Phytotherapy Research最新文献_第9页

The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy. 药用植物在调节表观遗传机制中的作用：对癌症预防和治疗的意义。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-04 DOI: 10.1002/ptr.8481

Khadra Afaf Bendrihem, Aicha Mouane, Manel Azzi, Mohamed Aimene Mihoubi, Maria Atanassova, Barbara Sawicka, Wafa Zahnit, Mohammed Messaoudi

{"title":"The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy.","authors":"Khadra Afaf Bendrihem, Aicha Mouane, Manel Azzi, Mohamed Aimene Mihoubi, Maria Atanassova, Barbara Sawicka, Wafa Zahnit, Mohammed Messaoudi","doi":"10.1002/ptr.8481","DOIUrl":"https://doi.org/10.1002/ptr.8481","url":null,"abstract":"Cancer remains a significant global health challenge, with its progression driven by both genetic mutations and reversible epigenetic modifications. This review highlights the potential of phytochemicals to modulate epigenetic mechanisms for cancer prevention and treatment. Natural compounds such as quercetin, EGCG, genistein, and β-elemene interact with key processes such as DNA methylation, histone modifications, and non-coding RNA regulation. These mechanisms enable the reactivation of tumor suppressor genes, increased sensitivity to conventional therapy and mitigation of drug resistance. For instance, EGCG improves the efficacy of cisplatin by altering DNA methylation patterns, while genistein influences breast cancer progression through HER2 pathway regulation. However, challenges such as low bioavailability, variability in compound composition, and the need for robust clinical validation remain. Further high-quality clinical trials are required to confirm the efficacy and safety of these compounds in cancer prevention and therapy.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies. 类黄酮在脊髓损伤中的研究进展：治疗机制和给药策略。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-02 DOI: 10.1002/ptr.8488

Shizhe Li, Shutao Gao, Yukun Hu, Jingsheng Feng, Weibin Sheng

{"title":"Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies.","authors":"Shizhe Li, Shutao Gao, Yukun Hu, Jingsheng Feng, Weibin Sheng","doi":"10.1002/ptr.8488","DOIUrl":"https://doi.org/10.1002/ptr.8488","url":null,"abstract":"Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show a loss of motor and sensory functions below the level of injury. Current treatment protocols are based on early surgical decompression and pharmacotherapy. However, the efficacy of these interventions is suboptimal. Due to its complex pathophysiological mechanisms and the difficulty of central nervous system (CNS) regeneration, exploring effective therapeutic interventions remains daunting. Flavonoids are secondary metabolites unique to plants that have attracted attention in recent years for their potential efficacy and are now commonly used in the treatment of inflammation, tumors, and other diseases. For SCI, related studies are still exploring; some compounds, such as quercetin, fisetin, and hesperetin, have shown good anti-inflammatory and anti-apoptotic properties, which help to restore the function of the injured spinal cord. However, flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, and the inability to achieve long-term controlled release. Some studies have proposed potential drug delivery strategies-including nanoparticles, hydrogels, and collagen scaffolds-to enhance efficacy. In this paper, we summarize the therapeutic mechanisms and drug delivery strategies of flavonoids in SCI by searching the relevant literature in recent years and propose future research directions to provide new ideas for the multimodal treatment of SCI.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baicalin attenuated metabolic dysfunction-associated fatty liver disease by suppressing oxidative stress and inflammation via the p62-Keap1-Nrf2 signalling pathway in db/db mice. 黄芩苷在db/db小鼠中通过p62-Keap1-Nrf2信号通路抑制氧化应激和炎症，从而减轻代谢功能障碍相关的脂肪肝疾病。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2023-09-11 DOI: 10.1002/ptr.8010

Wen-Jing Liu, Wei-Wen Chen, Jia-Ying Chen, Yi-Bin Sun, Dennis Chang, Chen-Xiang Wang, Jin-Dong Xie, Wei Lin, Shao-Hua Li, Wen Xu, Yan-Xiang Lin, Yan-Fang Zheng, Xian Zhou, Ming-Qing Huang

{"title":"Baicalin attenuated metabolic dysfunction-associated fatty liver disease by suppressing oxidative stress and inflammation via the p62-Keap1-Nrf2 signalling pathway in db/db mice.","authors":"Wen-Jing Liu, Wei-Wen Chen, Jia-Ying Chen, Yi-Bin Sun, Dennis Chang, Chen-Xiang Wang, Jin-Dong Xie, Wei Lin, Shao-Hua Li, Wen Xu, Yan-Xiang Lin, Yan-Fang Zheng, Xian Zhou, Ming-Qing Huang","doi":"10.1002/ptr.8010","DOIUrl":"10.1002/ptr.8010","url":null,"abstract":"Metabolic dysfunction-associated fatty liver disease (MAFLD) is the main cause of chronic liver disease. Baicalin (Bai), a bioactive molecule found in Scutellaria baicalensis Georgi, possesses antioxidant and antiinflammatory properties. These activities suggest Bai could be a promising therapeutic agent against NAFLD; however, its specific effects and underlying mechanism are still not clear. This study aims to explore the effect of Bai to attenuate MAFLD and associated molecular mechanisms. Bai (50, 100 or 200 mg/kg) was orally administered to db/db mice with MAFLD for 4 weeks or db/m mice as the normal control. Bai markedly attenuated lipid accumulation, cirrhosis and hepatocytes apoptosis in the liver tissues of MAFLD mice, suggesting strong ability to attenuate MAFLD. Bai significantly reduced proinflammatory biomarkers and enhanced antioxidant enzymes, which appeared to be modulated by the upregulated p62-Keap1-Nrf2 signalling cascade; furthermore, cotreatment of Bai and all-trans-retinoic acid (Nrf2 inhibitor) demonstrated markedly weakened liver protective effects by Bai and its induced antioxidant and antiinflammatory responses. The present study supported the use of Bai in attenuating MAFLD as a promising therapeutic agent, and its strong mechanism of action in association with the upregulating the p62-keap1-Nrf2 pathway.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1663-1678"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents. 作为 Nrf2/ARE 信号通路调节剂和潜在胃保护剂的天然氧杂蒽酮。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-02-19 DOI: 10.1002/ptr.8160

Natalie Vivien Gunter, Soek Sin Teh, Ibrahim Jantan, Kung Pui Law, Hiroyuki Morita, Siau Hui Mah

{"title":"Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents.","authors":"Natalie Vivien Gunter, Soek Sin Teh, Ibrahim Jantan, Kung Pui Law, Hiroyuki Morita, Siau Hui Mah","doi":"10.1002/ptr.8160","DOIUrl":"10.1002/ptr.8160","url":null,"abstract":"Oxidative stress is implicated in the initiation, pathogenesis, and progression of various gastric inflammatory diseases (GID). The prevalence of these diseases remains a concern along with the increasing risks of adverse effects in current clinical interventions. Hence, new gastroprotective agents capable of inhibiting oxidative stress by modulating cellular defense systems such as the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway are critically needed to address these issues. A candidate to solve the present issue is xanthone, a natural compound that reportedly exerts gastroprotective effects via antioxidant, anti-inflammatory, and cytoprotective mechanisms. Moreover, xanthone derivatives were shown to modulate the Nrf2/ARE signaling pathway to counter oxidative stress in both in vitro and in vivo models. Thirteen natural xanthones have demonstrated the ability to modulate the Nrf2/ARE signaling pathway and have high potential as lead compounds for GID as indicated by their in vivo gastroprotective action-particularly mangiferin (2), α-mangostin (3), and γ-mangostin (4). Further studies on these compounds are recommended to validate the Nrf2 modulatory ability in relation to their gastroprotective action.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1721-1734"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salidroside improves blood-brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β. 水杨甙通过GSK3β抑制小胶质细胞的活化，从而改善低压氧小鼠血脑屏障的完整性和认知功能。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-10-04 DOI: 10.1002/ptr.8264

Xianxie Zhang, Huiting Zhang, Zuoxu Liu, Tianke Huang, Ru Yi, Zengchun Ma, Yue Gao

{"title":"Salidroside improves blood-brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β.","authors":"Xianxie Zhang, Huiting Zhang, Zuoxu Liu, Tianke Huang, Ru Yi, Zengchun Ma, Yue Gao","doi":"10.1002/ptr.8264","DOIUrl":"10.1002/ptr.8264","url":null,"abstract":"Salidroside, an active component found in Rhodiola rosea L., has emerged as a potential therapeutic agent for the prevention and treatment of hypoxic brain injury, while the precise target and mechanism of salidroside were remain unclear. The study utilized techniques such as network pharmacology, transcriptome sequencing to investigate the mechanism and target of salidroside in regulating blood-brain barrier (BBB) function to protect hypoxic brain injury in vivo. Utilized macromolecular docking and molecular biology techniques to explore the molecular mechanism of salidroside in alleviating brain injury induced by hypoxia in BV2 cell model. The results show that salidroside alleviated the learning and memory dysfunction and pathological injury in mice exposed to hypobaric hypoxia, reduced brain water content and attenuate the inflammatory response and oxidative stress, effectively reversed S100β in serum and promoted the repair of BBB. GSK3β is an important therapeutic target of salidroside in the treatment of hypoxic cognitive impairment, and salidroside can specifically bind GSK3β in the ATP binding pocket, inducing the phosphorylation of GSK3β, targeting downstream Nrf-2 to regulate microglia activity, promoting the accumulation of β-catenin, thereby inhibiting microglial activation, improving the BBB integrity injury and achieving a neuroprotective effect. This study demonstrates that salidroside can inhibit the activation of microglia by inducing GSK3β phosphorylation, achieve neuroprotective effects and alleviate learning and memory dysfunction in hypobaric hypoxia mice. This study provides a theoretical basis for the development of salidroside and the clinical application of Rhodiola rosea L.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1808-1825"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies. 通过天然产品靶向炎症性肠病中的程序性细胞死亡：从分子机制到靶向疗法的新见解。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-05-05 DOI: 10.1002/ptr.8216

Mengjie Wang, Zhiyuan Wang, Zhichao Li, Yuan Qu, Jiting Zhao, Lei Wang, Xinpeng Zhou, Ziqi Xu, Di Zhang, Ping Jiang, Bing Fan, Ying Liu

{"title":"Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies.","authors":"Mengjie Wang, Zhiyuan Wang, Zhichao Li, Yuan Qu, Jiting Zhao, Lei Wang, Xinpeng Zhou, Ziqi Xu, Di Zhang, Ping Jiang, Bing Fan, Ying Liu","doi":"10.1002/ptr.8216","DOIUrl":"10.1002/ptr.8216","url":null,"abstract":"Inflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised intestinal barrier and inflammatory infiltration. This disorder's pathogenesis is mainly attributed to extensive damage or death of intestinal epithelial cells, along with abnormal activation or impaired death regulation of immune cells and the release of various inflammatory factors, which contribute to the inflammatory environment in the intestines. Thus, maintaining intestinal homeostasis hinges on balancing the survival and functionality of various cell types. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, and neutrophil extracellular traps, are integral in the pathogenesis of IBD by mediating the death of intestinal epithelial and immune cells. Natural products derived from plants, fruits, and vegetables have shown potential in regulating PCD, offering preventive and therapeutic avenues for IBD. This article reviews the role of natural products in IBD treatment by focusing on targeting PCD pathways, opening new avenues for clinical IBD management.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1776-1807"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy. 生育三烯酚在癌症治疗中作为化疗增敏剂的治疗潜力。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-02-14 DOI: 10.1002/ptr.8131

Bethsebie Lalduhsaki Sailo, Suravi Chauhan, Mangala Hegde, Sosmitha Girisa, Mohammed S Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Ajaikumar B Kunnumakkara

{"title":"Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy.","authors":"Bethsebie Lalduhsaki Sailo, Suravi Chauhan, Mangala Hegde, Sosmitha Girisa, Mohammed S Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Ajaikumar B Kunnumakkara","doi":"10.1002/ptr.8131","DOIUrl":"10.1002/ptr.8131","url":null,"abstract":"Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents to treat cancer. Various strategies like dosage modification of drugs, nanoparticle-based delivery of chemotherapeutics, antibody-drug conjugates, and so on are being used to target and reverse chemoresistance, one among such is combination therapy. It uses the combination of two or more therapeutic agents to reverse multidrug resistance and improve the effects of chemotherapy. Phytochemicals are known to exhibit chemosensitizing properties and are found to be effective against various cancers. Tocotrienols (T3) and tocopherols (T) are natural bioactive analogs of vitamin E, which exhibit important medicinal value and potential curative properties apart from serving as an antioxidant and nutrient supplement. Notably, T3 exhibits a variety of pharmacological activities like anticancer, anti-inflammatory, antiproliferative, and so on. The chemosensitizing property of tocotrienol is exhibited by modulating several signaling pathways and molecular targets involved in cancer cell survival, proliferation, invasion, migration, and metastasis like NF-κB, STATs, Akt/mTOR, Bax/Bcl-2, Wnt/β-catenin, and many more. T3 sensitizes cancer cells to chemotherapeutic drugs including cisplatin, doxorubicin, and paclitaxel increasing drug concentration and cytotoxicity. Discussed herewith are the chemosensitizing properties of tocotrienols on various cancer cell types when combined with various drugs and biological molecules.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1694-1720"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising natural products targeting protein tyrosine phosphatase SHP2 for cancer therapy. 以蛋白酪氨酸磷酸酶 SHP2 为靶点的有望用于癌症治疗的天然产品。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-04-01 DOI: 10.1002/ptr.8185

Jiani Lu, Danmei Yu, Hongtao Li, Pengcheng Qin, Hongzhuan Chen, Lili Chen

{"title":"Promising natural products targeting protein tyrosine phosphatase SHP2 for cancer therapy.","authors":"Jiani Lu, Danmei Yu, Hongtao Li, Pengcheng Qin, Hongzhuan Chen, Lili Chen","doi":"10.1002/ptr.8185","DOIUrl":"10.1002/ptr.8185","url":null,"abstract":"The development of Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors is a hot spot in the research and development of antitumor drugs, which may induce immunomodulatory effects in the tumor microenvironment and participate in anti-tumor immune responses. To date, several SHP2 inhibitors have made remarkable progress and entered clinical trials for the treatment of patients with advanced solid tumors. Multiple compounds derived from natural products have been proved to influence tumor cell proliferation, apoptosis, migration and other cellular functions, modulate cell cycle and immune cell activation by regulating the function of SHP2 and its mutants. However, there is a paucity of information about their diversity, biochemistry, and therapeutic potential of targeting SHP2 in tumors. This review will provide the structure, classification, inhibitory activities, experimental models, and antitumor effects of the natural products. Notably, this review summarizes recent advance in the efficacy and pharmacological mechanism of natural products targeting SHP2 in inhibiting the various signaling pathways that regulate different cancers and thus pave the way for further development of anticancer drugs targeting SHP2.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1735-1757"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis. 中医药与免疫骨质疏松症的关系：对骨质疏松症治疗和管理的启示。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2024-12-03 DOI: 10.1002/ptr.8397

Xiaolei Ding, Jie Yang, Yuchi Wei, Mingyue Wang, Zeyu Peng, Rong He, Xiangyan Li, Daqing Zhao, Xiangyang Leng, Haisi Dong

{"title":"The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis.","authors":"Xiaolei Ding, Jie Yang, Yuchi Wei, Mingyue Wang, Zeyu Peng, Rong He, Xiangyan Li, Daqing Zhao, Xiangyang Leng, Haisi Dong","doi":"10.1002/ptr.8397","DOIUrl":"10.1002/ptr.8397","url":null,"abstract":"Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced bone mass and heightened fracture risk, posing a significant health and economic challenge to aging societies worldwide. Osteoimmunology-an emerging field of study-investigates the intricate relationship between the skeletal and the immune systems, providing insights into the immune system's impact on bone health and disease progression. Recent research has demonstrated the essential roles played by various immune cells (T cells, B cells, macrophages, dendritic cells, mast cells, granulocytes, and innate lymphoid cells) in regulating bone metabolism, homeostasis, formation, and remodeling through interactions with osteoclasts (OC) and osteoblasts (OB). These findings underscore that osteoimmunology provides an essential theoretical framework for understanding the pathogenesis of various skeletal disorders, including OP. Traditional Chinese medicine (TCM) and its active ingredients have significant clinical value in OP treatment. Unfortunately, despite their striking multieffect pathways in the pharmacological field, current research has not yet summarized them in a comprehensive and detailed manner with respect to their interventional roles in immune bone diseases, especially OP. Consequently, this review addresses recent studies on the mechanisms by which immune cells and their communication molecules contribute to OP development. Additionally, it explores the potential therapeutic benefits of TCM and its active components in treating OP from the perspective of osteoimmunology. The objective is to provide a comprehensive framework that enhances the understanding of the therapeutic mechanisms of TCM in treating immune-related bone diseases and to facilitate the development of novel therapeutic strategies.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1826-1846"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Dietary Fiber on Blood Pressure and Vascular Dysfunction Through Regulation of Sympathetic Tone and Immune Response in Genetic Hypertension. 膳食纤维通过调节遗传性高血压患者交感神经张力和免疫反应对血压和血管功能障碍的保护作用。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-04-01 Epub Date: 2025-03-23 DOI: 10.1002/ptr.8484

Cristina González-Correa, Javier Moleón, Sofía Miñano, Iñaki Robles-Vera, Néstor de la Visitación, Eduardo Guerra-Hernández, Marta Toral, Rosario Jiménez, Juan Duarte, Miguel Romero

{"title":"Protective Effect of Dietary Fiber on Blood Pressure and Vascular Dysfunction Through Regulation of Sympathetic Tone and Immune Response in Genetic Hypertension.","authors":"Cristina González-Correa, Javier Moleón, Sofía Miñano, Iñaki Robles-Vera, Néstor de la Visitación, Eduardo Guerra-Hernández, Marta Toral, Rosario Jiménez, Juan Duarte, Miguel Romero","doi":"10.1002/ptr.8484","DOIUrl":"10.1002/ptr.8484","url":null,"abstract":"The mechanisms underlying the antihypertensive effect of dietary fibers remain poorly understood. This study investigates whether dietary fiber supplementation can prevent cardiovascular damage and high blood pressure in a genetic model of neurogenic hypertension. Six-week-old male spontaneously hypertensive rats (SHR) and their respective normotensive control, Wistar Kyoto rats (WKY), were divided into four groups: Untreated WKY, untreated SHR, SHR treated with resistant starch (SHR + RS), and SHR treated with inulin-type fructans (SHR + ITF) for 12 weeks. Additionally, a faecal microbiota transplantation (FMT) experiment was conducted, transferring faecal content from treated SHR donors to recipient SHRs. A diet rich in RS fiber reduced vascular oxidative stress, inflammation, and high blood pressure. These protective effects were associated with a reshaped gut microbiota, leading to increased short-chain fatty acid production, reduced endotoxemia, decreased sympathetic activity, and a restored balance between Th17 and Treg lymphocytes in mesenteric lymph nodes and aorta. Elevated plasma levels of acetate and butyrate in the SHR + RS group correlated with increased expression of aortic GPR41, GRP43 and PPARδ. Conversely, ITF treatment failed to prevent hypertension or endothelial dysfunction in SHR. FMT from the SHR + RS group to recipient SHR partially replicated these beneficial effects. This study highlights the antihypertensive benefits of dietary insoluble RS fiber, which are attributed to enhanced short-chain fatty acids production in the gut. This leads to improved gut permeability, reduced sympathetic tone, and diminished vascular T-cell accumulation. Therefore, dietary interventions with RS fiber may offer promising therapeutic strategies for preventing hypertension.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1858-1875"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0