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The Role of the Thymus Gland in Atopic Dermatitis 胸腺在特应性皮炎中的作用
Journal of Dermatology Research Reviews & Reports Pub Date : 2024-03-31 DOI: 10.47363/jdmrs/2024(5)154
Glen Alvin, Mike Chan
{"title":"The Role of the Thymus Gland in Atopic Dermatitis","authors":"Glen Alvin, Mike Chan","doi":"10.47363/jdmrs/2024(5)154","DOIUrl":"https://doi.org/10.47363/jdmrs/2024(5)154","url":null,"abstract":"The thymus gland is a vital organ for maintaining a vigilant immune system. It develops at the perinatal stage, maturing during childhood and involutes during adolescence. The thymus secretes numerous cells, chemokines and lymphokines to sustain its function. The Thymus and activation-regulated chemokine (TARC/CCL17) is a member of the T-helper 2 chemokine that aids in immunosurveillance in allergic disease. The TARC is a robust objective biomarker involved in the pathogenesis of Atopic Dermatitis, enabling the monitoring of many aspects of the disease. Arguably, it is currently the most sensitive clinical biomarker of Atopic Dermatitis. TARC has enabled atopic dermatologic management to be precise and personal. The regeneration of the thymus gland will be favourable to conserving many of its essential tasks in the body.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews & Reports","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140360085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous Oral Bullous Pemphigoid and Paraneoplastic Pemphigus Following Photoimmunotherapy 光免疫疗法后同时出现口腔大疱性类天疱疮和副肿瘤性类天疱疮
Journal of Dermatology Research Reviews & Reports Pub Date : 2024-02-29 DOI: 10.47363/jdmrs/2024(5)153
Joseph D Harrington, Brandon M Locke, Robert J Diecidue
{"title":"Simultaneous Oral Bullous Pemphigoid and Paraneoplastic Pemphigus Following Photoimmunotherapy","authors":"Joseph D Harrington, Brandon M Locke, Robert J Diecidue","doi":"10.47363/jdmrs/2024(5)153","DOIUrl":"https://doi.org/10.47363/jdmrs/2024(5)153","url":null,"abstract":"Head and neck cancers pose a significant challenge to clinicians to treat the disease while limiting the amount of morbidity to the patient. Given this need, new trials and medications have been explored to provide tissue sparing therapies. One of these methods being trialed at our institution is photoimmunotherapy with the PD1 inhibitor pembrolizumab. A patient with multiple recurrences of squamous cell carcinoma of the oral cavity underwent trial with photoimmunotherapy, but developed severe lip ulceration and swelling that required the patient to discontinue the trial. Biopsy and antibody testing revealed elevated levels of BP180 and BP230 indicating bullous pemphigoid. In addition, elevated Envoplakin was noted confirming a simultaneous paraneoplastic pemphigus diagnosis. Given the growing number of case reports showing an association of paraneoplastic pemphigus and bullous pemphigoid with pembrolizumab and other PD1 inhibitors, further investigation should be undertaken to better understand the incidence of these diseases with photoimmunotherapy.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews & Reports","volume":"2012 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of a 50-Year-Old Female with Dermatomyositis Secondary to a Paraneoplasm (Infiltrating Ductal Carcinoma, Grade 2) 一例 50 岁女性皮肌炎继发于副肿瘤（2 级浸润性导管癌）的病例
Journal of Dermatology Research Reviews & Reports Pub Date : 2024-02-29 DOI: 10.47363/jdmrs/2024(5)152
Katrina Marie M Salvosa, Maria Franchesca S Quinio Calayag
{"title":"A Case of a 50-Year-Old Female with Dermatomyositis Secondary to a Paraneoplasm (Infiltrating Ductal Carcinoma, Grade 2)","authors":"Katrina Marie M Salvosa, Maria Franchesca S Quinio Calayag","doi":"10.47363/jdmrs/2024(5)152","DOIUrl":"https://doi.org/10.47363/jdmrs/2024(5)152","url":null,"abstract":"Introduction: Dermatomyositis is an autoimmune disorder with an incidence of 5 to 10 per 1 million per year. 10 to 20% of patients with adult-onset Dermatomyositis have an underlying malignancy. There are currently no specific cutaneous markers for Paraneoplastic Dermatomyositis. This case highlights a patient with uncommon features of paraneoplasm after breast malignancy. Case Report: A 50-year-old female with Infiltrating Ductal Carcinoma, presented with patches on the face, neck, chest, upper back, outer arms, dorsal hands, thighs, hair loss and weakness. Histopathology revealed widened basal layer vacuolization with widened spaces between collagen bundles filled with mucin deposition, and pigment incontinence in the papillary dermis. Direct immunofluorescence showed granular deposits of IgG, C3, IgM and IgA in the basement membrane zone, which are consistent with Dermatomyositis. The patient was prescribed with Clobetasol ointment mixed equally with petrolatum on the body and Mometasone cream on the face. She was subsequently started on Prednisone at 0.5 mkd with eventual tapering, Omeprazole, and Calcium + Vitamin D tablet daily. Hydroxychloroquine 200 mg/tab daily was added. Referral to Rheumatology for co-management and Surgery for management of the breast mass was also done. Conclusion: This case emphasizes the rare occurrence of a Paraneoplastic Dermatomyositis following a diagnosis of breast malignancy. A careful review upon diagnosis may detect occult malignancies especially in patients who present primarily with cutaneous Dermatomyositis. Clinicopathologic correlation and a multi-disciplinary approach, with Surgery, Oncology, Rheumatology and Dermatopathology are needed to identify the underlying cause and facilitate successful treatment of a neoplasm followed by improvement of Dermatomyositis.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews & Reports","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collagen Biostimulatores in the Vulva’s Region 外阴部位的胶原蛋白生物刺激器
Journal of Dermatology Research Reviews & Reports Pub Date : 2024-02-29 DOI: 10.47363/jdmrs/2024(5)151
Viviane Leandro Almeida, Mirele Renata Fadel de Morais Teodoro, Patrícia Leite Nogueira
{"title":"Collagen Biostimulatores in the Vulva’s Region","authors":"Viviane Leandro Almeida, Mirele Renata Fadel de Morais Teodoro, Patrícia Leite Nogueira","doi":"10.47363/jdmrs/2024(5)151","DOIUrl":"https://doi.org/10.47363/jdmrs/2024(5)151","url":null,"abstract":"Objective: To investigate in the literature the importance of collagen biostimulators in the female intimate region and their repercussions for women’s sexual health and well-being. Methods: This is an integrative literature review. The PICo strategy was applied: P: Women; I: Care of the intimate area; Co: Applicability of collagen biostimulators. Also, the following databases were used: Embase, Medical Literature Analysis and Retrieval System Online, SCOPUS, Web of Science, and the Scientific Electronic Library Online virtual library. Results: n = 89 studies were found, which were selected after a thorough investigation of n = 4 articles. Final considerations: This research aimed to provide more information about the importance of collagen biostimulators in the female intimate region and its repercussions for women’s sexual health and well-being, facilitating the understanding of the topic addressed due to the lack of studies.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews & Reports","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Water Absorption and 3D Expansion of Different Injectable Hyaluronic Acids 不同注射用透明质酸的吸水性和三维扩展性
Journal of Dermatology Research Reviews & Reports Pub Date : 2024-01-31 DOI: 10.47363/jdmrs/2024(5)150
Mariana Brito da Cruz
{"title":"Water Absorption and 3D Expansion of Different Injectable Hyaluronic Acids","authors":"Mariana Brito da Cruz","doi":"10.47363/jdmrs/2024(5)150","DOIUrl":"https://doi.org/10.47363/jdmrs/2024(5)150","url":null,"abstract":"Hyaluronic acid’s water absorption and expansion capacities define a filler’s ability to lift the tissues. Therefore, studying these properties is essential to better understand filler’s clinical performance. The aim of this study was to evaluate and compare water absorption and expansion (bidimensional and three-dimensional) of five Fillmed fillers (Universal, Fine Lines, Volume, Lips and Lips Soft). Water absorption was measured through swelling ratio 24 hours post-hydration. For two-dimensional expansion, samples were analysed quantitatively and qualitatively, using calibrated photographs, before and two hours after hydration. Three-dimensional volume was evaluated before and immediately after injecting the fillers, and 30 minutes, 2 hours and 24 hours post-injection in ex vivo pig skin. The tissue was scanned with the 3Shape TRIOS scanner and resulting STL files were compared. Group comparisons were analyzed with the one-way ANOVA test, and a p-value ≤ 0,05 was established. Lips showed a statistically higher swelling ratio than other fillers (p < 0,05). Fine Lines had the lowest swelling ratio, even if only statistically significant when compared to Universal (p= 0,021). Fine Lines had a significantly higher initial bidimensional width than all fillers (p <0,05) except Lips Soft. 24 hours post-injection, Fine Lines had the highest three-dimensional volume, which was statistically higher than Volume’s (p= 0,049). All fillers absorbed water and expanded, with Fine Lines tending to have the highest three-dimensional expansion, despite its lowest viscosity and water absorption. Further studies with larger sample sizes are needed to investigate the influence of other properties over water absorption and expansion.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"639 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140476338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid Laser in the Vitiligo Treatment 混合激光在白癜风治疗中的应用
Journal of Dermatology Research Reviews &amp; Reports Pub Date : 2023-12-31 DOI: 10.47363/jdmrs/2023(4)149
Aristides Arellano
{"title":"Hybrid Laser in the Vitiligo Treatment","authors":"Aristides Arellano","doi":"10.47363/jdmrs/2023(4)149","DOIUrl":"https://doi.org/10.47363/jdmrs/2023(4)149","url":null,"abstract":"Vitiligo is a chronic (long-lasting) disorder that causes some areas of the skin to lose their natural color. No one knows exactly what causes vitiligo, but it may be an autoimmune disease in which the immune system attacks and destroys the cells that produce the pigmentation","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"119 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139133307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unusual Case of Mixed Superficial and Adenoid Basal Cell Carcinoma in a 57-year-old Filipino Female 57 岁菲律宾女性混合表皮和腺样基底细胞癌的罕见病例
Journal of Dermatology Research Reviews &amp; Reports Pub Date : 2023-12-31 DOI: 10.47363/jdmrs/2023(4)148
Angeli Elaine A Pangilinan
{"title":"An Unusual Case of Mixed Superficial and Adenoid Basal Cell Carcinoma in a 57-year-old Filipino Female","authors":"Angeli Elaine A Pangilinan","doi":"10.47363/jdmrs/2023(4)148","DOIUrl":"https://doi.org/10.47363/jdmrs/2023(4)148","url":null,"abstract":"Introduction: Basal cell carcinoma (BCC) is the most common cutaneous malignancy worldwide often occurring in sun-exposed areas. While the nodular variant accounts for the majority of cases, the adenoid type is extremely rare, comprising about 1.3% of all BCCs. Contrary to the typical presentation of BCC, adenoid BCC features a large sized lesion and a tendency to involve non-sun exposed areas such as the trunk. This case study presents a unique form of mixed superficial and adenoid BCC in a 57-year-old Filipino female. Case Report: A 57-year-old female presented with a 2-year history of a slowly enlarging bluish-black plaque with rolled borders on the left flank with noted bleeding, pain, and pruritus. Dermoscopy revealed arborizing vessels, leaf-like structures, blue gray globules, and white streaks, consistent with BCC. Histopathology showed a diagnosis of a superficial and adenoid type of BCC. Conclusion: Encounters with unusual forms of cutaneous carcinoma may arise in dermatologic practice. Dermoscopy serves as a powerful tool in identifying suspicious lesions and a pre-operative biopsy is done to correlate with the clinical diagnosis. Hence, the dermatologist will be able to decide the appropriate treatment option based on the clinical presentation and histopathologic type.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"76 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Irritant Contact Dermatitis of the Face: New Natural Approaches in the Topical Treatment 面部严重刺激性接触性皮炎:局部治疗的新自然方法
Journal of Dermatology Research Reviews &amp; Reports Pub Date : 2023-06-30 DOI: 10.47363/jdmrs/2023(4)147
O. De Pità, FR Selvi F, Lup I
{"title":"Severe Irritant Contact Dermatitis of the Face: New Natural Approaches in the Topical Treatment","authors":"O. De Pità, FR Selvi F, Lup I","doi":"10.47363/jdmrs/2023(4)147","DOIUrl":"https://doi.org/10.47363/jdmrs/2023(4)147","url":null,"abstract":"Contact dermatitis is a common skin condition characterized by inflammation, be it acute or chronic, occurring as a result of interaction with irritant substances. It can be categorized as either irritant contact dermatitis (ICD) or allergic contact dermatitis (ACD). Contact dermatitis is currently one of the most common occupational diseases, with capability of involving any given part of skin and a predilection for the face and extremities. Irritant-contact dermatitis represents the majority of cases (around 80%), while the remaining instances are caused by interaction with allergens. Nonetheless, correctly diagnosing and treating forms of ICD remains difficult, with treatments for contact dermatitis currently based on the identification and avoidance of the underlying cause, along with the use of topical steroids and emollients, with creams frequently recommended in preventative skin care programs for the workplace.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126299130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Healing of Two Very Large Pelvic-Perineal Chronic Fistulized Ulcers in A Patient with Congenital Myelomeningocele Treated with A Carbohydrate Polymer with Zinc Oxide: Case Report 碳水化合物聚合物氧化锌治疗2例先天性髓脊膜膨出患者盆腔-会阴慢性瘘管性溃疡成功愈合一例
Journal of Dermatology Research Reviews &amp; Reports Pub Date : 2023-04-30 DOI: 10.47363/jdmrs/2023(4)146
Suárez Vargas Daniel, Franco Lugo Desireé, Cueto García Jorge
{"title":"Successful Healing of Two Very Large Pelvic-Perineal Chronic Fistulized Ulcers in A Patient with Congenital Myelomeningocele Treated with A Carbohydrate Polymer with Zinc Oxide: Case Report","authors":"Suárez Vargas Daniel, Franco Lugo Desireé, Cueto García Jorge","doi":"10.47363/jdmrs/2023(4)146","DOIUrl":"https://doi.org/10.47363/jdmrs/2023(4)146","url":null,"abstract":"Importance: A new successful therapeutic option for chronic complicated pressure lesions using a Carbohydrate Polymer with Zinc Oxide (CPZO®). Introduction: A 20-year-old male patient diagnosed with congenital Myelomeningocele was seen and examined in our office on December 08, 2014. When we first received the patient, he had two very large fistulized pressure ulcers stage IV in the gluteal and perianal areas. Both ulcers presented evidence of infection, with purulent fecal discharge, and extensive inflammation and destruction of surrounding tissue. Conclusions and Relevance: This case proves the therapeutic efficiency of CPZO® a new Medical Device II with pro- healing, anti-inflammatory and bactericidal properties on a young male patient with chronic complicated severe pressure ulcers.","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115143965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification of Erythematosquamous Dermatosis by the Method of Random Forest 用随机森林法分类红斑鳞状皮肤病
Journal of Dermatology Research Reviews &amp; Reports Pub Date : 2023-02-28 DOI: 10.47363/jdmrs/2023(4)143
Ashutosh Kumar Singh, Dwaiypayan Mukhopadhyay
{"title":"Classification of Erythematosquamous Dermatosis by the Method of Random Forest","authors":"Ashutosh Kumar Singh, Dwaiypayan Mukhopadhyay","doi":"10.47363/jdmrs/2023(4)143","DOIUrl":"https://doi.org/10.47363/jdmrs/2023(4)143","url":null,"abstract":"Machine Learning (ML) methods have found wide applications in dermatology (Chan et al., 2020) [1]. Thomsen, Iversen, Titlestad & Winther (2020) reviewed 2175 publications and found that the most common usage of ML methods was in the binary classification of malignant melanoma from images [2]. Adamson and Smith have a word of advice about usage of ML methods in diagnosis of skin diseases that inclusivity must be kept in mind for classification results to be accurate [3]. Steele et al. searched PubMed, Embase, and CENTRAL, and found that the performance of ML methods was variable, and overall accuracy measure was not a good measure for sub-group accuracy [4].","PeriodicalId":203275,"journal":{"name":"Journal of Dermatology Research Reviews &amp; Reports","volume":"2 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132466978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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