP73), alpha-fetoprotein (AFP), liver function indicators, and traditional Chinese medicine (TCM) syndrome types of primary liver cancer (hereinafter referred to as “liver cancer”). Methods In total, 156 liver cancer patients (liver cancer group) and 52 healthy individuals (health group) were selected as the research subjects to detect their GP73, AFP expression, and liver function-related indicators. The obtained data were statistically analyzed using SPSS 21.0 software. Results (1) The positive expression rate of GP73 in the liver cancer group was 50%; the positive expression rates of qi stagnation and blood stasis syndrome, heat toxin in liver and gallbladder syndrome, and yin deficiency of liver and kidney syndrome were 37.9, 54.3, and 59.6%, respectively. There was no statistically significant difference between the groups (p > 0.05). The positive expression rate of AFP was 50%. The positive expression rates of qi stagnation and blood stasis syndrome, heat-toxin in liver and gallbladder syndrome, and yin deficiency of liver and kidney syndrome were 41.7, 54.3, and 59.6%, respectively. There was a statistically significant difference between the groups (p < 0.05). (2) The GP73 levels of patients with different syndrome types in the liver cancer group were ranked from high to low as yin deficiency of liver and kidney syndrome, heat toxin in liver and gallbladder syndrome, and qi stagnation and blood stasis syndrome. The differences between the groups were statistically significant (p < 0.05). The AFP levels of patients with different syndrome types in the liver cancer group were ranked from high to low as heat toxin in liver and gallbladder syndrome, yin deficiency of liver and kidney syndrome, and qi stagnation and blood stasis syndrome. There was no statistically significant difference between the groups (p > 0.05). (3) Analysis of liver function indicators in the liver cancer group: the alanine transaminase (ALT) levels of patients with different syndrome types were in descending order from high to low, including yin deficiency of liver and kidney syndrome, heat toxin in liver and gallbladder syndrome, and qi stagnation and blood stasis syndrome. The differences between groups were statistically significant (p < 0.05). The aspartate aminotransferase (AST) levels of patients with different syndrome types were ranked from high to low as follows: heat toxin in liver and gallbladder syndrome, yin deficiency of liver and kidney syndrome, and qi stagnation and blood stasis syndrome. The difference between groups was statistically significant (p < 0.05). The levels of albumin (ALB) in patients with different syndrome types were ranked from high to low, including heat toxin in liver and gallbladder syndrome, qi stagnation and blood stasis syndrome, and yin deficiency of liver and kidney syndrome. The differences between groups were statistically significant (p < 0.05","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"33 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Formononetin on Lipopolysaccharide-Induced Depressive-Like Behaviors and Neuroinflammation in Mice","authors":"Mengyuan Li, Hui Liu, Shuaijun Peng, Pan Su, Erping Xu, Ming Bai, Yucheng Li","doi":"10.1055/s-0043-1773797","DOIUrl":"https://doi.org/10.1055/s-0043-1773797","url":null,"abstract":"Abstract Objective The objective of this article is to explore the effect of formononetin (FMN) on depressive-like behaviors and neuroinflammation in lipopolysaccharide (LPS)-induced mice. Methods After acclimatization, male Institute of Cancer Research mice were randomly divided into normal group, LPS group, paroxetine group (20 mg/kg), FMN low-dose group (20 mg/kg, FMN20), and FMN high-dose group (40 mg/kg, FMN40), with eight mice in each group. The depressive-like behaviors were observed by sucrose preference test, tail suspension test (TST), and open field test. The protein and mRNA levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the hippocampus were determined by enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction. The expression level of ionized calcium-binding adapter molecule 1 (Iba-1) in the hippocampus was observed by immunofluorescence staining to evaluate the activation level of microglia. Results Compared with the control group, the sucrose preference rate, the activity time of the central area, the distance of the central area, and the number of times of entering the central area were significantly decreased in the LPS group (p < 0.01), and the immobility time of TST was significantly prolonged (p < 0.05), the expression levels of IL-6, IL-1β, and TNF-α protein and mRNA in hippocampus were significantly increased (p < 0.01), and the fluorescence intensity of Iba-1 in CA1, CA3, and DG regions of hippocampus was significantly increased (p < 0.01). Compared with the LPS group, the sucrose preference rate, central area activity time, central area activity distance, and the number of times of entering the central area were significantly increased (p < 0.05 or p <0.01) in the FMN group, and TST immobility time was significantly shortened (p < 0.01), the expression levels of IL-6, IL-1β, and TNF-α protein and mRNA in the hippocampus were significantly decreased (p < 0.05 or p < 0.01), and the fluorescence intensity of Iba-1 in CA1, CA3, and DG regions of hippocampus was significantly decreased (p < 0.01). Conclusion FMN could inhibit LPS-induced activation of microglia, reduce hippocampal neuroinflammation, and improve depressive-like behaviors in mice.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Granulomatous Mastitis with Half-Yin and Half-Yang Syndrome","authors":"Zhikun Li, Xufeng Cheng, Wenke Zhang, Huiduo Zhao","doi":"10.1055/s-0043-1773795","DOIUrl":"https://doi.org/10.1055/s-0043-1773795","url":null,"abstract":"Abstract Granulomatous mastitis (GM) is a refractory chronic mastitis, which belongs to the category of “acne mammary abscess” and “ulcer” in Traditional Chinese External Medicine. According to yin-yang syndrome differentiation, the disease can be divided into yin syndrome, yang syndrome, and half-yin and half-yang syndrome. Among them, the theories and treatment of yin syndrome and yang syndrome are relatively comprehensive in Traditional Chinese External Medicine. However, the half-yin and half-yang syndrome lacks a specific theoretical elaboration and treatment system, which is a special and complex syndrome of the disease, limiting the improvement of the clinical efficacy of the disease. The core pathogenesis of GM with half-yin and half-yang syndrome is “obstruction of nutritive and defensive phases, and yin-yang obstruction.” The clinical features are local yin syndrome complicated with yang syndrome, and the disease is lingering and difficult to cure. For syndrome differentiation, it is advisable to “attach more importance to the local while less importance to the whole body.” The treatment should be based on the general principle of “eliminating yin and transforming yang.” For the use of herbs, it is recommended to adopt the methods of “the combination of the herbs in cold and warm nature, mainly with herbs in warm nature, attaching more importance to use the herbs with the function of ascending and less to descending.” Finally, restore the normal circulation of qi and blood as well as the balance of yin and yang to achieve the purpose of treatment.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Potential of Acupuncture in Chronic Prostatitis/Chronic Pelvic Pain Syndrome","authors":"Yang Yu, Xunchao Peng, Chenglin Tang","doi":"10.1055/s-0043-1774412","DOIUrl":"https://doi.org/10.1055/s-0043-1774412","url":null,"abstract":"Abstract Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents the most common type of CP, characterized by complex pathogenesis and a wide array of symptoms, making diagnosis and treatment challenging. Acupuncture, a widely used treatment for chronic and painful conditions, has demonstrated clinical efficacy in restoring prostate function and enhancing the quality of life for affected patients. This article critically examines the intricate pathogenesis of CP/CPPS and explores the related therapeutic mechanisms of acupuncture. Additionally, it summarizes the advancements made in the last decades regarding the use of acupuncture for treating CP/CPPS and elucidates potential effect pathways, laying the groundwork for further fundamental research.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Effects of Neuroglobin on Ferroptosis in the Nerve Cells","authors":"Wenjin Gao, Chen Mo, Wei Feng, Xinmin Pan, Haojie Qin","doi":"10.1055/s-0043-1773796","DOIUrl":"https://doi.org/10.1055/s-0043-1773796","url":null,"abstract":"Abstract Objectives The objective of this article was to explore the effects of neuroglobin (NGB) on ferroptosis in the nerve cells. Methods The NGB knockdown model of HT22 cells was constructed, and the ferroptosis-related indexes of cell proliferation activity, contents of iron ion, malondialdehyde (MDA), superoxide and reactive oxygen, and the changes of nuclear factor E2-related factor 2 (Nrf2) expression were examined in the normal group, erastin group, NGB siRNA group, and NGB siRNA + Erastin group, respectively. Results Compared with the normal group, cell proliferation activity and Nrf2 expression were significantly lower in the erastin group, NGB siRNA group, and NGB siRNA + erastin group, and ferroptosis-related indexes such as iron ion content, MDA content, superoxide content, and reactive oxygen species content were significantly reduced, and the difference between NGB siRNA + erastin group, erastin group, and NGB siRNA group was statistically significant (p < 0.05). Conclusion Knockdown of NGB in cells enhances the action of the ferroptosis inducer erastin, and NGB may regulate the cellular ferroptosis process through Nrf2. This research may provide references for the clinical treatment of nervous system disease with Chinese medicine.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}