Physiological reviews最新文献_第3页

The ion channels of endomembranes. 内膜的离子通道

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-03-07 DOI: 10.1152/physrev.00025.2023

Meiqin Hu, Xinghua Feng, Qiang Liu, Siyu Liu, Fangqian Huang, Haoxing Xu

{"title":"The ion channels of endomembranes.","authors":"Meiqin Hu, Xinghua Feng, Qiang Liu, Siyu Liu, Fangqian Huang, Haoxing Xu","doi":"10.1152/physrev.00025.2023","DOIUrl":"10.1152/physrev.00025.2023","url":null,"abstract":"The endomembrane system consists of organellar membranes in the biosynthetic pathway [endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the degradative pathway (early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes). These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist across endomembranes: Ca2+ gradients for most endomembrane organelles and H+ gradients for the acidic compartments. Ion (Na+, K+, H+, Ca2+, and Cl-) channels on the organellar membranes control ion flux in response to cellular cues, allowing rapid informational exchange between the cytosol and organelle lumen. Recent advances in organelle proteomics, organellar electrophysiology, and luminal and juxtaorganellar ion imaging have led to molecular identification and functional characterization of about two dozen endomembrane ion channels. For example, whereas IP3R1-3 channels mediate Ca2+ release from the ER in response to neurotransmitter and hormone stimulation, TRPML1-3 and TMEM175 channels mediate lysosomal Ca2+ and H+ release, respectively, in response to nutritional and trafficking cues. This review aims to summarize the current understanding of these endomembrane channels, with a focus on their subcellular localizations, ion permeation properties, gating mechanisms, cell biological functions, and disease relevance.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1335-1385"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the multifaceted intricacies of the Na⁺-Cl^- cotransporter, a highly regulated key effector in the control of hydromineral homeostasis. 驾驭 Na+-Cl- 共转运体的多面复杂性，它是控制水矿物质平衡的高度调节和关键效应器。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-02-08 DOI: 10.1152/physrev.00027.2023

A V Rioux, T R Nsimba-Batomene, S Slimani, N A D Bergeron, M A M Gravel, S V Schreiber, M J Fiola, L Haydock, A P Garneau, P Isenring

{"title":"Navigating the multifaceted intricacies of the Na+-Cl- cotransporter, a highly regulated key effector in the control of hydromineral homeostasis.","authors":"A V Rioux, T R Nsimba-Batomene, S Slimani, N A D Bergeron, M A M Gravel, S V Schreiber, M J Fiola, L Haydock, A P Garneau, P Isenring","doi":"10.1152/physrev.00027.2023","DOIUrl":"10.1152/physrev.00027.2023","url":null,"abstract":"The Na+-Cl- cotransporter (NCC; SLC12A3) is a highly regulated integral membrane protein that is known to exist as three splice variants in primates. Its primary role in the kidney is to mediate the cosymport of Na+ and Cl- across the apical membrane of the distal convoluted tubule. Through this role and the involvement of other ion transport systems, NCC allows the systemic circulation to reclaim a fraction of the ultrafiltered Na+, K+, Cl-, and Mg+ loads in exchange for Ca2+ and [Formula: see text]. The physiological relevance of the Na+-Cl- cotransport mechanism in humans is illustrated by several abnormalities that result from NCC inactivation through the administration of thiazides or in the setting of hereditary disorders. The purpose of the present review is to discuss the molecular mechanisms and overall roles of Na+-Cl- cotransport as the main topics of interest. On reading the narrative proposed, one will realize that the knowledge gained in regard to these themes will continue to progress unrelentingly no matter how refined it has now become.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1147-1204"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological basis for xenotransplantation from genetically modified pigs to humans. 转基因猪向人类异种移植的生理基础：综述。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-03-22 DOI: 10.1152/physrev.00041.2023

Leigh Peterson, Magdi H Yacoub, David Ayares, Kazuhiko Yamada, Daniel Eisenson, Bartley P Griffith, Muhammad M Mohiuddin, Willard Eyestone, J Craig Venter, Ryszard T Smolenski, Martine Rothblatt

{"title":"Physiological basis for xenotransplantation from genetically modified pigs to humans.","authors":"Leigh Peterson, Magdi H Yacoub, David Ayares, Kazuhiko Yamada, Daniel Eisenson, Bartley P Griffith, Muhammad M Mohiuddin, Willard Eyestone, J Craig Venter, Ryszard T Smolenski, Martine Rothblatt","doi":"10.1152/physrev.00041.2023","DOIUrl":"10.1152/physrev.00041.2023","url":null,"abstract":"The collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-nonhuman primate (NHP) xenotransplantation and achieved prolonged pig xenograft survival. These studies informed the design of Revivicor's (Revivicor Inc, Blacksburg, VA) genetically engineered pigs with 10 genetic modifications (10 GE) (including the inactivation of 4 endogenous porcine genes and insertion of 6 human transgenes), whose hearts and kidneys have now been studied in preclinical human xenotransplantation models with brain-dead recipients. Additionally, the first two clinical cases of pig-to-human heart xenotransplantation were recently performed with hearts from this 10 GE pig at the University of Maryland. Although this review focuses on xenotransplantation of hearts and kidneys, multiple organs, tissues, and cell types from genetically engineered pigs will provide much-needed therapeutic interventions in the future.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1409-1459"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiology and systems biology of stress resilience. 压力复原力的神经生物学和系统生物学。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-03-14 DOI: 10.1152/physrev.00042.2023

Raffael Kalisch, Scott J Russo, Marianne B Müller

{"title":"Neurobiology and systems biology of stress resilience.","authors":"Raffael Kalisch, Scott J Russo, Marianne B Müller","doi":"10.1152/physrev.00042.2023","DOIUrl":"10.1152/physrev.00042.2023","url":null,"abstract":"Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts to unravel the factors and mechanisms that make resilience possible and to harness its insights for the development of preventative interventions in individuals at risk for acquiring stress-related dysfunctions. Biological resilience research has been lagging behind the psychological and social sciences but has seen a massive surge in recent years. At the same time, progress in this field has been hampered by methodological challenges related to finding suitable operationalizations and study designs, replicating findings, and modeling resilience in animals. We embed a review of behavioral, neuroimaging, neurobiological, and systems biological findings in adults in a critical methods discussion. We find preliminary evidence that hippocampus-based pattern separation and prefrontal-based cognitive control functions protect against the development of pathological fears in the aftermath of singular, event-type stressors [as found in fear-related disorders, including simpler forms of posttraumatic stress disorder (PTSD)] by facilitating the perception of safety. Reward system-based pursuit and savoring of positive reinforcers appear to protect against the development of more generalized dysfunctions of the anxious-depressive spectrum resulting from more severe or longer-lasting stressors (as in depression, generalized or comorbid anxiety, or severe PTSD). Links between preserved functioning of these neural systems under stress and neuroplasticity, immunoregulation, gut microbiome composition, and integrity of the gut barrier and the blood-brain barrier are beginning to emerge. On this basis, avenues for biological interventions are pointed out.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1205-1263"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Best practices for data management and sharing in experimental biomedical research. 生物医学实验研究数据管理与共享的最佳实践。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-03-07 DOI: 10.1152/physrev.00043.2023

Teresa Cunha-Oliveira, John P A Ioannidis, Paulo J Oliveira

{"title":"Best practices for data management and sharing in experimental biomedical research.","authors":"Teresa Cunha-Oliveira, John P A Ioannidis, Paulo J Oliveira","doi":"10.1152/physrev.00043.2023","DOIUrl":"10.1152/physrev.00043.2023","url":null,"abstract":"Effective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building on results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community and benefiting researchers' careers. In experimental biomedicine, comprehensive data management is vital due to the typically intricate protocols, extensive metadata, and large datasets. Low-throughput experiments, in particular, require careful management to address variations and errors in protocols and raw data quality. Transparent and accountable research practices rely on accurate documentation of procedures, data collection, and analysis methods. Proper data management ensures long-term preservation and accessibility of valuable datasets. Well-managed data can be revisited, contributing to cumulative knowledge and potential new discoveries. Publicly funded research has an added responsibility for transparency, resource allocation, and avoiding redundancy. Meeting funding agency expectations increasingly requires rigorous methodologies, adherence to standards, comprehensive documentation, and widespread sharing of data, code, and other auxiliary resources. This review provides critical insights into raw and processed data, metadata, high-throughput versus low-throughput datasets, a common language for documentation, experimental and reporting guidelines, efficient data management systems, sharing practices, and relevant repositories. We systematically present available resources and optimal practices for wide use by experimental biomedical researchers.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1387-1408"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hormonal control of parturition. 分娩的荷尔蒙控制

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-02-08 DOI: 10.1152/physrev.00019.2023

Emily Hamburg-Shields, Sam Mesiano

{"title":"The hormonal control of parturition.","authors":"Emily Hamburg-Shields, Sam Mesiano","doi":"10.1152/physrev.00019.2023","DOIUrl":"10.1152/physrev.00019.2023","url":null,"abstract":"Parturition is a complex physiological process that must occur in a reliable manner and at an appropriate gestation stage to ensure a healthy newborn and mother. To this end, hormones that affect the function of the gravid uterus, especially progesterone (P4), 17β-estradiol (E2), oxytocin (OT), and prostaglandins (PGs), play pivotal roles. P4 via the nuclear P4 receptor (PR) promotes uterine quiescence and for most of pregnancy exerts a dominant block to labor. Loss of the P4 block to parturition in association with a gain in prolabor actions of E2 are key transitions in the hormonal cascade leading to parturition. P4 withdrawal can occur through various mechanisms depending on species and physiological context. Parturition in most species involves inflammation within the uterine tissues and especially at the maternal-fetal interface. Local PGs and other inflammatory mediators may initiate parturition by inducing P4 withdrawal. Withdrawal of the P4 block is coordinated with increased E2 actions to enhance uterotonic signals mediated by OT and PGs to promote uterine contractions, cervix softening, and membrane rupture, i.e., labor. This review examines recent advances in research to understand the hormonal control of parturition, with focus on the roles of P4, E2, PGs, OT, inflammatory cytokines, and placental peptide hormones together with evolutionary biology of and implications for clinical management of human parturition.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"1121-1145"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ceramides are fuel gauges on the drive to cardiometabolic disease. 神经酰胺是通往心脏代谢疾病的 "燃料计"。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-02-01 DOI: 10.1152/physrev.00008.2023

Joseph L Wilkerson, Sean M Tatum, William L Holland, Scott A Summers

引用次数: 0

The anterior chamber of the eye technology and its anatomical, optical, and immunological bases. 眼球前房技术及其解剖学、光学和免疫学基础。

IF 29.9 1区医学

Physiological reviews Pub Date : 2024-07-01 Epub Date: 2024-01-11 DOI: 10.1152/physrev.00024.2023

Shao-Nian Yang, Yue Shi, Per-Olof Berggren

{"title":"The anterior chamber of the eye technology and its anatomical, optical, and immunological bases.","authors":"Shao-Nian Yang, Yue Shi, Per-Olof Berggren","doi":"10.1152/physrev.00024.2023","DOIUrl":"10.1152/physrev.00024.2023","url":null,"abstract":"The anterior chamber of the eye (ACE) is distinct in its anatomy, optics, and immunology. This guarantees that the eye perceives visual information in the context of physiology even when encountering adverse incidents like inflammation. In addition, this endows the ACE with the special nursery bed iris enriched in vasculatures and nerves. The ACE constitutes a confined space enclosing an oxygen/nutrient-rich, immune-privileged, and less stressful milieu as well as an optically transparent medium. Therefore, aside from visual perception, the ACE unexpectedly serves as an excellent transplantation site for different body parts and a unique platform for noninvasive, longitudinal, and intravital microimaging of different grafts. On the basis of these merits, the ACE technology has evolved from the prototypical through the conventional to the advanced version. Studies using this technology as a versatile biomedical research platform have led to a diverse range of basic knowledge and in-depth understanding of a variety of cells, tissues, and organs as well as artificial biomaterials, pharmaceuticals, and abiotic substances. Remarkably, the technology turns in vivo dynamic imaging of the morphological characteristics, organotypic features, developmental fates, and specific functions of intracameral grafts into reality under physiological and pathological conditions. Here we review the anatomical, optical, and immunological bases as well as technical details of the ACE technology. Moreover, we discuss major achievements obtained and potential prospective avenues for this technology.","PeriodicalId":20193,"journal":{"name":"Physiological reviews","volume":" ","pages":"881-929"},"PeriodicalIF":29.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degenerate Neuronal and Circuit Mechanisms Important for Generating Rhythmic Motor Patterns 生成节律性运动模式的重要退化神经元和电路机制

IF 33.6 1区医学

Physiological reviews Pub Date : 2024-06-13 DOI: 10.1152/physrev.00003.2024

Ronald L Calabrese, Eve Marder

引用次数: 0

A versatile delivery vehicle for cellular oxygen and fuels, or metabolic sensor? - A review and perspective on the functions of myoglobin 细胞氧气和燃料的多功能输送工具，还是代谢传感器？- 肌红蛋白功能的回顾与展望

IF 33.6 1区医学

Physiological reviews Pub Date : 2024-05-02 DOI: 10.1152/physrev.00031.2023

Kiran Kumar Adepu, Andriy Anishkin, Sean H. Adams, Sree V Chintapalli

引用次数: 0