Phytotherapy Research最新文献

{"title":"Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.","authors":"Yuehua Wang, Yuying Ma, Peng Tuo, Abid Naeem, Yijun Tang, Qianying Su, Huajian Li, Xiaokang Gao, Xiaoli Wang","doi":"10.1002/ptr.8485","DOIUrl":"https://doi.org/10.1002/ptr.8485","url":null,"abstract":"<p><p>Forsythoside A (FTA) is a key component found in the fruit and leaves of Forsythia suspensa, having anti-inflammatory and antioxidant properties. However, it is unclear whether FTA can have a protective effect against acute alcoholic liver injury (ALI) and how it may exert this effect. This research examined the potential protective effects of FTA against acute ALI using cell and animal models. The protective properties of FTA against acute ALI were attributed to its anti-inflammatory and antioxidant actions by detecting the markers of oxidative stress and inflammation. The underlying mechanism was explored through the utilization of Western blotting, Molecular Docking, and Microscale Thermophoresis techniques. The results showed that pretreatment with high doses of FTA had a significant protective effect on acute ALI in both cell and animal models. The pretreatment with high doses of FTA inhibited alcohol-induced oxidative stress and inflammation, raising antioxidative enzyme activity in both models. Furthermore, FTA has been shown to bind to TLR4, thereby inhibiting alcohol-induced activation of the NF-κB signaling pathway, leading to a decrease in cellular oxidative stress and inflammatory reactions. This interaction also facilitates the ubiquitination-mediated degradation of TLR4, ultimately diminishing its regulatory impact on the NF-κB signaling cascade. FTA has a significant protective effect on acute ALI. It binds to TLR4 to inhibit the activation of the NF-κB signaling pathway by alcohol, thereby reducing oxidative stress and inflammation and exerting a protective effect. The results of our study provide a theoretical basis for the development of FTA for the prevention and treatment of acute ALI.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Traditional Chinese Medicine in Adjuvant Treatment of Type 1 Diabetes.","authors":"Jian Luo, Fuli Hu, Zhuolin Jia, Xiaoli Zhu, Ye Zhou, Changhe Hu, Lingying Yu, Zhimin Chen","doi":"10.1002/ptr.8514","DOIUrl":"https://doi.org/10.1002/ptr.8514","url":null,"abstract":"<p><p>Type 1 diabetes (T1DM) is one of the most common chronic metabolic diseases in the world. Insulin replacement therapy and drug adjuvant therapy are the main means of modern medical treatment of T1DM; still, there are adverse reactions such as drug resistance, which seriously hinder the therapeutic effect. As a unique medical method in China, traditional Chinese medicine (TCM) has a significant effect on the treatment of T1DM. TCM therapy can reduce the symptoms of T1DM, prevent complications, improve insulin resistance, and promote insulin secretion. In recent years, the research field of TCM in the treatment of T1DM has made considerable progress. The research on the treatment of T1DM by Chinese herbal medicine, TCM prescription, acupuncture, and moxibustion shows good anti-T1DM effect and significantly improves the survival rate of patients. This article aims to summarize the methods of TCM in the treatment of T1DM, expounds on the mechanism of action in the treatment of T1DM, and discusses the limitations and opportunities of TCM in the treatment of T1DM.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Oxo-22α-Hydroxy-Rotundic Acid Alleviates Hyperlipidemia in Mice by Modulating Lipid Metabolism Through the AMPK-SREBP-1c-PPARα Pathway.","authors":"Mengjia Sun, Pinfei Zhong, Guishan Xu, Wei Zeng, Min Yu, Jiamin Cao, Jing Jin, Jie Chen, Zhongxiang Zhao","doi":"10.1002/ptr.8518","DOIUrl":"https://doi.org/10.1002/ptr.8518","url":null,"abstract":"<p><p>3-Oxo-22α-hydroxy-rotundic acid (ITP3) demonstrated notable hypolipidemic activity. However, the molecular mechanism of its hypolipidemic activity has not been elucidated. The present study aimed to evaluate its lipid-lowering efficacy using in vivo and in vitro hyperlipidemia models and to further elucidate its potential mechanism of action in hyperlipidemia. Endophytic fungi in plants of the genus Ilex were utilized for microbial transformation of rotundic acid (RA) to generate an adequate quantity of ITP3. Free fatty acid (FFA) treatment of HepG2 cells and C57BL/6J mice was used to evaluate the hypolipidemic effects of ITP3 in vivo and in vitro. A metabolomics approach combined with Western blot analysis was used to reveal the potential mechanism of the anti-hyperlipidemia of ITP3. The results showed that ITP3 exhibited good lipid-lowering activity in vivo and in vitro models of hyperlipidemia. In addition, metabolomics analysis revealed significant changes in serum and intracellular metabolite lipid levels, which were restored by ITP3. Mechanistically, ITP3 can inhibit lipid synthesis and activate lipid oxidation via the AMPK-SREBP-1c-PPARα pathway, thereby ameliorating lipid metabolism disorders. ITP3 exhibits a promising lipid-lowering effect via the AMPK-SREBP-1c-PPARα pathway, thereby improving lipid metabolism. This work highlights ITP3 as a potential phytochemical candidate for the treatment of hyperlipidemia.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Sinigrin as Active Compound of Rape Pollen for Treating Benign Prostatic Hyperplasia Through PI3K/AKT/mTOR Axis.","authors":"Bingliang Chen, Yingchao Wang, Guoda Song, Meicheng Liu, Peng Lv, Bin Yang, Hui Zhuge, Yu Tang, Yi Wang, Jianbiao Yao, Jianfang Wang, Jihong Liu, Xiaming Liu","doi":"10.1002/ptr.8447","DOIUrl":"https://doi.org/10.1002/ptr.8447","url":null,"abstract":"<p><p>Benign prostatic hyperplasia (BPH) is a common proliferative disease in older males. PuleanPian, containing rape pollen (RP), is a certified BPH medicine, but its main active compound and mechanism are unknown. This study aims to identify the main active compound of RP for the treatment of BPH. BPH rat models were induced with estradiol/testosterone (E2/T) and treated with RP or its alcohol extract (ALRP). RNA-seq and metabolomics were conducted, and RP compounds were identified via liquid chromatography-mass spectrometry (LC-MS). In vitro experiments used BPH-1 and RWPE-1 cells. E2/T induced BPH symptoms, alleviated by RP and ALRP treatment. RP possibly acts through phosphatidylinositol-3-kinase (PI3K)/AKT pathways, promoting autophagy. LC-MS identified five main RP compounds, with sinigrin implicated in BPH treatment via the PI3K/AKT(AKT Serine/Threonine Kinase 1)/mammalian target of rapamycin (mTOR) axis. Sinigrin may be the active compound in RP for BPH treatment, acting through the PI3K/AKT/mTOR axis.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Moschamindole Induces Glioma Cell Apoptosis by Blocking Mia40-Dependent Mitochondrial Intermembrane Space Assembly and Oxidative Respiration.","authors":"","doi":"10.1002/ptr.8506","DOIUrl":"https://doi.org/10.1002/ptr.8506","url":null,"abstract":"<p><strong>Retraction: </strong>G.-D. Huang, F.-F. Chen, J.-H. Yang, G.-X. Ma, Z.-J. Liao, W.-P. Li, Z.-Y. Li, and L. Chen, \"Moschamindole Induces Glioma Cell Apoptosis by Blocking Mia40-Dependent Mitochondrial Intermembrane Space Assembly and Oxidative Respiration,\" Phytotherapy Research 35, no. 6 (2021): 3390-3405, https://doi.org/10.1002/ptr.7061. The above article, published online on 15 April 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Angelo Izzo; and John Wiley & Sons Ltd. The authors were made aware of reports from a third party which indicated that panels used in Figure 6F from this article had been duplicated in two other articles (Liu et al. 2021 [https://doi.org/10.3892/or.2021.8087]; and Huang et al. 2021 [https://doi.org/10.1016/j.neuint.2021.105051]). The authors reported this information to the journal and stated that the Caspase-3/7 activity detection assay was performed by a technical service company and that original data were no longer available. The authors therefore requested retraction for their article. The publisher has additionally confirmed that the assay images in each publication describe different experimental conditions and that one article (Huang et al. 2021 [https://doi.org/10.1016/j.neuint.2021.105051]) contains many of the same authors as the article published in this journal. The retraction has been agreed to because the evidence of duplicated assay images with other publications, in which the same data is reported with different scientific conditions, fundamentally compromises the validity of the conclusions presented in this article. The authors did not respond to our notice regarding the retraction.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glabridin Alleviates Metabolic Disorders in Diet-Induced Diabetic Mice.","authors":"Xiaoxue Yang, Kaiyi Lai, Jiayu Zhang, Ziyi Chen, Wenwen Ding, Yu Jiang, Ying Liu","doi":"10.1002/ptr.8517","DOIUrl":"https://doi.org/10.1002/ptr.8517","url":null,"abstract":"<p><p>Glabridin (GLD) is a flavonoid derived from licorice. This study aims to evaluate GLD's therapeutic potential in ameliorating type 2 diabetes mellitus (T2DM) and elucidate its underlying mechanisms of action. A T2DM model was established using male C57BL/6J mice fed a high-fat, high-glucose diet. GLD was administered via intraperitoneal injection at doses of 10, 20, and 30 mg/kg BW, with MET (200 mg/kg BW) as a positive control. Fasting blood glucose levels, glucose tolerance, insulin tolerance, pyruvate tolerance, and serum parameters were analyzed, along with key markers of glycogen synthesis, gluconeogenesis, lipid metabolism, mitochondrial function, and endoplasmic reticulum (ER) stress. GLD significantly lowered blood glucose levels in the diabetic mice. It suppressed gluconeogenesis by inhibiting PEPCK and G6P, while promoting glycogen synthesis by activating GCK and inhibiting GSK-3β. Additionally, GLD enhanced insulin signaling by increasing IRS1 and IRS2 levels and promoting AKT phosphorylation, thereby improving insulin sensitivity. In lipid metabolism, GLD reduced hepatic steatosis and lipid accumulation by downregulating lipogenesis-related genes (SREBP1c, FAS, ACC1, and SCD1) and upregulating lipolysis-related genes (PPARα and LCAD). In energy metabolism, GLD increased mitochondrial membrane potential, reduced reactive oxygen species levels, and enhanced the expression of genes associated with mitophagy (PINK1 and Parkin) and mitochondrial biogenesis (PGC-1α, SIRT1, and TFAM). Moreover, GLD mitigated ER stress by decreasing GRP78 and CHOP levels, suppressing PERK phosphorylation, and inhibiting key stress response genes. GLD improves insulin sensitivity and exerts antidiabetic effects by ameliorating metabolic disorders, supporting its potential as a therapeutic agent for T2DM.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre-Hypertensive and Hypertensive Individuals: A Systematic Review and Meta-Analysis.","authors":"Rebeca Lachovicz, Vera Ferro-Lebres, Juliana Almeida-de-Souza, José Alberto Pereira","doi":"10.1002/ptr.8509","DOIUrl":"https://doi.org/10.1002/ptr.8509","url":null,"abstract":"<p><p>Annually, approximately 10 million deaths are attributed to hypertension, highlighting the critical need for effective treatments beyond conventional medications due to their limitations. Therefore, the aim of this study was to evaluate the impact of Olea europaea L. on blood pressure in adults with prehypertension and hypertension. The search, conducted from November/2022-October/2024 was performed on EBSCO, CABI, CNKI, Cochrane Library, DOAJ, PUBMED, SCOPUS, and WEB OF SCIENCE databases using Hypertension AND Olea europaea L. Eligible studies included those evaluating the effect of Olea europaea L. on systolic/diastolic blood pressure in hypertensive or pre-hypertensive adults. Exclusion criteria were multi-preparation interventions. Data on reference, country, sample, intervention/control details, duration, and differences in systolic and diastolic blood pressure, adverse effects, and medication use were extracted manually. The mean differences, heterogeneity (I²) and quality of the studies were assessed using Review Manager (version 5.4). From 211 found studies, 3 met the eligibility criteria, considering 248 participants analysed. An antihypertensive effect was observed on systolic and diastolic blood pressure in the pre- vs. post-intervention in the global analysis (systolic -6.03 mmHg, 95% CI: [-11.60, -0.46], I² = 82%, p = 0.03; diastolic -2.38 mmHg, 95% CI: [-4.96, 0.20], I² = 50%, p = 0.07) and in the sub-analysis that included the studies with the highest dose (1000 mg/day) (systolic -11.45 mmHg, 95% CI:[-13.99, -8.91], I² = 0%, p ≤ 0.001; diastolic -4.65 mmHg, 95% CI: [-6.56, -2.74], I² = 0%, p ≤ 0.001). Olive leaf extract (1000 mg/day) may reduce systolic and diastolic blood pressure by -11.45 and -4.65 mmHg, respectively. However, limitations include variable trial quality and exclusion of studies not written in English. Additional comprehensive clinical studies are essential to confirm its efficacy and safety.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Reports of Suspected Adverse Reactions to Ashwagandha: Analysis of Data From the Italian Nutrivigilance System.","authors":"Ilaria Ippoliti, Silvia Di Giacomo, Paola Angela Moro, Francesca Maida, Gabriela Mazzanti, Francesca Menniti Ippolito, Giuseppe Marano","doi":"10.1002/ptr.8497","DOIUrl":"https://doi.org/10.1002/ptr.8497","url":null,"abstract":"","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin Alleviates Breast Cancer-Related Depression by Inhibiting Neutrophil Extracellular Traps via Inhibition of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor Axis.","authors":"Qing Zhu, Ye Tao, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi","doi":"10.1002/ptr.8513","DOIUrl":"https://doi.org/10.1002/ptr.8513","url":null,"abstract":"<p><p>Breast cancer is associated with a higher incidence of depression and decreased quality of life. Previous studies have indicated that quercetin can mitigate the advancement of breast cancer-related depression (BCRD); however, the specific mechanism by which quercetin affects BCRD is yet to be determined. In this study, we aimed to examine the effect of quercetin on BCRD and explore the underlying mechanisms. We established a mouse model of BCRD and administered quercetin. LC-MS was used to analyze and determine distinct alterations in metabolites in mouse tumor samples. Polymorphonuclear neutrophils (PMNs) were extracted from mouse femurs and treated with PMA and quercetin/Sphingosine 1-phosphate (S1P). Mouse breast cancer cells 4 T1 were treated with lipopolysaccharides (LPS), neutrophil extracellular traps (NETs) and S1P. Neuronal cells were treated with LPS, NETs, S1P, and Corticosterone. Pearson's correlation coefficient was used to evaluate the relationship between differential metabolites and NETs. Quercetin inhibited NET formation in BCRD mice. In vitro, quercetin reversed NET-induced 4 T1 cell proliferation, migration, and ROS production. Quercetin also reversed the effects of NET-induced 4 T1 cells on neuronal cells. LC-MS analysis demonstrated that quercetin ameliorated the metabolic abnormalities in the tumors of BCRD mice. Pearson's correlation analysis showed that S1P, Oleoyl glycine, N-Arachidonoylglycine, 2, 3-butanediol apiosylglucoside, and tetracosatetraenoyl carnitine levels positively correlated with MPO DNA levels. Furthermore, in vitro, S1P enhanced NET-induced 4 T1 cell proliferation, migration, and ROS production, as well as enhanced NET-induced 4 T1 cell damage to neuronal cells. Quercetin alleviated BCRD by inhibiting NETs via inhibition of the S1P/S1PR axis.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B-Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling.","authors":"Qian Hu, Mengyao Wang, Meng Chen, Jinjin Wang, Ting Niu","doi":"10.1002/ptr.8439","DOIUrl":"10.1002/ptr.8439","url":null,"abstract":"<p><p>Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous subtype of non-Hodgkin lymphoma, with two-thirds of patients relapsing or resisting existing therapies, highlighting the urgent need for effective treatments. Toosendanin (TSN), a triterpenoid from Meliae Cortex, exhibits significant anti-cancer activity by modulating cell survival and proliferation. This study investigates the anti-lymphoma effects and underlying mechanisms of TSN, proposing it as a potential therapeutic agent to address the challenges of DLBCL. Network pharmacology, molecular docking, and transcriptome sequencing were employed to predict TSN's anti-DLBCL potential. Findings were validated through in vitro and in vivo experiments, including cell viability assays, flow cytometry, quantitative PCR, Western blotting, reverse experiments with small-molecule inhibitors or genetic editing, and a cell-derived xenograft (CDX) model. Bioinformatics analyses revealed TSN's strong binding affinity to PI3Kα/β and Polo-like kinase 1 (PLK1). Experiments showed that TSN downregulated the PI3K/Akt signaling pathway and reduced PLK1 mRNA and protein levels, inducing apoptosis, cell cycle arrest, and cell death in DLBCL cells. RNA sequencing and metabolic assays indicated TSN upregulated cholesterol biosynthesis in DLBCL cells. Co-treatment with a statin enhanced TSN's anti-DLBCL effects while mitigating hepatic and pulmonary toxicity. This study identifies TSN as a dual inhibitor of PI3K and PLK1 with significant therapeutic potential for DLBCL. It also proposes a lipid-modulating strategy to enhance TSN's cytotoxicity while reducing adverse effects, offering a promising approach to improve DLBCL treatment outcomes.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":"1930-1945"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}