Physiological reviews最新文献_第5页

Sensing molecular carbon dioxide - a translational focus for respiratory disease 传感分子二氧化碳——呼吸系统疾病的转化焦点

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-07-16 DOI: 10.1152/physrev.00022.2024

István Vadász, Eoin P Cummins, Deborah H. Brotherton, S Marina Casalino Matsuda, Laura A. Dada, Ori Green, Dustin T. King, Vitalii Kryvenko, Masahiko Shigemura, Peter H. S. Sporn, Moritz J. Strowitzki, Martin J. Cann, Jacob I. Sznajder

引用次数: 0

Diaphragm Muscle: A Pump That Can Not Fail. 横膈肌：一个不能失败的泵。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-07-11 DOI: 10.1152/physrev.00043.2024

Gary C Sieck,Matthew J Fogarty

{"title":"Diaphragm Muscle: A Pump That Can Not Fail.","authors":"Gary C Sieck,Matthew J Fogarty","doi":"10.1152/physrev.00043.2024","DOIUrl":"https://doi.org/10.1152/physrev.00043.2024","url":null,"abstract":"In mammals, breathing requires an inspiratory pump to generate a negative intrathoracic pressure and thus pull air into the lungs for gas exchange. Exclusively in mammals, the diaphragm muscle (DIAm) is the major inspiratory pump, which separates the thoracic and abdominal cavities. With DIAm contraction a negative intrathoracic and positive abdominal pressure are generated (i.e., transdiaphragmatic pressure (Pdi). During breathing,the DIAm is very active, with a duty cycle (time active vs inactive) similar to that of the heart. Like the heart, this is a pump that cannot fail! Thus, in controlling breathing, the nervous system must activate DIAm to accomplish pump function while avoiding fatigue. The timing of DIAm activations must also be coordinated with activation of the upper airway muscles (the pipes) to avoid airway occlusion and aspiration, the intercostal and abdominal muscles to appropriately stiffen the body cavities. Similarly, neural control and coordination of the DIAm in non-ventilatory behaviors (airway protection, swallowing, vocalization and voiding) is equally complex, with coordinated activation of the DIAm and abdominal muscles. It is becoming increasingly clear that impaired non-ventilatory functions underlie the pathophysiology of a variety of medical conditions. In this review, we will delve into the detailed mechanistic underpinnings of the neural control of the DIAm and the symphonic coordination of its activation during breathing and other behaviors. We will attempt to move the field from considering the DIAm only as an inspiratory pump, emphasising neural control of airway, intercostal and abdominal muscles that must be coordinated with DIAm activation.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"4 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in alcohol metabolism: from the gut to the brain. 酒精代谢的最新进展：从肠道到大脑。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-07-10 DOI: 10.1152/physrev.00053.2024

Modan R Goldman,Mariel Molina-Castro,Jumar C Etkins,Theodore L Koide,Vijay A Ramchandani,Martin H Plawecki,Julie A Mennella,Marta Yanina Pepino

{"title":"Recent advances in alcohol metabolism: from the gut to the brain.","authors":"Modan R Goldman,Mariel Molina-Castro,Jumar C Etkins,Theodore L Koide,Vijay A Ramchandani,Martin H Plawecki,Julie A Mennella,Marta Yanina Pepino","doi":"10.1152/physrev.00053.2024","DOIUrl":"https://doi.org/10.1152/physrev.00053.2024","url":null,"abstract":"Globally, alcohol is the most widely used psychoactive drug and a leading cause of premature death among individuals aged 15-49 years. Understanding the absorption, distribution, metabolism, and excretion of alcohol in the human body, otherwise known as alcohol pharmacokinetics, is essential for predicting its behavioral effects and toxic consequences. This review examines the evolutionary origins of alcohol consumption and metabolism, focusing on the activity of alcohol dehydrogenase enzymes across species, which serve as key catalysts in alcohol oxidation. It also highlights recent advances in understanding central alcohol metabolism and updates on the potential clinical significance of non-oxidative pathways of alcohol metabolism and endogenous alcohol production, particularly in the context of liver disease. In addition, the review inspects factors that modulate alcohol metabolism, including genetic polymorphisms, biological sex, food intake, women's reproductive status, and clinical interventions such as medications and metabolic surgeries. Understanding these sources of variability in alcohol metabolism is crucial for identifying individual risk factors and tailoring strategies to reduce alcohol-related harm. This comprehensive review offers a current perspective on alcohol pharmacokinetics, valuable insights into its implications for health, behavior, and potential innovative therapeutic targets.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"147 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon. 男性型雄激素性脱发的生理学前沿：超越雄激素水平。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-07-10 DOI: 10.1152/physrev.00005.2024

Sabrina Altendorf,Marta Bertolini,Alizée Le Riche,Antonella Tosti,Ralf Paus

{"title":"Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon.","authors":"Sabrina Altendorf,Marta Bertolini,Alizée Le Riche,Antonella Tosti,Ralf Paus","doi":"10.1152/physrev.00005.2024","DOIUrl":"https://doi.org/10.1152/physrev.00005.2024","url":null,"abstract":"Male pattern androgenetic alopecia (mpAGA), the most common form of hair loss in men, represents a heritable, androgen-dependent complex trait distinct from female pattern hair loss. Despite the psychosocial burden of mpAGA in some affected individuals and associations with other morbidities, we portray mpAGA as an essentially physiological phenomenon in which defined hair follicle (HF) populations in developmentally preprogrammed scalp skin regions undergo a dramatic, but reversible (mini-)organ transformation in genetically predisposed individuals. Histologically, mpAGA exhibits progressive HF miniaturization (terminal-to-vellus conversion) and anagen shortening. Clinically, this results in a characteristic balding pattern of frontotemporal and vertex scalp skin, associated with telogen effluvium. It remains unclear how exactly androgens induce this phenotype, since neither androgen receptor polymorphisms nor changes in androgen serum or local androgen skin levels persuasively explain it. It also is as yet unresolved if mpAGA-associated HF transformation and hair cycle changes are primarily driven by the HF mesenchyme, e.g. by excessive emigration and/or reduced inductive potential of dermal papilla fibroblasts, or by intraepithelial events such as prostaglandin D2-dependent reduced HF epithelial stem cell progenitor generation. While critically revisiting our limited current understanding of mpAGA physiology and the role of mpAGA-associated genes we discuss potential targets for future therapeutic intervention beyond androgens and highlight selected dysregulated signaling pathways in mpAGA. We underscore mpAGA as an instructive, accessible model for interrogating under-investigated physiological roles of immune cells, oxidative stress, aging/senescence, and the microbiome in human organ remodeling and hair cycle regulation, and define major open research questions beyond androgen receptor- mediated signaling.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"111 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I Interferons in health and disease-Molecular aspects and clinical implications. I型干扰素在健康和疾病中的作用——分子方面和临床意义。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-07-10 DOI: 10.1152/physrev.00047.2024

Clio P Mavragani,Mary K Crow

{"title":"Type I Interferons in health and disease-Molecular aspects and clinical implications.","authors":"Clio P Mavragani,Mary K Crow","doi":"10.1152/physrev.00047.2024","DOIUrl":"https://doi.org/10.1152/physrev.00047.2024","url":null,"abstract":"Type I interferons (IFNs), particularly IFNα and IFNβ, play a crucial role in the human immune response against viral infections. This review delves into the multifaceted antiviral, immunomodulatory and antitumor physiological roles of type I IFNs, while describing their contribution to the pathogenesis of various disease pathologies including cancer, systemic and organ specific autoimmunity, neuroinflammation and atherosclerosis. Genetic determinants influencing activation of type I IFN pathways and therapeutic interventions either targeting or stimulating these pathways in the context of autoimmunity and cancer respectively are also discussed. Ultimately, the current understanding of the role of type I IFNs as biomarkers indicative of distinct clinical and serological phenotypes, their correlation with disease activity, their predictive role in therapeutic outcomes across diverse clinical scenarios, as well as the challenges associated with their implementation in clinical practice, are thoroughly addressed. Together, these insights underscore the significant potential of type I IFNs, as mediators and therapeutic targets, to reshape clinical decision-making, while highlighting the urgent need for robust, standardized methodologies for assessment of type I IFNs and their integration into routine practice.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"4 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of extracellular vesicles on tumor evolution and resistance to therapy. 细胞外囊泡对肿瘤演变和耐药性的影响。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-07-01 Epub Date: 2025-02-21 DOI: 10.1152/physrev.00019.2024

Enrique Bastón, Juan García-Agulló, Héctor Peinado

{"title":"The influence of extracellular vesicles on tumor evolution and resistance to therapy.","authors":"Enrique Bastón, Juan García-Agulló, Héctor Peinado","doi":"10.1152/physrev.00019.2024","DOIUrl":"10.1152/physrev.00019.2024","url":null,"abstract":"Disruption of cellular communication that regulates normal physiology is often a key factor in the development of disease, including cancer. Extracellular vesicles (EVs) are mediators of cell-cell communication, modulating local and distant microenvironments and playing an important role influencing tumor progression at both early and late stages. Indeed, EV-mediated communication participates in the initial steps of primary tumor transformation and proliferation as well as the preparation of the premetastatic niche and subsequent metastasis. In this context, the presence of DNA in EVs (EV-DNA) is particularly intriguing, with important biological implications and significant potential as a biomarker in liquid biopsies. In this review we discuss the mechanisms involved in EV-shed DNA and the potential impact in tumor evolution. In addition, it has become apparent in recent years that the secretion of EVs also influences the behavior of the surrounding microenvironment. An important unresolved challenge in oncology is the resistance of tumors to treatment, one of the primary causes of high cancer mortality. The role of EVs in therapy resistance has garnered considerable interest. In the latter part of this review, we also examine the potential involvement of EVs in resistance to therapy.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1173-1212"},"PeriodicalIF":29.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments. 细胞外囊泡与肺部疾病：从发病机制到生物标志物和治疗。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-07-01 Epub Date: 2025-03-24 DOI: 10.1152/physrev.00032.2024

Kyong-Su Park, Cecilia Lässer, Jan Lötvall

{"title":"Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments.","authors":"Kyong-Su Park, Cecilia Lässer, Jan Lötvall","doi":"10.1152/physrev.00032.2024","DOIUrl":"10.1152/physrev.00032.2024","url":null,"abstract":"Nanosized extracellular vesicles (EVs) are released by all cells to convey cell-to-cell communication. EVs, including exosomes and microvesicles, carry an array of bioactive molecules, such as proteins and RNAs, encapsulated by a membrane lipid bilayer. Epithelial cells, endothelial cells, and various immune cells in the lung contribute to the pool of EVs in the lung microenvironment and carry molecules reflecting their cellular origin. EVs can maintain lung health by regulating immune responses, inducing tissue repair, and maintaining lung homeostasis. They can be detected in lung tissues and biofluids such as bronchoalveolar lavage fluid and blood, offering information about disease processes, and can function as disease biomarkers. Here, we discuss the role of EVs in lung homeostasis and pulmonary diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, pulmonary fibrosis, and lung injury. The mechanistic involvement of EVs in pathogenesis and their potential as disease biomarkers are discussed. Finally, the pulmonary field benefits from EVs as clinical therapeutics in severe pulmonary inflammatory disease, as EVs from mesenchymal stem cells attenuate severe respiratory inflammation in multiple clinical trials. Further, EVs can be engineered to carry therapeutic molecules for enhanced and broadened therapeutic opportunities, such as the anti-inflammatory molecule CD24. Finally, we discuss the emerging opportunity of using different types of EVs for treating severe respiratory conditions.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1733-1821"},"PeriodicalIF":29.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The flux of energy in critical illness and the obesity paradox. 危重疾病中的能量流动和肥胖悖论。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-07-01 Epub Date: 2025-02-21 DOI: 10.1152/physrev.00029.2024

Ariel Jaitovich, Jesse B Hall

{"title":"The flux of energy in critical illness and the obesity paradox.","authors":"Ariel Jaitovich, Jesse B Hall","doi":"10.1152/physrev.00029.2024","DOIUrl":"10.1152/physrev.00029.2024","url":null,"abstract":"During critical illness, systemic inflammation causes organ-specific metabolic changes. In the immune and inflammatory compartments, predominantly anabolic reprogramming supports cellular replication and inflammatory response execution. Pari passu, catabolism of adipose tissue and skeletal muscle supplies carbon skeletons and enthalpy for inflammatory and immune cell anabolism. The liver plays a key role during these metabolic shifts in enabling adequate supply of glucose and ketone bodies to the circulation. Although often perceived as passive surrogates of prehospitalization frailty, body mass constituents are active parties of an overarching metabolic trade-off that is key for survival after acute insults. Muscle and adipose tissue remodel in response to critical illness and thus profoundly influence the systemic metabolic landscape during and after hospitalization. Whether obesity's effect on patient systemic metabolism and survival is paradoxically beneficial or not remains controversial. Substrate-induced epigenetic changes lead to abnormal transcriptional programs that in turn regulate metabolic pathways critical to patient survival. We present a summary of major mechanisms involved in the flux of energy in critical illness from body mass into immune response execution and suggest future research avenues focused on perturbed immune-metabolic and epigenetic programs that could lead to improved understanding of these processes, and eventually to better outcomes for the critically ill.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1487-1552"},"PeriodicalIF":29.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TPCs: FROM PLANT TO HUMAN. TPCs：从植物到人类。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-07-01 Epub Date: 2025-04-03 DOI: 10.1152/physrev.00044.2024

Yvonne Eileen Klingl, Arnas Petrauskas, Dawid Jaślan, Christian Grimm

{"title":"TPCs: FROM PLANT TO HUMAN.","authors":"Yvonne Eileen Klingl, Arnas Petrauskas, Dawid Jaślan, Christian Grimm","doi":"10.1152/physrev.00044.2024","DOIUrl":"10.1152/physrev.00044.2024","url":null,"abstract":"In 2005, the Arabidopsis thaliana two-pore channel TPC1 channel was identified as a vacuolar Ca2+-release channel. In 2009, three independent groups published studies on mammalian TPCs as nicotinic acid adenine dinucleotide phosphate (NAADP)-activated endolysosomal Ca2+ release channels, results that were eventually challenged by two other groups, claiming mammalian TPCs to be phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2]-activated Na+ channels. By now this dispute seems to have been largely reconciled. Lipophilic small molecule agonists of TPC2, mimicking either the NAADP or the PI(3,5)P2 mode of channel activation, revealed, together with structural evidence, that TPC2 can change its selectivity for Ca2+ versus Na+ in a ligand-dependent fashion (N- vs. P-type activation). Furthermore, the NAADP-binding proteins Jupiter microtubule-associated homolog 2 protein (JPT2) and Lsm12 were discovered, corroborating the hypothesis that NAADP activation of TPCs only works in the presence of these auxiliary NAADP-binding proteins. Pathophysiologically, loss or gain of function of TPCs has effects on autophagy, exocytosis, endocytosis, and intracellular trafficking, e.g., LDL cholesterol trafficking leading to fatty liver disease or viral and bacterial toxin trafficking, corroborating the roles of TPCs in infectious diseases such as Ebola or COVID-19. Defects in the trafficking of epidermal growth factor receptor and β1-integrin suggested roles in cancer. In neurodegenerative lysosomal storage disease models, P-type activation of TPC2 was found to have beneficial effects on both in vitro and in vivo hallmarks of Niemann-Pick disease type C1, Batten disease, and mucolipidosis type IV. Here, we cover the latest on the structure, function, physiology, and pathophysiology of these channels with a focus initially on plants followed by mammalian TPCs, and we discuss their potential as drug targets, including currently available pharmacology.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1695-1732"},"PeriodicalIF":29.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular dissection of the role of ACE2 in glucose homeostasis. ACE2在葡萄糖稳态中作用的分子解剖。

IF 29.9 1区医学

Physiological reviews Pub Date : 2025-07-01 Epub Date: 2025-02-07 DOI: 10.1152/physrev.00027.2024

Kavaljit H Chhabra, Robin Shoemaker, Chandana B Herath, Merlin C Thomas, Catalin M Filipeanu, Eric Lazartigues

{"title":"Molecular dissection of the role of ACE2 in glucose homeostasis.","authors":"Kavaljit H Chhabra, Robin Shoemaker, Chandana B Herath, Merlin C Thomas, Catalin M Filipeanu, Eric Lazartigues","doi":"10.1152/physrev.00027.2024","DOIUrl":"10.1152/physrev.00027.2024","url":null,"abstract":"Angiotensin-converting enzyme 2 (ACE2) was discovered 25 years ago as a negative regulator of the renin-angiotensin system, opposing the effects of angiotensin II. Beyond its well-demonstrated roles in cardiovascular regulation and COVID-19 pathology, ACE2 is involved in a plethora of physiopathological processes. In this review, we summarize the latest discoveries on the role of ACE2 in glucose homeostasis and regulation of metabolism. In the endocrine pancreas, ACE2 is expressed at low levels in β-cells, but loss of its expression inhibits glucose-stimulated insulin secretion and impairs glucose tolerance. Conversely, overexpression of ACE2 improved glycemia, suggesting that recombinant ACE2 might be a future therapy for diabetes. In the skeletal muscle of ACE2-deficient mice a progressive triglyceride accumulation was observed, whereas in diabetic kidney the initial increase in ACE2 is followed by a chronic reduction of expression in kidney tubules and impairment of glucose metabolism. At the intestinal level dysregulation of the enzyme alters the amino acid absorption and intestinal microbiome, whereas at the hepatic level ACE2 protects against diabetic fatty liver disease. Not least, ACE2 is upregulated in adipocytes in response to nutritional stimuli, and administration of recombinant ACE2 decreased body weight and increased thermogenesis. In addition to tissue-specific regulation of ACE2 function, the enzyme undergoes complex cellular posttranslational modifications that are changed during diabetes evolution, with at least proteolytic cleavage and ubiquitination leading to modifications in ACE2 activity. Detailed characterization of ACE2 in a cellular and tissue-specific manner holds promise for improving therapeutic outcomes in diabetes and metabolic disorders.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"935-973"},"PeriodicalIF":29.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0