Physiological reviews最新文献_第5页

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis T2DM和LOAD之间的神经病理学联系：系统回顾和荟萃分析

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-03-10 DOI: 10.1152/physrev.00040.2024

Erwin Lemche, Tibor Hortobágyi, Clemens Kiecker, Federico Turkheimer

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The pathogenesis of cerebral small vessel diseases and vascular cognitive impairment 脑血管病的发病机制与血管性认知障碍

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-02-18 DOI: 10.1152/physrev.00028.2024

Hugh S. Markus, Anne Joutel

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Physiologic mechanisms underlying polycystic kidney disease 多囊肾病的生理机制

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-02-13 DOI: 10.1152/physrev.00018.2024

Alessandra Boletta, Michael J. Caplan

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Psycho-physiological foundations of human physical activity behavior and motivation: Theories, systems, mechanisms, evolution, and genetics 人类体育活动行为和动机的心理生理基础：理论、系统、机制、进化和遗传学

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-01-24 DOI: 10.1152/physrev.00021.2024

Markus Gerber, Boris Cheval, Robyn Cody, Flora Colledge, Vivien Hohberg, Yann C. Klimentidis, Christin Lang, Vera Nina Looser, Sebastian Ludyga, Matthew Stults-Kolehmainen, Oliver Faude

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The (dys)regulation of energy storage in obesity 肥胖症中能量储存的调节

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-01-18 DOI: 10.1152/physrev.00002.2024

Barry E Levin, Nori Geary, Thomas A Lutz

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NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease NADPH氧化酶：细胞稳态和疾病的氧化还原调节

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-01-16 DOI: 10.1152/physrev.00034.2023

Damir Kračun, Lucia R. Lopes, Eugenia Cifuentes-Pagano, Patrick J. Pagano

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The TRP Channels Serving as Chemical-to-Electrical Signal Converter TRP通道作为化学-电信号转换器

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-01-15 DOI: 10.1152/physrev.00012.2024

Yuhua Tian, Jie Zheng

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Kisspeptin and Neurokinin B: roles in reproductive health Kisspeptin和Neurokinin B：在生殖健康中的作用

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-01-15 DOI: 10.1152/physrev.00015.2024

Kanyada Koysombat, Jovanna Tsoutsouki, Aaran H. Patel, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara

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Pathophysiology of syncope: current concepts and their development. 晕厥的病理生理学：当前概念及其发展。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI: 10.1152/physrev.00007.2024

David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk

{"title":"Pathophysiology of syncope: current concepts and their development.","authors":"David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk","doi":"10.1152/physrev.00007.2024","DOIUrl":"10.1152/physrev.00007.2024","url":null,"abstract":"Syncope is a symptom in which transient loss of consciousness occurs as a consequence of a self-limited, spontaneously terminating period of cerebral hypoperfusion. Many circulatory disturbances (e.g. brady- or tachyarrhythmias, reflex cardioinhibition-vasodepression-hypotension) may trigger a syncope or near-syncope episode, and identifying the cause(s) is often challenging. Some syncope may involve multiple etiologies operating in concert, whereas in other cases multiple syncope events may be due to various differing causes at different times. In this communication, we address the current understanding of the principal contributors to syncope pathophysiology including examination of the manner in which concepts evolved, an overview of factors that constitute consciousness and loss of consciousness, and aspects of neurovascular control and communication that are impacted by cerebral hypoperfusion leading to syncope. Emphasis focuses on 1) current understanding of the way transient systemic hypotension impacts brain blood flow and brain function; 2) the complexity and temporal sequence of vascular, humoral, and cardiac factors that may accompany the most common causes of syncope; 3) the range of circumstances and disease states that may lead to syncope; and 4) clinical features associated with syncope and in particular the reflex syncope syndromes.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"209-266"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches. 肌球蛋白 II 发力机制。新实验技术和方法带来的启示。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-01-01 Epub Date: 2024-03-07 DOI: 10.1152/physrev.00014.2023

Dilson E Rassier, Alf Månsson

{"title":"Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches.","authors":"Dilson E Rassier, Alf Månsson","doi":"10.1152/physrev.00014.2023","DOIUrl":"10.1152/physrev.00014.2023","url":null,"abstract":"Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so-called \"power stroke\" that causes the sliding of actin filaments. The general features of the myosin-actin interactions are well accepted, but there are critical issues that remain poorly understood, mostly due to technological limitations. In recent years, there has been a significant advance in structural, biochemical, and mechanical methods that have advanced the field considerably. New modeling approaches have also allowed researchers to understand actomyosin interactions at different levels of analysis. This paper reviews recent studies looking into the interaction between myosin II and actin filaments, which leads to power stroke and force generation. It reviews studies conducted with single myosin molecules, myosins working in filaments, muscle sarcomeres, myofibrils, and fibers. It also reviews the mathematical models that have been used to understand the mechanics of myosin II in approaches focusing on single molecules to ensembles. Finally, it includes brief sections on translational aspects, how changes in the myosin motor by mutations and/or posttranslational modifications may cause detrimental effects in diseases and aging, among other conditions, and how myosin II has become an emerging drug target.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1-93"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0