Phytotherapy Research最新文献

{"title":"The Impact of Okra (Abelmoschus esculentus) Supplementation on Diabetes and Obesity Biomarkers in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ying Fan, Lei Wu, Yalan Zhang, Qin Hu, Jing Mei, Kousalya Prabahar, Benjamin Hernández-Wolters, Hamed Kord-Varkaneh, Changjiang Lei, Su Zheng","doi":"10.1002/ptr.70071","DOIUrl":"https://doi.org/10.1002/ptr.70071","url":null,"abstract":"<p><p>Conflicting results have been reported regarding the effects of okra on diabetes biomarkers in patients with type 2 diabetes. These inconsistencies may stem from factors such as dosage, intervention duration, and study design. To address these discrepancies, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effects of okra (Abelmoschus esculentus) supplementation on diabetes and obesity markers in patients with type 2 diabetes. Relevant studies published up to July 15, 2024, were identified through comprehensive searches in databases including Scopus, Web of Science, PubMed/Medline, and Embase. Studies were included if they assessed the effects of okra supplementation on diabetes and obesity biomarkers in patients with type 2 diabetes. A random-effects model was employed to calculate effect sizes, reported as weighted mean differences (WMD) with 95% confidence intervals (CI). A total of six eligible RCTs was included in the final analysis. The meta-analysis revealed that okra supplementation significantly reduced fasting blood glucose (FBG) (WMD: -21.72 mg/dL, 95% CI: -36.86 to -6.58, p = 0.005) and glycated hemoglobin (HbA1c) levels (WMD: -0.42%, 95% CI: -0.64 to -0.19, p < 0.001). However, no significant effects were observed on insulin levels (WMD: 0.54 μU/mL, 95% CI: -1.03 to 2.12, p = 0.498), insulin resistance as assessed by HOMA-IR (WMD: -0.31, 95% CI: -1.37 to 0.75, p = 0.566), body mass index (BMI) (WMD: -0.24 kg/m², 95% CI: -0.62 to 0.14, p = 0.220), or body weight (WMD: -0.83 kg, 95% CI: -2.55 to 0.87, p = 0.338). This systematic review and meta-analysis is the first to confirm the positive effects of okra supplementation on glycemic control in patients with type 2 diabetes, specifically by reducing FBG and HbA1c levels.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Plants to Patients: Advancing Cancer Therapy With Bioengineered Exosomes and AI-Driven Innovations.","authors":"Gamal A Atia, Ahmed Abdeen, Ehab S Taher, Wafaa Y Alghonemy, Eman M El Nashar, Norah S Al-Zahrani, Ekramy M Elmorsy, Shifan Khanday, Abeer Alshambky, Noha Taymour, Ahmed M Atwa, Donia E Zaghamir, Helal F Hetta, Mohamed E Mohamed, Kasim S Abass, Naiera Shannour, Heba Allah M Elbaghdady, Md Azizul Haque, Ali El-Far","doi":"10.1002/ptr.70040","DOIUrl":"https://doi.org/10.1002/ptr.70040","url":null,"abstract":"<p><p>Cancer is a leading global cause of death, with complex pathogenesis and treatment challenges like poor selectivity, toxicity, and drug resistance. Nanotechnology offers transformative solutions, with plant-derived exosomes (EXOs) emerging as promising green nanomaterials for personalized cancer therapy because of their biocompatibility and minimal antigenicity, and eco-friendly production. This review discusses the potential of plant EXOs in cancer treatment, covering isolation methods, advantages over mammalian EXOs (e.g., stability, cost-effectiveness, and evasion of drug resistance mechanisms), and preclinical applications. For instance, ginger EXOs suppress colorectal cancer via cytokine modulation, grapefruit EXOs target brain tumors, and lemon EXOs induce apoptosis in triple-negative breast cancer. Plant EXOs also enhance drug delivery when loaded with chemotherapeutics, nucleic acids, or immunomodulators, improving precision and reducing off-target effects. Despite their promise, challenges remain in scalability, purity, long-term safety for non-oral routes, and clinical translation. Future research must optimize isolation techniques, clarify molecular mechanisms, and validate pharmacokinetics to advance clinical adoption. This review offers a complete examination of plant EXOs, including biogenesis, characterization, engineering strategies, anti-cancer mechanisms (e.g., apoptosis induction, immune modulation), and therapeutic applications. It also addresses hurdles like standardization and regulatory gaps while advocating interdisciplinary collaboration to bridge lab-to-clinic gaps. By harnessing plant EXOs' potential, this work highlights a path toward sustainable, targeted cancer therapies, urging further innovation to overcome existing barriers and realize their full clinical impact.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botanical Antinutrients as Natural Modulators of Postprandial Hyperglycemia and Hyperlipidemia: A Narrative Review.","authors":"Anuj Kumar Borah, Sagnik Nag, Megha Chetri, Amit Talukdar, Chongtham Sovachandra Singh, Hemanta Chutia, Vetriselvan Subramaniyan, Amlan Das","doi":"10.1002/ptr.70076","DOIUrl":"https://doi.org/10.1002/ptr.70076","url":null,"abstract":"<p><p>Postprandial elevation in blood monosaccharide and lipid levels is recognized as a significant challenge to systemic homeostasis and physiology, which can be minimized by controlling and monitoring the use of antinutrients. Delve into the investigations made with botanical antinutrients towards modulating intestinal carbohydrate and lipid digestion and subsequent nutrient absorption. A literature search was performed utilizing Google Scholar, PubMed, and Scopus with search strings \"antinutrients,\" \"antinutrients and obesity,\" \"pancreatic lipase inhibitors and obesity,\" \"alpha-glucosidase inhibitors and obesity,\" \"amylase inhibitors and obesity,\" \"SGLT1 inhibitors\", \"inhibitors of intestinal monosaccharide absorption,\" and \"inhibitors of intestinal lipid absorption.\" Exclusion: (a) microorganism-originated compounds and (b) botanical compounds demonstrating antihyperlipidemic and antihyperglycemic effects supported only by in silico studies. This literature enlightens documented shreds of evidence of natural plant-derived antinutrients, the level of investigation, and the proposed mechanism of action. In vitro (enzymatic and cell-based) and in vivo (obese and diabetic animals) studies have demonstrated that among the numerous botanical antinutrients noted for hyperlipidemia and hyperglycemia, Betulinic acid, Vaticanol A, Vaticanol E, and Berberine are supermolecules that tackle both conditions in animal models. Further, these compounds target the enzyme cyclooxygenase-2 (COX2), a common culprit in metabolic disorders. The current state of the art sheds light on the potential use of botanical compounds, as monotherapy or in combination therapy, to be projected as a single solution for two problems, that is, hyperglycemia and hyperlipidemia. However, more robust experimentation, dose optimization, in vivo effectiveness, toxicological aspects, clinical safety and efficacy are to be validated.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol Suppresses SHH-MB Growth via ROS-Induced Stress: Evidence From In Vitro and In Vivo Studies.","authors":"Bohong Wang, Tao Xu, Lisheng Yu, Chenjie Qiu, Jing Xu, Xiangmao Zhao, Chao Xu, Feng Tan, Hansong Sheng, Nu Zhang, Shangyu Xu","doi":"10.1002/ptr.70077","DOIUrl":"https://doi.org/10.1002/ptr.70077","url":null,"abstract":"<p><p>Celastrol, a bioactive compound derived from the traditional Chinese herb Tripterygium wilfordii, has demonstrated various pharmacological properties, including anticancer effects. Medulloblastoma (MB), particularly the Sonic Hedgehog (SHH) subtype, remains a challenge due to its aggressive nature and limited therapeutic options. This study aims to investigate the inhibitory effects of celastrol on Sonic Hedgehog medulloblastoma (SHH-MB) cells in vitro and in vivo, focusing on its underlying mechanisms and signaling pathways. The effects of celastrol on cell proliferation were evaluated using the Cell Counting Kit-8 (CCK-8) assay, Ki-67 immunofluorescence staining, and colony formation assay. The scratch wound healing assay and transwell invasion assay were used to explore its effects on cell migration and invasion. An SHH-MB mouse xenograft model was constructed to assess the anti-cancer effect of celastrol. Flow cytometry was employed to detect the apoptotic effect and intracellular reactive oxygen species (ROS) levels, and Western blotting was used to analyze apoptosis-related proteins. In terms of mechanism exploration, through molecular reverse virtual screening, analysis of the medulloblastoma Gene Expression Omnibus (GEO) database, and transcriptomic analysis, it was speculated that celastrol might affect the PI3K-AKT pathway through TGFB2. Finally, Western blotting was used to verify the results related to this pathway. Celastrol significantly inhibited SHH-MB cell proliferation and induced apoptosis in both in vitro and in vivo models. Celastrol increased intracellular ROS levels, contributing to apoptosis, and effectively suppressed SHH-MB cell migration, invasion, and colony formation. Transcriptomic analysis revealed that celastrol downregulates TGF-beta2 and CXCL12 mRNA expression, potentially through the NF-κB signaling pathway, further supporting its antiproliferative effects. Celastrol demonstrates significant antitumor activity against SHH-MB by inducing ROS-mediated apoptosis and inhibiting proliferation, migration, and invasion. Its effects may involve suppression of the CXCL12/NF-κB signaling axis, providing a promising therapeutic strategy for SHH-MB treatment. Further research is warranted to explore its clinical applications.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Impact of Resveratrol Supplementation on Anthropometric Indices in Patients With Type 2 Diabetes.","authors":"Maryam Lahouti, Pishva Arzhang, Leila Azadbakht","doi":"10.1002/ptr.70074","DOIUrl":"https://doi.org/10.1002/ptr.70074","url":null,"abstract":"<p><p>Some evidence suggests that resveratrol may have anti-obesity effects on diabetic patients; while other studies have not confirmed this claim. This study aimed to systematically review the literature and evaluate the impact of resveratrol supplementation on body weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and hip circumference (HC) in individuals with type 2 diabetes (T2D). We conducted comprehensive searches in electronic databases such as Web of Science, PubMed, Scopus, and the Cochrane Library up to February 2023. We included randomized controlled trials (RCTs) including adult T2D patients who received resveratrol supplementation and reported at least one anthropometric measure. Two independent researchers performed data extraction and quality assessment. We determined overall effect sizes using a random-effects model and assessed heterogeneity using the I² statistic and Cochrane's Q test. A total of 11 trials with 614 participants were included. The pooled effect size showed that taking resveratrol supplements significantly decreased body weight (WMD: -0.44 kg, 95% CI: -0.88 to -0.00, p = 0.048), BMI (WMD: -0.19 kg/m², 95% CI: -0.37 to -0.01, p = 0.03), and WC (WMD: -0.80 cm, 95% CI: -1.35 to -0.24, p = 0.005). However, we did not find any significant effects on HC or WHR. This meta-analysis revealed significant reductions in body weight, BMI, and WC among T2D patients who consumed resveratrol. However, there was no significant effect on HC and WHR. Further high-quality, long-term studies are necessary to confirm these findings.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zingibroside R1 Isolated From Achyranthes bidentata Blume Ameliorates LPS/D-GalN-Induced Liver Injury by Regulating Succinic Acid Metabolism via the Gut Microbiota.","authors":"Pengli Guo, Mengnan Zeng, Meng Liu, Yuhan Zhang, Jufang Jia, Ziyu Zhang, Shulei Liang, Xiaoke Zheng, Weisheng Feng","doi":"10.1002/ptr.70067","DOIUrl":"https://doi.org/10.1002/ptr.70067","url":null,"abstract":"<p><p>Achyranthes bidentata Blume is a traditional Chinese medicine used to treat liver and kidney protection and improve liver injury; however, its active components and mechanism of action remain unclear. This study focused on the monomer compound zingibroside R1 (R1) from Achyranthes bidentata Blume, specifically studying its effects on liver injury through the modulation of succinic acid-mediated immunity and inflammation via the gut microbiota. We isolated R1 and investigated its therapeutic effects in a lipopolysaccharide (LPS)- and D-galactosamine-induced acute liver injury mouse model. Liver tissue pathology, serum biomarkers, oxidative stress parameters, immune inflammation, and the gut microbiota composition were assessed. Metabolic profiling was performed via UPLC-Q-TOF-MS, and faecal microbiota transplantation experiments were conducted to validate the role of the gut microbiota in the hepatoprotective effects of R1. R1 treatment significantly alleviated LPS/GalN-induced liver injury, reducing liver haemorrhaging, hepatocyte necrosis, nuclear shrinkage, and inflammatory infiltration. R1 treatment also decreased the serum ALT and AST levels and mitigated oxidative stress. The levels of inflammation and immunity were markedly reduced following R1 treatment. Gut microbiota analysis revealed that R1 treatment restored Lactobacillus levels. Metabolomic analysis indicated that R1 influenced key metabolic pathways, including purine metabolism and glycerophospholipid metabolism pathways, and succinic acid was identified as a critical metabolite in the gut-liver interaction. Faecal microbiota transplantation (FMT) results confirmed that the therapeutic effect of R1 on liver injury is exerted by the gut microbiota, which affects the inflammation mediated by succinic acid metabolism. R1 from Achyranthes bidentata Blume provides hepatoprotective protection against LPS/GalN-induced liver injury by modulating the gut microbiota and succinic acid metabolism. These findings underscore the potential of R1 as a therapeutic agent for treating liver diseases, highlighting the importance of the gut microbiota in mediating liver health.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.","authors":"Dayan Xiong, Miao Lin, Weixi Xie, Xiaohua Zhang, Lei Huang, Lang Deng, Xiaoting Huang, Wei Liu, Siyuan Tang","doi":"10.1002/ptr.70024","DOIUrl":"https://doi.org/10.1002/ptr.70024","url":null,"abstract":"<p><p>Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present significant clinical challenges due to high mortality rates and limited treatment options. This study explores the protective effects of Lysionotin, a flavonoid from Lysionia odorata, known for its anti-inflammatory and antioxidant properties. We aim to elucidate its mechanisms in a murine ALI model. In vitro experiments confirm Lysionotin enhances antioxidant defenses and protects endothelial cells from LPS-induced injury. Mechanistic studies, including kinase screening and molecular docking, show Lysionotin activates Nrf2 via AMPK binding, facilitated by the Slco4a1 channel. Lysionotin preserves endothelial function and reduces oxidative stress in ALI mice by boosting antioxidant activity and attenuating inflammation. It enhances the antioxidant capacity of LPS-induced PMVECs via the AMPK/Nrf2 pathway. SLCO4A1 was validated as critical for Lysionotin-mediated AMPK activation. Pretreatment with Lysionotin significantly enhances antioxidant capacity, reduces oxidative damage and inflammation, and maintains endothelial integrity in ALI mice. This study provides the first evidence of Lysionotin's protective effects against LPS-induced ALI, offering a foundation for novel therapies and identifying potential clinical targets for further research.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monosaccharide and Disaccharide Saponins of Shade-Dried Gynostemma Pentaphyllum Confer Metabolic Benefits in Mice With Non-Alcoholic Fatty Liver Disease.","authors":"Fei Teng, Haihui Liu, Yaping Jiang, Shuyang Xu, Xunjiang Wang, Xu Wang, Ziqing Yang, Min Li, Rufeng Wang, Zhengtao Wang, Li Yang, Jingjing Zhu, Lili Ding","doi":"10.1002/ptr.70049","DOIUrl":"https://doi.org/10.1002/ptr.70049","url":null,"abstract":"<p><p>Gynostemma pentaphyllum (Thunb.), a traditional medicinal plant, is processed through different methods such as roller drying and shade drying. Shade-dried G. pentaphyllum (SDGPs) contained monosaccharide and disaccharide saponins, while roller-dried G. pentaphyllum (RDGPs) contained trisaccharide and tetrasaccharide saponins. These methods may affect its bioactive compounds, but their influence on non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aims to compare the anti-NAFLD effects of G. pentaphyllum processed by these two methods and identify the active ingredients involved. Saponin fractions and monomers from both processing methods were isolated using chromatography. A mouse model of NAFLD was induced by a high-fat and cholesterol diet to assess the therapeutic effects of the fractions. Molecular docking, surface plasmon resonance, and transcription analysis were used to evaluate the interactions of saponins with the Farnesoid X receptor (FXR). SDGPs exhibited better therapeutic effects on NAFLD in mice, with monosaccharide saponins being more effective than trisaccharide saponins. Gypenoside TN-1 outperformed Gypenoside XLVI in treating the NAFLD phenotype. Molecular analysis revealed a stronger binding affinity of monosaccharide saponins to FXR. SDGPs, especially the monosaccharide saponins, provide greater therapeutic benefits in treating NAFLD, likely through activation of the FXR-FGF15 signaling pathway. These findings suggest that shade drying may be a more effective method for enhancing the therapeutic potential of G. pentaphyllum for NAFLD treatment.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atractylenolide III Mitigates Alzheimer's Disease by Enhancing Autophagy via the YY1-TFEB Pathway.","authors":"Xiaowei Zhang, Shuang Chu, Yanli Huang, Zhonghua Li, Junying Song, Pan Wang, Yunfang Su, Zhenqiang Zhang, Zhishen Xie","doi":"10.1002/ptr.70069","DOIUrl":"https://doi.org/10.1002/ptr.70069","url":null,"abstract":"<p><p>Autophagy dysregulation serves as a significant pathogenic factor in Alzheimer's disease (AD), with transcription factor EB (TFEB) acting as a pivotal transcription factor that governs the process of autophagy. Atractylenolide III (AT-III), a terpenoid compound found in medicinal Atractylodes macrocephala Koidz, is well-known for its role in antioxidant and anti-inflammatory activities. The purpose of this study is to explore the beneficial impact of AT-III on AD pathology and identify the mechanisms involved. C. elegans CL4176, SH-SY5Y APP_SWE, and APP/PS1 mice were used to investigate the efficacy and possible mechanism of AT-III on the treatment of AD. AT-III reduced amyloid protein (Aβ) deposition in C. elegans CL4176 heads, prolonged the paralysis time, and reduced Aβ levels in SH-SY5Y APP_SWE cells. AT-III improved the learning and memory ability of APP/PS1 mice and decreased the deposition of Aβ plaques. Transcriptomics and experimental validation showed that AT-III stimulated transcription and translation of autolysosome-associated genes. AT-III enhanced co-localization of LC3 and LAMP2 with Aβ in APP/PS1 mice. Meanwhile, AT-III increased TFEB transcriptional activity, mRNA, and protein levels in the nucleus. Furthermore, AT-III enhanced the expression of Yin Yang 1 (YY1) protein, an upstream regulator of TFEB, and led to the stimulation of autophagy and lysosome biogenesis both in vivo and in vitro. The observed effects were reversed upon silencing YY1. AT-III may regulate the YY1-TFEB pathway, thereby restoring autophagy flux disturbances and ameliorating AD-related pathological changes and cognitive decline. This study provides a promising lead compound for intervention in AD.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids Being Chemo-Preventive Agents Induce Programmed Cell Death: Mechanisms and Therapeutic Potentials.","authors":"Mateen Nawaz, Arooj Nawaz, Muhammad Nadeem Khan, Tanziela Tanziela, Aysha Zahid, Wusheng Zhong, Shuli Xie, Zhanqin Huang, Yongdong Niu","doi":"10.1002/ptr.70018","DOIUrl":"10.1002/ptr.70018","url":null,"abstract":"<p><p>Flavonoids have a chemo-preventive effect on cancer due to their antioxidant properties and ability to limit proliferation, suppress angiogenesis, and modulate the immune system through cellular death. The immense potential of natural flavonoids in initiating diverse signaling cascades offers a compelling strategy to combat uncontrolled cell proliferation. In disease therapeutics and chemo-prevention, flavonoids have attracted considerable attention due to their ability to activate a range of Programmed cell death (PCD) pathways. PCD is a fundamental mechanism in developmental and defensive systems, with several sub-types based on cell death execution and distinct morphological characteristics. Recent comprehensive studies on cell death have unveiled new insights into various types of cellular destruction and their crucial involvement in the treatment of diseases, including cancer. This review aims to provide a concise yet comprehensive overview of programmed cell death and the impact of flavonoids on initiating these diverse forms of cellular demise. It will delve into the mechanisms through which flavonoids exert their effects, focusing on their potential in cancer prevention and their role in elucidating the molecular pathways underlying programmed cell death. Additionally, the review will explore how comprehending the mechanisms of drugs targeting different cell death pathways in therapy, in both preclinical and clinical studies, may contribute to developing novel therapeutic regimens and mitigating resistance to previously employed medicines.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}