Chinese medicine and natural products最新文献

{"title":"Correlation between the Distribution of Traditional Chinese Medicine Syndromes and Molecular Types of Breast Cancer in Perichemotherapy Period","authors":"Bingxin Meng, Xufeng Cheng, Qi Liu, Huiduo Zhao, Beibei Wang, Liuyan Xu","doi":"10.1055/s-0043-1777332","DOIUrl":"https://doi.org/10.1055/s-0043-1777332","url":null,"abstract":"Abstract Objectives  The objective of this study was to explore the correlation between the distribution of traditional Chinese medicine (TCM) syndromes and molecular types of breast cancer in the perichemotherapy period. Methods  A total of 325 cases with perichemotherapy breast cancer was classified according to syndrome differentiation in TCM , and R × C table χ 2 test was used to examine and analyze the relationship between TCM syndromes and molecular types of breast cancer in the perichemotherapy period. Results  (1) In the early stage of chemotherapy, there was no significant difference in the distribution of different TCM syndromes among molecular types, mainly liver depression syndrome and liver depression and phlegm coagulation syndrome ( p  > 0.05). (2) In the middle stage of chemotherapy, there were significant differences in the distribution of spleen deficiency and phlegm-dampness syndrome among HER-2 positive (HR positive), HER-2 positive (HR negative), and Luminal A type, Luminal B type (HER-2 negative), and triple-negative type ( p  < 0.01). (3) After chemotherapy, there were significant differences in the distribution of spleen and kidney yang deficiency syndrome and marrow sea insufficiency syndrome among HER-2 positive (HR negative), triple-negative type, and HER-2 positive (HR positive), Luminal A type, Luminal B type (HER-2 negative), and triple-negative type ( p  < 0.01). Conclusion  (1) In the middle stage of chemotherapy, HER-2 positive (HR positive) and HER-2 positive (HR negative) are more likely to show spleen deficiency and phlegm-dampness syndrome than other molecular types. (2) In the late stage of chemotherapy, the HER-2 positive (HR negative) and triple-negative type is more likely to show spleen-kidney yang deficiency syndrome than other molecular types, and the triple-negative type is more likely to show marrow sea insufficiency syndrome than other molecular types.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"45 1","pages":"e183 - e190"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139360722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Salvianolic Acid B and Ginsenoside Rg1 on Hemorrhagic Transformation after Stroke","authors":"Rongrong Xing, Yiyu Wang, Linlin Wang, Haishang Shen, Yi Jin, Haoying Yu, Rongxia Liu, B. Jiang","doi":"10.1055/s-0043-1770074","DOIUrl":"https://doi.org/10.1055/s-0043-1770074","url":null,"abstract":"Abstract Objective  Application of recanalization on stroke patients is not only limited with time window, but also accompanied with the risk of hemorrhagic transformation. In present study, the effects of salvianolic acid B and ginsenoside Rg1 combination (SalB/Rg1) on time window and hemorrhagic transformation against ischemic stroke was evaluated on middle cerebral artery occlusion (MCAO) mice. Methods  The protection and time window of SalB/Rg1 were estimated through infarct volume, neurobehavioral deficits, and histomorphological examination. The prohibition of SalB/Rg1 against hemorrhagic transformation was detected on MCAO mice stimulated with dextrose and reperfusion. Hemorrhagic transformation was assessed by the Heidelberg Bleeding Classification. The mechanism of SalB/Rg1 against hemorrhagic transformation was identified by immunofluorescence staining and in situ gelatin zymography. Results  First, SalB/Rg1 significantly reduced infarct volume and improved neurobehavior in a dose-dependent manner. Then, the protective time window up to 9 hours was detected for SalB/Rg1 against stroke. Both the dose-dependent efficiency and longtime protection of SalB/Rg1 were further identified based on cytoarchitecture through histopathological stain. Second, SalB/Rg1 downregulated hemorrhagic score, infarct volume, and abnormal neurobehavior. Finally, the inhibition of SalB/Rg1 against hemorrhagic transformation was found to accompany with its protection on the integrity of neurovascular unit. Around the edge area of infarction, SalB/Rg1 attenuated the astrocyte activation, maintained the abundance of junction protein (claudin-5) between endothelial cells, considerably decreased matrix metallopeptidase 9 activity through in situ gelatin zymography. Conclusion  SalB/Rg1 is a promising strategy for further development against stroke, especially against hemorrhagic transformation.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115919832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Senile Chronic Insomnia with Spirit-Calming and Blood-Nourishing Decoction Combined with Guasha (Scraping) and Acupuncture","authors":"Huiya Fu, Yinfeng Huang, Zhen Wang, Xi-yan Gao","doi":"10.1055/s-0043-1770076","DOIUrl":"https://doi.org/10.1055/s-0043-1770076","url":null,"abstract":"Abstract Objective  To observe the efficacy of treating senile chronic insomnia with spirit-calming and blood-nourishing decoction combined with Guasha (scraping) and acupuncture therapy. Methods  Seventy elderly patients with chronic insomnia were included and numbered by their visiting sequence. They were randomly divided into the control group and the observation group, 35 patients for each. Spirit-calming and blood-nourishing decoction was given to the control group, whereas Guasha (scraping) and acupuncture were applied together with the spirit-calming and blood-nourishing decoction to the observation group. Both groups were treated for 4 weeks before comparing their Pittsburgh Sleep Quality Index (PSQI) score and clinic efficacy. Results  PSQI scores of both groups were significantly lowered. Compared with the control group, the differences are statistically significant ( p  < 0.01). After treatment, the PSQI score of the observation group is (6.80 ± 1.37), whereas that of the control group is (10.83 ± 2.51). PSQI score of the observation group is lower ( p  < 0.01). The effective rate was 85.7% in the observation group and 62.9% in the control group. Difference of the effective rates of both groups is statistically significant ( p  < 0.01). Conclusion  Spirit-calming and blood-nourishing decoction combined with Guasha (scraping) and acupuncture is significantly effective in treating senile chronic insomnia. The combined therapy can effectively relieve the symptoms.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129071190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zhang Zhongjing Cultural Brand Construction from the Perspective of Traditional Chinese Medicine Culture and Wellness Tourism","authors":"Erping Xu, Baoguang Liu, M. Bai, Ya-lin Liu, Yucheng Li, Baoying Wang, Yiheng Chen, Miao Xie, Ying Dong","doi":"10.1055/s-0043-1770073","DOIUrl":"https://doi.org/10.1055/s-0043-1770073","url":null,"abstract":"Abstract Nowadays, traditional Chinese medicine (TCM) culture and wellness tourism are developing toward integration with an inherent and inevitable basis. A new business mode of TCM wellness tourism bred has emerged, injecting new vitality into the development of TCM culture and innovation of tourism. As the cultural representative of TCM industry, Zhang Zhongjing culture should seize the opportunity to make a breakthrough in its brand construction with the help of wellness tourism. The main construction strategies include actively launching books or films and television dramas based on the deeds of Zhang Zhongjing and other famous TCM doctors, turning herbs cultivation bases into special tourism and sightseeing parks, establishing research and dissemination bases of TCM culture, and building TCM wellness tourism bases that integrate learning, rehabilitation, and tourism, using information technology and cultural media platforms to introduce Zhang Zhongjing culture to the world.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131229715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitophagy Regulation by Kangxian Yixin Granule in a Mouse Model of Dilated Cardiomyopathy","authors":"Shun-xiang Liu, Xuanding Hei, Hong Wu, Zhentao Wang","doi":"10.1055/s-0043-1770075","DOIUrl":"https://doi.org/10.1055/s-0043-1770075","url":null,"abstract":"Abstract Objective  Kangxian Yixin granule (KXYXG) has been found to be effective in the clinical treatment of dilated cardiomyopathy (DCM). We aim to explore the effect of KXYXG and the underlying mechanism in a mouse model of DCM. Methods  Thirty specific pathogen-free (SPF) male cTnT R141W mice with DCM were randomly divided into the model group, KXYXG (20.4 g/kg/d) group and coenzyme Q10 (CoQ10) (1.5 mg/kg/d) group; 10 SPF male C57BL/6J mice were included to form the normal group. The mice in KXYXG group and CoQ10 group were administered by oral gavage for 8 weeks. M-echocardiography was used to evaluate the cardiac function in mice, and hematoxylin and eosin staining and transmission electron microscopy were performed to observe morphological characters. The colocalization and expression levels of mitophagy-related proteins were observed using immunofluorescence and western blot. Results  Compared with the normal group, the model group showed ventricular remodeling, cardiac insufficiency, disordered arrangement of cardiomyocytes, as well as disordered mitochondria and irregular and diffuse swelling. Furthermore, the model group had lower mitophagy protein colocalization and autophagy flux. Furthermore, PINK1 and Parkin expression levels decreased in the mice with DCM ( p <  0.05). KXYXG could decrease the left ventricular end-diastolic and end-systolic diameters and mitochondrial injury, rescue cardiac dysfunction and remodeling, and protect against myocardial ultrastructure changes in the mice with DCM. KXYXG also increased the colocalization levels of mitophagy-related proteins and PINK1 and Parkin expression levels compared with those in the model group ( p <  0.05). Conclusion  KXYXG can protect against heart injury by possibly activating the PINK1/Parkin pathway and mitophagy in mice with DCM.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124622427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis and Construction of Core Indicator Field of Pediatric Bronchitis Treated by Chinese Herbs Acupoint Application Therapy","authors":"Zhenzhen Qian, Rui Li, J. Duan, Zhiwei Jing, Ruijun Gao","doi":"10.1055/s-0043-1762571","DOIUrl":"https://doi.org/10.1055/s-0043-1762571","url":null,"abstract":"Abstract Objective  Our objective was to explore the commonly used herbs, acupoints, and efficacy evaluation indicators of Chinese herbs acupoint application therapy in the treatment of pediatric bronchitis, screen and construct the core index field, and systematically evaluate the efficacy and safety of Chinese herbs acupoint application therapy in the treatment of this disease. Methods  Chinese periodical databases such as China National Knowledge Infrastructure, Wanfang database, VIP Information, and Chinese Biomedical Literature database were searched, and the literature information was extracted manually to establish data tables for data analysis and the key efficacy evaluation index field. The quality of the included studies was assessed using the Cochrane Systematic Bias Risk Assessment Tool and the relevant efficacy indicators were meta-analyzed using RevMan 5.3 software. Results  The most commonly used herbs in acupoint application therapy were wind-cold dispersing herbs and cough-asthma relieving herbs. Feishu (BL 13), Danzhong (RN 17), and Tiantu (RN 22) were the main acupoints. The core indicators were effective rate, improvement of main symptoms/signs, onset time, disappearance time, traditional Chinese medicine (TCM) syndrome score, and symptom score. Meta-analysis results showed that the total effective rate was 0.11 (0.08, 0.33) ( Z  = 8.64, p  < 0.00001), I 2  = 39%; due to the heterogeneity of cough, expectoration, asthma, and other indicators, the meta-analysis was abandoned. Conclusion  In terms of total efficiency, Chinese medicine acupoint application therapy is superior to conventional Western medicine in efficacy and shortening the time of symptoms of pediatric asthmatic bronchitis. However, as the quality of the evidence included in the study is medium and low, and in the selection of indicators, there are more composite and relatively subjective indicators such as total effective rate, TCM syndrome score, and symptom score. Therefore, it is necessary to further standardize the efficacy indicators in this field and carry out high-quality and detailed Chinese medicine clinical randomized controlled trials.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133092686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture Clinical Trials on Knee Osteoarthritis","authors":"Chang-zhen Gong","doi":"10.1055/s-0043-1769104","DOIUrl":"https://doi.org/10.1055/s-0043-1769104","url":null,"abstract":"Abstract The outcomes of eight acupuncture clinical trials on knee osteoarthritis were published in well-regarded English-language mainstream medical journals between 1975 and 2022. Reported trial results were equally balanced between positive and negative outcomes, thus producing an overall impression of ambiguity in regard to the efficacy of acupuncture in the treatment of knee osteoarthritis. This paper reviews these trials, analyzes the factors taken into account in each trial, and has posited two reasons for the continuing lack of consensus in regard to the medical effectiveness of acupuncture: the difficulty of designing scientifically consistent clinical-trial studies; and an institutional bias toward ambiguity on the part of scientific and medical journals.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125391612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wenyang-Yiqi Granule Suppresses Oxygen-Glucose Deprivation-Induced Cardiomyocyte Autophagy Through Mammalian Target of Rapamycin Activation in H9c2 Cells","authors":"Shuibo Gao, Xiaofang Yu, Lihua Han, Hong Wu","doi":"10.1055/s-0043-1764132","DOIUrl":"https://doi.org/10.1055/s-0043-1764132","url":null,"abstract":"Abstract Background  Wenyang-Yiqi Granule (WYYQ) is a four-component herbal formula, widely used to treat heart failure in China. It is known to regulate autophagy, but the mechanism(s) are unknown. Methods  H9c2 cells were treated with WYYQ for 24 hours prior to oxygen-glucose deprivation (OGD). Expressions of the autophagy markers Beclin-1 and light chain 3 (LC3) were evaluated via quantitative polymerase chain reaction analysis. Protein levels of Beclin-1, LC3, p62, and mammalian targets of rapamycin (mTOR) were determined by Western blot analysis. Transmission electron microscopy was used to explore the effects of WYYQ on autophagosome formation. Results  Treatment with WYYQ dramatically restrained OGD-induced autophagy, which was characterized by an inhibition of Beclin-1 and increased LC3 mRNA expression. In addition, WYYQ decreased the expression of Beclin-1 and the ratio of LC3-II/LC3-I; however, the abundance of p62 was enhanced at the protein level. Manipulation of the LC3-II/LC3-I ratio, p62 abundance, and autophagosome formation in response to WYYQ were associated with mTOR activity. Conclusions  These findings show that WYYQ plays a protective role during hypoxic-ischemic stress through the suppression of excessive autophagy, which may be partially explained by its effects on mTOR. These data provide novel insight into the cardioprotective effects of WYYQ during cardiomyocyte autophagy.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123081718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of the Liver–Brain Cotreatment of Depression with Supplemented Danzhi Xiaoyao Powder","authors":"Yajing Li, Baoying Wang, Yucheng Li, M. Bai, Erping Xu","doi":"10.1055/s-0042-1757463","DOIUrl":"https://doi.org/10.1055/s-0042-1757463","url":null,"abstract":"Traditional Chinese medicine (TCM) has unique advantages in preventing and treating depression based on holistic concepts and syndrome differentiation and treatment. Liver depression and spleen deficiency are the main syndrome of depression. Danzhi Xiaoyao powder has the efficacy of soothing the liver and relieving depression, nourishing blood, and strengthening spleen. Present studies have proven that it has antidepressant efficacy for the syndrome of liver depression and spleen deficiency. The basic research on pharmacodynamic substances has found that the main active ingredients of Danzhi Xiaoyao powder in the treatment of depression include bupleurum saponin, paeonol, gardenoside, angelica polysaccharide, sulfate polysaccharide, paeoniflorin, albiflorin, atractylone, etc. In clinical practice, Danzhi Xiaoyao powder is often modified to make it more suitable according to the characteristics of pathogenesis and changes in the disease condition. Our research group has found that “brain and spirit failure and liver failing to disperse” are the main pathogenesis of depression. Based on the theory of “liver–brain cotreatment,” the treatment principle of “dispersing the liver and relieving depression, strengthening brain and benefiting intelligence” was put forward. On the basis of Danzhi Xiaoyao powder, Shichangpu (Acori Tatarinowii Rhizoma) was added to enlighten the mind and Yuanzhi (Polygalae Radix) to calm the mind and benefit intelligence. The modified Danzhi Xiaoyao powder was formulated, and its clinical effects on depression were remarkable. Animal experiments also confirmed that modified Danzhi Xiaoyao powder can significantly improve the depression-like behavior of depression model rats and the mechanism may be related to the regulation of the hypothalamic–pituitary–adrenal axis, the increase of the content of 5-hydroxytryptamine, and norepinephrine, which provides a reference for the further promotion of the clinical application of modified Danzhi Xiaoyao powder in the treatment of depression.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123818385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Clinical Application of Chaihu Decoction","authors":"Bo Huang, Yingfeng Liu, Yajing Lyu","doi":"10.1055/s-0042-1757461","DOIUrl":"https://doi.org/10.1055/s-0042-1757461","url":null,"abstract":"The classified prescriptions from Chaihu decoction have been widely used in ancient and modern times. In spite of many previous research studies, the extensiveness and diversity of their applications have not been systematically studied. The author applied Chaihu Wendan decoction to treat phlegm and qi stagnation in the middle energizer, applied Chaihu Guizhi decoction to treat simultaneous disease of Shaoyang and Taiyang, applied Chaihu Xiexin decoction to treat simultaneous disease of the spleen, stomach, liver, and gallbladder, applied Chaihu Ermiao powder to treat simultaneous disease of hand Shaoyang and foot Taiyin, applied Chaihu Erchen decoction to treat simultaneous disease of Shaoyang and Taiyin, applied Chailing decoction to treat simultaneous disease of hand Shaoyin and foot Taiyang, applied Chaihu Guizhi Ganjiang decoction to treat Shaoyang and Taiyin cold fluid retention and heat stagnation syndrome of Shaoyang complicated with Taiyin, applied Chaihu Xingren decoction to treat simultaneous disease of hand Shaoyang and hand Taiyin, applied Chaihu Sanren decoction to treat the disease caused by damp-heat stagnation in the hand Shaoyang and the foot Taiyin, and applied Chaihu Ganlu Xiaodu pellet to treat the diseases of hand Shaoyang and foot Yangming. The effects were all remarkable.","PeriodicalId":204577,"journal":{"name":"Chinese medicine and natural products","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122479051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}