Phytotherapy Research最新文献

{"title":"Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.","authors":"Lu Liu, Zhongxia Wang, Yulin Qi, Ang Huang, Caiping He, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai","doi":"10.1002/ptr.70023","DOIUrl":"10.1002/ptr.70023","url":null,"abstract":"<p><p>Aberrant activation of the cGAS-STING pathway has been implicated in the pathogenesis of diverse inflammatory diseases. Kurarinone, a flavonoid compound isolated from Sophorae tonkinensis Radix et Rhizoma, has been reported to exhibit anti-inflammatory effects and is used to treat inflammatory diseases. But the effect of kurarinone on the cGAS-STING pathway has not been well studied. We aimed to investigate the impact of Kurarinone on cGAS-STING pathway activation and its protective effect against cGAS-STING-mediated inflammatory diseases. BMDMs and THP-1 cells pretreated with Kurarinone or vehicle were stimulated with ISD or various STING agonists; the protein level of p-IRF3 was analyzed by western blotting, and the secretion and mRNA level of inflammatory cytokines were detected by ELISA and qPCR, respectively. To further explore the potential targets and molecular mechanisms of Kurarinone, nucleocytoplasmic separation assays, STING oligomerization experiments, cellular thermal shift assays, drug affinity responsive target stability assays, and molecular docking were conducted. Additionally, DSS-induced inflammatory bowel disease and ConA-induced autoimmune hepatitis models were used to evaluate the effects of Kurarinone on cGAS-STING-mediated inflammatory diseases. In vitro, Kurarinone inhibited the phosphorylation of STING and IRF3, reduced IFNβ release, and downregulated the transcription of IFNβ, IL-1β, CXCL10, IL-6, TNF-α, and ISG15, in ISD-stimulated BMDMs and THP-1 cells. Additionally, Kurarinone suppressed IRF3 nuclear translocation, disrupted the interaction between STING and IRF3, but did not affect STING oligomerization. Furthermore, Kurarinone reduced the thermostability of STING while increasing its susceptibility to proteolytic degradation. The molecular docking results indicated a strong interaction between Kurarinone and STING. In vivo, Kurarinone attenuated the inflammatory response in DSS-induced inflammatory bowel disease and ConA-induced autoimmune hepatitis models by inhibiting cGAS-STING signaling activation. In conclusion, Kurarinone targets the STING protein to interfere with the interaction between IRF3 and STING, thereby inhibiting the activation of the cGAS-STING signaling pathway. Additionally, Kurarinone ameliorates inflammatory diseases by suppressing the cGAS-STING pathway. This study provides a potential candidate drug for the clinical treatment of STING-driven inflammatory diseases.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3450-3465"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Plant-Derived Dietary Supplements on Lipid Profiles in Menopausal Women: An Updated Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.","authors":"Soo-Hyun Park, Mi-Ra Oh, Jangho Lee, Hyo-Kyoung Choi, Jin-Taek Hwang","doi":"10.1002/ptr.8511","DOIUrl":"10.1002/ptr.8511","url":null,"abstract":"<p><p>A Comprehensive evaluation of plant-derived supplements for hypolipidemic effects in menopausal women requires robust clinical trials and integrated analysis of diverse research findings. To address this, we conducted a systematic review and meta - analysis to evaluate the effects of plant-derived supplements on lipid profiles in menopausal women. Relevant studies were identified through systematic searches in MEDLINE, Embase, Web of Science, and CENTRAL until June 2022. Randomized controlled trials assessing the effects of plant-derived supplements on lipid profiles in menopausal women were included. A total of 61 studies were reviewed, and 60 studies with 6127 participants were included in the meta-analysis. Study quality was evaluated using the Cochrane Risk of Bias tool, and pooled data were analyzed with a random effects model for meta-analysis. The analysis revealed significant reductions in total cholesterol (SMD = -0.17, 95% CI: -0.26 to -0.08), triglycerides (SMD = -0.16, 95% CI: -0.26 to -0.05), and LDL-cholesterol (SMD = -0.19, 95% CI: -0.27 to -0.10). Subgroup analysis revealed that phytoestrogens, particularly from soy, were especially effective. Favorable outcomes were also observed in postmenopausal women with amenorrhea for over 1 year and in interventions lasting 3-12 months. However, variations in supplement formulations and insufficient dosage-specific data limited the findings. Further clinical research on plant-derived supplements should be accumulated to clarify their effects. Despite these limitations, this review provides updated evidence and highlights promising materials for improving blood lipid profiles. It also offers insights into optimizing clinical trial designs for dietary supplements, paving the way for more targeted and effective interventions. The study protocol (CRD42022383752) was registered in the PROSPERO database.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3486-3507"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Up-to-Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials.","authors":"Dilaram Nijat, Qingzhe Zhao, Gulhasal Abdurixit, Jianhua He, Haipeng Liu, Jinyao Li","doi":"10.1002/ptr.70037","DOIUrl":"10.1002/ptr.70037","url":null,"abstract":"<p><p>Atherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi-target therapeutic potential against atherosclerosis by modulating inflammatory responses, oxidative stress, lipid metabolism, and gut microbiota interactions. This review systematically evaluates (1) the anti-atherogenic mechanisms of key TCM herbs (e.g., Panax ginseng, Salvia miltiorrhiza ) and bioactive compounds (e.g., ginsenosides, tanshinones), (2) their synergistic effects in proprietary formulations, and (3) clinical evidence for cardiovascular protection. Notably, we highlight how TCM compounds like berberine and resveratrol target the gut-vascular axis by regulating microbiota-derived metabolites (e.g., TMAO) and improving endothelial function. While preclinical studies show promising results through Nrf2/HO-1 activation, NF-κB inhibition, and plaque stabilization, translational challenges persist, including the lack of standardization and microbiome-dependent efficacy variations. We conclude that integrating TCM's multi-component advantages with cutting-edge technologies such as bioinformatics, nanotechnology, and patient-specific multiomics including microbiome profiling could revolutionize atherosclerosis management, though rigorous clinical validation and standardization remain imperative.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3709-3735"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review.","authors":"Ozgur Kutuk, Ayse Kaplan","doi":"10.1002/ptr.70013","DOIUrl":"10.1002/ptr.70013","url":null,"abstract":"<p><p>Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer-related deaths in Western societies. Hence, novel preventive and therapeutic ways are still in great demand to reduce the incidence and mortality rate of ovarian cancer. Phytoestrogens, referred to as dietary estrogens, provide benefits to all mammals, including humans. Research indicates that phytoestrogens may be possible hormonal treatment options for ovarian cancer patients. They are non-steroidal plant compounds that undergo metabolism to produce compounds structurally and functionally related to ovarian and placental estrogens. Some studies suggest that estrogen receptors (ER-α and ER-β) and G protein-coupled estrogen receptor (GPER) are potential targets for ovarian cancer prevention and treatment. Current studies indicate multiple signal pathways of phytoestrogens in the management of ovarian cancer. Even so, literature suggests that the signaling mechanisms in ovarian cancer and the signaling mechanisms of phytoestrogens are still not exactly understood. With this, phytoestrogens may act on multiple signaling pathways such as ER (endoplasmic reticulum)-dependent signaling, GnRH receptor, FSH or LH receptors and hormones, and GFR, which help to regulate the expression of AKT, RAS, RAF, Caspase-3, NF-kB, and Bcl-2. In summary, this narrative review discusses the possible targets of phytoestrogens in ovarian cancer and sheds a light on improving novel phytoestrogens-based dietary supplements against ovarian cancers.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3601-3612"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K/AKT Pathway.","authors":"Xu Gao, Shuyan Lyu, Tengyu Lin, Juan He, Weiye Pan, Jiaxin He, Xiaocheng Wang, Xian Lin, Jian Chen, Qingwen Wang","doi":"10.1002/ptr.70009","DOIUrl":"10.1002/ptr.70009","url":null,"abstract":"<p><p>Oxyimperatorin (OIMP) is a coumarin extracted from the roots of the traditional Chinese medicinal plant Bai Zhi (Angelica dahurica). This study aimed to investigate the potential effects and underlying mechanisms of OIMP in the progression of rheumatoid arthritis (RA). CCK-8, immunofluorescence, flow cytometry, and EdU assays were performed to evaluate the effects of OIMP on the functions of RA fibroblast-like synoviocytes (RA-FLSs). RNA sequencing (RNA-seq), quantitative real-time PCR (RT-qPCR), Western blot, kinase assay, and network pharmacological analysis were conducted to elucidate the mechanism of action of OIMP in RA. OIMP inhibited the proliferation of RA-FLSs by suppressing DNA replication and inducing cell cycle arrest. It also promoted the apoptosis and impaired the migratory and invasive capabilities of RA-FLSs. Moreover, OIMP disrupted the cell cycle by downregulating the mRNA and protein levels of cyclin B1 and cyclin-dependent kinase 1 (CDK1), and promoted apoptosis by reducing survivin expression and inducing DNA damage. In vivo, OIMP suppressed synovial organoid growth and alleviated symptoms in collagen-induced arthritis (CIA) mice. RNA-seq and Western blot further confirmed that OIMP inhibited the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling axis. Network pharmacological analysis suggested a pivotal role of the PI3K/AKT pathway in mediating OIMP's effects in RA. Additionally, OIMP was shown to bind to AKT1. In conclusion, OIMP may act as a potential AKT1 inhibitor that suppresses the pathologies of RA through targeting the PI3K/AKT pathway.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3526-3544"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Roles of Exercise and Quercetin in Modulating Cancer Pathways and Cognitive Function.","authors":"Ping Lei","doi":"10.1002/ptr.70016","DOIUrl":"10.1002/ptr.70016","url":null,"abstract":"<p><p>Exercise training has been demonstrated to ameliorate adverse effects among cancer patients undergoing various treatment approaches. Exercise training has been demonstrated to ameliorate adverse effects among patients with early-stage (I-III) breast, prostate, and colorectal cancers undergoing various treatment approaches. However, the application of exercise in advanced or metastatic cancers requires careful clinical evaluation and supervision. Studies indicate that exercise correlates with diminished pain and fatigue, as well as enhanced quality of life for cancer patients. Besides exercise training, flavonoids such as quercetin have exhibited beneficial effects across various cancer types, bolstering the body's defense mechanisms. The integration of exercise and quercetin supplementation in cancer treatment has potential, yet the underlying molecular mechanisms and signaling pathways remain incompletely understood. This manuscript explores the intricate interplay between exercise and quercetin at the molecular level, emphasizing their combined effects on cancer therapy. Through a comprehensive review of existing literature, we highlight the multifaceted roles of exercise and quercetin in modulating molecular signaling pathways involved in cancer progression and treatment response. Insights into these mechanisms shed light on the synergistic effects of exercise and quercetin, paving the way for the development of novel therapeutic strategies in cancer management. This review underscores the importance of further research to elucidate the precise molecular mechanisms underlying the interplay of exercise and quercetin and their implications for cancer treatment.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3613-3647"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Mitochondrial Dysfunction by Natural Products for the Treatment of Diabetic Kidney Disease.","authors":"Jin-Ling Huo, Peipei Li, Qi Feng, Wenjia Fu, Shaokang Pan, Dongwei Liu, Zhang-Suo Liu","doi":"10.1002/ptr.70059","DOIUrl":"https://doi.org/10.1002/ptr.70059","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD) is one of the most common complications of diabetes and is the primary cause of end-stage renal disease (ESRD). However, due to its complex pathological mechanism, there is a lack of effective targeted drugs for DKD. Natural products, such as Corbrin Capsule, Huang Kui Jiaonang, and uremic clearance granule, which are derived from Chinese herbal medicine, have several advantages and potential in the treatment of various human diseases, especially DKD, and they have become promising treatment strategies for DKD. Recent research has suggested that mitochondrial dysfunction plays a vital role in the progression of DKD, and many natural products have been found to ameliorate or delay DKD by improving mitochondrial function. In this review, we mainly describe mitochondrial dysfunction involved in the progression of DKD and summarize natural products targeting mitochondrial dysfunction through multiple signaling pathways in the treatment of DKD, providing new insights and promising therapeutic targets for DKD.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Ferroptosis With Natural Products to Treat Diabetes and Its Complications: Opportunities and Challenges.","authors":"Hanyang Yu, Lu Fu, Chen Zhang, Shuguang Wang, Jiaying Song, Yingying Zhu, Furong Wang","doi":"10.1002/ptr.70028","DOIUrl":"https://doi.org/10.1002/ptr.70028","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a common chronic metabolic disorder, and the recommended pharmacotherapies in DM guidelines can effectively alleviate symptoms of DM, but some drugs may have certain side effects. In contrast, natural products and their derivatives have shown promising therapeutic effects on DM with fewer side effects. Additionally, ferroptosis, as a form of cell death, is involved in the normal physiological and pathological regulation of the body. Numerous studies have demonstrated the crucial role of ferroptosis in the occurrence and progression of diabetes and its complications. Furthermore, there is evidence that natural compounds can play a role in the prevention and treatment of diabetes and its complications by inhibiting ferroptosis. This review aims to enhance the understanding of the role and iron death mechanism of natural compounds in the treatment of diabetes and its complications. It also emphasizes the significance of utilizing natural products for managing diabetes and its complications. We conducted a systematic literature search using PubMed, Web of Science, and Clinical Trials: The search used keywords including natural products, natural compounds, oxidative stress, diabetes mellitus, and diabetic kidney disease. Comprehensive research and compilation of existing literature were conducted. Ferroptosis is a newly discovered form of cell death that is caused by an excess of iron and the buildup of reactive oxygen species (ROS) and lipid peroxides (LPO). These factors can affect ferroptosis through various signaling pathways, including the system Xc^-/GSH/GPX4 axis, AMPK, and the E-cadherin-NF2-Hippo-YAP pathway. Additionally, p53 has been identified as a regulator of ferroptosis. In the development of type 2 diabetes mellitus (T2DM) and its complications, ferroptosis has been found to play a crucial role in numerous studies. These studies have also elucidated the specific pathways of ferroptosis in diabetes-related conditions such as diabetic cardiomyopathy (DCM), diabetic kidney disease (DKD), diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and diabetic foot ulcers (DFU). Natural products have been widely used to treat diabetes and its complications, and some have been found to have inhibitory effects on ferroptosis. This article also provides a detailed overview of the toxicity, side effects, and current research progress of natural products in this context. Ferroptosis plays a crucial role in the development of T2DM and its associated complications, with multiple signaling pathways involved in its regulation. Natural compounds have been shown to have an impact on diabetes and its complications by inhibiting ferroptosis and regulating the associated signaling pathways. As such, natural products hold great potential for the treatment of diabetes and its complications.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Aged Garlic Supplementation on Blood Pressure and Lipid Profile: A Dose-Response Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Sara Bashiri, Faranak TaghipourSheshdeh, Sahar Foshati, Moein Askarpour, Afsane Ahmadi, Siavash Babajafari","doi":"10.1002/ptr.70032","DOIUrl":"https://doi.org/10.1002/ptr.70032","url":null,"abstract":"<p><p>Numerous clinical trials have examined the effects of aged garlic (AG) on metabolic factors, yielding inconsistent results. This systematic review and meta-analysis aimed to evaluate the impact of aged garlic on blood pressure (BP) and lipid profiles (LP). A comprehensive search was conducted across Scopus, PubMed, Medline via Ovid, ISI Web of Science, and Google Scholar until May 2024. We included clinical trials that assessed various forms of aged garlic as an intervention on systolic and diastolic blood pressure (SBP and DBP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated using a random-effects model. Nineteen trials were included in this analysis. AG consumption significantly reduced SBP (WMD: -2.49 mmHg; 95% CI: -4.02 to -0.95; I² = 29.76%) and LDL (WMD: -4.41 mg/dL; 95% CI: -8.28 to -0.54; I² = 55.78%). However, it did not significantly affect DBP and HDL, although the effect on TC approached significance (WMD: -4.74 mg/dL; 95% CI: -9.49 to 0.01; I² = 74.84%). Subgroup analyses indicated that AG significantly affected SBP and TG in participants with cardiovascular diseases (CVDs), while it also considerably impacted DBP in patients with hypercholesterolemia. Aged garlic may be a beneficial complementary approach for reducing BP and lipid levels in specific populations. Further high-quality trials are needed to confirm these findings.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Ginsenosides in the Treatment of Endocrine Diseases: Roles and Mechanisms.","authors":"Jing Li, Hongyan Qiu, Xiaoxiao Liu, Liang Zhu, Ningning Hou, Xiaodong Sun, Qinying Li","doi":"10.1002/ptr.70033","DOIUrl":"https://doi.org/10.1002/ptr.70033","url":null,"abstract":"<p><p>Endocrine diseases continue to surge as a global health concern, posing a serious threat to human health and placing a tremendous burden on society. The pathophysiology of endocrine diseases is intricate and multifactorial, often associated with dysregulation in feedback mechanisms or malfunctions within the endocrine system. Numerous studies have been conducted to develop pharmacological agents that prevent or alleviate endocrine disorders. Ginsenosides, the primary bioactive compounds derived from ginseng, exhibit beneficial properties for the treatment and prevention of common endocrine disorders. In this review, we summarize recent research progress on the therapeutic application of ginsenosides in the management of various endocrine disorders. In conclusion, this review aims to provide novel insights into the therapeutic potential and applications of ginsenosides for treating endocrine diseases and to lay a foundation for future clinical studies on ginsenosides.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}