治疗肺部疾病的草药天然抗氧化剂的潜在候选物:关注氧化还原平衡和天然产物。

IF 6.3 2区 医学 Q1 CHEMISTRY, MEDICINAL
Xing Chang, Siyuan Zhou, Zhaoqi Yan, Qin Zhang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Ruxiu Liu
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引用次数: 0

摘要

氧化应激是指氧化和抗氧化过程之间的不平衡。活性氧(ROS)是体内氧化还原反应的正常副产物。当ROS过量产生或抗氧化能力不足时,ROS在气道组织和肺泡细胞中积累,可能诱发OS。这种情况可导致活化的炎症细胞在肺微循环、气道和肺泡中迁移和积聚,进一步增强肺部炎症反应,引发炎症级联反应。炎症不可避免地导致肺组织损伤和重塑,从而导致肺部疾病。自从诺贝尔奖得主屠呦呦发现疟疾抑制剂青蒿素以来,人们对天然抗氧化剂对肺部疾病的影响进行了广泛评估。最近,许多天然抗氧化剂的活性成分已被证明在调节肺泡、内皮细胞和肿瘤细胞的氧化还原失衡方面是有效的。因此,补充天然抗氧化剂可能是减轻哮喘、慢性阻塞性肺疾病、肺纤维化和肺癌的有效策略。本文综述了通过调节氧化还原失衡来预防各种肺部疾病的天然抗氧化剂的研究进展。抗氧化剂具有独特的优势和巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Candidates of Natural Antioxidants From Herbs for Treating Lung Disorders: Focus on Redox Balance and Natural Products.

Oxidative stress (OS) refers to an imbalance between oxidation and antioxidation processes. Reactive oxygen species (ROS) are normal byproducts of redox reactions occurring in vivo. When there is an overproduction of ROS or an insufficient antioxidant capacity, ROS accumulate in airway tissues and alveolar cells, potentially inducing OS. This condition can cause the migration and accumulation of activated inflammatory cells in the pulmonary microcirculation, airways, and alveoli, further enhancing lung inflammatory responses and triggering an inflammatory cascade. Inflammation inevitably results in pulmonary tissue damage and remodeling, leading to pulmonary diseases. Since the discovery of artemisinin, a malaria inhibitor, by Nobel laureate Youyou Tu, the effects of natural antioxidants on pulmonary diseases have been extensively evaluated. Recently, many active components of natural antioxidants have been shown to be effective in modulating redox imbalances in alveolar, endothelial, and tumor cells. Therefore, the supplementation of natural antioxidants may be an effective strategy to mitigate asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. This paper reviews the advances in natural antioxidants for protecting against various pulmonary diseases by regulating redox imbalance. Antioxidants offer unique advantages and substantial potential.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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