Preventive medicine最新文献

{"title":"Stage at diagnosis and cancer-specific survival for stomach, lung, colorectal, and bladder cancers among Armenians in California","authors":"Ani S. Movsisyan Vernon ,&nbsp;Laura Fejerman ,&nbsp;Jeffrey S. Hoch ,&nbsp;Theresa H. Keegan","doi":"10.1016/j.ypmed.2024.108214","DOIUrl":"10.1016/j.ypmed.2024.108214","url":null,"abstract":"<div><h3>Objective</h3><div>To observe stage at diagnosis and cancer-specific survival for common cancers among Armenians in California.</div></div><div><h3>Methods</h3><div>We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with stomach, lung, colorectal, and bladder cancers diagnosed during 1988–2019. We used multivariable logistic regression models to calculate odds of late-stage diagnoses among Armenian and non-Armenian, non-Hispanic White patients and examine the association of sociodemographic factors with late-stage diagnoses among the Armenian patient population. We used Cox proportional hazards models to calculate cancer-specific survival among Armenian patients compared to non-Armenian, non-Hispanic White patients.</div></div><div><h3>Results</h3><div>Of the 639,224 cancer diagnoses identified, 6642 were among Armenian patients. Armenian individuals were more likely to be diagnosed with late-stage colorectal (OR = 1.12, 95 % CI = 1.03–1.22), lung (OR = 1.26, 95 % CI = 1.12–1.42), and stomach (OR = 1.43, 95 % CI = 1.17–1.74) cancers. Among Armenian patients, low nSES and public insurance were associated with late-stage diagnoses. Armenian individuals had better survival than non-Armenian, non-Hispanic White individuals for stomach (HR = 0.85, 95 % CI = 0.76–0.94), lung (HR = 0.86, 95 % CI = 0.82–0.91), colorectal (HR = 0.82, 95 % CI = 0.77–0.88), and bladder (HR = 0.87, 95 % CI = 0.76–0.99) cancers.</div></div><div><h3>Conclusion</h3><div>While Armenian patients were at greater risk of late-stage diagnoses of colorectal, lung, and stomach cancers, they had better survival compared to non-Armenian, non-Hispanic White patients. Further research is needed to understand factors impacting survival in Armenian individuals, including genetic, behavioral, and social factors. Our findings of lower nSES and public health insurance associated with late-stage diagnoses suggest a need for increased access to care and cancer screening among the Armenian population in California.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108214"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the determinants to accept dementia screening among patients at high risk of dementia based on the theory of planned behavior: A cross-sectional study","authors":"Li Tang ,&nbsp;Zhuang Zhuang ,&nbsp;Meilin Luo ,&nbsp;Yuting Cai ,&nbsp;Qiyuan Lyu","doi":"10.1016/j.ypmed.2024.108215","DOIUrl":"10.1016/j.ypmed.2024.108215","url":null,"abstract":"<div><h3>Background</h3><div>Dementia represents a major public health challenge. Despite numerous initiatives promoting screening for early cognitive impairment to help prevent or delay its onset, participation remains limited. Moreover, there is limited evidence regarding screening intentions and predictors among populations at high risk of dementia. This study used the theory of planned behavior to identify modifiable factors associated with screening participation.</div></div><div><h3>Methods</h3><div>This cross-sectional survey was conducted from November 16, 2021, to April 2, 2022, and involved 439 individuals at high risk of dementia selected using convenience sampling from two major regional communities in Guangzhou, China. A validated custom questionnaire based on the theory of planned behavior was used for data collection, and logistic regression and structural equation modeling were applied to identify related predictors.</div></div><div><h3>Results</h3><div>Overall, 62 % of the participants expressed willingness to undergo dementia screening. Behavioral intention was primarily associated with Perceived behavioral control (PBC, path coefficient = 0.36), Subjective norm (path coefficient = 0.16), and Attitude (path coefficient = 0.13). Additionally, PBC was associated with a positive attitude toward dementia screening (path coefficient = 0.39).</div></div><div><h3>Conclusions</h3><div>PBC, subjective norm, and attitudes are associated with dementia screening willingness among high-risk groups. Healthcare professionals and policymakers should focus on enhancing favorable attitudes toward screening, increasing familial encouragement, and reducing perceived barriers to developing effective prevention or intervention strategies.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108215"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to recommended blood-based screening tests for cancer and chronic diseases: A systematic literature review","authors":"Quang A. Le ,&nbsp;Takako Kiener ,&nbsp;Heather A. Johnson ,&nbsp;Kevin H. Li ,&nbsp;Paul J. Limburg ,&nbsp;A. Mark Fendrick ,&nbsp;John B. Kisiel ,&nbsp;Derek W. Ebner","doi":"10.1016/j.ypmed.2024.108213","DOIUrl":"10.1016/j.ypmed.2024.108213","url":null,"abstract":"<div><h3>Introduction</h3><div>Blood-based tests represent a compelling option for early detection and management of cancers and other chronic diseases. While they may increase patient engagement, assumptions about greater adherence in clinical practice need further evaluation. This systematic review aimed to evaluate real-world adherence to established blood-based tests for commonly recommended screening indications to inform expectations for average-risk colorectal cancer (CRC) screening.</div></div><div><h3>Methods</h3><div>A comprehensive and systematic search of PubMed, Embase, and citations was conducted to identify literature published from 2010 to 2023. Included studies examined adherence to United States Preventive Services Task Force (USPSTF) grade A/B blood test recommendations for type 2 diabetes, dyslipidemia, hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Prostate-specific antigen (PSA) testing adherence for prostate cancer screening (grade C USPSTF recommendation), the only widely accessible blood-based single-cancer screening test for average-risk adults, was also included. Studies without venipuncture-derived blood were excluded.</div></div><div><h3>Results</h3><div>Of 53,067 articles, 69 were included. Adherence rates of blood-based screening tests were highly variable, with median values and interquartile range (IQR) of 66.3 % (59.2–71.1), 67.8 % (54.4–72.4), 34 % (21.9–50.5), and 36.8 % (29.1–59.1) for diabetes, dyslipidemia, HCV, and HIV, respectively. PSA testing adherence was 37.2 % (30–48.5). Information and selection bias were common risks of bias.</div></div><div><h3>Conclusions</h3><div>Real-world adherence to recommended blood-based screening is suboptimal. Future research is needed to determine whether these findings are generalizable to blood-based CRC screening and to assess how such a strategy could impact clinical, economic, and health equity outcomes.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108213"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of individual and neighborhood socioeconomic status with outcomes of a smoking cessation intervention provided in the lung cancer screening setting","authors":"Jaqueline C. Avila ,&nbsp;Efren J. Flores ,&nbsp;Yan-Jhu Su ,&nbsp;Jennifer S. Haas ,&nbsp;Elyse R. Park ,&nbsp;Nancy A. Rigotti","doi":"10.1016/j.ypmed.2024.108207","DOIUrl":"10.1016/j.ypmed.2024.108207","url":null,"abstract":"<div><h3>Background</h3><div>Lung cancer screening (LCS) offers a teachable moment for smoking cessation. This study assesses whether individual- or neighborhood-level SES is associated with tobacco abstinence and completion of a smoking cessation intervention in the LCS context.</div></div><div><h3>Methods</h3><div>Secondary analysis of a clinical trial (<span><span>NCT03611881</span><svg><path></path></svg></span>) that tested the effectiveness of smoking cessation treatment for smokers scheduled for LCS (<em>N</em> = 615) in eastern Massachusetts, USA from 2019 to 2024. Outcomes were self-reported 7-day smoking abstinence and study follow-up completion at 6-months. Independent variables were individual SES (high school or less [low SES] vs. post-high school education [high SES]); neighborhood SES (Area Deprivation Index [ADI], range: 0–100, categorized as: highest 15 % [low SES] vs. remaining 85 % scores [high SES]), and a combination of both measures. Logistic regression models tested the association between outcomes and SES measures, adjusted for covariates.</div></div><div><h3>Results</h3><div>32 % of participants had low individual SES. The mean sample ADI was 19.9 (SD: 12.8). Smoking cessation was higher among those with high vs. low neighborhood SES (15.7 % vs. 7.4 %, <em>p</em>-value = 0.03). Study completion was marginally higher among those with high vs. low individual SES (84.5 % vs. 78.1 %, <em>p</em> = 0.05). In multivariable models, these associations were not significant, but individuals with high individual and low neighborhood SES were more likely to complete the study than those with both low individual and low neighborhood SES, (OR: 6.04, 95 %CI: 1.47–24.7).</div></div><div><h3>Conclusion</h3><div>Individual and neighborhood SES were not independently associated with the study outcomes in the multivariable analysis, but combinations of individual and neighborhood SES differentially affected treatment completion.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108207"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School-based environment and physical activity in adolescents: A systematic review and meta-analysis","authors":"Huihui Wang ,&nbsp;Jian Pang ,&nbsp;Xiaoguang Yang ,&nbsp;Yuanyuan Jia ,&nbsp;Xinru Huang ,&nbsp;Laikang Yu ,&nbsp;Xiao Hou","doi":"10.1016/j.ypmed.2025.108221","DOIUrl":"10.1016/j.ypmed.2025.108221","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness of school environmental factors in promoting adolescents' physical activity.</div></div><div><h3>Methods</h3><div>A systematic search of five databases (PubMed, Embase, Web of Science, EBSCO, and Cochrane Library) was conducted from the earliest available records up to September 2023. Meta-analyses were performed for each school environmental factor, provided that at least two studies reported on the association between that factor and adolescents' physical activity. The factors examined included seven school social environmental factors and six school physical environmental factors.</div></div><div><h3>Results</h3><div>18 studies comprising 340,749 participants were included in the meta-analysis. A significant positive correlation was observed between the school environment and adolescents' physical activity. Specifically, the school social environment was positively associated with adolescents' physical activity. In particular, school-offered daily physical education, school-organized extracurricular physical activities, encouragement of using sports equipment or facilities, and outdoor obstacle course were all significantly positively correlated with adolescents' physical activity. While the overall school physical environment did not show a significant relationship with adolescents' physical activity, the number of school physical activity facilities demonstrated a significant positive correlation with adolescents' physical activity.</div></div><div><h3>Conclusions</h3><div>This meta-analysis demonstrates the role of school environment in promoting adolescents' physical activity. School social environmental factors, including school-offered daily physical education, school-organized extracurricular physical activities, encouragement to use sports resources, and outdoor obstacle courses, are particularly effective in enhancing adolescents' physical activity. Among school physical environmental factors, the number of physical activity facilities was found to be a key factor in promoting adolescents' physical activity.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108221"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long working hours and cardiovascular disease mortality: Prospective evidence from the United States","authors":"Yiran Gu ,&nbsp;Timothy A. Matthews ,&nbsp;Jian Li","doi":"10.1016/j.ypmed.2025.108225","DOIUrl":"10.1016/j.ypmed.2025.108225","url":null,"abstract":"<div><h3>Aims</h3><div>Cardiovascular disease (CVD) is the leading cause of death in the United States (U.S.). This study aimed to explore prospective associations between long working hours with CVD mortality using a large, national study in the U.S.</div></div><div><h3>Methods</h3><div>Data from the Midlife in the U.S. (MIDUS) Study were used, including 4051 currently employed participants without prior experience of myocardial infarction or stroke at baseline in 1995–1996. Working hours were categorized into: &lt;35 h/week, 35–40 h/week (reference), 41–48 h/week, 49–54 h/week, and ≥ 55 h/week. Mortality data were extracted from the National Death Index (NDI) through Spring 2021. Cox proportional hazards regression was applied to analyze the prospective associations between working hours at baseline and CVD mortality, adjusting for sociodemographic and lifestyle factors. Stratified analyses by socioeconomic status (i.e., education and financial situation) were also conducted.</div></div><div><h3>Results</h3><div>Long working hours (≥55 h/week) were significantly associated with increased CVD mortality (adjusted HR 1.50; 95 % CI 1.03–2.17) compared to the reference group. Subgroup analyses showed that individuals with low education level or poor financial situation had a higher risk of CVD mortality when working long hours.</div></div><div><h3>Conclusion</h3><div>Long working hours are a significant risk factor for CVD mortality in this national sample of U.S. workers, and participants with low socioeconomic status are more vulnerable to the effects of long working hours on CVD deaths. These findings highlight the need for considering working hour interventions in public health strategies to improve cardiovascular health outcomes in the workforce.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108225"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in modifiable risk factors for dementia among midlife adults in the United States: The National Health and nutrition examination survey 1999–2018","authors":"Yanan Zhang ,&nbsp;Amirhossein Fakhre Yaseri ,&nbsp;Ambar Kulshreshtha ,&nbsp;Casey Crump ,&nbsp;Jingkai Wei","doi":"10.1016/j.ypmed.2024.108208","DOIUrl":"10.1016/j.ypmed.2024.108208","url":null,"abstract":"<div><h3>Objective</h3><div>Dementia has a large public health burden, and modifiable risk factors, particularly in midlife, may provide an opportunity for early prevention. We aimed to examine trends in age-adjusted prevalence of modifiable risk factors for dementia and the number of modifiable risk factors among midlife adults from 1999 to 2018.</div></div><div><h3>Methods</h3><div>A total of 14,851 participants aged 40 to 64 years without a history of cardiovascular disease in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were included in the analysis. The age-adjusted prevalence of six modifiable risk factors consistently measured across all surveys, including hypertension, diabetes, hyperlipidemia, obesity, smoking, and heavy drinking, as well as the average number of these modifiable risk factors, were estimated and compared across survey periods. Subgroup analyses were conducted by sex, race/ethnicity, education, and family income.</div></div><div><h3>Results</h3><div>The age-adjusted prevalence of diabetes (p for linear trend &lt;0.0001) and obesity (p for linear trend = 0.0001) showed increasing trends from 1999 to 2018 among midlife adults in the U.S. and in virtually all subgroups, while smoking showed a decreasing trend (p for linear trend &lt;0.0001). The average number of modifiable risk factors remained around two (p for linear trend = 0.84).</div></div><div><h3>Conclusion</h3><div>The prevalence of diabetes and obesity increased in this large, nationally representative U.S. study population, while the prevalence of smoking decreased. More effective public health interventions are needed to mitigate the impact of these risk factors and ultimately reduce the burden of dementia in aging populations.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108208"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study","authors":"Jian Zhang ,&nbsp;Jingwei Zhang ,&nbsp;Pengfei Li ,&nbsp;Yandan Xu ,&nbsp;Xuesong Zhou ,&nbsp;Jia Qiu ,&nbsp;Xiuli Tang ,&nbsp;Zhongao Ding ,&nbsp;Mingjia Xu ,&nbsp;Chongjian Wang","doi":"10.1016/j.ypmed.2024.108217","DOIUrl":"10.1016/j.ypmed.2024.108217","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the associations between short-term air pollution exposure and acute exacerbation of chronic bronchitis (AECB).</div></div><div><h3>Methods</h3><div>AECB data were collected from hospital surveillance systems in Shanghai, China, during 2018–2022. Exposure pollution data were obtained from China high resolution high quality near-surface air pollution datasets and assigned to individuals based on their residential addresses. The time-stratified case crossover design combined with the conditional logistic regression model were used to estimate the associations between air pollution and AECB. Weighted quantile sum regression evaluated combined pollution effects and key pollutants.</div></div><div><h3>Results</h3><div>A total of 2202 hospitalized cases with AECB were included. On day 7 of the average lag (lag 07-day), the odds ratios (<em>OR</em>) of air pollution (Particulate matter with aerodynamic diameters of ≤2.5 μm (PM_2.5), 2.5–10 μm (PM_2.5_–₁₀), and ≤ 10 μm (PM₁₀), Ozone (O₃), Sulfur dioxide (SO₂), Nitrogen dioxide (NO₂)) with AECB increased by 10 μg/m³ were 1.07 (95 % confidence interval (<em>CI</em>): 1.02–1.12), 1.13 (1.06, 1.21), 1.06 (1.03–1.09), 1.03 (1.01–1.06), 2.05 (1.51–2.80) and 1.11 (1.05–1.18), respectively. Combined exposure was also positively associated with the risk of AECB (<em>OR</em> 1.04, 95 % <em>CI</em> 1.00–1.08), with O₃ being the most significant.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that short-term exposure to air pollution was significantly associated with higher risk of AECB. O₃ might contribute the most to AECB. Policymakers should pay more attention to air pollution control.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108217"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U.S. national trends in cervical cancer screening by sexual orientation and race/ethnicity in cisgender women","authors":"Kelley Baumann ,&nbsp;Caryn E. Peterson ,&nbsp;Stacie Geller ,&nbsp;Saria Awadalla ,&nbsp;Hunter K. Holt","doi":"10.1016/j.ypmed.2025.108223","DOIUrl":"10.1016/j.ypmed.2025.108223","url":null,"abstract":"<div><h3>Introduction</h3><div>Changes in up-to-date cervical cancer screening (CCS) over time by sexual orientation and race/ethnicity were estimated to identify trends in screening disparities.</div></div><div><h3>Methods</h3><div>This 2024 retrospective, cross-sectional analysis of National Health Interview Survey data (years 2013, 2015, 2019 and 2021) included 40,818 cisgender women aged 21–65 without hysterectomy. Joinpoint analysis was performed to calculate the annual percent change (APC) of up-to-date CCS from 2013 to 2021. Logistic regression (years 2019 and 2021) was used to describe the relationship between up-to-date screening and sexual orientation, race/ethnicity, and the interaction thereof.</div></div><div><h3>Results</h3><div>The adjusted odds of up-to-date CCS were 22 % lower for lesbian, gay, and/or bisexual (LGB) compared to heterosexual women (OR = 0.78, <em>p</em> = 0.01). Up-to-date CCS fell significantly from 80.50 % in 2013 to 75.00 % in 2021 for heterosexual respondents (APC = -0.97 %, <em>p</em> &lt; 0.01), but was stable across years for LGB respondents. Up-to-date CCS decreased for Hispanic (APC = -1.52, <em>p</em> &lt; 01) and non-Hispanic White only heterosexual women (APC = -0.63, <em>p</em> = 0.02). It also decreased for non-Hispanic Black/African American only LGB women (APC = -2.67, <em>p</em> &lt; 0.01) falling from 85.22 % in 2013 to 67.91 % in 2021. By multiplicative interaction, LGB Hispanic women were more up-to-date than their heterosexual counterparts (<em>p</em> = 0.05).</div></div><div><h3>Conclusions</h3><div>In 2021 there were approximately 19.72 million women aged 21–65 who were not up-to-date with CCS. 1.76 million LGB women were not up-to-date for CCS, and a greater proportion of these women identified as non-Hispanic Black/African American. CCS must be improved for all cisgender women, and specific attention should be given to those who identify as LGB and/or Black/African American.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108223"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity-related metabolic signature and cardiometabolic diseases and multimorbidity: A cohort study from UK biobank","authors":"Jiacheng Wang ,&nbsp;Yi Zheng ,&nbsp;Yanfeng Jiang ,&nbsp;Chen Suo ,&nbsp;Tiejun Zhang ,&nbsp;Xingdong Chen ,&nbsp;Kelin Xu","doi":"10.1016/j.ypmed.2024.108211","DOIUrl":"10.1016/j.ypmed.2024.108211","url":null,"abstract":"<div><h3>Objective</h3><div>Physical activity has protective effects on cardiometabolic diseases (CMDs), but the role of metabolism related to physical activity in this process is unclear.</div></div><div><h3>Methods</h3><div>In the prospective cohort study from UK Biobank between 2006 and 2022, participants free of CMDs at baseline were included (<em>n</em> = 73,990). We identified physical activity-related metabolites and constructed metabolic signature using linear regression and elastic net regression. Association between physical activity, metabolic signature, and CMDs (type 2 diabetes [T2D], coronary heart disease [CHD], and stroke) were explored using Cox and mediation analyses. Interactions between the metabolic signature and genetic susceptibility (categorized into “low” and “high” based on the median of polygenic risk scores) were assessed by additive hazard models and relative excess risk due to interaction (RERI). Multi-state models evaluated the association between metabolic signature and disease progression.</div></div><div><h3>Results</h3><div>We found 58 metabolites were related to physical activity, of which 17 were used to construct metabolic signature. The metabolic signature was associated with reduced risk of T2D (HR = 0.13[0.10–0.16]), CHD (HR = 0.40[0.34–0.47]), and stroke (HR = 0.67[0.53–0.86]), and mediated 40.56 % of the association between physical activity and T2D. The metabolic signature exhibited additive interactions with genetic risk for T2D (RERI = 1.57[1.09–2.05]) and CHD (RERI = 0.27[0.05–0.49]). Finally, the metabolic signature was associated with a reduced risk of transition from CMD to CMM (HR = 0.58[0.42–0.81]).</div></div><div><h3>Conclusion</h3><div>Physical activity-related metabolic signature is linked to reduced risks of CMDs and CMM. We once again emphasize the importance of physical activity for CMDs prevention from a metabolic perspective, especially for individuals at high genetic risk.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"191 ","pages":"Article 108211"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}