Meshkat Naeimi Darestani, Behzad Houshmand, Seyed Ali Mosaddad, Mohammadreza Talebi
{"title":"Assessing the Surface Modifications of Contaminated Sandblasted and Acid-Etched Implants Through Diode Lasers of Different Wavelengths: An <i>In Vitro</i> Study.","authors":"Meshkat Naeimi Darestani, Behzad Houshmand, Seyed Ali Mosaddad, Mohammadreza Talebi","doi":"10.1089/photob.2023.0009","DOIUrl":"https://doi.org/10.1089/photob.2023.0009","url":null,"abstract":"<p><p><b><i>Objective:</i></b> The present study was conducted to compare the effects of 810 nm, 980 nm, and dual (810: 50%-980: 50%) diode lasers on the surface modifications of implants contaminated by a standard strain of <i>Escherichia coli</i>. <b><i>Methods:</i></b> Based on the operation on their surface, the implants were divided into six groups: \"Group 1\" was the positive control group undergoing no specific procedures. \"Groups 2, 3, 4, 5, and 6\" were contaminated by a standard strain of <i>E. coli</i>; \"Group 2\" was also set as the negative control group. \"Groups 3, 4, and 5\" were irradiated by 810 nm, 980 nm, and dual lasers (810: 50%-980: 50%; 1.5W, 320 μm fiber) for 30 sec, respectively. \"Group 6\" was treated using standard titanium brushes. All groups were examined to evaluate the surface modifications by the X-ray diffraction analysis, scanning electron microscope, and atomic force microscopy. <b><i>Results:</i></b> The values of carbon, oxygen, aluminum, titanium, and vanadium were significantly different in the surface composition of the contaminated implants from the control groups (<i>p</i> = 0.010, 0.033, 0.044, 0.016, and 0.037, respectively). In all target areas, there were significant differences in surface roughness (<i>p</i> < 0.0001); the same was also true about the pairwise comparison of the study groups (<i>p</i> < 0.0001). \"Group 5\" demonstrated lower morphological surface changes and roughness degrees. <b><i>Conclusions:</i></b> Overall, laser irradiation could alter the surfaces of the contaminated implants. Titanium brushes and 810/980 nm lasers resulted in similar morphological alterations. Dual lasers enjoyed the least degree of morphological alterations and surface roughness.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"201-211"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Potassium Titanyl Phosphate Laser and Sodium Hypochlorite on Postoperative Pain Intensity Following Pulpotomy in Teeth with Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial.","authors":"Muhammed Ayhan, Demet Altunbaş","doi":"10.1089/photob.2022.0152","DOIUrl":"https://doi.org/10.1089/photob.2022.0152","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study evaluated the postoperative pain intensity in permanent teeth with symptomatic irreversible pulpitis treated by pulpotomy using physiological saline, sodium hypochlorite (NaOCl), or the potassium titanyl phosphate (KTP) laser. <b><i>Materials and methods:</i></b> Ninety patients diagnosed with symptomatic irreversible pulpitis in permanent molars were randomly divided into three groups according to the pulpotomy procedures. Preoperative pain levels were recorded. Complete hemostasis was achieved with physiological saline (control group), NaOCl, or the KTP laser after initial bleeding control. Patients were asked to mark their pain level on the visual pain scale at 6, 24, 48, and 72 h and 7 and 30 days depending on the severity of pain. The permanent restoration was completed after 7 days. Data were statistically analyzed using Kruskal-Wallis, Mann-Whitney <i>U</i>, Friedman, and Bonferroni tests at a significance level of <i>p</i> < 0.05. <b><i>Results:</i></b> According to the present study, the statistical difference between the groups in terms of preoperative pain and percussion pain levels was insignificant (<i>p</i> > 0.05). There was no significant difference between groups in terms of demographic data (<i>p</i> > 0.05). The postoperative pain level of the KTP laser group was significantly lower at 6 h compared with the saline group (<i>p</i> < 0.05). There was no significant difference between groups in terms of the postoperative pain level at other time intervals (<i>p</i> > 0.05). The highest pain scores were observed in all groups at 6 h (<i>p</i> < 0.05). <b><i>Conclusions:</i></b> The KTP laser can be preferred primarily for reducing postoperative pain in pulpotomy treatments. The KTP laser or NaOCl-assisted pulpotomy can be an effective treatment for pain reduction in permanent teeth with symptomatic irreversible pulpitis. This report is registered at clinicaltrials.gov (ID: NCT05424796).</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9794656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>In Vitro</i> Evaluation of the Different Supragingival Prophylaxis Tips on Enamel Surfaces.","authors":"Gizem Ince Kuka, Bahar Kuru, Hare Gursoy","doi":"10.1089/photob.2022.0137","DOIUrl":"https://doi.org/10.1089/photob.2022.0137","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Periodontal instrumentation during supragingival prophylaxis may increase enamel surface roughness, which may lead to increased dental biofilm accumulation and demineralization of the enamel. The aim of this study was to evaluate the changes of the enamel surface profilometrically after the application of different scaler tips used for the professional supragingival prophylaxis. <b><i>Materials and methods:</i></b> Forty-eight enamel block samples obtained from extracted human maxillary premolar teeth were prepared and randomly assigned to four different treatment groups. Each treatment group was instrumented by the same clinician with different tools as Group 1: Er:YAG laser chisel tip, Group 2: scaler, Group 3: new generation universal curette; and Group 4: ultrasonic device. Sample surfaces were evaluated with a profilometer before and after instrumentations and after the polishing process. <b><i>Results:</i></b> Baseline roughness of the prepared enamel samples was similar between the groups. After instrumentation and polishing, the Er:YAG laser chisel tip revealed the most irregular surface morphology, whereas the new generation curette induced the smoothest surface. <b><i>Conclusions:</i></b> New generation universal curette is a promising tool, which can be used safely for supragingival calculus removal without the need for polishing on enamel surfaces.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"212-217"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photobiomodulation for Skin Pigmentation Disorders: A Dual-Function Treatment.","authors":"Michael R Hamblin","doi":"10.1089/photob.2023.0040","DOIUrl":"10.1089/photob.2023.0040","url":null,"abstract":"","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"199-200"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Alqerban, Saeed N Asiri, Fahad Alharbi, Nasser Alqhtani, Adel Alenazi, Ali Robaian, Abdulaziz Samran
{"title":"Incorporation of Zirconium Oxide Nanoparticles in Adhesive Resin for Bonding of Brackets to Enamel Conditioned with Er,Cr:YSGG, Photodynamic Therapy, and Phosphoric Acid.","authors":"Ali Alqerban, Saeed N Asiri, Fahad Alharbi, Nasser Alqhtani, Adel Alenazi, Ali Robaian, Abdulaziz Samran","doi":"10.1089/photob.2022.0132","DOIUrl":"https://doi.org/10.1089/photob.2022.0132","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To evaluate the effect of enamel conditioning methods, that is, total-etch and rinse (TER), Er,Cr:YSGG (ECYL), and photodynamic therapy (PDT) on the shear bond strength (SBS) of orthodontic metallic brackets bonded using Zirconium oxide experimental adhesive (ZOEA). <b><i>Methods:</i></b> Sixty human incisor buccal surfaces were cleaned and allocated into three groups based on the method of enamel surface treatment, that is, TER using 37% phosphoric acid gel, methylene blue photosensitizer activated by PDT and ECYL (<i>n</i> = 20 each). Each group was further divided into two subgroups (<i>n</i> = 10) based on the type of adhesive, that is, ZOEA and experimental adhesive (EA). Metallic brackets were seated using composite resin. Samples were placed in a universal testing machine for SBS and failure mode using the ARI index. One-way analysis of variance and post hoc Tukey were used for multiple comparisons. ARI was presented in percentages in different investigated groups. <b><i>Results:</i></b> TER+ZOEA (17.16 ± 0.41 MPa) displayed the highest bond integrity. However, group PDT+EA (11.34 ± 0.25 MPa) demonstrated the lowest bond scores. The intergroup comparison revealed that the TER system displayed significantly higher SBS values than the PDT and ECYL groups (<i>p</i> < 0.05). The intragroup comparison revealed that enamel conditioned with TER and brackets bonded with ZOEA and EA displayed comparable bond integrity (<i>p</i> > 0.05). <b><i>Conclusions:</i></b> Enamel conditioned with TER bonded to a metallic bracket displayed better bond strength than PDT and ECYL. Zirconium oxide nanoparticles incorporated in adhesive have proved to be promising in improving the bond integrity of adhesive.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Increased Improvement in Speech-Language Skills After Transcranial Photobiomodulation Plus Speech-Language Therapy, Compared to Speech-Language Therapy Alone: Case Report with Aphasia.","authors":"Karla Estrada-Rojas, Nidia Patricia Cedeño Ortiz","doi":"10.1089/photob.2022.0024","DOIUrl":"10.1089/photob.2022.0024","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This is a case report showing that transcranial photobiomodulation (tPBM) combined with traditional, speech-language therapy improved and accelerated the results from speech-language therapy, in a stroke person with aphasia (PWA). <b><i>Background:</i></b> tPBM is a safe, noninvasive technique using red and near-infrared light to improve the metabolism of cells. tPBM helps by promoting neuromodulation, while decreasing neuroinflammation and promoting vasodilation. Several studies have shown that tPBM can help individuals with stroke or traumatic brain injury achieve significant cognitive improvements. <b><i>Methods:</i></b> A 38-year-old female, who sustained an ischemic stroke on the left side of the brain, received two, 5-month series of treatments. The first series of treatments included traditional speech-language therapy, for the first 5 months poststroke. The second series of treatments included tPBM in combination with speech-language therapy, for the next 5 months. The tPBM treatments included application of red (630 and 660 nm) and near-infrared (850 nm) wavelengths of photons applied to left hemisphere scalp areas. The major cortical language areas were subjacent to the scalp placements along the line of the Sylvian fissure. At each session, first a light-emitting diode (LED) cluster head with red (630 and 660 nm) and near-infrared (850 nm) wavelengths, with an irradiance (power density) of 200 mW/cm<sup>2</sup>, a beam size of 4.9 cm<sup>2</sup>, and a fluence (energy density) of 12 J/cm<sup>2</sup> per minute, was applied to the left side of the scalp/brain, along the Sylvian fissure for 60 sec at each at the following eight, language network target areas: frontal pole, prefrontal cortex, and inferior frontal gyrus (Broca's area); supramarginal gyrus and angular gyrus in the parietal lobe; inferior motor/sensory cortex (mouth area); and posterior superior temporal gyrus (Wernicke's area) and superior temporal sulcus in the temporal lobe, for a total of 8 min. Second, for the next 20 min (1200 sec), simultaneous with speech-language therapy, an LED PBM helmet was applied to the scalp/head. This helmet contained 256 separate LED lights, near-infrared (810 nm) wavelength, 60 mW power per LED light, total power, 15 W; energy, 72 Joules; fluence, 28.8 J/cm<sup>2</sup>; and irradiance, 24 mW/cm<sup>2</sup>. <b><i>Results and conclusions:</i></b> During the initial, 5-month treatment series with traditional speech-language therapy only, there was little to no improvement in dysarthria and expressive language. During the second, 5-month treatment series, however, with tPBM applied first, to the left hemisphere only, and second, to both hemispheres during each session plus simultaneous speech-language therapy, there was marked improvement in the dysarthria and expressive language. After the first 5-month series, this PWA had utilized a slow rate of speech with a production of ∼25 to 30 words-per-minute during con","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 5","pages":"234-240"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Intratissue Laser Ablation in Facial Morphological Modification.","authors":"Quan-Feng Luo","doi":"10.1089/photob.2022.0145","DOIUrl":"https://doi.org/10.1089/photob.2022.0145","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To conduct a retrospective analysis of the therapeutic effects of laser ablation in maxillofacial applications. <b><i>Methods:</i></b> Laser ablation was performed in 97 patients, 27 cases of facial fat accumulation, 40 cases of sagging caused by facial aging, 16 cases of soft tissue asymmetry, and 14 cases of facial hyperplasia. Laser parameters were as follows: lipolysis 8 W, 90-120 J/cm<sup>2</sup>, and the ablation of hyperplastic tissue 9-10 W, 150-200 J/cm<sup>2</sup>. The subcutaneous thickness, facial morphology, patient's self-evaluation, and satisfaction were evaluated. <b><i>Results:</i></b> Laser ablation reduced the subcutaneous thickness, and tightened loose skin. The patient's appearance looked younger and more beautiful. The curves of the facial contours were more of Oriental beauty. The hyperplasia site became thinner, and the facial asymmetry was corrected or significantly improved. Most of the patients were satisfied with the outcome. There were no serious complications besides swelling. <b><i>Conclusions:</i></b> Laser ablation can effectively treat thickening and relaxation of maxillofacial soft tissues. With low risk, few complications, and quick recovery, it can be used as a first-line treatment for maxillofacial soft tissue plastic surgery.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 4","pages":"182-188"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9335550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Could Photobiomodulation Be Incorporated into Indoor Lighting?","authors":"Michael R Hamblin","doi":"10.1089/photob.2023.0027","DOIUrl":"https://doi.org/10.1089/photob.2023.0027","url":null,"abstract":"","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 4","pages":"145-146"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulo Jorge Romão Varela, Piedade Aurora Gonçalves Barros, Pedro Giorgetti Montagner, Michelle B Provout, Elizabeth F Martinez, Selly Sayuri Suzuki, Aguinaldo Silva Garcez
{"title":"Can Collagen Membrane on Bone Graft Interfere with Light Transmission and Influence Tissue Neoformation During Photobiomodulation? A Preliminary Study.","authors":"Paulo Jorge Romão Varela, Piedade Aurora Gonçalves Barros, Pedro Giorgetti Montagner, Michelle B Provout, Elizabeth F Martinez, Selly Sayuri Suzuki, Aguinaldo Silva Garcez","doi":"10.1089/photob.2022.0070","DOIUrl":"https://doi.org/10.1089/photob.2022.0070","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study qualitatively and quantitatively evaluated the transmission of light through a collagen membrane and the consequent local bone formation in a critical bone defect <i>in vitro</i> and in an animal model. <b><i>Background:</i></b> Currently, bone substitutes and collagen membranes are used to promote new bone formation; however, when associated with photobiomodulation, biomaterials can act as a barrier, hindering the passage of light radiation to the area to be treated. <b><i>Methods:</i></b> Light transmittance was evaluated <i>in vitro</i> with a power meter and a 100 mW, 808 nm laser source with and without membrane. Twenty-four male rats received a critical surgical defect of 5 mm in diameter in the calvarial bone, subsequently a biomaterial (Bio-Oss; Geistlich<sup>®</sup>, Switzerland) was applied, and the animals were divided into the following three groups: G1-collagen membrane and no irradiation; G2-collagen membrane and photobiomodulation (irradiation with 4 J of 808 nm); and G3-photobiomodulation (4 J) followed by a collagen membrane. Histomophometric analyses were performed at 7 and 14 days after euthanasia. <b><i>Results:</i></b> The membrane reduced the light transmittance (808 nm) by an average of 78%. Histomophometric analyses showed significant differences in new blood vessels on day 7 and bone neoformation on day 14. Irradiation without membrane interposition resulted in a 15% more neoformed bone compared with the control (G1), and 6.5% more bone compared with irradiation over the membrane (G2). <b><i>Conclusions:</i></b> The collagen membrane interferes with light penetration during photobiomodulation, decreases light dosimetry on the wound area, and interferes with bone neoformation.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 4","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luismar Barbosa da Cruz, Carlos Eduardo Girasol, Pedro Soler Coltro, Rinaldo Roberto de Jesus Guirro, Luciano Bachmann
{"title":"Optical Properties of Human Skin Phototypes and Their Correlation with Individual Angle Typology.","authors":"Luismar Barbosa da Cruz, Carlos Eduardo Girasol, Pedro Soler Coltro, Rinaldo Roberto de Jesus Guirro, Luciano Bachmann","doi":"10.1089/photob.2022.0111","DOIUrl":"https://doi.org/10.1089/photob.2022.0111","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aims to correlate human skin phototypes with complete optical characterization (absorption, scattering, effective attenuation, optical penetration, and albedo coefficients) based on individual typology angle (ITA) values and colorimetric parameters. <b><i>Methods:</i></b> A colorimeter was used to group 12, fresh, <i>ex vivo</i> human skin samples according to their phototype; the CIELAB color scale and ITA values were employed. An integrating sphere system and the inverse adding-doubling algorithm were applied during optical characterization, conducted from 500 to 1300 nm. <b><i>Results:</i></b> On the basis of ITA values and their classification, the skin samples were separated into six groups: two intermediates, two tan, and two brown. In the visible range, for lower ITA values (darker skins), the absorption and effective attenuation coefficient parameters increased, whereas the albedo and depth penetration parameters decreased. In the infrared region, all the phototypes had similar parameters. The scattering coefficient was similar for all the samples and did not change with ITA values. <b><i>Conclusions:</i></b> ITA analysis, a quantitative method, showed that the human skin tissue's optical properties and pigmentation colors were highly correlated.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 4","pages":"175-181"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}