Physiological reviews最新文献_第3页

An umbrella review of systematic reviews of the impact of wrist-worn wearables on health outcomes. 对穿戴在手腕上的可穿戴设备对健康结果影响的系统审查进行总括性审查。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-12-29 DOI: 10.1152/physrev.00049.2024

Marija Glisic,Adea Llane,Stevan Stojic,Erand Llanaj,Zayne Milena Roa-Díaz,Peter Francis Raguindin,Lum Kastrati,Lara Weed,Mintu P Turakhia,Euan Ashley,Taulant Muka,John P A Ioannidis

{"title":"An umbrella review of systematic reviews of the impact of wrist-worn wearables on health outcomes.","authors":"Marija Glisic,Adea Llane,Stevan Stojic,Erand Llanaj,Zayne Milena Roa-Díaz,Peter Francis Raguindin,Lum Kastrati,Lara Weed,Mintu P Turakhia,Euan Ashley,Taulant Muka,John P A Ioannidis","doi":"10.1152/physrev.00049.2024","DOIUrl":"https://doi.org/10.1152/physrev.00049.2024","url":null,"abstract":"We conducted an umbrella review to synthesize the evidence on the effectiveness of interventions incorporating wrist-worn wearables* feedback on diverse health outcomes including health promotion (i.e., health behaviors and disease risk perception) morbidity, mortality, functioning, and other health-related metrics in humans. We searched in MEDLINE, Web of Science, Embase and Cochrane Library until 18th March 2025 for eligible systematic reviews. After screening 9 487 citations, we identified 39 systematic reviews, which included 98 original studies (one observational study, 95 randomized controlled trials, and two pre-post studies). The reviews primarily focused on adult populations, individuals with cardiometabolic conditions, and cancer survivors. The original interventional studies mainly included Fitbit (40.2%), Polar (12.4%), and ActiGraph (10.3%) devices. Over 80% of the clinical trials involved complex behavioral interventions with wearable-based feedback, and the control groups varied. Most systematic reviews were rated as low confidence, with common flaws including inadequate considerations for risk-of-bias and heterogeneity. Interventions incorporating wrist-worn activity trackers increased physical activity in diverse populations. The effect of interventions incorporating wrist-wearables' feedback on cardiometabolic risk markers, quality of life, depression/anxiety and pain was limited and remained inconsistent. Our findings rely on existing systematic reviews, which may vary in quality, review methodologies and comprehensiveness. There is also potential for missing more recent evidence not yet captured in these reviews. These limitations should be considered when interpreting our results. Acknowledging these caveats, wrist-worn wearables seem to increase physical activity, and may have also additional benefits that require further study.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"15 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Central Control of Gastrointestinal Functions in Health and Disease. 健康与疾病中胃肠功能的中枢控制。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-12-23 DOI: 10.1152/physrev.00010.2025

Kirsteen N Browning,R Alberto Travagli,Carolina Pellegrini

{"title":"Central Control of Gastrointestinal Functions in Health and Disease.","authors":"Kirsteen N Browning,R Alberto Travagli,Carolina Pellegrini","doi":"10.1152/physrev.00010.2025","DOIUrl":"https://doi.org/10.1152/physrev.00010.2025","url":null,"abstract":"Thanks to its extensive intrinsic (enteric) neural networks spanning its entire length, the gastrointestinal (GI) tract has long been recognized for its ability to operate independently of the central nervous system (CNS). Despite that, the CNS provides both sympathetic and parasympathetic inputs to the GI tract, that confers an additional layer of regulation, modulation, and integration over GI functions. The sympathetic nervous system provides neurovascular control of GI blood flow in addition to its effects to decrease mucosal secretion, regulate sphincter tone, and modulate motility, principally via prejunctional and presynaptic actions. The parasympathetic nervous system, however, exerts both excitatory and inhibitory effects; the extent to which this influences gut functions varies throughout the length of the GI tract. Recent studies have also demonstrated that, in addition to regulation via the autonomic nervous system, 'higher' CNS nuclei also provide a significant degree of influence over GI functions under both physiological and pathophysiological conditions In addition to describing the anatomical neurocircuits and physiological functions of the extrinsic inputs to the GI tract, this review will also discuss the roles of brainstem, midbrain, and cortical nuclei that influence the gut within the context of relevant physiological and pathophysiological conditions.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"3 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crossroads between autoimmunity and cancer: Underlying mechanisms and clinical implications. 自身免疫和癌症之间的十字路口：潜在机制和临床意义。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-12-22 DOI: 10.1152/physrev.00012.2025

Ada Gjyrezi,Charalampos Skarlis,Clio Mavragani,Paraskevi Giannakakou

引用次数: 0

Hacking the functions of sleep: Non-invasive approaches to stimulate sleep neurophysiology. 破解睡眠功能：非侵入性方法刺激睡眠神经生理学。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-11-20 DOI: 10.1152/physrev.00007.2025

Elena Krugliakova,Friederike Breuer,Nico Adelhöfer,Alejandra Alonso,Luciana Besedovsky,Keith Murphy,Emma Peters,Karolina Raczek,Björn Rasch,Leila Salvesen,Sophia Snipes,Sarah Schoch,Thomas Schreiner,Rick Wassing,Til Ole Bergmann,Martin Dresler

{"title":"Hacking the functions of sleep: Non-invasive approaches to stimulate sleep neurophysiology.","authors":"Elena Krugliakova,Friederike Breuer,Nico Adelhöfer,Alejandra Alonso,Luciana Besedovsky,Keith Murphy,Emma Peters,Karolina Raczek,Björn Rasch,Leila Salvesen,Sophia Snipes,Sarah Schoch,Thomas Schreiner,Rick Wassing,Til Ole Bergmann,Martin Dresler","doi":"10.1152/physrev.00007.2025","DOIUrl":"https://doi.org/10.1152/physrev.00007.2025","url":null,"abstract":"Sleep is essentially contributing to human health and wellbeing through multiple biological functions, including restoration and biosynthesis, brain clearance, energy metabolism, immunological and endocrine processing, synaptic plasticity, memory consolidation, and regulation of cognitive and emotional processes. Sleep disturbances are highly prevalent and are both a symptom and a contributing risk factor for psychiatric, neurological, and somatic disorders. Given the limitations of pharmacological interventions, non-invasive neuromodulation techniques ranging from non-invasive transcranial (TMS, tDCS, tACS, tRNS, tTIS, and TUS) to peripheral sensory (auditory, olfactory, visual, tactile, vestibular) and electrical nerve (galvanic vestibular, transcutaneous vagus nerve, and median nerve) stimulation have gained increasing attention as potential tools to modulate sleep physiology. These techniques offer promising avenues for both therapeutic applications and fundamental research into sleep-dependent neuroplasticity, interregional communication, and oscillatory activity. However, sleep is not a uniform state but a highly complex and dynamic phenomenon, with intricate macrostructural (e.g., NREM-REM sleep balance, sleep efficiency) and microstructural characteristics (e.g., hierarchically nested slow waves and spindles) that contribute to a variety of functions. This complexity necessitates precise targeting strategies, often employing real-time brain-state-de pendent stimulation, to modulate specific sleep-related processes effectively. In this review, we summarise the functions of sleep and the available non-invasive tools for its modulation, addressing key methodological challenges and providing recommendations for best practices in sleep neuromodulation.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"8 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain structural networks underlying language 语言背后的大脑结构网络

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-11-10 DOI: 10.1152/physrev.00004.2025

Angela Dorkas Friederici

引用次数: 0

Adaptive episodic memory: How multiple memory representations drive behaviour in humans and non-humans. 适应性情景记忆：多重记忆表征如何驱动人类和非人类的行为。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-11-04 DOI: 10.1152/physrev.00005.2025

Hannah Tarder-Stoll,Melanie J Sekeres,Brian Levine,Morris Moscovitch

{"title":"Adaptive episodic memory: How multiple memory representations drive behaviour in humans and non-humans.","authors":"Hannah Tarder-Stoll,Melanie J Sekeres,Brian Levine,Morris Moscovitch","doi":"10.1152/physrev.00005.2025","DOIUrl":"https://doi.org/10.1152/physrev.00005.2025","url":null,"abstract":"Episodic memory is a declarative long-term memory of a specific past experience. As such, it is multifaceted, encompassing both the objective and subjective components of that experience. These components can be flexibly represented at different levels of granularity, from precise, context-specific details to generalized, gist-like representations. In this review, we suggest that 1) multiple representations of an episodic memory at different levels of granularity are simultaneously encoded into a memory trace and 2) the relative weighting of these representations determines the extent to which a memory is reconstructed or reproduced at retrieval. We propose that this representational flexibility drives adaptive behavior by prioritizing reconstruction or reproduction depending on the age of the memory, its relationship to prior knowledge, current attentional goals, or task demands, and individual differences. Drawing on research in humans and non-human animals, we show a close correspondence between psychological and neural representations of a memory across encoding, consolidation, and retrieval. Specifically, we discuss how hippocampal activity in humans and engram formation and activation in rodents support the reproduction of detailed memory representations, while schema formation across species, mediated by the medial prefrontal cortex, facilitates reconstruction and generalization to guide behavior. Finally, we consider how species- and individual-level differences shape episodic memory representations. By integrating findings across species, we illustrate how the correspondence between neural and psychological representations enables multiple memory representations to balance stability and flexibility, ultimately driving adaptive behavior.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"18 4 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum for Lutsenko et al., volume 105, 2025, p. 441-491. Lutsenko等人的勘误表，第105卷，2025年，第441-491页。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-10-01 DOI: 10.1152/physrev.00011.2024_cor

引用次数: 0

The human placenta and its role in reproductive outcomes revisited. 人类胎盘及其在生殖结果中的作用重新审视。

IF 28.7 1区医学

Physiological reviews Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1152/physrev.00039.2024

Irving L M H Aye, Stephen Tong, D Stephen Charnock-Jones, Gordon C S Smith

{"title":"The human placenta and its role in reproductive outcomes revisited.","authors":"Irving L M H Aye, Stephen Tong, D Stephen Charnock-Jones, Gordon C S Smith","doi":"10.1152/physrev.00039.2024","DOIUrl":"10.1152/physrev.00039.2024","url":null,"abstract":"<p><p>The placenta performs many key tasks that are essential for the healthy growth and development of the human fetus. Placental dysfunction has multiple manifestations, but they share the common property of lacking a mechanistic understanding of etiology. The clinical consequences of placental dysfunction are a major determinant of the global burden of disease. Currently, the primary clinical method for assessing placental function is ultrasonic Doppler flow velocimetry of the umbilical and uterine arteries. More recently, some biomarkers have emerged that can predict or diagnose placentally related complications of pregnancy. However, methods for identifying and characterizing placental dysfunction have developed relatively little over the last 20 years and perform poorly, and there remains an absence of disease-modifying therapies targeted at the placenta. Understanding disease mechanisms is made more difficult due to the profound differences in pregnancy and placentation comparing humans and the most commonly used laboratory animals, limiting the utility of animal models. The use of omics methods in human samples may yield progress: omics analyses of maternal blood show promise in identifying better predictors of disease, and single-cell analyses, including spatial omics of healthy and abnormal placentas, could identify therapeutic targets. Limitations in cellular models of the placenta have been significantly overcome in the last 5 to 10 years by the development of human cell models, including human trophoblast stem cells and organoids, and the use of these model systems may allow hypothesis testing experiments in a more clinically relevant context than animal models or immortalized cell lines.</p>","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"2305-2376"},"PeriodicalIF":28.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications. 膜转运的SLC-ome：从分子发现到生理学和临床应用。

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-09-30 DOI: 10.1152/physrev.00001.2024

Gergely Gyimesi,Susan Tweedie,Elspeth Bruford,Matthias A Hediger

{"title":"The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.","authors":"Gergely Gyimesi,Susan Tweedie,Elspeth Bruford,Matthias A Hediger","doi":"10.1152/physrev.00001.2024","DOIUrl":"https://doi.org/10.1152/physrev.00001.2024","url":null,"abstract":"Membrane transporters are essential for human health, mediating the movement of nutrients, electrolytes, metabolites and other molecules across cellular and organellar membranes. Genes encoding these proteins account for approximately 5.2% of the human protein coding genome. Nearly half of these belong to the solute carriers (SLC) supergroup, the largest class of membrane transport proteins, collectively termed the \"SLC-ome.\" The current SLC-ome comprises 464 SLCs organized into 76 SLC families, of which 24% (111 SLCs) remain orphan transporters with unknown or incompletely characterized function. An additional 52 SLC-like proteins bring the total to 516 membrane transport proteins. SLCs function as molecular gatekeepers, and their dysfunction contributes to a wide spectrum of human diseases, including cancer, diabetes, and immunological, cardiovascular and neurodegenerative disorders. Pathological consequences of SLC defects include hypertension, hyperglycemia, hypercholesterolemia, nutritional deficiencies, metal ion imbalance, oxidative stress, and dysfunction of mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In addition, genetic defects in SLCs are the cause of many rare diseases. Several SLCs require additional subunits to form functional heteromeric complexes, while others exhibit additional or alternative roles, such as acting as transceptors. In this review, we provide updated physiological, structural, mechanistic, and pharmacological insights for each of the 516 human SLC and SLC-like proteins. We also summarize their classification, structural architecture, transport mechanisms and pharmaceutical relevance, and present the most recent SLC gene nomenclature assignments approved by the HUGO Gene Nomenclature Committee (HGNC).","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":"24 1","pages":""},"PeriodicalIF":33.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications 重力、微重力和人工重力：生理效应、实现和应用

IF 33.6 1区医学

Physiological reviews Pub Date : 2025-09-29 DOI: 10.1152/physrev.00055.2024

Nandu Goswami, Andrew Philip Blaber, Giovanna Valenti, Helmut Hinghofer-Szalkay, Joyce Evans, Damian Miles Bailey, Joan Vernikos, Alexander Choukér, David Andrew Green, Olivier White, Jack J. W. A. van Loon, Victor A. Convertino

引用次数: 0