Status of Clinical Application of Yufeng Ningxin Preparations and the Meta-Analysis of Its Efficacy and Safety in the Treatment of Cardiovascular and Cerebrovascular Diseases

Abstract Objective  The objective of this study was to analyze the status of the clinical application of Yufeng Ningxin (YFNX) preparations and systematically evaluate their efficacy and safety in the treatment of cardiovascular and cerebrovascular diseases. Methods  Through searching databases of China National Knowledge Infrastructure, Wanfang, SinoMed, VIP, PubMed, Embase, and the Cochrane Library, the literature of clinical research on YFNX preparations in treating malignant tumors of cardiovascular and cerebrovascular diseases from the establishment of the databases to February 2021 was collected. The clinical randomized controlled trials and case–control studies of cardiovascular and cerebrovascular diseases treated with these preparations were analyzed. Two reviewers independently screened literature, extracted data, and assessed the risk of bias in the included studies, and meta-analysis was performed by using ReMan 5.3 software to analyze the efficacy and safety of YFNX preparations in the treatment of cardiovascular and cerebrovascular diseases. Results  A total of 29 clinical studies were finally included. The dosage forms were dropping pills, tablets, capsules, and granules. The preparations were used for the treatment of coronary heart disease, hypertension, neuropathic headache, etc. This study systematically evaluated the efficacy and safety of YFNX preparations in the treatment of coronary heart disease, hypertension, and nervous headache. A total of 1,162 cases were included in 13 studies, 582 cases of the YFNX preparation group and 580 cases of the Western medicine group. The results of meta-analysis showed that the clinical efficacy of YFNX preparations combined with the Western medicine group in the treatment of coronary heart disease and hypertension, improving electrocardiogram and reducing the frequency and duration of angina attacks, was better than that of the simple Western medicine group, and the difference was statistically significant. Conclusion  YFNX preparations are effective for coronary heart disease, hypertension, and neuropathic headache, and the adverse reactions are few.