Phytotherapy Research最新文献

{"title":"Ashwagandha: Is It Safe? Part 1: A Regulatory Review.","authors":"T Brendler, R Al-Mondhiry, L Lang, R Marles, M Tallon, A Raghu","doi":"10.1002/ptr.70151","DOIUrl":"10.1002/ptr.70151","url":null,"abstract":"<p><p>Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU). Once executed, this could lead to a ban on its use as an ingredient in food supplements. This review summarizes how AS is regulated in some of the primary world marketplaces.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"4845-4857"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Plant Bioactives as Regulators of Histone Modifications: Bridging Epigenetics and Anticancer Therapy.","authors":"Mengxiao Wang, Junyi Liang, Xinping Zhu, Yushuang Xing, Shijun Chang, Di Jia, Weiming Zhao","doi":"10.1002/ptr.70386","DOIUrl":"10.1002/ptr.70386","url":null,"abstract":"<p><p>Cancer remains a leading cause of global mortality, with tumor heterogeneity, recurrence, metastasis, and drug resistance posing significant challenges to conventional therapies, which are often limited by toxicity and efficacy. Epigenetic regulation, particularly histone modifications such as methylation, acetylation, phosphorylation, and lactylation, plays a pivotal role in orchestrating gene expression and tumor progression, representing promising yet complex therapeutic targets. Bioactive compounds derived from natural plants, characterized by multi-target activity and low toxicity, have emerged as potent modulators of histone modifications, capable of influencing tumor growth, metastasis, and the tumor microenvironment. Here, we provide a comprehensive review of recent advances elucidating how natural products influence cancer progression and reshape the tumor immune microenvironment by regulating histone modifications. We integrate current knowledge of key histone marks, modifying enzymes, and signaling pathways, proposing a unified framework linking natural compounds, epigenetic regulation, and tumorigenesis. By uncovering these molecular mechanisms, we highlight that plant bioactive compounds can reshape the tumor immune microenvironment through histone modifications to inspire the development of novel, safer, and more effective anticancer agents.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"5208-5254"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of 12-Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study.","authors":"Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade","doi":"10.1002/ptr.70096","DOIUrl":"10.1002/ptr.70096","url":null,"abstract":"<p><p>Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi-center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long-term administration over 12 months. Male and female adults (N = 191) aged between 18 and 65 years were included in the study. Clinical assessments were done at baseline, followed by monthly for 12 months, whereas laboratory and other study assessments were done at baseline, 6 and 12 months. The primary outcome was the clinical adverse events reported by the patients, whereas secondary outcomes were Clinical Global Impression-Improvement scale (CGI-I), health-related Short Form-12 Quality of Life (SF-12 QoL), and laboratory estimations of serum for cortisol, hepatic, renal, and thyroid function. ARE administration for 12 months reported 18 mild adverse events, which were resolved without intervention. The study reported no clinical significant changes in serum alanine transaminases (baseline: 31.31 ± 9.28 IU/L, end of study: 33.68 ± 6.80 IU/L), aspartate transaminases (baseline: 30.61 ± 7.18 IU/L, end of study: 29.02 ± 4.63 IU/L). Serum cortisol levels decreased significantly (p < 0.001), while lipid profile and plasma glucose levels remained unaffected. Serum testosterone (free and total) significantly increased (p < 0.05). SF-12 scores demonstrated significant improvements at 12 months (p < 0.001), indicating enhanced health-related quality of life. CGI assessment indicated overall improvement in 68.7% of patients, particularly notable in those aged ≥ 50 years. This study validates the long-term safety of ARE use over 12 months. Trial Registration: ClinicalTrials.gov identifier: CTRI/2022/10/046180; NCT06244147.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"4802-4812"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia-Reperfusion Injury and Atherosclerosis Development.","authors":"Lydia Symeonidi, Panagiota-Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios-Leandros Skaltsounis, Ioanna Andreadou","doi":"10.1002/ptr.70391","DOIUrl":"10.1002/ptr.70391","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. While studies suggest that berry fruits offer beneficial effects in CVD prevention, the bioactive compounds within different berries vary, and the specific mechanisms behind their protective effects are not yet fully elucidated. Our study aimed to evaluate and compare the cardioprotective and anti-atherosclerotic effects of Morus alba (white mulberries, WMex) and Vaccinium myrtillus L. fruit extracts (blueberries, BBex), focusing on acute myocardial infarction (AMI), CVD risk factors, atherosclerosis development, and the underlying mechanisms. WMex and BBex were produced and their qualitative compositions were characterized. We evaluated the infarct size (IS) limiting potential of 8-weeks supplementation with both WMex and BBex at nutritional doses in mice with western diet (WD)-induced metabolic syndrome (MS). We further evaluated atherosclerosis development mitigation after 4-weeks supplementation with the extracts in both male and female WD-fed ApoE^-/- mice as well as the putative cardioprotective and atheroprotective mechanisms. The total flavonoids in WMex and BBex were 49.50 and 98.92 mg rutin/g extract, respectively, while the total phenolic content was 50.74 and 110.00 mg gallic acid/g extract, respectively. Both extracts limited IS compared to Control by suppressing apoptosis. WMex upregulated endothelial nitric oxide synthase (eNOS) phosphorylation and pathway along with circulating nitrite levels. WMex suppressed the extent of atheromatic area in both male and female ApoE^-/- mice, while BBex was effective in females without any of the extracts affecting estrogen levels. WMex downregulated NF-kB-ICAM-1 axis in the atherosclerotic area and reduced circulating triglyceride levels. None of the extracts caused signs of toxicity, supporting a safety profile. In conclusion, WMex exerts potent cardioprotective and anti-atherosclerotic properties in vivo and could be further exploited for CVD prevention.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"5299-5315"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148056187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luteolin Improves BBB Integrity Following Ischemic Stroke Injury by Downregulating the Expression of LRP1 and MMP9.","authors":"Jia-Min Li, Jiao-Yan Yu, Ting Sun, Ming-Lei Fan, Qing-Qing Liu, Xi Li, Ya-Ya Du, Meng-Jia Zhang, Bin Wang, Qi Yang","doi":"10.1002/ptr.70121","DOIUrl":"10.1002/ptr.70121","url":null,"abstract":"<p><p>Ischemic stroke is a prevalent neurological disorder often resulting in brain tissue injury and blood-brain barrier (BBB) damage. Luteolin (LUT), a natural polyphenolic compound in grape skin, wine, and other plants, has neuroprotective properties against ischemic stroke. However, it remains unclear whether its protective effect involves alterations in BBB integrity. This study aimed to examine the BBB-protective impact of LUT in a photothrombotic (PT) mouse model and oxygen-glucose deprivation (OGD) cell model and investigate its underlying mechanism. First, we used neurofunctional scoring, 2,3,5-triphenyltetrazolium chloride staining, Nissl staining, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) to evaluate the neuroprotective effects of LUT in ischemic stroke. Furthermore, we assessed the impact of LUT on BBB permeability using Evans Blue staining, brain water content, transendothelial electrical resistance, FITC, and flow cytometry techniques. We also examined the expression of tight junction (TJ) proteins related to BBB integrity using Western blotting. Finally, we validated the potential mechanism of action of LUT using short hairpin RNA (shRNA) technology. LUT alleviated the cerebral infarct area and neuronal apoptosis in the PT mouse model, reduced brain water content and Evans Blue leakage, decreased bEnd.3 cell apoptosis in the OGD model, increased transmembrane resistance, and reduced FITC leakage. LUT also counteracted the degradation of TJ proteins and decreased the expression of MMP9. Furthermore, the improvement was weakened when LRP1 was interfered with using shRNA. Our study suggests that LUT has the potential to improve BBB damage and exert neuroprotective effects following ischemic stroke. The mechanism of action may involve the inhibition of LRP1 and subsequent reduction in MMP9 expression.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"4898-4912"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine Improved the Therapeutic Efficacy of UC-MSCs for DSS-Induced Colitis via Aerobic Glycolysis.","authors":"Mengye Wu, Cuiping Li, Jianqi Feng, Xiaolu Guo, Rui Fang, Qinghai Lian, Xiaoran Zhang, Jianping Ma, Yanling Li, Shujuan Xie, Haiyan Zhang, Yanwen Peng","doi":"10.1002/ptr.70372","DOIUrl":"10.1002/ptr.70372","url":null,"abstract":"<p><p>The global prevalence of inflammatory bowel disease (IBD) continues increasing, but effective targeted treatments remain elusive. Recently, mesenchymal stem cells (MSCs) have emerged as a promising candidate for IBD treatment, with energy metabolism playing a critical role. Berberine (BBR), a natural extract from Berberidaceae plants, has been shown to modulate various cell functions by reprogramming metabolism in immune-related diseases. This study aims to investigate the influence of BBR on the therapeutic effectiveness of MSCs in colitis. Using the colitis mice model, we compared the therapeutic effects of BBR treated MSCs (MSC_BBR) and untreated MSCs by evaluating colon length, Disease Activity Index, and histopathological change. Various methods were employed to detect the differences of MSC_BBR and MSCs, including seahorse analysis for energy metabolism, RNA-seq and qPCR for gene transcription, western blotting for protein expression, flow cytometry for phenotypic analysis, and cytokine production. Our results revealed that BBR treatment activated the AMPK signaling pathway, upregulated the expression of glucose transporter 1 (GLUT1), and promoted aerobic glycolysis in MSCs. Comparing to MSCs, MSC_BBR exhibited the increased expression of tumor necrosis factor-stimulated gene-6 (TSG-6), enhanced immunomodulatory function and superior therapeutic efficacy. Inhibition of either glycolysis or TSG-6 expression impaired the therapeutic effect of MSC_BBR, while overexpression of GLUT1 or TSG-6 obviously improved the therapeutic efficacy of MSCs. BBR treatment improved the therapeutic effect of MSCs in colitis by promoting aerobic glycolysis, providing a safe new approach for optimizing MSCs-based therapy in IBD through reprogramming energy metabolism.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"5193-5207"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, Repairing Damaged Gut Barrier and Regulating Intestinal Microbiota.","authors":"Xiaolei Yang, Chenyang Zhu, Bei Liu, Ping Yang, Zhonglian Cao, Jingru Liang, Jiarong Hu, Qiuxia Yu, Yu Zhong, Wandi Du, Junwei Chow, Shiwei Yan, Haiyang Liu, Longzhou Li, Tiandian Wang, Yanyun Gu, Guo Ma","doi":"10.1002/ptr.70205","DOIUrl":"10.1002/ptr.70205","url":null,"abstract":"<p><p>Astragaloside IV (AS-IV), a main active ingredient derived from Astragali Radix, displays a favorable effect in treating type 2 diabetes mellitus (T2DM). This study was aimed to figure out its antidiabetic mechanisms. The db/db mice were treated with AS-IV, and the metabolism phenotype and epithelial barrier permeability were tested. Trans-epithelial resistance assay was performed in Caco-2 cells. Metagenomic sequencing was used to determine the gut microbiota composition and function. The content of short-chain fatty acid (SCFA) in feces was determined using Agilent 8890-5977B GC-MS. Despite increasing mice body weight, AS-IV significantly reduced hyperglycemia in the db/db mice, decreased the ratio of liver weight/body weight, alleviated hepatic total cholesterol and triglyceride levels. AS-IV reduced inflammation through suppressing pro-inflammatory genes (Il1b, Tnf, Ccl2) and elevating anti-inflammatory genes (Il10, Il4, Il13, Il33) in the colonic epithelium. AS-IV also reversed the increased intestinal permeability and decreased expression of tight junction (TJ) proteins Claudin-1, ZO-1 in the db/db mice and Claudin-1, Occludin in Caco-2 cells. Additionally, metagenomic sequencing showed AS-IV altered composition and function of gut microbiota. The 80 species of gut microbiota were markedly changed, e.g., boosting of Alistipes spp. and Prevotella copri, decreasing of relative abundance of Ruminococcus gnavus and Enterocloster bolteae. AS-IV upregulated the SCFA related pathway, increased the content of SCFA, upregulated the transcription levels of SCFA receptors (i.e., GPR41, GPR43 and GPR109a), thereby improved glucose metabolism in the db/db mice. These findings demonstrate that AS-IV exhibited favorable antidiabetic effects by improving glucose metabolism and altering intestinal microbiota symbiosis via repairing the damaged gut barrier. This study will provide valuable reference for the development of new antidiabetic drugs and medication of T2DM.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"5016-5029"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ashwagandha on Reproductive Health: A Systematic Review of Sex-Specific Hormonal and Fertility Outcomes.","authors":"Debajyoti Roy, Maitrayee Ghosh, Dipan Roy, Nitin Sharma, Rohit Bhatia, Naresh Kumar Rangra","doi":"10.1002/ptr.70128","DOIUrl":"10.1002/ptr.70128","url":null,"abstract":"<p><p>Reproductive health is a major component of overall well-being, which is regulated by various factors like nutrition, stress and lifestyle; all of these in turn influence fertility and sexual function. Ideal reproductive health requires constant upkeep in individuals of both males and females, with natural products like ashwagandha gaining significant attention for their potential advantages. Various studies are exploring the effect of ashwagandha in the reproductive systems of both males and females. These studies are emphasizing some specific parameters like polycystic ovary syndrome, stress-induced menstrual irregularities in the case of the female reproductive system and sperm count and quality in the case of the male reproductive system. In order to study the impact of ashwagandha on the reproductive system, we conducted a systematic review involving a search of major databases like MEDLINE/PubMed, Web of Science, Scopus, Science Direct, and Google Scholar, following PRISMA guidelines. Our review included a detailed analysis of preclinical and clinical research articles that evaluated the role of ashwagandha in improving reproductive health and sexual dysfunction. This study specifically looked at its impact on the reproductive system. The findings of this study indicate that ashwagandha has the potential to improve sexual health. It can also serve as a therapeutic agent in certain reproductive disorders due to its antioxidant nature. In conclusion, ashwagandha appears to be a promising natural adjunct to the enhancement of reproductive health; however, more study is needed to understand its long-term effects and dosing more fully.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"4813-4832"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N6-(2-Hydroxyethyl) Adenosine Alleviates Hepatic Steatosis and Insulin Resistance by Inhibiting JunB+ Adipocytes.","authors":"Keyan Zhang, Mengdie Lu, Yan Yang, Jingping Huang, Liyin Li, Yishu Yan, Ruiyi Li, Jing Yang","doi":"10.1002/ptr.70287","DOIUrl":"10.1002/ptr.70287","url":null,"abstract":"<p><p>N6-(2-hydroxyethyl) adenosine (HEA), the main active component of Cordyceps species, has garnered attention for its multifaceted hypolipidemic and antihyperglycemic activities. However, the influence by which HEA affects the progression of nonalcoholic fatty liver disease (NAFLD) remains unclear. This study sought to investigate the efficacy and mechanisms of HEA in treating NAFLD. The mouse NAFLD models were induced by high-fat diet feeding or methionine-choline-deficient diet feeding. AML12 and HepG2 cells were used for the in vitro study. Lipidemic and glycemic parameters, untargeted lipidomic, cellular thermal shift assay, and so forth were used to explore the beneficial effects of HEA in NALFD. HEA effectively alleviated the progression of NAFLD by regulating glucolipid metabolism and insulin resistance both in vitro and in vivo. Lipidomic data suggested that HEA markedly reduced triglyceride levels by blocking hepatic de novo lipogenesis and shifting fatty acids into mitochondria for oxidation and into structural lipids. Moreover, stimulation of the supernatant of adipocytes with HEA was more effective than treatment with HEA only in terms of hepatic de novo lipogenesis in HepG2 cells. Mechanistically, HEA significantly reduced the population of JunB+ adipocytes, which exerts lower thermogenic capacity. Further studies verified that HEA interacted with ASP-12, ASP-13, and TYR-15 of JunB subunits through hydrogen bonding, leading to activated PGC-1α activity and governing thermogenic adipocyte heterogeneity and consequent biological responses. These findings highlight the capacity of HEA to alleviate NAFLD through the JunB pathway, paving a new way to treat NAFLD by influencing adipocyte functionality.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"5090-5103"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy.","authors":"Hye Jin Lee, Yu Jin So, Il-Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang","doi":"10.1002/ptr.70085","DOIUrl":"10.1002/ptr.70085","url":null,"abstract":"<p><p>Psoriasis is a persistent inflammatory dermatological condition, predominantly influenced by genetic factors, immune system dysfunction, and environmental stimuli. It presents as red papules and silvery-white scales, resulting in physical discomfort and contributing to various comorbidities, including mental health disorders, arthritis, and cardiovascular complications, which collectively impose considerable medical and socioeconomic burdens. Conventional treatments, such as immunosuppressants and biologics, may alleviate symptoms but frequently entail significant side effects and the potential for dependency. This review evaluates the therapeutic potential of natural compounds, emphasizing their capacity to influence critical cellular pathways involved in the pathogenesis of psoriasis. Natural compounds exhibit anti-inflammatory, keratinocyte-regulating, and antioxidant properties, influencing mechanisms like the Th17/IL-17 axis and oxidative stress. The results indicate that natural compounds may function as an adjunctive treatment, providing a safer alternative to existing therapies by mitigating side effects and improving symptom management.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"4759-4791"},"PeriodicalIF":8.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}