Phytotherapy Research最新文献_第10页

Sinigrin Selectively Mitigates the Acute-Cardiac Inflammatory Response Through an AMPK-Dependent Mechanism. 紫荆素通过ampk依赖性机制选择性减轻急性心脏炎症反应。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-25 DOI: 10.1002/ptr.8453

Anjali Veeram, Rohan R Patekar, Sandip B Bharate, Sai Balaji Andugulapati, Ramakrishna Sistla

{"title":"Sinigrin Selectively Mitigates the Acute-Cardiac Inflammatory Response Through an AMPK-Dependent Mechanism.","authors":"Anjali Veeram, Rohan R Patekar, Sandip B Bharate, Sai Balaji Andugulapati, Ramakrishna Sistla","doi":"10.1002/ptr.8453","DOIUrl":"https://doi.org/10.1002/ptr.8453","url":null,"abstract":"Inflammatory cardiomyopathy is an inflammatory condition characterised by infiltrating inflammatory cells into the heart, which causes impaired myocardial function. Sinigrin (SNG) has been reported to possess antioxidant and anti-inflammatory properties. This study aimed to investigate the therapeutic benefit of SNG against endotoxin/Poly(I:C)-induced acute-cardiac inflammation using in vitro and in vivo models. Experimental procedure: THP-1, HCF and H9C2 cells were employed as an in vitro model, while lipopolysaccharide (LPS)/Poly(I:C)-induced cardiac inflammation model served as an in vivo to examine the anti-inflammatory potential of SNG using molecular biology techniques, cardiac function and histological assessments. The network pharmacological approach revealed that SNG could target the myocarditis-responsible genes. mRNA/protein expression studies showed that SNG treatment significantly mitigated the LPS + Poly(I:C)-induced expression of pro-inflammatory and myocarditis-responsive genes. Further analysis revealed that SNG treatment significantly reduced the LPS + Poly(I:C)-induced elevation of neutrophil, lymphocyte count, AST, ALT, LDH and CK-MB levels; infiltration of inflammatory cells, cardiomyocyte degeneration, cardiac troponin and macrophage markers, on the other hand, improved the platelet levels. Cardiac functional parameters by Langendorff indicated that SNG potentially ameliorated the LPS + Poly(I:C)-induced elevation of LVP and other parameters and improved cardiac functions. Molecular docking studies demonstrated that sinigrin forms a H-bond with Asn-111 (significant interaction) and binds to the activator site of AMPK with a docking score of -8.88 kcal/mol. The current study reveals that sinigrin exerts potent anti-inflammatory and antioxidant activities by modulating AMPK signalling. These findings support sinigrin's potential as a promising option for treating acute myocardial inflammation and open avenues for translational research.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies. 葫芦素B的多方面治疗作用：来自临床前研究的最新证据。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-18 DOI: 10.1002/ptr.8454

Meenal Sahu, Tripti Paliwal, Smita Jain, Kanika Verma, Dipjyoti Chakraborty, Shivangi Jaiswal, Jaya Dwivedi, Swapnil Sharma

{"title":"Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies.","authors":"Meenal Sahu, Tripti Paliwal, Smita Jain, Kanika Verma, Dipjyoti Chakraborty, Shivangi Jaiswal, Jaya Dwivedi, Swapnil Sharma","doi":"10.1002/ptr.8454","DOIUrl":"https://doi.org/10.1002/ptr.8454","url":null,"abstract":"The most prevalent and bioactive cucurbitacin is Cucurbitacin B (CuB, C32H46O8), which is a tetracyclic triterpene chiefly present in the Cucurbitaceae family. CuB has a wide spectrum of pharmacological properties namely antioxidant, anticancer, hepatoprotective, anti-inflammatory, antiviral, hypoglycaemic, insecticidal, and neuroprotective properties, owing to its ability to regulate several signaling pathways, including the Janus kinase/signal transducer and activator of transcription-3 (JAK/STAT3), AMP-activated protein kinase (AMPK), nuclear factor (NF)-κB, nuclear factor erythroid 2-related factor-2/antioxidant responsive element (Nrf2/ARE), phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), Hippo-Yes-associated protein (YAP), focal adhesion kinase (FAK), cancerous inhibitor of protein phosphatase-2A/protein phosphatase-2A (CIP2A/PP2A), Wnt and Notch pathways. The present review highlights the medicinal attributes of Cucurbitacin B (CuB) with special emphasis on their signaling pathways to provide key evidence of its therapeutic utility in the near future.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation. 天麻素通过调节ADRA1/NF-κB/NLRP3通路减轻神经炎症，改善3xTg-AD转基因小鼠的Tau病理和血脑屏障功能障碍。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-18 DOI: 10.1002/ptr.8461

Bo Li, Li Wang, Yan Xiao, Yang Wang, Yuanshang Wang, Yaqian Peng, Anni Zhang, Zhi Tang, Xiaolan Qi

{"title":"Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation.","authors":"Bo Li, Li Wang, Yan Xiao, Yang Wang, Yuanshang Wang, Yaqian Peng, Anni Zhang, Zhi Tang, Xiaolan Qi","doi":"10.1002/ptr.8461","DOIUrl":"https://doi.org/10.1002/ptr.8461","url":null,"abstract":"Background and aim: Gastrodin, an active compound derived from the traditional Chinese herbal medicine Gastrodia, demonstrates a variety of pharmacological effects, particularly in the enhancement of neural functions. Thus, the aim of this study is to explore the therapeutic effects of gastrodin on Alzheimer's disease (AD) and its underlying molecular mechanisms.Experimental procedure: Cognitive function was assessed via Morris water maze and Y-maze tests. Tau pathology, neuroinflammation, and BBB dysfunction were analyzed using various techniques, including Western blot, immunohistochemistry, and ELISA. ADRA1 overexpression was induced by lentiviral infection, and gastrodin's impact on NF-κB p65, NLRP3, IL-1β, and IL-18 levels was evaluated.Key results: In the in vivo experiment, gastrodin enhanced learning and spatial memory in 3xTg-AD mice, as well as reducing p-Tau protein expression in the hippocampus and cortex. Gastrodin inhibited the ADRA1/NF-κB/NLRP3 pathway, which decreased glial cell activation and inflammatory cytokines IL-1β and IL-18, improving neuron and BBB function. In the in vitro experiment, gastrodin inhibited the activation of the NF-κB/NLRP3 pathway due to ADRA1 overexpression and prevented the Aβ42-induced increase in ADRA1/NF-κB/NLRP3 protein expression in SH-SY5Y cells. It also reduced IL-1β and IL-18 cytokine release, restoring tight junction protein expression in bEnd.3 cells.Conclusions and implications: gastrodin ameliorates learning and memory abilities by alleviating neuroinflammation and tau pathology, restoring the structure and function of neurons and BBB, suggesting that gastrodin may serve as an effective drug for the treatment of AD.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aurantio-Obtusin Regulates Gut Microbiota and Serum Metabolism to Alleviate High-Fat Diet-Induced Obesity-Associated Non-Alcoholic Fatty Liver Disease in Mice. Aurantio-Obtusin调节肠道微生物群和血清代谢以减轻小鼠高脂肪饮食诱导的肥胖相关的非酒精性脂肪性肝病

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-14 DOI: 10.1002/ptr.8459

Zhaoyong Li, Yao Jin, Huashan Zhao, Yuyan Gu, Yaxin Zhang, Saibo Cheng, Lifang Zhang, Peikun He, Xiaoyu Liu, Yuhua Jia

{"title":"Aurantio-Obtusin Regulates Gut Microbiota and Serum Metabolism to Alleviate High-Fat Diet-Induced Obesity-Associated Non-Alcoholic Fatty Liver Disease in Mice.","authors":"Zhaoyong Li, Yao Jin, Huashan Zhao, Yuyan Gu, Yaxin Zhang, Saibo Cheng, Lifang Zhang, Peikun He, Xiaoyu Liu, Yuhua Jia","doi":"10.1002/ptr.8459","DOIUrl":"https://doi.org/10.1002/ptr.8459","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a progressive condition with limited effective treatments. This study investigated the therapeutic effects of Aurantio-obtusin (AO), a bioactive compound from Cassiae Semen, on obesity-associated NAFLD. An obesity-related NAFLD model was established in ApoE-/- mice fed a high-fat diet (HFD) for 24 weeks, with AO administered during the last 16 weeks. Mouse body weight, adipose tissue weights, liver weights, serum lipid levels, hepatic steatosis, inflammatory damage, and colonic tissue barrier integrity were evaluated. Gut microbial communities and serum metabolic profiles were analyzed using 16S rRNA sequencing and untargeted metabolomics. Hepatic lipid metabolism-related gene expression was assessed using molecular biology techniques. AO treatment significantly ameliorated HFD-induced adiposity, hyperlipidemia, and NAFLD symptoms. It preserved intestinal barrier integrity, modulated gut microbial composition by enriching beneficial taxa, and improved serum metabolic profiles. AO favorably adjusted hepatic lipid metabolism by upregulating PPARα and CPT1A while downregulating SREBP1, FASN, and SCD1. Correlation analysis revealed significant associations among gut microbial composition, serum metabolites, and disease indicators. AO's therapeutic benefits in NAFLD might be attributed to its ability to modulate gut microbial community composition and serum metabolic profile, enhance intestinal barrier function, and regulate hepatic lipid metabolism gene expression. AO presents a promising therapeutic agent for obesity-associated NAFLD, warranting further investigation into its potential clinical applications.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B-Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling. 仙丹素通过抑制PI3Kα/β和PLK1信号通路诱导细胞周期阻滞和凋亡抑制弥漫性大b细胞淋巴瘤生长

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-13 DOI: 10.1002/ptr.8439

Qian Hu, Mengyao Wang, Meng Chen, Jinjin Wang, Ting Niu

{"title":"Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B-Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling.","authors":"Qian Hu, Mengyao Wang, Meng Chen, Jinjin Wang, Ting Niu","doi":"10.1002/ptr.8439","DOIUrl":"https://doi.org/10.1002/ptr.8439","url":null,"abstract":"Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous subtype of non-Hodgkin lymphoma, with two-thirds of patients relapsing or resisting existing therapies, highlighting the urgent need for effective treatments. Toosendanin (TSN), a triterpenoid from Meliae Cortex, exhibits significant anti-cancer activity by modulating cell survival and proliferation. This study investigates the anti-lymphoma effects and underlying mechanisms of TSN, proposing it as a potential therapeutic agent to address the challenges of DLBCL. Network pharmacology, molecular docking, and transcriptome sequencing were employed to predict TSN's anti-DLBCL potential. Findings were validated through in vitro and in vivo experiments, including cell viability assays, flow cytometry, quantitative PCR, Western blotting, reverse experiments with small-molecule inhibitors or genetic editing, and a cell-derived xenograft (CDX) model. Bioinformatics analyses revealed TSN's strong binding affinity to PI3Kα/β and Polo-like kinase 1 (PLK1). Experiments showed that TSN downregulated the PI3K/Akt signaling pathway and reduced PLK1 mRNA and protein levels, inducing apoptosis, cell cycle arrest, and cell death in DLBCL cells. RNA sequencing and metabolic assays indicated TSN upregulated cholesterol biosynthesis in DLBCL cells. Co-treatment with a statin enhanced TSN's anti-DLBCL effects while mitigating hepatic and pulmonary toxicity. This study identifies TSN as a dual inhibitor of PI3K and PLK1 with significant therapeutic potential for DLBCL. It also proposes a lipid-modulating strategy to enhance TSN's cytotoxicity while reducing adverse effects, offering a promising approach to improve DLBCL treatment outcomes.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of 5-Geranyloxy-7-Methoxy-Coumarin as Antiadipogenic Constituent of Peels From Citrus limon. 柠檬果皮抗脂肪成分5-香叶氧基-7-甲氧基香豆素的鉴定。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-11 DOI: 10.1002/ptr.8391

Franz Bucar, Lisa Raimann, Gabriele Schoiswohl, Alexander Kollau, Bernd Mayer, Astrid Schrammel

引用次数: 0

Enhancing NK Cell Antitumor Activity With Natural Compounds: Research Advances and Molecular Mechanisms. 天然化合物增强NK细胞抗肿瘤活性的研究进展及分子机制

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-11 DOI: 10.1002/ptr.8456

Yu Wu, Mingxiao Yin, Wenjiao Xia, Baokai Dou, Xiaoyu Liu, Ru Sun

{"title":"Enhancing NK Cell Antitumor Activity With Natural Compounds: Research Advances and Molecular Mechanisms.","authors":"Yu Wu, Mingxiao Yin, Wenjiao Xia, Baokai Dou, Xiaoyu Liu, Ru Sun","doi":"10.1002/ptr.8456","DOIUrl":"https://doi.org/10.1002/ptr.8456","url":null,"abstract":"In recent years, immunotherapy has become a novel antitumor strategy in addition to traditional surgery, radiotherapy, and chemotherapy and has exhibited promising results in clinical applications. Despite significant breakthroughs in immunotherapy, such as immune checkpoint blockade and CAR-T cell therapy, it remains necessary to develop more efficacious, safer, and cheaper immunotherapeutic drugs due to factors including small reaction populations, acquired resistance, adverse side effects, and high costs. Natural killer (NK) cells are preeminent cytotoxic lymphocytes of the innate immune system that act as the first line of defense against tumors and synergistically enhance the adaptive immune response of T lymphocytes. Therefore, boosting the antitumor function of NK cells is an important direction in the development of immunotherapy. For decades, various immunotherapies such as adoptive cell therapy, antibody drugs, cytokines supplement, and chemical immunomodulators have been developing rapidly to improve the function of NK cells. Compared to biological immunotherapy, immunomodulators derived from natural products have outstanding advantages of low immunogenicity, multi-targeting, and cost-effectiveness. Currently, increasing attention is being focused on discovering NK cell-stimulating agents from natural products, such as polysaccharides, alkaloids, terpenoids, saponins, phenolics, and quinones. This review aims to categorize and summarize the comprehensive research progress on these natural products, discuss their potential molecular mechanisms in regulating NK cells, and explore their clinical applications as standalone treatments or in combination with conventional chemotherapy regimens.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Saffron Supplementation on Glycolipid Metabolism and Blood Pressure in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 补充藏红花对代谢综合征及相关疾病患者糖脂代谢和血压的影响：随机对照试验的系统回顾和荟萃分析

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-11 DOI: 10.1002/ptr.8421

Xiaolei Zhang, Jinxin Miao, Yagang Song, Mingsan Miao

{"title":"Effects of Saffron Supplementation on Glycolipid Metabolism and Blood Pressure in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Xiaolei Zhang, Jinxin Miao, Yagang Song, Mingsan Miao","doi":"10.1002/ptr.8421","DOIUrl":"https://doi.org/10.1002/ptr.8421","url":null,"abstract":"Saffron is a traditional herbal medicine used to treat conditions associated with metabolic syndrome (MetS). However, the conclusions of relevant clinical studies have been inconsistent. This study aimed to assess the impact of saffron supplementation on the metabolism of glycolipids and blood pressure in individuals with MetS and related disorders. Web of Science, PubMed, Cochrane Library, Scopus, and Embase were comprehensively searched for studies investigating saffron supplementation for MetS and related disorders up to February 2024. Stata 17.0 was used to conduct the Meta-analysis. Twenty-five randomized controlled trials (RCTs) were included in this study, involving 1486 participants with MetS and related conditions. Compared to placebo, saffron supplementation triggered significant reductions in fasting blood glucose (FBG) (WMD: -6.67 mg/dL; 95% CI: -10.55, -2.78; p = 0.001; I2 = 50.0%), glycosylated hemoglobin A1c (HbA1c) (WMD: -0.25%; 95% CI: -0.35, -0.14; p < 0.001; I2 = 0.0%), total cholesterol (TC) (WMD: -4.77 mg/dL; 95% CI: -8.83, -0.71; p = 0.021; I2 = 31.8%), systolic blood pressure (SBP) (WMD: -1.15 mmHg; 95% CI: -1.66, -0.64; p < 0.001; I2 = 41.8%), and diastolic blood pressure (DBP) (WMD: -1.61 mmHg; 95% CI: -1.88, -1.34; p < 0.001; I2 = 7.0%). However, no significant changes were observed for homeostatic model assessment for insulin resistance (HOMA-IR), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and waist circumference (WC). Saffron supplementation has an improving effect on FBG, HbA1c, TC, DBP, and SBP in patients with MetS and related disorders. Nonetheless, additional high-quality RCTs involving diverse ethnic populations are necessary to validate this effect.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer Potential. 硫代葡萄糖苷及其水解衍生物：具有抗癌潜力的植物化学物质。

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-01 Epub Date: 2024-12-27 DOI: 10.1002/ptr.8419

Nataša Joković, Strahinja Pešić, Jelena Vitorović, Andrija Bogdanović, Javad Sharifi-Rad, Daniela Calina

{"title":"Glucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer Potential.","authors":"Nataša Joković, Strahinja Pešić, Jelena Vitorović, Andrija Bogdanović, Javad Sharifi-Rad, Daniela Calina","doi":"10.1002/ptr.8419","DOIUrl":"10.1002/ptr.8419","url":null,"abstract":"Recent research has increasingly focused on phytochemicals as promising anticancer agents, with glucosinolates (GSLs) and their hydrolytic derivatives playing a central role. These sulfur-containing compounds, found in plants of the Brassicales order, are converted by myrosinase enzymes into biologically active products, primarily isothiocyanates (ITCs) and indoles, which exhibit significant anticancer properties. Indole-3-carbinol, diindolylmethane, sulforaphane (SFN), phenethyl isothiocyanate (PEITC), benzyl isothiocyanate, and allyl isothiocyanate have shown potent anticancer effects in animal models, particularly in breast, prostate, lung, melanoma, bladder, hepatoma, and gastrointestinal cancers. Clinical studies further support the chemopreventive effects of SFN and PEITC, particularly in detoxifying carcinogens and altering biochemical markers in cancer patients. These compounds have demonstrated good bioavailability, low toxicity, and minimal adverse effects, supporting their potential therapeutic application. Their anticancer mechanisms include the modulation of reactive oxygen species, suppression of cancer-related signaling pathways, and direct interaction with tumor cell proteins. Additionally, semi-synthetic derivatives of GSLs have been developed to enhance anticancer efficacy. In conclusion, GSLs and their derivatives offer significant potential as both chemopreventive and therapeutic agents, warranting further clinical investigation to optimize their application in cancer treatment.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1035-1089"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-Caryophyllene Augments Radiotherapy Efficacy in GBM by Modulating Cell Apoptosis and DNA Damage Repair via PPARγ and NF-κB Pathways. 通过PPARγ和NF-κB途径调节细胞凋亡和DNA损伤修复，β-卡里叶烯可增强GBM放疗疗效

IF 6.1 2区医学

Phytotherapy Research Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1002/ptr.8413

Hui-Wen Chan, Wei-Chan Lin, Deng-Yu Kuo, Hui-Yen Chuang

{"title":"Beta-Caryophyllene Augments Radiotherapy Efficacy in GBM by Modulating Cell Apoptosis and DNA Damage Repair via PPARγ and NF-κB Pathways.","authors":"Hui-Wen Chan, Wei-Chan Lin, Deng-Yu Kuo, Hui-Yen Chuang","doi":"10.1002/ptr.8413","DOIUrl":"10.1002/ptr.8413","url":null,"abstract":"Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy with limited treatment options. Radiotherapy (RT) is often used for treating unresectable GBM; however, the outcomes are often limited due to the radioresistance of GBM. Therefore, the discovery of potential radiosensitizers to enhance GBM responses to RT is crucial. Beta-caryophyllene (BCP), a natural cannabinoid, promotes cancer apoptosis by upregulating the PPARγ signaling pathway and can cross the blood-brain barrier due to its lipophilic nature. This study aimed to evaluate the radiosensitizing potential of BCP in GBM cells. U87MG and GL261 cells and a GL261 tumor-bearing model were treated with RT, BCP, or both. Treatment efficacy was assessed using the MTT assay and tumor growth tracking, and the underlying mechanisms were investigated using western blotting, immunofluorescence staining, and other analyses. BCP synergistically enhanced the efficacy of RT in cell culture, as evidenced by the combination index determined through the MTT assay. This enhancement was mediated by the BCP-induced deceleration of DNA damage repair, as demonstrated by sustained γH2AX signal, upregulated PPARγ levels, and reduced expression of pAKT, pERK, and NF-κB, indicating apoptosis induction and inhibition of survival pathways. BCP significantly inhibited tumor growth in GL261 tumor-bearing mice with no discernible side effects. These findings indicate that BCP may serve as a potential radiosensitizer for improving RT outcomes in GBM by inhibiting DNA repair, inducing apoptosis, and suppressing anti-apoptotic and survival pathways.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"776-788"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0