Procedia Chemistry最新文献_第3页

Activities of Ficus fistulosa Leave Extract and Fractions against Hepatitis C Virus 榕叶提取物及其组分抗丙型肝炎病毒活性研究

Procedia Chemistry Pub Date : 2016-01-01 Epub Date: 2016-02-11 DOI: 10.1016/j.proche.2016.01.028

Achmad Fuad Hafid , Adita Ayu Permanasari , Lidya Tumewu , Myrna Adianti , Chie Aoki , Aty Widyawaruyanti , Soetjipto , Maria Inge Lusida , Hak Hotta

{"title":"Activities of Ficus fistulosa Leave Extract and Fractions against Hepatitis C Virus","authors":"Achmad Fuad Hafid , Adita Ayu Permanasari , Lidya Tumewu , Myrna Adianti , Chie Aoki , Aty Widyawaruyanti , Soetjipto , Maria Inge Lusida , Hak Hotta","doi":"10.1016/j.proche.2016.01.028","DOIUrl":"10.1016/j.proche.2016.01.028","url":null,"abstract":"<div>Hepatitis C Virus (HCV) is a major global disease which often leads to chronicity and is potential to liver failure. There is no anti-HCV vaccine and the high diversity of viral genotypes will probably make it very difficult to develop a vaccine. Therefore, the development of new drugs for HCV treatment is highly required. It is commonly known that numerous important modern drugs have been developed from molecules originally isolated from natural sources. In this study, we tested the leave extract and fractions of Ficus fistulosa for their anti-HCV activities by cell culture method using Huh7it cells and HCV JFH1a. The result showed that ethanol extract of Ficus fistulosa (FFL) inhibited HCV JFH1a with IC50 value of 20.43±4.51μg/ml. Toxicity test also indicated that FFL was not toxic with CC50 value of >200μg/ml. The extract was further fractionated using chloroform (FFLC) and butanol (FFLB) successively. FFLC showed anti-HCV activity with IC50 value of 5.67±1.54μg/ml and CC50 value of >100μg/ml (Selectivity index >17.65). Further separation of FFLC by open column chromatography resulted in 12 subfractions (FFLC1-C12). Two subfractions, FFLC10, and FFLC11 showed high selectivity index (>100) with IC50 value of 0.60±0.30μg/ml and 0.43±0.29μg/ml, respectively. Therefore the leave extract (FFL) and fractions (FFL10, FFL11) of Ficus fistulosa would be a good candidate to develop antiviral against HCV.</div>","PeriodicalId":20431,"journal":{"name":"Procedia Chemistry","volume":"18 ","pages":"Pages 179-184"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.proche.2016.01.028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87807762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Uranium and Plutonium Extraction by N,N-dialkylamides Using Multistage Mixer-settler Extractors 多级混合沉降萃取器萃取N,N-二烷基酰胺提取铀和钚

Procedia Chemistry Pub Date : 2016-01-01 Epub Date: 2016-12-01 DOI: 10.1016/j.proche.2016.10.022

Yasutoshi Ban, Shinobu Hotoku, Nao Tsutsui, Asuka Suzuki, Yasuhiro Tsubata, Tatsuro Matsumura

{"title":"Uranium and Plutonium Extraction by N,N-dialkylamides Using Multistage Mixer-settler Extractors","authors":"Yasutoshi Ban, Shinobu Hotoku, Nao Tsutsui, Asuka Suzuki, Yasuhiro Tsubata, Tatsuro Matsumura","doi":"10.1016/j.proche.2016.10.022","DOIUrl":"10.1016/j.proche.2016.10.022","url":null,"abstract":"<div>N,N-Dialkylamides (monoamides) are known as extractants for U and Pu, and many studies have been carried out mainly by single-stage batch method. We have focused on two monoamides: N,N-di(2-ethylhexyl)-2,2-dimethylpropanamide (DEHDMPA) and N,N-di(2-ethylhexyl)butanamide (DEHBA), and proposed a multistage extraction process for recovering U and Pu by these monoamides. A continuous counter-current experiment was carried out to demonstrate the validity of this process. This process consisted of two cycles, and the 1st cycle and the 2nd cycle employed DEHDMPA and DEHBA as extractants, respectively. The feed solution for the 1st cycle was 5.1mol/dm3 (M) nitric acid containing 0.92M U, 1.6mM Pu, and 0.6mM Np. The raffinate collected in the 1st cycle was used as the feed for the 2nd cycle. The ratios of U recovered in the U fraction and U-Pu fraction were 99.1% and 0.8%, respectively, and the ratios of U in the used solvents were <0.04%. The ratio of Pu recovered in the U-Pu fraction was 99.7%, and the ratio of Pu in the used solvents was in the order of 10–3–10–4%. The concentration ratio of U with respect to Pu in the U-Pu fraction was 9, and this indicated that Pu was not isolated. The decontamination factor of U with respect to Pu in the U fraction was obtained as 4.5×105. These results supported the validity of the proposed process.</div>","PeriodicalId":20431,"journal":{"name":"Procedia Chemistry","volume":"21 ","pages":"Pages 156-161"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.proche.2016.10.022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80345730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Spectroscopic Studies of Neodymium(III) and Praseodymium(III) Compounds in Molten Chlorides 熔融氯化物中钕(III)和镨(III)化合物的光谱研究

Procedia Chemistry Pub Date : 2016-01-01 Epub Date: 2016-12-01 DOI: 10.1016/j.proche.2016.10.057

Hugues Lambert , Benoit Claux , Clint Sharrad , Pavel Soucek , Rikard Malmbeck

引用次数: 3

Study on the Agglomeration Kinetics of Uranium Peroxide 过氧化铀的团聚动力学研究

Procedia Chemistry Pub Date : 2016-01-01 Epub Date: 2016-12-01 DOI: 10.1016/j.proche.2016.10.037

Murielle Bertrand , Luz Adriana MOJICA Rodriguez , Hervé Muhr , Edouard Plasari , Et Frédéric Auger

引用次数: 0

Parametric Performance Study of Tunnel Boring Machine (TBM) In the Titiwangsa Main Range Granite, Malaysia☆ 马来西亚Titiwangsa主岭花岗岩隧道掘进机(TBM)参数性能研究

Procedia Chemistry Pub Date : 2016-01-01 DOI: 10.1016/J.PROCHE.2016.03.143

A. Rahim, H. Zabidi, M. Trisugiwo, A. G. Rafek

引用次数: 1

Anatase as Antibacterial Material in Ceramic Tiles 锐钛矿在瓷砖中的抗菌作用

Procedia Chemistry Pub Date : 2016-01-01 DOI: 10.1016/J.PROCHE.2016.03.109

M. Hasmaliza, H. Foo, K. Mohd

引用次数: 30

Preparation and Characterization of North Sumatera Natural Zeolite Polyurethane Nanocomposite Foams for Light-weight Engineering Materials 北苏门答腊天然沸石聚氨酯纳米复合泡沫材料的制备与表征

Procedia Chemistry Pub Date : 2016-01-01 DOI: 10.1016/J.PROCHE.2016.03.150

Fransiskus Gultom, B. Wirjosentono, Thamrin, H. Nainggolan, Eddiyanto

引用次数: 12

The Effect of using Different Bed Powder in PZT Synthesis 不同床粉对PZT合成的影响

Procedia Chemistry Pub Date : 2016-01-01 DOI: 10.1016/J.PROCHE.2016.03.113

N. F. K. Bahanurddin, J. J. Mohamed, Z. Ahmad

引用次数: 0

Synthesis of Single-layer Graphene: A Review of Recent Development 单层石墨烯的合成研究进展

Procedia Chemistry Pub Date : 2016-01-01 DOI: 10.1016/J.PROCHE.2016.03.135

H. C. Lee, Wei‐Wen Liu, S. Chai, A. Mohamed, C. Lai, C. Khe, C. Voon, U. Hashim, N. Hidayah

引用次数: 92

Influence of Al2O3/ Y-TSZ Mixture as Filler Loading on the Radiopacity of PMMA Denture Base Composites Al2O3/ Y-TSZ混合填料对PMMA义齿基托复合材料放射透明度的影响

Procedia Chemistry Pub Date : 2016-01-01 Epub Date: 2016-03-24 DOI: 10.1016/j.proche.2016.03.065

A.O. Alhareb , H.M. Akil , Z.A. Ahmad

{"title":"Influence of Al2O3/ Y-TSZ Mixture as Filler Loading on the Radiopacity of PMMA Denture Base Composites","authors":"A.O. Alhareb , H.M. Akil , Z.A. Ahmad","doi":"10.1016/j.proche.2016.03.065","DOIUrl":"10.1016/j.proche.2016.03.065","url":null,"abstract":"<div>The radiopacity of alumina/yttrium stabilizer zirconia (Al2O3/Y-TSZ) particles with nitrile butadiene rubber (NBR) dispersed in PMMA denture base material has been investigated. PMMA matrix without filler was prepared from PMMA powder with 0.5% benzoyl peroxide (PBO) as the control material. The similar PMMA matrix was mixed with Al2O3/Y-TSZ (1:1) together with NBR particles as the reinforcement. The amount of NBR was fixed at 7.5wt %, however, Al2O3/Y-TSZ varied from 1 to 10wt %, respectively. Samples with 4mm thickness for each composition were irradiated using 60 KV, 10mA, 0.4 s to examine their radiopacity. This radiopacity was compared to radiopacity of aluminum plate which having the same thickness. The result shows that the radiopacity (i.e. the lower optical density the higher radiopacity) of reinforced PMMA matrix slightly increased from 1.40 to 1.05, respectively, with the increased of filler loading compared to unreinforced PMMA matrix.</div>","PeriodicalId":20431,"journal":{"name":"Procedia Chemistry","volume":"19 ","pages":"Pages 646-650"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.proche.2016.03.065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75766601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8