Preventive medicine最新文献

{"title":"Food insecurity and substance use among young adults in the United States","authors":"Sarah A. Pitman ,&nbsp;Keryn E. Pasch ,&nbsp;Natalie S. Poulos ,&nbsp;Cayley E. Velazquez","doi":"10.1016/j.ypmed.2024.108148","DOIUrl":"10.1016/j.ypmed.2024.108148","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to examine the association between food insecurity and substance use among young adults aged 18–25 in the U.S.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey was completed by a diverse sample of 1024 young adults (50.2 % female; 62 % non-white; <em>m</em> age = 21.7[<em>SD</em> = 2.26]) between January–April 2022. Logistic regression analyses were used to examine the association between food insecurity and current cigarette use, Electronic Nicotine Delivery System (ENDS) use, cannabis use, alcohol use, and binge drinking controlling for socio-demographic and economic factors, mental health, and experiences of discrimination.</div></div><div><h3>Results</h3><div>Nearly 70 % of participants reported being food insecure over the past year. Substance use was also common: 45.9 % of participants reported current cigarette use, 50.9 % ENDS use, 57 % cannabis use, 65.9 % alcohol use, and 50.4 % engaged in binge drinking in the past two weeks. Being food insecure was associated with greater odds of cigarette use (OR = 2.49, 95 % CI = [1.77, 3.50]), ENDS use (OR = 2.18, 95 % CI = [1.58, 3.01]), cannabis use (OR = 1.73, 95 % CI = [1.26, 2.37]), alcohol use (OR = 1.60, 95 % CI = [1.16, 2.19]) and binge drinking (OR = 1.98, 95 % CI = [1.44, 2.72]), controlling for all other factors.</div></div><div><h3>Conclusion</h3><div>Food insecurity may serve as an important indicator of substance use among young adults. Practitioners should consider screening for food insecurity, providing information about food access, and developing interventions to address food insecurity among the young adults with whom they work. Future research should examine these associations prospectively to better understand how food insecurity may contribute to the initiation and/or escalation of substance use.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108148"},"PeriodicalIF":4.3,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atlas on risk factors for gastrointestinal cancers: A systematic review of Mendelian randomization studies","authors":"Yi-Xuan Huang ,&nbsp;Jun-Hua Wu ,&nbsp;Yu-Qiang Zhao ,&nbsp;Wan-Nian Sui ,&nbsp;Tian Tian ,&nbsp;Wen-Xiu Han ,&nbsp;Jing Ni","doi":"10.1016/j.ypmed.2024.108147","DOIUrl":"10.1016/j.ypmed.2024.108147","url":null,"abstract":"<div><h3>Objective</h3><div>Gastrointestinal cancers are one of the most frequent cancer types and seriously threaten human life and health. Recent studies attribute the occurrence of gastrointestinal cancers to both genetic and environmental factors, yet the intrinsic etiology remains unclear. Mendelian randomization is a powerful well-established statistical method that is based on genome-wide association study (GWAS) to evaluate the causal relationship between exposures and outcomes. In the present study, we aimed to conduct a systematic review of Mendelian randomization studies investigating any causal risk factors for gastrointestinal cancers.</div></div><div><h3>Methods</h3><div>We systematically searched Mendelian randomization studies that addressed the associations of genetically predicted exposures with five main gastrointestinal cancers from September 2014 to March 2024, as well as testing the research quality and validity.</div></div><div><h3>Results</h3><div>Our findings suggested robust and consistent causal effects of body mass index (BMI), basal metabolic rate, fatty acids, total cholesterol, total bilirubin, insulin like growth factor-1, eosinophil counts, interleukin 2, alcohol consumption, coffee consumption, apolipoprotein B on colorectal cancer risks, BMI, waist circumference, low-density lipoprotein (LDL), total testosterone, smoking on gastric cancer risks, BMI, fasting insulin, LDL, waist circumference, visceral adipose tissue (VAT), immune cells, type 2 diabetes mellitus (T2DM) on pancreatic cancer risks, waist circumference, smoking, T2DM on esophageal adenocarcinoma risks, and VAT, ferritin, transferrin, alcohol consumption, hepatitis B virus infection, rheumatoid arthritis on liver cancer risks, respectively.</div></div><div><h3>Conclusion</h3><div>Larger, well-designed Mendelian randomization studies are practical in determining the causal status of risk factors for diseases.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108147"},"PeriodicalIF":4.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moral values and vaccination behavior in Russia during the COVID-19 pandemic","authors":"Dmitry Kislitsyn ,&nbsp;Peter Meylakhs ,&nbsp;Dmitry Schapov ,&nbsp;Dmitry Kurakin ,&nbsp;Ekaterina Aleksandrova","doi":"10.1016/j.ypmed.2024.108143","DOIUrl":"10.1016/j.ypmed.2024.108143","url":null,"abstract":"<div><h3>Objective</h3><div>Effective persuasive communication necessitates message matching; the conveyed message should resonate with the recipient's characteristics, including individual moral values. While studies examining the relationship between moral values and vaccination behavior have been conducted in a limited number of countries, this study seeks to provide evidence on this relationship beyond Western democracies.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey was conducted from November 4 to December 17, 2021, in Russia. Participants reported their COVID-19 vaccination behavior and completed the Moral Foundations Questionnaire, designed to measure the endorsement of moral values (<em>n</em> = 415). Regression analysis was employed to assess the association between each moral foundation and COVID-19 vaccination behavior.</div></div><div><h3>Results</h3><div>Our findings indicate that the moral foundations of Care, Loyalty, Fairness, and Sanctity significantly influence vaccination behavior. Individuals who strongly endorse Fairness (AME = −0.019; 95 % CI = −0.033, −0.005) and Sanctity (AME = −0.016; 95 % CI = −0.031, −0.002) were less likely to be vaccinated. Conversely, individuals endorsing Care (AME = −0.018; 95 % CI = −0.031, −0.005) and Loyalty (AME = −0.015; 95 % CI = −0.028, −0.001) were less likely to report refusal of vaccination. These results remain robust after adjusting for sociodemographic variables related to vaccination barriers.</div></div><div><h3>Conclusion</h3><div>Our findings carry public health implications; an understanding of the moral psychology underlying vaccination behavior can facilitate more targeted and effective health communication. Employing skillfully crafted moral appeals may mitigate negative attitudes toward vaccination and enhance vaccination rates.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108143"},"PeriodicalIF":4.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the evidence on physical activity prescriptions for youth","authors":"Elizabeth L. Budd ,&nbsp;Esmeralda Castro ,&nbsp;Heather F. Terral ,&nbsp;Zachary S. Farley ,&nbsp;Nichole R. Kelly","doi":"10.1016/j.ypmed.2024.108145","DOIUrl":"10.1016/j.ypmed.2024.108145","url":null,"abstract":"<div><h3>Objective</h3><div>Despite the well-documented benefits of physical activity (PA), globally, only 20 % of youth engage in sufficient PA. Reviews support the benefits of PA prescriptions on promoting adults' PA, but no comparable reviews exist on studies among youth. This systematic review 1) assesses the state of the evidence regarding PA prescriptions from healthcare practitioners on youths' PA; and 2) identifies gaps to inform future research and practice.</div></div><div><h3>Methods</h3><div>A search of five databases in October 2023 identified 3067 articles. After title and/or abstract reviews, 64 full articles were reviewed for inclusion criteria. Study, sample, and PA prescription characteristics and findings regarding youths' PA were extracted.</div></div><div><h3>Results</h3><div>Nine articles published 2001–2023 from the United States (<em>n</em> = 6), Spain (<em>n</em> = 1), Northern Ireland (<em>n</em> = 1), and the United States and Mexico (<em>n</em> = 1) were identified. Seven occurred in medical settings and two in schools. Study designs were generally strong (e.g., randomized controlled trials) and study durations were generally short (3–4 months). All but two studies measured youths' PA with self-report questionnaires. Most PA prescriptions were provided in verbal and written forms and tailored based on youths' baseline PA. Overall, healthcare practitioner-delivered PA prescriptions show minimal effects on youths' PA. Neither of the two studies that objectively measured PA found significant PA increases in objectively measured PA.</div></div><div><h3>Conclusions</h3><div>There is insufficient research on healthcare practitioner delivered PA prescriptions to promote youths' PA to determine effectiveness. Future research with objectively measured PA and more diverse youth samples would advance the evidence.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108145"},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in exposure to second-hand smoke among adolescent boys and girls in 122 countries: Evidence from the Global Youth Tobacco Survey","authors":"Boyi Huai,&nbsp;Kiara C-M Chang,&nbsp;Filippos T. Filippidis","doi":"10.1016/j.ypmed.2024.108146","DOIUrl":"10.1016/j.ypmed.2024.108146","url":null,"abstract":"<div><h3>Background</h3><div>Secondhand smoke exposure (SHS) is a major modifiable risk factor for morbidity and premature mortality. No study has assessed inequalities by sex in SHS exposure among adolescents globally. This study aims to explore the variations in SHS exposure among adolescents globally based on sex.</div></div><div><h3>Methods</h3><div>Most recent data from 122 countries and territories that conducted the Global Youth Tobacco Survey between 1 January 2013 and 31 December 2020, comprising 557,332 respondents aged 11–17 years, were used to assess the prevalence of SHS exposure at home, in other enclosed public places, and at school. Multivariable Poisson regression models were performed to investigate the association between sex and SHS exposure in each country.</div></div><div><h3>Results</h3><div>A total of 195,299 (35.0 %) adolescents reported exposure to SHS at home, 256,938 (46.1 %) in other enclosed public places, 258,528 (46.4 %) at school, and 399,644 (71.7 %) in any place. There were important inequalities in the prevalence of SHS exposure between countries. More girls than boys reported exposure to SHS at home in 54 countries (vs. one country with prevalence higher in boys than girls) and in other enclosed public places in 50 countries (vs. six countries). In contrast, the prevalence of SHS exposure at school was significantly higher in boys than girls in 25 countries while the opposite was observed in 14 countries.</div></div><div><h3>Conclusions</h3><div>These findings emphasize the disparities in SHS exposure between adolescent boys and girls and, hence, highlight the urgent need to strengthen smoke-free policies and adopt targeted policies to address them.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108146"},"PeriodicalIF":4.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis evaluating the effectiveness of minimally supervised home and community exercise interventions in improving physical activity, body adiposity and quality of life in adults living with HIV","authors":"Jeannine Anyingu A. Aminde ,&nbsp;Nicola W. Burton ,&nbsp;Caroline Thng ,&nbsp;Kelly Clanchy","doi":"10.1016/j.ypmed.2024.108144","DOIUrl":"10.1016/j.ypmed.2024.108144","url":null,"abstract":"<div><div>People living with HIV (PLWH) are physically inactive and risk cardiometabolic dysfunction. Home and community exercise (HCE) is pragmatic, cost-effective and improves health in varied chronic conditions. This review aimed to synthesize evidence on the effectiveness of minimally supervised HCE for physical activity (PA), adiposity, quality of life (QoL), and other physical and psychological health indices for PLWH.</div></div><div><h3>Methods</h3><div>Databases were searched for studies published January 2000 to April 2023. Risk of bias in experimental and quasi-experimental studies was assessed with the Cochrane Risk-of-Bias for Randomized Trials and Risk-of-Bias in Non-Randomized Studies of Interventions tools, respectively. A random-effects meta-analysis was conducted.</div></div><div><h3>Results</h3><div>From 9648 records, 13 studies (14 HCE groups) with 857 PLWH (average ages 29-56 years) were included; 12 comparator and one single group trial. Aerobic and strength HCE significantly improved PA relative to control by 0.377 units (95 %CI = 0.097, 0.657; <em>p</em> = 0.008) and 1097steps/day (95 %CI = 39.27, 2156.62; <em>p</em> = 0.042). There was a reduction from baseline in percent body fat of 3.36 % (95 %CI = -6.10, 0.42; <em>p</em> = 0.025), but no change in BMI (−0.21 kg/m2; 95 %CI = -0.67, 0.24; <em>p</em> = 0.351) relative to control. HCE improved QoL relative to control in the physical domain by 13points (95 %CI = 6.15, 19.86; <em>p</em> &lt; 0.001), but not in other domains like general health (6.6points; 95 %CI = -1.19, 14.36; <em>p</em> &lt; 0.097). HCE completed at moderate intensity or higher was associated with improvement in outcomes more so than lower intensity HCE. Walking-only interventions were at least as beneficial as other activities. No adverse events were recorded.</div></div><div><h3>Conclusion</h3><div>Minimally supervised HCE can improve PA, body fat, physical QoL and other health indices in PLWH.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108144"},"PeriodicalIF":4.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“I've been really happy since I got that letter!”: Longitudinal patient perspectives on lung cancer screening communication","authors":"Sara E. Golden ,&nbsp;Liana Schweiger ,&nbsp;Sarah Ono ,&nbsp;Anne C. Melzer ,&nbsp;Santanu Datta ,&nbsp;James Davis ,&nbsp;Christopher Slatore","doi":"10.1016/j.ypmed.2024.108142","DOIUrl":"10.1016/j.ypmed.2024.108142","url":null,"abstract":"<div><h3>Objective</h3><div>Experts recommend structured shared decision making when discussing lung cancer screening (LCS) and reporting low-dose computed tomography (LDCT) results. We examined patients' reactions to pre- and post-LDCT results communication processes at three medical centers in the US with established LCS programs.</div></div><div><h3>Methods</h3><div>Multicenter, qualitative, longitudinal study of patients considering and receiving LCS using data from semi-structured interviews guided by a patient-centered communication model using conventional content analysis. We conducted 61 interviews among 32 patients (sixteen of whom had a nodule on their LDCT) at one month and 12 months after an initial LCS decision making interaction.</div></div><div><h3>Results</h3><div>Participants were mostly satisfied with LCS communication processes pre- and post-LDCT even though guideline concordant shared decision making was rare. Most participants reported no more than mild distress even if the LDCT detected a pulmonary nodule, felt relief after getting the results, and reported the perceived benefits of LCS outweighed their distress. Nearly all participants were satisfied with recommended follow-up plans. They reported that they trusted their clinicians and health care system to provide appropriate care and recommendations. They did not appear to regret their decision since almost all participants planned to get their next LDCT. However, they were at risk of non-adherence to follow-up recommendations since they often relied on the health care system to ensure they received timely follow-up.</div></div><div><h3>Conclusions</h3><div>Despite receiving guideline discordant decision-making communication, patients seem very satisfied, rarely experience severe distress, and have low decisional regret after LCS decision making and receiving the results of their LDCT.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108142"},"PeriodicalIF":4.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn pulse oximetry screening coverage in a nationwide complex survey sample: An assessment of a congenital heart disease early detection program at the regional level in Brazil","authors":"Arn Migowski ,&nbsp;Gustavo Tavares Lameiro da Costa ,&nbsp;Helena Cramer Veiga Rey","doi":"10.1016/j.ypmed.2024.108141","DOIUrl":"10.1016/j.ypmed.2024.108141","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the coverage of newborn pulse oximetry screening (POS) in Brazil, as well as identifies associated factors and the proportion of positive screening results.</div></div><div><h3>Methods</h3><div>Coverage was estimated based on the most recent National Health Survey (2019). Adjusted marginal prevalence ratios were estimated via poisson regression model with robust variance.</div></div><div><h3>Results</h3><div>The POS coverage was 66.3 % (95 %CI: 65.5–67.1; <em>N</em> = 3,140,023) and was higher in children born in privately funded hospitals (PFHs) than in the Unified Health System (SUS): 78.1 % (76.7–79.5) versus 61.1 % (60.2–62.1). In the North region, the POS coverage in PFHs (64.9 %, 59.7–70.1) was lower than that in the South (82.5 %, 79.4–85.6) and the Southeast (81.5 %, 79.3–83.6); it was even lower in SUS in the North (44.0 %; 42.4–45.6). After a federal ordinance providing financial resources to postscreening diagnostic, the screening coverage in SUS increased from 57.6 % (56.2–59.1) to 64.6 % (63.3–65.9). The proportion of positive screening tests was 9.2 % (8.9–9.5) in SUS and 7.8 % (7.3–8.3) in PFHs, of which 40.8 % (40.5–41.1) underwent complementary exams in SUS and 57.2 % (56.7–57.7) in PFHs. In the multivariate model, the main independent predictors of POS were the coverage of other newborn screening tests.</div></div><div><h3>Conclusions</h3><div>Inequalities were found between major regions and healthcare systems. Government financial incentives have reduced this inequality, although the percentage of postscreening complementary exams remains insufficient and unequal. The main independent predictors of screening prevalence were those related to the organization of health services.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108141"},"PeriodicalIF":4.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091743524002962/pdfft?md5=c267af2118b2a8aab8d382ff656d8916&pid=1-s2.0-S0091743524002962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to promote colorectal cancer screening among people with a family history of colorectal cancer: A scoping review","authors":"Tun Firzara Abdul Malik ,&nbsp;Hooi Chin Beh ,&nbsp;Christine Shamala Selvaraj ,&nbsp;Christian David Mallen ,&nbsp;Chirk Jenn Ng ,&nbsp;Yew Kong Lee","doi":"10.1016/j.ypmed.2024.108137","DOIUrl":"10.1016/j.ypmed.2024.108137","url":null,"abstract":"<div><h3>Background</h3><div>The global incidence of colorectal cancer (CRC) is rising, with people having a family history of CRC (PFH-CRC) facing double the risk compared to the average-risk population. Despite this, CRC screening uptake among PFH-CRC remains low. There is a lack of systematic mapping of interventions promoting CRC screening in this high-risk population.</div></div><div><h3>Objective</h3><div>We conducted a scoping review to identify the types of interventions targeting PFH-CRC, their effectiveness in increasing CRC screening uptake, and the elements associated with the outcomes.</div></div><div><h3>Methods</h3><div>The Joanna Briggs Institute methodology for scoping review was followed. The search for eligible articles was conducted from the inception of each database until 17 July 2024 in PubMed, EMBASE, CINAHL, Cochrane, PsycINFO and Web of Science with no restrictions on language.</div></div><div><h3>Results</h3><div>Thirty studies from 1995 to 2023 across 13 countries were included; mostly from high-income countries. There was considerable variability in study design, intervention characteristics, and screening outcomes. Eleven studies used theoretical frameworks in intervention development. Fourteen studies reported statistically significant increases in screening uptake among PFH-CRC, most using complex, multiple-component interventions. Tailored print materials and patient navigation more consistently demonstrated increased screening uptake, while counselling yielded mixed results.</div></div><div><h3>Conclusion</h3><div>Interventions for promoting CRC screening uptake in PFH-CRC commonly incorporate print material, patient navigation and counselling, often combined into complex interventions. Future research should include more implementation studies to translate these interventions into real-world settings. Additionally, there are gaps in research from low- and middle-income countries, highlighting the need for further research in these resource-limited settings.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108137"},"PeriodicalIF":4.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity and the N-terminal pro-brain natriuretic peptide in a middle-aged Japanese population: The interaction with alcohol consumption, 2005–2006","authors":"Yuichiro Nishida ,&nbsp;Megumi Hara ,&nbsp;Naoto Taguchi ,&nbsp;Kazuyo Nakamura ,&nbsp;Hinako Nanri ,&nbsp;Takeshi Imaizumi ,&nbsp;Tatsuhiko Sakamoto ,&nbsp;Chisato Shimanoe ,&nbsp;Mikako Horita ,&nbsp;Takuma Furukawa ,&nbsp;Chiharu Iwasaka ,&nbsp;Koichi Shinchi ,&nbsp;Yasuki Higaki ,&nbsp;Keitaro Tanaka","doi":"10.1016/j.ypmed.2024.108138","DOIUrl":"10.1016/j.ypmed.2024.108138","url":null,"abstract":"<div><h3>Objective</h3><p>Higher N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are a strong risk factor for cardiovascular disease. The current study aimed to clarify the cross-sectional association of physical activity (PA) with NT-proBNP and to identify the interaction of PA with alcohol consumption or cigarette smoking in middle-aged individuals.</p></div><div><h3>Methods</h3><p>The study included 4613 individuals (1824 men and 2789 women) (November 2005–November 2006). Total PA, steps, light-intensity PA (LPA), and moderate-to-vigorous-intensity PA (MVPA) were assessed using accelerometer. Serum NT-proBNP levels were measured. Cross-sectional associations of total PA and steps with NT-proBNP were analyzed using multiple regression with adjustment for potential confounders. The isotemporal substitution model was used to assess activity intensity-specific association. The interaction between PA and alcohol consumption or smoking was also examined.</p></div><div><h3>Results</h3><p>Total PA was independently and inversely associated with NT-proBNP in the entire sample (<em>P</em> = 0.04). The inverse association of substituting LPA with MVPA for NT-proBNP was clearer in men than in women (<em>P</em>_interaction = 0.04). Inverse associations of total PA or steps with NT-proBNP were clearer in heavy drinkers than in moderate drinkers and non-drinkers in the entire sample (<em>P</em>_interaction &lt; 0.05). In men, the inverse association of substituting LPA with MVPA for NT-proBNP was also clearer in heavy drinkers (<em>P</em>_interaction = 0.02). No interactions of PA with smoking were detected.</p></div><div><h3>Conclusions</h3><p>Higher total PA was associated with better NT-proBNP in middle-aged individuals. Additionally, the effect of substituting LPA with MVPA on NT-proBNP was greater in men than in women. Furthermore, the association between PA and NT-proBNP may be modified by alcohol consumption.</p></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108138"},"PeriodicalIF":4.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}