Preventive medicine最新文献

{"title":"Association of ‘weekend warrior’ physical activity pattern and erectile dysfunction: A large cross-sectional study in Brazil","authors":"Eduardo Rossato de Victo ,&nbsp;Rafael Mathias Pitta ,&nbsp;Luana de Lima Queiroga ,&nbsp;Gerson Ferrari ,&nbsp;Claudio Farias-Valenzuela ,&nbsp;Paloma Ferrero-Hernández ,&nbsp;Oskar Kaufmann ,&nbsp;Nelson Wolosker","doi":"10.1016/j.ypmed.2025.108352","DOIUrl":"10.1016/j.ypmed.2025.108352","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between the weekend warrior physical activity pattern and erectile dysfunction, including analyses stratified by age group and obesity.</div></div><div><h3>Methods</h3><div>Data from 15,655 men aged &gt;40 screened at a Brazilian hospital (2008–2022) were analyzed. Physical activity was assessed using the International Physical Activity Questionnaire. Participants were grouped into three physical activity patterns: not meeting recommendations (defined as &lt;150 min/week of moderate-to-vigorous physical activity), weekend warrior (defined as ≥150 min/week on one or two days), and regularly active (defined as ≥150 min/week on three or more days). Erectile dysfunction was assessed using the International Index of Erectile Function score (&lt;22 indicating erectile dysfunction). Logistic regression tested the association between erectile dysfunction and physical activity patterns using unadjusted and adjusted models (adjusted for age, lifestyle and clinical conditions).</div></div><div><h3>Results</h3><div>Erectile dysfunction prevalence was 22.4 %. The weekend warrior pattern was initially associated with erectile dysfunction, but this association lost significance after adjustment. The regularly active pattern remained associated with lower erectile dysfunction likelihood in adjusted model (OR: 0.90; 95 %CI: 0.82–0.99). Among adults, this association persisted (OR: 0.90; 95 %CI: 0.82–0.99). In non-obese individuals, the regularly active pattern was also associated with lower erectile dysfunction likelihood (OR: 0.88; 95 %CI: 0.79–0.98), while in obese individuals, the association was significant only in the unadjusted model.</div></div><div><h3>Conclusion</h3><div>The weekend warrior pattern did not show significance in adjusted models, while the regularly active pattern is associated with a lower likelihood of erectile dysfunction, particularly among adults and non-obese individuals.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108352"},"PeriodicalIF":4.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherosclerotic cardiovascular disease measures in foreign-born Latino patients by country of birth compared with U.S.-born Latinos","authors":"Nakai Corral ,&nbsp;N.D. Jorge Kaufmann ,&nbsp;Miguel Marino ,&nbsp;Jennifer A. Lucas ,&nbsp;Steffani R. Bailey ,&nbsp;Dave Boston ,&nbsp;Sophia Giebultowicz ,&nbsp;John Heintzman","doi":"10.1016/j.ypmed.2025.108349","DOIUrl":"10.1016/j.ypmed.2025.108349","url":null,"abstract":"<div><h3>Objective</h3><div>The burden of atherosclerotic cardiovascular disease (ASCVD) may differ based on the country of birth in Latinos, therefore, we aimed to examine differences in the utilization of ASCVD screening services, which have not been studied using large healthcare datasets.</div></div><div><h3>Methods</h3><div>Data included electronic health record (EHR) data from a multistate network of United States (U.S.) community health centers from 2014 to 2020. The study population (<em>N</em> = 49,177) was foreign-born Latinos (from ten different Latin countries) and U.S.-born Latino patients aged 40–83 years seeking care at 149 U.S. community health centers across 14 states. To compare the prevalence of documented medical record data necessary for ASCVD risk calculation, we performed a cross-sectional anlaysis, using logistic regression, adjusted for demographic and health services utilization factors.</div></div><div><h3>Results</h3><div>The adjusted odds ratio (aOR) comparing foreign-born to U.S.-born Latinos was 1.17 (95 % CI = 1.01, 1.35). When stratifying by country of birth, patients from specific countries had higher odds of documented data when compared to their U.S.-born counterparts (Dominican Republic: aOR = 1.13, 95 % CI = 1.03, 1.24; El Salvador: aOR = 1.26, 95 % CI = 1.08, 1.47; Guatemala: aOR = 1.17, 95 % CI = 1.02, 1.34; Mexico: aOR = 1.19, 95 % CI = 1.01, 1.41).</div></div><div><h3>Conclusions</h3><div>Foreign-born Latinos from El Salvador, Guatemala, the Dominican Republic, and Mexico are more likely to have documented information in their EHR necessary to assess cardiovascular risk. These findings underscore the clinical importance of data disaggregation in Latino patients as specific national birthplace may be associated with the adequacy of cardiovascular screening.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108349"},"PeriodicalIF":4.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal relationships between the built and natural environment, air pollution, noise and dementia: results from two UK-based cohort studies","authors":"Yu-Tzu Wu ,&nbsp;Sean Beevers ,&nbsp;Benjamin Barratt ,&nbsp;Carol Brayne ,&nbsp;Ester Cerin ,&nbsp;Rachel Franklin ,&nbsp;Victoria Houlden ,&nbsp;Bob Woods ,&nbsp;Eman Zied Abozied ,&nbsp;Matthew Prina ,&nbsp;Fiona Matthews","doi":"10.1016/j.ypmed.2025.108348","DOIUrl":"10.1016/j.ypmed.2025.108348","url":null,"abstract":"<div><h3>Objective</h3><div>Recent epidemiological studies have investigated a variety of environmental risk factors for dementia. However, most existing studies have focused on single environmental factors and reported mixed results. The aim of this study is to examine the interrelationships between multiple environment factors and their joint associations with cognitive health in later life.</div></div><div><h3>Methods</h3><div>This study was based on the Cognitive Function and Ageing Study II and Wales, two population-based cohort studies of 11,055 people aged ≥65 across five urban and rural areas in the UK. Using geospatial data, a wide range of environmental variables were generated for the participants and integrated into five domains through a latent approach, including the built environment, natural environment, noise, air pollution and deprivation. Multistate modelling was used to investigate their longitudinal associations with dementia and death adjusting for individual sociodemographic factors.</div></div><div><h3>Results</h3><div>The effect sizes of joint associations between the built environment (HR: 1.00; 95 %CI: 0.66, 1.52), natural environment (HR: 0.95; 95 %CI: 0.66, 1.36), air pollution (HR: 0.91; 95 %CI: 0.78, 1.07), deprivation (HR: 1.02; 95 %CI: 0.96, 1.09) and incident dementia were generally small. The strongest association was found in noise, where a high level of exposure was associated with an increased risk of incident dementia (HR: 1.22; 95 %CI: 0.97, 1.54). However, the confidence intervals were wide.</div></div><div><h3>Conclusions</h3><div>The joint associations between multiple environmental factors and incident dementia were found to be modest. Given mixed results in this field, future research should address methodological challenges and enhance evidence for population-level interventions on dementia risk factors.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108348"},"PeriodicalIF":4.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in smokers' responses to novel efficacy messages inside cigarette packages following Canada's 2024 labeling policy update: A pre-post longitudinal study","authors":"Yanwen Sun ,&nbsp;Desiree Vidana-Perez ,&nbsp;Jeff Niederdeppe ,&nbsp;Minji Kim ,&nbsp;Chih-Hiang Yang ,&nbsp;Emily Hackworth ,&nbsp;David Hammond ,&nbsp;James F. Thrasher ,&nbsp;on behalf of the Insert Project Team","doi":"10.1016/j.ypmed.2025.108347","DOIUrl":"10.1016/j.ypmed.2025.108347","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the impact of Canada's innovative inside-pack efficacy messages about cessation benefits and tips to quit, whose content was updated in 2024.</div></div><div><h3>Methods</h3><div>We analyzed data from an open cohort of Canadian adults who smoke, surveyed every three months from February 2023 to November 2024 (<em>n</em> = 12,022 observations, 4716 individuals). At each survey, participants reported the frequency of reading health messages inside packs in the past 30 days (Never/Rarely = reference vs Sometimes/Often/Very often); perceived cessation benefits from inside-pack messages (Not at all-Extremely); forgoing cigarettes due to inside-pack messages in the prior 30 days (No = reference vs Yes); and confidence/self-efficacy to quit smoking (Not at all–Extremely). Linear and logistic generalized estimating equation models regressed these outcomes on implementation period (pre- vs post-implementation surveys). Analyzing participants followed to the subsequent survey (<em>n</em> = 6959 observations, 2356 individuals), mixed-effects logistic models regressed quit attempts in the three-month interval since the prior survey on message responses from the prior survey. All models adjusted for sociodemographics, smoking-related variables, and post-stratification weights.</div></div><div><h3>Results</h3><div>Self-reported reading inside-pack messages (OR = 1.18; 95 %CI = 1.04, 1.34), perceived cessation benefits (β = 0.07; 95 %CI = 0.01, 0.12), forgoing cigarettes (OR = 1.14; 95 %CI = 1.01, 1.28), and self-efficacy (β = 0.08; 95 %CI = 0.04, 0.13) all increased from pre-to post-implementation. Participants who reported reading messages more frequently (OR = 1.54; 95 %CI = 1.09–2.00), perceived greater cessation benefits (OR = 1.31; 95 %CI = 1.22, 1.42), forwent cigarettes (OR = 1.88; 95 %CI = 1.48, 2.37) and had greater self-efficacy (OR = 1.32; 95 %CI = 1.19, 1.47) were more likely to quit at followup.</div></div><div><h3>Conclusions</h3><div>After Canada implemented new efficacy messages inside packs, message engagement and predictors of cessation behaviors increased. Other countries may consider similar policies.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108347"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health and COVID-19 vaccination: An individual participant data meta-analysis of adult Latino participants","authors":"Stephanie De Anda ,&nbsp;Elizabeth L. Budd ,&nbsp;Pimwadee Chaovalit ,&nbsp;Amy H. Vu ,&nbsp;Leslie D. Leve ,&nbsp;David S. DeGarmo","doi":"10.1016/j.ypmed.2025.108335","DOIUrl":"10.1016/j.ypmed.2025.108335","url":null,"abstract":"<div><h3>Objective</h3><div>Although disparities in vaccination have been well documented, limited research has examined how specific Social Determinants of Health (SDOH) are associated with COVID-19 vaccination outcomes among Latino subgroups. The aims of the study are to investigate 1) the relative effects of distinct SDOH on reasons for and against vaccination among Latino adults and 2) how these effects may vary by language spoken at home.</div></div><div><h3>Methods</h3><div>A meta-analysis was conducted utilizing person- and study-level data from 13,406 Latino participants in the United States across 12 study samples from 2020 to 2023. Analyses evaluated SDOH effects on (a) reasons for and (b) against vaccination, as well as (c) the ratio of the two. Three SDOH were entered in a single model to compare their relative effect sizes: education, economic insecurity, and healthcare insecurity.</div></div><div><h3>Results</h3><div>Education and economic insecurity had the largest effect sizes compared to healthcare insecurity, which was not associated with outcomes. Greater economic insecurity was associated with more reasons against relative to reasons for vaccination. Spanish spoken at home moderated the effect of education levels, increasing both reasons for and against vaccination for highly educated participants, relative to non-Spanish speaking participants.</div></div><div><h3>Conclusions</h3><div>Findings inform future efforts aimed at reducing health disparities. The overall pattern of results suggests tailored interventions aimed at supporting COVID-19 vaccine attitudes in Latino communities should provide supports early and in accessible formats<em>,</em> particularly for communities with low educational levels and who use Spanish at home.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108335"},"PeriodicalIF":4.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A content analysis of cannabis edible product characteristics, packaging features, and online promotions","authors":"Bing Han,&nbsp;Yuyan Shi","doi":"10.1016/j.ypmed.2025.108336","DOIUrl":"10.1016/j.ypmed.2025.108336","url":null,"abstract":"<div><h3>Objective</h3><div>As legal cannabis markets expand in the United States, edibles have become increasingly popular, particularly among youth. This study aimed to assess cannabis edible product characteristics, packaging features, and online promotions that may be appealing or misleading to consumers.</div></div><div><h3>Methods</h3><div>During November 2023 and August 2024, we identified active online cannabis dispensaries in the United States from the National Cannabis Industry Association's member directory and conducted a content analysis of 2282 cannabis edible products to assess front-of-package information on product characteristics, child-oriented features, health and non-health claims, warnings, as well as online promotional strategies.</div></div><div><h3>Results</h3><div>Over half of the products were gummies, and more than 80 % contained at least 100 mg of total tetrahydrocannabinol (THC). Few packages included individual packaging or serving size information. Child-appealing elements were prevalent: over 20 % of products displayed animated or human-like characters, nearly all products were flavored with fruit flavor being the most common, and more than half featured packaging with four or more colors. Non-health claims appeared on 27.7 % of products, cannabis-infused labels on 48.1 %, and underage use warnings on 16.4 %. Product-specific promotions were present for 77.0 % of products, and nearly all had storewide promotions.</div></div><div><h3>Conclusions</h3><div>Cannabis companies frequently utilized marketing strategies that may make edibles appealing or misleading to consumers, particularly youth. Further research understanding how these marketing strategies influence consumer perceptions and appeal is needed to inform regulations on cannabis packaging and promotion.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108336"},"PeriodicalIF":4.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the relationship between mental health and e-cigarette initiation among sexual and gender minority youth and young adults in the United States compared to their cisgender, heterosexual peers, 2021–2023","authors":"Elexis C. Kierstead ,&nbsp;Padmini Kucherlapaty ,&nbsp;Michael S. Liu ,&nbsp;Elizabeth K. Do ,&nbsp;Cassandra Brazinsky ,&nbsp;Elizabeth C. Hair","doi":"10.1016/j.ypmed.2025.108331","DOIUrl":"10.1016/j.ypmed.2025.108331","url":null,"abstract":"<div><h3>Objective</h3><div>To understand the relationship between mental health, e-cigarette use and sexual and gender minority (SGM) identity given that minority stress worsens mental health and poor mental health increases the risk of e-cigarette use among SGM people.</div></div><div><h3>Methods</h3><div>Data were obtained from a United States probability-based longitudinal cohort study of 15–21 year olds, recruited in Fall 2021 and followed through Fall 2023. The analytic sample included participants who had not used e-cigarettes prior to Fall 2021 (<em>N</em> = 1908). Participants who identified as lesbian or gay, bisexual or another identity; or whose sex assigned at birth differed from their gender identity, were considered SGM. Mental health was assessed using the Depression, Anxiety, and Stress (DASS-21) scale. Weighted bivariate analyses examined mental health, e-cigarette initiation, and demographics by SGM identity. Weighted logistic regression models stratified by SGM identity examined the relationship between mental health and e-cigarette initiation, controlling for covariates.</div></div><div><h3>Results</h3><div>Approximately 21.6 % of the sample identified as SGM and 10.8 % initiated e-cigarette use by 2023. Significantly more SGM participants reported severe or extremely severe mental health symptoms (45.5 % vs. 22.4 %, <em>p</em> &lt; 0.001). Poor mental health significantly predicted e-cigarette initiation among SGM participants (aOR: 2.50, 95 % CI: 1.10, 5.69), but not among non-SGM participants (aOR:1.65, 95 % CI: 0.97, 2.82).</div></div><div><h3>Conclusions</h3><div>Results inform prevention and cessation messaging for SGM youth. Tailored mental health resources could reduce the burden of nicotine addiction on this community.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108331"},"PeriodicalIF":4.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Firearm violence victimization among youth and young adults: A socio-ecological analysis of risk and protective factors","authors":"Bruce G. Taylor ,&nbsp;Caroline Lancaster ,&nbsp;Elizabeth A. Mumford ,&nbsp;Jackie Sheridan-Johnson ,&nbsp;Chandler C. Carter ,&nbsp;Kimberly J. Mitchell ,&nbsp;Weiwei Liu","doi":"10.1016/j.ypmed.2025.108332","DOIUrl":"10.1016/j.ypmed.2025.108332","url":null,"abstract":"<div><h3>Objective</h3><div>To examine individual, interpersonal, community/societal, and policy-level risk and protective factors associated with firearm violence victimization (FVV) among persons 10–34 years old, and to assess age group differences in these associations.</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 5311) were drawn from the AmeriSpeak panel (September 2023–January 2024), a nationally representative United States sample. Data sources included online surveys, the U.S. Census, FBI crime reports, and a state firearm law database. Structural equation modeling assessed multi-level influences on FVV, incorporating firearm access, carrying, and attitudes (FACSA), prior victimization, and other social, policy, and demographic factors. Interaction terms were used to assess age differences (10–17 years old versus 18–34 years old).</div></div><div><h3>Results</h3><div>In the fully specified model, only two variables—FACSA and Juvenile Victimization, Perpetration, and Trauma History (JVPTH) —remained statistically significant predictors of FVV. Permissive firearm laws indirectly elevated FVV risk by increasing firearm exposure. Age-stratified interactions showed no statistically significant differences in predictors between youth and young adults. This suggests that FACSA and JVPTH risk factors operate similarly across developmental stages.</div></div><div><h3>Conclusions</h3><div>Firearm-related behaviors and early-life trauma are central drivers of FVV. These two factors accounted for the greatest risk when controlling for other influences. Policy Implications: Prevention strategies should integrate early-life trauma intervention, firearm behavior education, and structural reforms to prevent FVV. Also, violence interruption strategies targeted toward young persons with histories of victimization could help prevent FVV. Addressing upstream firearm access and trauma exposure is critical to reducing FVV risk across developmental stages.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"197 ","pages":"Article 108332"},"PeriodicalIF":4.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Support staff distribution in K–12 US schools that experience shootings: A matched analysis” [Preventive Medicine, Volume 196, 2025 Jul;108296]","authors":"Keith L. Hullenaar ,&nbsp;Frederick Rivara ,&nbsp;Eric J. Bruns","doi":"10.1016/j.ypmed.2025.108333","DOIUrl":"10.1016/j.ypmed.2025.108333","url":null,"abstract":"","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"197 ","pages":"Article 108333"},"PeriodicalIF":4.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between locomotive syndrome and metabolic syndrome: A 6-year longitudinal study in Japanese workers","authors":"Takahiko Yoshimoto ,&nbsp;Tomohiro Shinozaki ,&nbsp;Ko Matsudaira","doi":"10.1016/j.ypmed.2025.108334","DOIUrl":"10.1016/j.ypmed.2025.108334","url":null,"abstract":"<div><h3>Objective</h3><div>Locomotive syndrome (LS), characterized by reduced mobility due to musculoskeletal problems, and metabolic syndrome (MetS) are significant public health concerns with considerable societal impact. This study aimed to investigate the bidirectional association between LS and MetS in a cohort of Japanese manufacturing workers using a 6-year longitudinal dataset.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used annual health checkup data from actively employed adults (aged ≥40) from 2016 to 2022. LS was assessed using the LS Risk Test, including the Two-Step Test, modified Stand-Up Test, and Geriatric Locomotive Function Scale. Cox proportional hazards models estimated hazard ratios (HRs) and 95 % confidence intervals (CIs) for the incidence of MetS and LS according to baseline status. Covariates included age, sex, and lifestyle-related behaviors. Sensitivity analyses excluding the COVID-19 pandemic period and subgroup analyses were also conducted.</div></div><div><h3>Results</h3><div>Among the 4301 participants without MetS at baseline, 20.4 % developed MetS during the follow-up period. LS was associated with an increased risk of MetS (adjusted HR: 1.34, 95 % CI: 1.16, 1.55). In contrast, among the 3359 participants without LS at baseline, 38.5 % developed LS; however, MetS was not associated with the incidence of LS (adjusted HR: 1.07, 95 % CI: 0.88, 1.31). Additional analyses confirmed the robustness of the findings.</div></div><div><h3>Conclusions</h3><div>LS was a significant risk factor for MetS, but MetS did not contribute to LS progression. These findings highlight the importance of mobility preservation in MetS prevention and suggest the need for workplace interventions that target musculoskeletal health among aging workers.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"198 ","pages":"Article 108334"},"PeriodicalIF":4.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}