Phytotherapy Research最新文献

{"title":"Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product-Based Therapies.","authors":"Xinyun Fan, Zibo Liu, Wenjing Yang, Hongying Zhang, Hao Zhong, Yan Pang, Xun Ye, Chunjie Wu, Liang Li","doi":"10.1002/ptr.70056","DOIUrl":"10.1002/ptr.70056","url":null,"abstract":"<p><p>Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden. Recent studies have shown that AD is characterized by complex interactions between multiple signaling pathways and targets, including allergies, inflammation, oxidative stress, apoptosis, and their interactions. This complex pathogenesis poses challenges for effective treatment but also contributes to the discovery of new therapeutic targets and the development of novel therapeutic drugs, which have important clinical significance. This review delves into the pathogenesis of AD in recent years and explores the therapeutic potential of alkaloids, phenols, flavonoids, terpenes, glycosides, and other natural products (NPs). Specifically, it explores how NPs correct immune cell subpopulation imbalance, regulate keratinocyte function, and reduce mast cell activation and cytokine secretion. These therapeutic effects are promoted by regulating pathways such as NF-κB, IgE-FcεRI, MAPK, and JAK/STAT. Future research should design new compounds with therapeutic potential based on the structure of NPs and focus on pharmacological experiments and clinical trials.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the Therapeutic Power of Natural Alkaloids in Triple-Negative Breast Cancer: State-of-the-Art Advances and Future Directions.","authors":"Xiao-Li Ren, Ya-Jun Zhong, Lei Hu, Gen Zhou, Bo Han, Wei Huang, Qian Zhao","doi":"10.1002/ptr.70075","DOIUrl":"10.1002/ptr.70075","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of ER, PR, and HER2, presenting significant challenges due to its heterogeneity and limited treatment options. Recent studies have identified naturally derived alkaloids as promising therapeutic agents, capable of targeting critical signaling pathways involved in TNBC progression, including PI3K/AKT/mTOR, STAT3, TGF-β, NF-κB, and p38 MAPK. This review provides a comprehensive overview of the past decade's advancements in alkaloid-based therapies for TNBC, emphasizing their impact on key pathways. Additionally, it discusses the challenges in clinical translation, such as poor bioavailability and toxicity, and explores future directions for their application in TNBC treatments, highlighting the potential for innovative and personalized therapeutic strategies. Overall, natural alkaloids hold significant promise in the quest for innovative TNBC treatments. By selectively targeting pivotal signaling pathways, these compounds could pave the way for more personalized therapy and improved patient outcomes; further high-quality studies are essential to firmly establish their clinical efficacy.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phillygenin Improves the Focal Adhesion Kinase/Glycogen Synthase Kinase 3β/β-Catenin Axis to Promote Mesenchymal Stem Cell Osteogenic Differentiation.","authors":"Yuchao Yang, Haidong Zhou, Yining Wang, Ming Yin, Fengying Gong, Shutong Wu, Zhiyin Luo, Zhenyu Bi, Jiahou Xu, Yongfu Chen, Konghe Hu, Jun Ouyang, Jiajun Tang","doi":"10.1002/ptr.8519","DOIUrl":"10.1002/ptr.8519","url":null,"abstract":"<p><p>Forsythiae Fructus, a traditional herb known for its anti-inflammatory and antioxidant properties, has demonstrated inconclusive effects on bone metabolism in prior studies. The aim of this study is to investigate whether phillygenin (PHI), an active component of Forsythiae Fructus, promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by modulating the FAK/GSK-3β/β-catenin signaling axis. Experimental procedure: In vivo, an ovariectomized (OVX) mouse model was employed to mimic postmenopausal bone loss. In vitro, osteoclastogenesis was evaluated using tartarate-resistant acid phosphatase (TRAP) enzymatic assays, while osteogenic differentiation of BMSCs was assessed through alkaline phosphatase (ALP) and alizarin red S (ARS) staining. Cell proliferation and viability were examined using the CCK-8 assay. Osteogenic markers, including ALP, RUNX2, osteopontin (OPN), as well as signaling proteins, such as phosphorylated FAK at Y397 (pFAKY397), phosphorylated glycogen synthase kinase-3 beta (pGSK-3β), and β-catenin, were analyzed by western blot and immunofluorescence analyses. Specific inhibitors of the FAK and β-catenin (Y15 and XAV-939) were employed for mechanistic validation. PHI treatment significantly decreased the number and size of osteoclasts in a dose-dependent way. In OVX mice, PHI preserved trabecular microarchitecture, increased bone mineral density, and inhibited osteoclast formation dose-dependently. Low doses of PHI significantly promoted osteogenic differentiation and mineralization of BMSCs without affecting cell proliferation and viability. Mechanistically, PHI upregulated the expression of pFAKY397, pGSK-3β, and β-catenin. Inhibition of the pathway, achieved through the use of Y15 and XAV-939, attenuated PHI-induced osteogenesis. These findings indicate that PHI enhances BMSCs osteogenesis via the FAK/GSK-3β/β-catenin axis, thereby restoring bone metabolic balance. The results highlight PHI's dual regulatory potential in the management of bone disorders, particularly, estrogen deficiency-related osteoporosis, and suggest its potential applications in the therapeutic intervention of bone diseases.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panax ginseng C. A. Mey. Targeting Pyroptosis for Treatment of Diabetes Related Metabolic Diseases: A Review of Potential Therapeutic Strategies.","authors":"Meng Sun, Guan-Cheng Liu, Meng-Yang Wang, Wen-Ting Wang, Zhi-Hong Zhang, Hui Yu, Hai-Ming Sun, Chun-Mei Wang, Wei Liu","doi":"10.1002/ptr.70047","DOIUrl":"https://doi.org/10.1002/ptr.70047","url":null,"abstract":"<p><p>Panax Ginseng C. A. Mey. is a traditional Chinese herb with a long history of application and significant activity in Asia. Modern studies have confirmed that the traditional efficacy of ginseng is closely related to metabolic diseases. Metabolic diseases are a globally increasing disease, involving the immune, digestive, and nervous systems. Research shows that pyroptosis may be a new entry point for the prevention and treatment of metabolic diseases. P. ginseng has shown great pharmacodynamics in the treatment of metabolic diseases such as diabetes mellitus (DM) and obesity. DM is a type of immune disease characterized by metabolic disorders and chronic inflammatory response, which is always a core problem in the medical community because it is often accompanied by some serious complications. Current research has made remarkable progress in P. ginseng targeting pyroptosis in the treatment of DM-related metabolic diseases, but there is still a long way to go to further explore the pathogenesis of metabolic diseases. However, the current specific drugs for metabolic diseases have obvious limitations, which are not conducive to the promotion and long-term use. This review summarizes the published research about P. ginseng and its active ingredients in the treatment of DM-related metabolic diseases. It fully demonstrates that P. ginseng targeting pyroptosis has a good application prospect in the treatment of DM-related metabolic diseases, providing a new perspective for the prevention and treatment of metabolic diseases in the future.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.","authors":"Hao Qiu, Chenhui Cai, Ying Zhang, Sizhen Yang, Xu Hu, Tongwei Chu","doi":"10.1002/ptr.8503","DOIUrl":"https://doi.org/10.1002/ptr.8503","url":null,"abstract":"<p><p>Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from Salvia miltiorrhiza, has been widely used to treat cardiovascular and cerebrovascular disorders, owing to its antioxidant and anti-inflammatory properties. In this study, we investigated the therapeutic effects of SAA on osteoporotic bone loss in vitro and in osteoporotic mice induced by ovariectomy (OVX) and explored the underpinning mechanisms. In vitro, SAA significantly restrained osteoclastogenesis and osteoclastic resorption in a dose- and time-dependent manner. SAA markedly blocked the expression of osteoclast-specific genes and proteins such as NFATc1 and c-Fos. Specifically, SAA reduced ROS production by enhancing the expression and nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) to activate HO-1 and catalase, with no effect on Bach1. In addition, SAA simultaneously suppressed the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathway, ultimately arresting NFATc1 expression to constrain the differentiation and function of osteoclasts. Micro-CT and histological evidence demonstrated that SAA at a nontoxic dose successfully reduced bone loss induced by OVX, with fewer mature osteoclasts. These findings revealed that SAA provides a potential treatment strategy for reducing osteoclast-related bone ailments, including osteoporosis.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Bowel Disease Induces Colorectal Cancer: Risk Factors, Triggering Mechanisms, and Treatment With Phyto-Derivatives.","authors":"Yuyu Zhang, Yi Zhang, Shiyi Yao, Liping Chen, Qin Dong, Ranwen Luo, Kaiyue Zheng, Jing Liu, Yiming Liu, Yutong Chen, Yuxin He, Zhejie Chen, Ling Li","doi":"10.1002/ptr.70015","DOIUrl":"10.1002/ptr.70015","url":null,"abstract":"<p><p>Colorectal cancer (CRC), one of the most prevalent malignant neoplasms, ranks as a leading cause of cancer-related mortality on a global scale. A particularly aggressive variant of CRC is colitis-associated colon cancer (CAC). Patients with chronic inflammatory bowel disease (IBD) are at increased risk for CAC. The pathogenesis of CAC is influenced by numerous factors and is highly complex. Due to the complexity of the mechanism by which chronic inflammation of the intestine leads to the transformation of colorectal cancer, there is currently no standardized strategy for the advance prophylaxis of CAC. Significantly, phyto-derivatives exhibit significant potential in the prevention of CAC. Currently, researches have demonstrated that natural products extracted from plants including polyphenols, alkaloids, saponins, terpenoids, polysaccharides, and plant extracellular vesicles can achieve significant anti-inflammatory, antioxidant, and gut microbiota regulating activities through oral administration. It is a valuable opportunity for the application of natural products in chronic intestinal inflammation to inhibit the transformation of intestinal inflammation into malignancy. In this review, we provide a comprehensive analysis of the predisposing factors and pathogenesis of CAC, along with the mechanisms through which various plant-derived compounds inhibit CAC development. This work aims to provide innovative and practical treatment strategies for the prevention of CAC.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3386-3418"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Programmed Cell Death as an Innovative Strategy Against Atherosclerosis: Potential of Natural Compound Supplements.","authors":"Jilin Fan, Tingting Zhu, Xiaoling Tian, Mengjie Wang, Zhichao Li, Wei Li","doi":"10.1002/ptr.70027","DOIUrl":"10.1002/ptr.70027","url":null,"abstract":"<p><p>Atherosclerosis (AS) is the primary pathological basis of various cardiovascular diseases. Its pathogenesis involves multiple processes, including inflammatory responses, lipid metabolism disorders, and cell death. Recently, programmed cell death (PCD), comprising apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis, has attracted considerable attention as a potential therapeutic target in AS progression. Furthermore, natural compounds with anti-atherosclerotic properties derived from plants have gained wide interest. These natural products regulate PCD through various mechanisms and demonstrate significant potential for the prevention and treatment of AS. Therefore, this review summarizes the molecular mechanisms of critical PCD pathways involved in AS and discusses the latest findings on natural products, such as flavonoids, polyphenols, saponins, and alkaloids that target PCD to alleviate AS. Based on these findings, this review highlights the importance of natural compounds targeting PCD as a therapeutic strategy against AS, providing novel theoretical insights and translational directions to promote the development of precise anti-atherosclerotic therapies derived from natural products.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3664-3708"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis revealed the therapeutic mechanisms of Gegen (Puerariae Lobatae Radix) water extract against ischemia-induced bladder overactivity through the inhibition of epoxide hydrolase 2.","authors":"Xinyi Tong, Yining Qiang, Mingchang Cheng, Yan Tie, Zhihui Sun, Yi Ma, Yushan Wu, Liping Xu, Pingxiang Xu, Xiaorong Li, Ming Xue, Xuelin Zhou","doi":"10.1002/ptr.8076","DOIUrl":"10.1002/ptr.8076","url":null,"abstract":"<p><p>The potential effects of Puerariae Lobatae Radix (Gegen in Chinese) water extract (GWE) on overactive bladder (OAB) were previously demonstrated through ex vivo examination of detrusor contraction. However, the mechanisms were not fully understood. The current aim was to investigate the therapeutic mechanisms of GWE against OAB in spontaneously hypertensive rats (SHR) with bladder ischemia. The therapeutic effect of GWE against OAB was evaluated by urodynamics. Hematoxylin & eosin (H&E) staining, Masson staining, and Doppler ultrasonic blood stream detector were utilized to observe bladder structures and local blood flow, respectively. To elucidate the mechanisms, an integrated omics approach was employed. The key proteins and metabolites were validated using Western Blotting and ELISA. A 3-week treatment of GWE demonstrated a significant improvement in urodynamic parameters. The results from Doppler detector, H&E staining, and Masson staining indicated that GWE improved vasodilation of bladder microvessels. Transcriptomic analysis revealed changes in genes such as Ptgfr and Ntsr1, which were involved in regulating intracellular Ca²⁺ concentration. Proteomic analysis suggested that the downregulation of epoxide hydrolase 2 (EPHX2), maintaining the balance of epoxyeicosatrienoic acids (EETs), was responsible for GWE-induced vasodilation. Metabolomic analysis further supported alterations in arachidonic acid (AA) metabolism. It is concluded that GWE treated OAB in SHR rats by improving bladder blood flow through the inhibition of EPHX2 and upregulation of EETs. This inhibition resulted in the improvement of bladder structure and the suppression of AA metabolism-mediated PTGES/PTGFR/PLCβ1/phospho-MLC signaling pathway.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3813-3828"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease.","authors":"Long Chen, Xin Wang, Qi Zheng, Hang Wang","doi":"10.1002/ptr.70005","DOIUrl":"10.1002/ptr.70005","url":null,"abstract":"<p><p>Alzheimer's disease (AD) as well as other memory disorders significantly impair cognitive and behavioral functions, posing a growing global health burden. Research increasingly supports the synergistic effects of natural products-bioactive compounds derived from plant-based diets-and regular physical exercise in promoting brain health. Natural products exhibit neuroprotective effects by modulating oxidative stress, reducing neuroinflammation, and enhancing synaptic plasticity, while exercise complements these benefits by improving neurogenesis, cerebral blood flow, and mitochondrial function. This review synthesizes current findings on the signaling mechanisms underlying the combined impact of natural products and physical exercise on brain function. We focus on their influence on key pathways, including brain-derived neurotrophic factor (BDNF) signaling, amyloid-beta clearance, and the regulation of neuroinflammation and oxidative stress. Evidence recommends that the integration of these interventions can attenuate cognitive decline, support behavioral resilience, and delay disease progression in AD and other memory disorders. We also highlight the translational challenges of implementing these strategies in clinical settings, including individual variability in response and adherence. Future research directions are discussed, emphasizing the potential of combining dietary and exercise-based interventions. This review aims to advance the understanding of how lifestyle interventions can enhance behavioral and brain functions in the situation of neurodegenerative disorders.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3800-3812"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuciferine Exerts Anti-Inflammatory Effects in Mice With Non-Alcoholic Steatohepatitis by Regulating the miR-23a-3p-SIRT1-NF-κB Pathway and Akkermansia muciniphila -Extracellular Vesicles.","authors":"Shengnan Zhu, Weijia Xu, Zhaowen Chen, Xuanhao Lei, Feng Guan, Jian Ge","doi":"10.1002/ptr.8528","DOIUrl":"10.1002/ptr.8528","url":null,"abstract":"<p><p>Nuciferine, a lotus leaf extract with low bioavailability, shows beneficial effects on hepatic metabolism and gut microbiota, but its anti-inflammatory mechanisms in non-alcoholic steatohepatitis (NASH) are unclear. This study aimed to clarify how nuciferine mitigates hepatic inflammation in NASH by exploring its interactions with immune pathways and gut microbiota. Initially, a NASH mouse model was induced using a methionine- and choline-deficient diet, with nuciferine administered orally. Furthermore, liver damage was assessed, and hepatic M1 (CD11B⁺ pro-inflammatory) and M2 (CD163⁺ anti-inflammatory) macrophages were quantified. Molecular assays measured SIRT1 gene expression, while miRNA sequencing and dual-luciferase assays explored its role in the SIRT1/NF-κB pathway. Additionally, gut microbiota were analyzed via 16S rRNA sequencing, and fluorescently labeled Akkermansia muciniphila -derived extracellular vesicles (Akk-EVs) were tracked in vivo and in vitro. Treatment with nuciferine reduced liver injury, decreasing pro-inflammatory M1 macrophages and increasing anti-inflammatory M2 macrophages. Meanwhile, it upregulated hepatic SIRT1, suppressing miR-23a-3p to inhibit the NF-κB pathway and promote M1-to-M2 polarization. Gut microbiota analysis showed nuciferine enriched Akkermansia muciniphila , and fluorescent imaging confirmed Akk-EVs entered liver tissues and macrophages, exerting direct anti-inflammatory effects. In conclusion, nuciferine protects against NASH through dual mechanisms: modulating the SIRT1/NF-κB pathway to reduce hepatic inflammation and enhancing Akk-EVs. These findings highlight its therapeutic potential for NASH, linking host immune responses with gut microbiota interactions.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"3508-3525"},"PeriodicalIF":6.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}