{"title":"治疗肺部疾病的草药天然抗氧化剂的潜在候选物:关注氧化还原平衡和天然产物。","authors":"Xing Chang, Siyuan Zhou, Zhaoqi Yan, Qin Zhang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Ruxiu Liu","doi":"10.1002/ptr.70008","DOIUrl":null,"url":null,"abstract":"<p><p>Oxidative stress (OS) refers to an imbalance between oxidation and antioxidation processes. Reactive oxygen species (ROS) are normal byproducts of redox reactions occurring in vivo. When there is an overproduction of ROS or an insufficient antioxidant capacity, ROS accumulate in airway tissues and alveolar cells, potentially inducing OS. This condition can cause the migration and accumulation of activated inflammatory cells in the pulmonary microcirculation, airways, and alveoli, further enhancing lung inflammatory responses and triggering an inflammatory cascade. Inflammation inevitably results in pulmonary tissue damage and remodeling, leading to pulmonary diseases. Since the discovery of artemisinin, a malaria inhibitor, by Nobel laureate Youyou Tu, the effects of natural antioxidants on pulmonary diseases have been extensively evaluated. Recently, many active components of natural antioxidants have been shown to be effective in modulating redox imbalances in alveolar, endothelial, and tumor cells. Therefore, the supplementation of natural antioxidants may be an effective strategy to mitigate asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. This paper reviews the advances in natural antioxidants for protecting against various pulmonary diseases by regulating redox imbalance. Antioxidants offer unique advantages and substantial potential.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential Candidates of Natural Antioxidants From Herbs for Treating Lung Disorders: Focus on Redox Balance and Natural Products.\",\"authors\":\"Xing Chang, Siyuan Zhou, Zhaoqi Yan, Qin Zhang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Ruxiu Liu\",\"doi\":\"10.1002/ptr.70008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oxidative stress (OS) refers to an imbalance between oxidation and antioxidation processes. Reactive oxygen species (ROS) are normal byproducts of redox reactions occurring in vivo. When there is an overproduction of ROS or an insufficient antioxidant capacity, ROS accumulate in airway tissues and alveolar cells, potentially inducing OS. This condition can cause the migration and accumulation of activated inflammatory cells in the pulmonary microcirculation, airways, and alveoli, further enhancing lung inflammatory responses and triggering an inflammatory cascade. Inflammation inevitably results in pulmonary tissue damage and remodeling, leading to pulmonary diseases. Since the discovery of artemisinin, a malaria inhibitor, by Nobel laureate Youyou Tu, the effects of natural antioxidants on pulmonary diseases have been extensively evaluated. Recently, many active components of natural antioxidants have been shown to be effective in modulating redox imbalances in alveolar, endothelial, and tumor cells. Therefore, the supplementation of natural antioxidants may be an effective strategy to mitigate asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. This paper reviews the advances in natural antioxidants for protecting against various pulmonary diseases by regulating redox imbalance. Antioxidants offer unique advantages and substantial potential.</p>\",\"PeriodicalId\":20110,\"journal\":{\"name\":\"Phytotherapy Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytotherapy Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ptr.70008\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytotherapy Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ptr.70008","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Potential Candidates of Natural Antioxidants From Herbs for Treating Lung Disorders: Focus on Redox Balance and Natural Products.
Oxidative stress (OS) refers to an imbalance between oxidation and antioxidation processes. Reactive oxygen species (ROS) are normal byproducts of redox reactions occurring in vivo. When there is an overproduction of ROS or an insufficient antioxidant capacity, ROS accumulate in airway tissues and alveolar cells, potentially inducing OS. This condition can cause the migration and accumulation of activated inflammatory cells in the pulmonary microcirculation, airways, and alveoli, further enhancing lung inflammatory responses and triggering an inflammatory cascade. Inflammation inevitably results in pulmonary tissue damage and remodeling, leading to pulmonary diseases. Since the discovery of artemisinin, a malaria inhibitor, by Nobel laureate Youyou Tu, the effects of natural antioxidants on pulmonary diseases have been extensively evaluated. Recently, many active components of natural antioxidants have been shown to be effective in modulating redox imbalances in alveolar, endothelial, and tumor cells. Therefore, the supplementation of natural antioxidants may be an effective strategy to mitigate asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. This paper reviews the advances in natural antioxidants for protecting against various pulmonary diseases by regulating redox imbalance. Antioxidants offer unique advantages and substantial potential.
期刊介绍:
Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field.
Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters.
By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.