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Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration. 改变连接的概念：揭示隧道纳米管生物学及其在大脑发育和神经变性中的作用。
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-03-11 DOI: 10.1152/physrev.00023.2024
Francesca Palese, Malalaniaina Rakotobe, Chiara Zurzolo
{"title":"Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration.","authors":"Francesca Palese, Malalaniaina Rakotobe, Chiara Zurzolo","doi":"10.1152/physrev.00023.2024","DOIUrl":"https://doi.org/10.1152/physrev.00023.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"87 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis T2DM和LOAD之间的神经病理学联系：系统回顾和荟萃分析
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-03-10 DOI: 10.1152/physrev.00040.2024
Erwin Lemche, Tibor Hortobágyi, Clemens Kiecker, Federico Turkheimer
{"title":"Neuropathological links between T2DM and LOAD: systematic review and meta-analysis","authors":"Erwin Lemche, Tibor Hortobágyi, Clemens Kiecker, Federico Turkheimer","doi":"10.1152/physrev.00040.2024","DOIUrl":"https://doi.org/10.1152/physrev.00040.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"8 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pathogenesis of cerebral small vessel diseases and vascular cognitive impairment 脑血管病的发病机制与血管性认知障碍
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-02-18 DOI: 10.1152/physrev.00028.2024
Hugh S. Markus, Anne Joutel
{"title":"The pathogenesis of cerebral small vessel diseases and vascular cognitive impairment","authors":"Hugh S. Markus, Anne Joutel","doi":"10.1152/physrev.00028.2024","DOIUrl":"https://doi.org/10.1152/physrev.00028.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"16 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologic mechanisms underlying polycystic kidney disease 多囊肾病的生理机制
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-02-13 DOI: 10.1152/physrev.00018.2024
Alessandra Boletta, Michael J. Caplan
{"title":"Physiologic mechanisms underlying polycystic kidney disease","authors":"Alessandra Boletta, Michael J. Caplan","doi":"10.1152/physrev.00018.2024","DOIUrl":"https://doi.org/10.1152/physrev.00018.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"31 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psycho-physiological foundations of human physical activity behavior and motivation: Theories, systems, mechanisms, evolution, and genetics 人类体育活动行为和动机的心理生理基础：理论、系统、机制、进化和遗传学
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-01-24 DOI: 10.1152/physrev.00021.2024
Markus Gerber, Boris Cheval, Robyn Cody, Flora Colledge, Vivien Hohberg, Yann C. Klimentidis, Christin Lang, Vera Nina Looser, Sebastian Ludyga, Matthew Stults-Kolehmainen, Oliver Faude
{"title":"Psycho-physiological foundations of human physical activity behavior and motivation: Theories, systems, mechanisms, evolution, and genetics","authors":"Markus Gerber, Boris Cheval, Robyn Cody, Flora Colledge, Vivien Hohberg, Yann C. Klimentidis, Christin Lang, Vera Nina Looser, Sebastian Ludyga, Matthew Stults-Kolehmainen, Oliver Faude","doi":"10.1152/physrev.00021.2024","DOIUrl":"https://doi.org/10.1152/physrev.00021.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"1 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The (dys)regulation of energy storage in obesity 肥胖症中能量储存的调节
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-01-18 DOI: 10.1152/physrev.00002.2024
Barry E Levin, Nori Geary, Thomas A Lutz
{"title":"The (dys)regulation of energy storage in obesity","authors":"Barry E Levin, Nori Geary, Thomas A Lutz","doi":"10.1152/physrev.00002.2024","DOIUrl":"https://doi.org/10.1152/physrev.00002.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"9 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease NADPH氧化酶：细胞稳态和疾病的氧化还原调节
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-01-16 DOI: 10.1152/physrev.00034.2023
Damir Kračun, Lucia R. Lopes, Eugenia Cifuentes-Pagano, Patrick J. Pagano
{"title":"NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease","authors":"Damir Kračun, Lucia R. Lopes, Eugenia Cifuentes-Pagano, Patrick J. Pagano","doi":"10.1152/physrev.00034.2023","DOIUrl":"https://doi.org/10.1152/physrev.00034.2023","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"1 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The TRP Channels Serving as Chemical-to-Electrical Signal Converter TRP通道作为化学-电信号转换器
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-01-15 DOI: 10.1152/physrev.00012.2024
Yuhua Tian, Jie Zheng
{"title":"The TRP Channels Serving as Chemical-to-Electrical Signal Converter","authors":"Yuhua Tian, Jie Zheng","doi":"10.1152/physrev.00012.2024","DOIUrl":"https://doi.org/10.1152/physrev.00012.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"5 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kisspeptin and Neurokinin B: roles in reproductive health Kisspeptin和Neurokinin B：在生殖健康中的作用
IF 33.6 1区 医学
Physiological reviews Pub Date : 2025-01-15 DOI: 10.1152/physrev.00015.2024
Kanyada Koysombat, Jovanna Tsoutsouki, Aaran H. Patel, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
{"title":"Kisspeptin and Neurokinin B: roles in reproductive health","authors":"Kanyada Koysombat, Jovanna Tsoutsouki, Aaran H. Patel, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara","doi":"10.1152/physrev.00015.2024","DOIUrl":"https://doi.org/10.1152/physrev.00015.2024","url":null,"abstract":"Physiological Reviews, Ahead of Print. <br/>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"29 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology of syncope: current concepts and their development. 晕厥的病理生理学：当前概念及其发展。
IF 29.9 1区 医学
Physiological reviews Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI: 10.1152/physrev.00007.2024
David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk
{"title":"Pathophysiology of syncope: current concepts and their development.","authors":"David G Benditt, Artur Fedorowski, Richard Sutton, J Gert van Dijk","doi":"10.1152/physrev.00007.2024","DOIUrl":"10.1152/physrev.00007.2024","url":null,"abstract":"<p><p>Syncope is a symptom in which transient loss of consciousness occurs as a consequence of a self-limited, spontaneously terminating period of cerebral hypoperfusion. Many circulatory disturbances (e.g. brady- or tachyarrhythmias, reflex cardioinhibition-vasodepression-hypotension) may trigger a syncope or near-syncope episode, and identifying the cause(s) is often challenging. Some syncope may involve multiple etiologies operating in concert, whereas in other cases multiple syncope events may be due to various differing causes at different times. In this communication, we address the current understanding of the principal contributors to syncope pathophysiology including examination of the manner in which concepts evolved, an overview of factors that constitute consciousness and loss of consciousness, and aspects of neurovascular control and communication that are impacted by cerebral hypoperfusion leading to syncope. Emphasis focuses on <i>1</i>) current understanding of the way transient systemic hypotension impacts brain blood flow and brain function; <i>2</i>) the complexity and temporal sequence of vascular, humoral, and cardiac factors that may accompany the most common causes of syncope; <i>3</i>) the range of circumstances and disease states that may lead to syncope; and <i>4</i>) clinical features associated with syncope and in particular the reflex syncope syndromes.</p>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"209-266"},"PeriodicalIF":29.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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