Phytotherapy Research最新文献_第2页

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review. Ashwagandha：安全吗？第二部分：临床前证据回顾。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-18 DOI: 10.1002/ptr.70090

Elizabeth M Williamson, Thomas Brendler

{"title":"Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review.","authors":"Elizabeth M Williamson, Thomas Brendler","doi":"10.1002/ptr.70090","DOIUrl":"https://doi.org/10.1002/ptr.70090","url":null,"abstract":"The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude that AS is a remarkably safe herb, but cases of liver toxicity, mainly reversible cholestasis or severe jaundice and pruritus, have been reported without being predicted by preclinical evidence. Further work is needed to clarify the constituents responsible and patient-related issues surrounding them. Several constituents, such as withaferin-A, have demonstrable antitumorigenic effects in animal models of liver cancer and injury induced by ischemia, cytotoxic drugs, and radiotherapy. AS has not shown genotoxicity or mutagenicity in standard tests; on the contrary, it was protective against chromosome abnormalities or micronuclei formation induced by known clastogenic agents. A folkloric reputation for inducing abortion or sterility is not borne out of preclinical experiments, and rare reports of cardiotoxicity could not be substantiated.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4. 藏红花素通过选择性靶向MKK4减轻Nrf2/GPX4介导的阻塞性肾病中的铁下垂。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-17 DOI: 10.1002/ptr.70092

Ziyun Xu, Liwei Zhu, Jingyi Wu, Yue Liu, Zhenfang Du, Minggang Wei, Haiyong Chen, Sheng Qiang

{"title":"Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4.","authors":"Ziyun Xu, Liwei Zhu, Jingyi Wu, Yue Liu, Zhenfang Du, Minggang Wei, Haiyong Chen, Sheng Qiang","doi":"10.1002/ptr.70092","DOIUrl":"https://doi.org/10.1002/ptr.70092","url":null,"abstract":"Renal fibrosis is a critical pathogenesis of chronic kidney disease (CKD). Crocin, an active compound derived from saffron (Crocus sativus L.), exhibits potent antioxidant and renal protection properties. However, the effects of crocin on renal fibrosis and its underlying mechanisms remain unclear. This study aimed to investigate the potential role and molecular mechanism of crocin in protecting renal cells from ferroptosis and improving renal fibrosis. The study utilized a unilateral ureteral obstruction (UUO) rat model and erastin-induced ferroptosis model in rat renal tubular epithelial (NRK-52E) cells to evaluate the effect of crocin on ferroptosis and renal fibrosis. Phospho-specific antibody microarray analysis was conducted to profile crocin-relevant phosphate proteins among 16 signaling pathways. Surface plasmon resonance (SPR) assessments were employed to explore molecular interactions between crocin and mitogen-activated protein kinase kinase 4 (MKK4). Co-immunoprecipitation (Co-IP) experiments were used to investigate interactions between MKK4 and Nrf2. Crocin attenuated renal fibrosis as demonstrated by reducing profibrotic markers in both the UUO model and erastin-treated NRK-52E cells. It also significantly inhibited ferroptosis in vivo and in vitro. Microarray profiling and molecular docking suggested that MKK4 was a critical regulator of ferroptosis and fibrosis. SPR analysis indicated that crocin inhibited p-MKK4 by directly interacting with MKK4. Co-IP further revealed that p-MKK4 interacted with Nrf2, leading to alleviating reactive oxygen species (ROS) levels and subsequently attenuating renal ferroptosis. Crocin exerts protective effects against renal fibrosis and ferroptosis via modulation of phospho-MKK4/Nrf2/ferroptosis signaling axis. These findings suggest crocin is a promising renoprotective agent for renal fibrosis, and MKK4 represents a potential target for ferroptosis-related kidney injury.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Antifibrotic Action of Foeniculum vulgare Root Bark Volatile Oil Through the HK2/PKM2/LDHA Pathway. 小茴香根皮挥发油通过HK2/PKM2/LDHA通路抗纤维化作用的研究

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-16 DOI: 10.1002/ptr.70050

Kehong Ming, Lieyang Peng, Yijing Pan, Meiliang Zhu, Yi Xiao, Siyi Ye, Kang Xu, Xianqiong Liu

{"title":"Investigating the Antifibrotic Action of Foeniculum vulgare Root Bark Volatile Oil Through the HK2/PKM2/LDHA Pathway.","authors":"Kehong Ming, Lieyang Peng, Yijing Pan, Meiliang Zhu, Yi Xiao, Siyi Ye, Kang Xu, Xianqiong Liu","doi":"10.1002/ptr.70050","DOIUrl":"https://doi.org/10.1002/ptr.70050","url":null,"abstract":"Foeniculum vulgare root bark (FVRB), a traditional ethnomedicine, demonstrates hepatoprotective properties and has been clinically employed in managing liver fibrosis. As volatile oils represent principal bioactive constituents of FVRB, the therapeutic potential of F. vulgare root bark volatile oil (FVRBO) against liver fibrosis remains unelucidated. This study investigates the antifibrotic mechanisms of FVRBO through integrated in vitro and in vivo approaches. The FVRBO was extracted using the steam distillation method, and the content of its main components was determined by gas chromatography. Liver fibrosis models were established using CCl4-induced mice and TGF-β1-induced JS-1 cells. Antifibrotic efficacy was validated through significant downregulation of fibrotic markers and inflammatory cytokines. Integrated transcriptomic and metabolomic analyses revealed FVRBO's mechanism. The principal constituents of FVRBO were quantified as dillapiole, apiole, and myristicin, with the extraction method demonstrating consistent stability. In vivo, FVRBO significantly attenuated CCl4-induced liver injury in mice, as evidenced by decreased liver and spleen indices, reduced serum ALT and AST levels, attenuated inflammatory infiltration, and suppressed collagen deposition in hepatic tissue. In vitro, FVRBO effectively inhibited TGF-β-induced JS-1 cell activation and downregulated fibrotic markers at mRNA and protein levels. Integrated transcriptomic-metabolomic analysis revealed FVRBO exerts antifibrotic efficacy by regulating the glycolysis pathway and suppressing the expression of HK2, PKM2, and LDHA. FVRBO exerts antifibrotic effects by modulating the glycolytic pathway and its associated gene expression. This study provides mechanistic evidence for FVRBO as a phytopharmaceutical candidate and establishes a foundation for developing natural-product-based anti-fibrotic therapeutics.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota-Targeted Polyphenol Interventions: A Novel Paradigm and Synergistic Strategies for Obesity Management. 针对肠道微生物群的多酚干预：肥胖管理的新范式和协同策略。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-15 DOI: 10.1002/ptr.70068

Yichen Cai, Jun Xu, Bing Wang

{"title":"Gut Microbiota-Targeted Polyphenol Interventions: A Novel Paradigm and Synergistic Strategies for Obesity Management.","authors":"Yichen Cai, Jun Xu, Bing Wang","doi":"10.1002/ptr.70068","DOIUrl":"https://doi.org/10.1002/ptr.70068","url":null,"abstract":"Obesity has emerged as a major metabolic disorder threatening global public health, with gut microbiota (GM) dysbiosis recognized as a key pathogenic driver. While existing reviews have explored associations between GM and obesity (e.g., the gut-liver axis), this review focuses specifically on polyphenols to establish a novel paradigm of \"GM-targeted polyphenol interventions.\" Naturally occurring polyphenols exhibit unique advantages in obesity management; however, their systemic effects critically depend on GM-mediated biotransformation. Herein, we propose the \"Polyphenol-GM Axis\" as the core mechanism underpinning polyphenol efficacy against obesity, synthesizing and integrating current evidence. This comprehensive review elucidates how polyphenols from diverse sources ameliorate obesity through GM modulation: (1) remodeling gut-liver crosstalk via bile acid metabolism; (2) inhibiting lipogenesis through GM-derived metabolites; (3) restoring intestinal barrier integrity; (4) blocking inflammatory cascades. We elucidate causal relationships between polyphenol-induced GM shifts and host metabolic outcomes, revealing targeted pathways for bidirectional \"microbiota-host\" regulation. Critically, we propose that combining GM-targeted polyphenol interventions with lifestyle modifications (diet/exercise) enables precision nutrition. This paradigm provides a theoretical foundation for developing polyphenol-based therapeutics beyond nutritional supplements. Future research should prioritize personalized GM modulation and structural optimization of polyphenols to accelerate their translation from functional foods to clinical agents for obesity management.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal Medicines for Weight Loss and Lipid Profile Improvement: A Scoping Review of Therapeutic Effects and Safety. 用于减肥和改善血脂的草药：治疗效果和安全性的范围综述。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-14 DOI: 10.1002/ptr.70072

Marcela Forgerini, Geovana Schiavo, Osvaldo Galo Neto, Gabriela Barbosa Nascimento, Johnny Wallef Leite Martins, Patrícia de Carvalho Mastroianni

{"title":"Herbal Medicines for Weight Loss and Lipid Profile Improvement: A Scoping Review of Therapeutic Effects and Safety.","authors":"Marcela Forgerini, Geovana Schiavo, Osvaldo Galo Neto, Gabriela Barbosa Nascimento, Johnny Wallef Leite Martins, Patrícia de Carvalho Mastroianni","doi":"10.1002/ptr.70072","DOIUrl":"https://doi.org/10.1002/ptr.70072","url":null,"abstract":"The demand for alternative weight loss therapies has surged, with herbal medicinal products gaining popularity due to their natural origins, perceived safety, and accessibility. However, evidence regarding their therapeutic effects and safety for weight loss remains limited. Thefore, this study aimed to identify herbal medicines used for weight loss and their efficacy and safety. A scoping review was conducted using PubMed, Embase, Scopus, and LILACS databases (September 2023). Studies evaluating the efficacy and safety of herbal medicines for weight loss in individuals aged 18 years or older were included. Study selection and data extraction were performed independently by two reviewers. A total of 74 studies involving 5508 participants were included. Most studies were double-blind randomized clinical trials (n = 50) and conducted in participants diagnosed with overweight and/or obesity (n = 70), predominantly in Asia (n = 40). The duration of interventions ranged from 10 to 613 days. The most frequently evaluated herbal medicines were Camellia sinensis (n = 16), Ephedra sp. (n = 13), Garcinia cambogia (n = 9), Citrus sp. (n = 5), and Glycyrrhiza sp. (n = 5). Five studies conducted post-intervention follow-ups. Only 10 studies did not report improvements in any parameter. Adverse events ranged from mild symptoms (e.g., headache) to severe reactions (e.g., increased blood pressure), with Ephedra sp. being linked to the most serious events. In conclusion, herbal medicinal products may offer benefits for weight loss. However, their use should be approached cautiously due to potential safety concerns.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin as a Multi-Target Natural Therapeutic in Aging-Related Diseases: Systemic Molecular and Cellular Mechanisms. 槲皮素作为衰老相关疾病的多靶点天然疗法：系统的分子和细胞机制。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-13 DOI: 10.1002/ptr.70078

Shengxue Zhou, Xinshang Qingman, Wei Zhang, Dahui Zhang, Shuang Liu

{"title":"Quercetin as a Multi-Target Natural Therapeutic in Aging-Related Diseases: Systemic Molecular and Cellular Mechanisms.","authors":"Shengxue Zhou, Xinshang Qingman, Wei Zhang, Dahui Zhang, Shuang Liu","doi":"10.1002/ptr.70078","DOIUrl":"https://doi.org/10.1002/ptr.70078","url":null,"abstract":"Quercetin, a flavonol subclass of dietary polyphenols, has garnered significant attention for its multi-targeted biological activities relevant to aging and chronic degenerative diseases. Acting through potent antioxidant, anti-inflammatory, anti-apoptotic, and metabolic regulatory mechanisms, quercetin modulates key molecular pathways implicated in age-related disorders across multiple systems, including the cardiovascular, skeletal, neurological, metabolic, and ocular domains. This review synthesizes these shared mechanisms to support a systems-level perspective on quercetin's therapeutic potential. By influencing these signaling cascades, quercetin exerts protective effects across a range of aging-associated disorders, namely cardiovascular diseases, osteoporosis, cerebrovascular accidents, diabetes, dementia, and eye-related diseases. This review is based on a comprehensive literature search conducted in PubMed, Scopus, and Web of Science up to March 2025, using keywords related to quercetin, polyphenols, aging, and associated diseases. Articles were selected based on relevance to molecular mechanisms, inclusion of in vitro, in vivo, or clinical data, and publication in peer-reviewed journals. Preventively, quercetin's capacity to modulate inflammation, oxidative stress, and apoptotic pathways offers promising strategies to delay disease onset and progression. Personalized approaches employing biomarker profiling and advanced delivery systems may optimize quercetin's bioavailability and therapeutic efficacy in targeted patient groups. This review provides a comprehensive overview of the molecular and cellular mechanisms by which quercetin modulates aging processes and age-related pathologies, and highlights advances aimed at overcoming its bioavailability limitations. Further clinical investigations are warranted to establish optimized dosing regimens and long-term safety profiles.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating the BI-1(TMBIM6)/AKT Signaling Pathway by Licochalcone D Treatment Inhibits Human Melanoma Cell Growth. 甘草查尔酮D调控BI-1(TMBIM6)/AKT信号通路抑制人黑色素瘤细胞生长

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-12 DOI: 10.1002/ptr.70089

Sun-Young Hwang, Cheol-Jung Lee, Kwanhwan Wi, Young-Kwon Kim, Soo-Bin Nam, Ju Yeon Lee, Goo Yoon, Geul Bang, Jung-Hyun Shim, Mee-Hyun Lee

{"title":"Modulating the BI-1(TMBIM6)/AKT Signaling Pathway by Licochalcone D Treatment Inhibits Human Melanoma Cell Growth.","authors":"Sun-Young Hwang, Cheol-Jung Lee, Kwanhwan Wi, Young-Kwon Kim, Soo-Bin Nam, Ju Yeon Lee, Goo Yoon, Geul Bang, Jung-Hyun Shim, Mee-Hyun Lee","doi":"10.1002/ptr.70089","DOIUrl":"https://doi.org/10.1002/ptr.70089","url":null,"abstract":"Skin cancer is a common type of cancer worldwide with increasing incidence and mortality rates. Phytochemicals, active compounds from plants, are known to exhibit diverse physiological activities with benefits of low cytotoxicity and cost. In this study, we aimed to assess the effects of Licochalcone D (LicoD) derived from Glycyrrhiza inflata on human melanoma cell proliferation and investigate its new underlying mechanisms. To assess the anticancer effects of LicoD on melanoma cells, we conducted MTT and soft agar assay, flow cytometry analysis, Western blots as well as TPA-induced inflammatory mouse model and immunohistochemical analysis. To further uncover the new mechanisms, we assessed MS/MS-based proteomic analysis and verified by knockdown and proliferation assays. LicoD (2.5, 5, and 10 μΜ) dose-dependently inhibited cell growth, induced G2/M phase arrest of cell cycle, and triggered apoptosis in SK-MEL-5 and SK-MEL-28 cells together with regulating the related markers. Importantly, we newly discovered that LicoD suppressed the expression of Bax inhibitor (BI)-1(TMBIM6), an upstream regulator of AKT signaling pathway, as confirmed by informatic analysis and Western blotting. Moreover, we demonstrated by shRNA-mediated knockdown of BI-1(TMBIM6) in melanoma cells that BI-1 plays a critical role in cell proliferation and anchorage-independent growth. Rescue assays using BIA further confirmed the functional contribution of BI-1 to the effects of LicoD. In addition, topical treatment of LicoD reduced epidermal hyperplasia and the expression of pAKT, BI-1 and COX-2 in TPA-induced inflammatory skin tissues. Taken together, our findings provide novel evidences that LicoD exerts anti-melanoma effects by down-regulation of BI-1(TMBIM6)/AKT signaling pathways in vitro and in vivo. These findings suggest essential insights for the future development of strategies in skin cancer prevention and treatment.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artesunate Enhances DUSP1-Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease. 青蒿琥酯增强dusp1依赖性线粒体完整性减轻糖尿病肾病肾纤维化

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-11 DOI: 10.1002/ptr.70091

Zikang Liu, Hongtu Hu, Yuxuan Jin, Jiwen Bao, Hanxue Zhao, Yurong Lin, Binbin Dai, Yangbin Pan

{"title":"Artesunate Enhances DUSP1-Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease.","authors":"Zikang Liu, Hongtu Hu, Yuxuan Jin, Jiwen Bao, Hanxue Zhao, Yurong Lin, Binbin Dai, Yangbin Pan","doi":"10.1002/ptr.70091","DOIUrl":"https://doi.org/10.1002/ptr.70091","url":null,"abstract":"Renal fibrosis is a hallmark of diabetic kidney disease (DKD), and currently available therapies offer limited efficacy. Artesunate (ART), a repurposed antimalarial agent, has recently demonstrated potential in mitigating renal fibrosis. This study aimed to investigate whether ART protects mitochondrial integrity and attenuates fibrosis in tubular epithelial cells (TECs) via the dual-specificity phosphatase 1 (DUSP1) pathway. Mitochondrial morphology and DUSP1 expression were examined in kidney tissues from DKD patients and db/db mice. ART (25 mg/kg) was administered to db/db mice to evaluate its in vivo effects on fibrosis, mitochondrial dynamics, and inflammation. In vitro, TECs stimulated with high glucose were used to assess mitochondrial function and fibrotic response after ART treatment. Mechanistic studies included RNA sequencing, molecular docking, and genetic modulation (DUSP1 knockdown and overexpression). Mitochondrial swelling, cristae disruption, and TFAM downregulation were observed in both human DKD samples and db/db mice, correlating with tubulointerstitial fibrosis. ART treatment restored mitochondrial structure, reduced fibrotic markers, and suppressed inflammatory cytokines in vivo. In vitro, ART reversed high-glucose-induced mitochondrial dysfunction and fibrotic signaling. Mechanistically, ART directly bound to and stabilized DUSP1, thereby inhibiting MAPK signaling. Knockdown of DUSP1 abolished the protective effects of ART, while DUSP1 overexpression mimicked ART's therapeutic actions. Notably, DUSP1 expression was significantly reduced in DKD patients, associated with greater fibrosis and worse renal function. ART attenuates renal fibrosis and restores mitochondrial homeostasis in DKD through DUSP1 stabilization and MAPK pathway inhibition. These findings support ART as a potential therapeutic agent targeting mitochondrial integrity and inflammation in diabetic kidney disease.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta-Analysis, Network Pharmacology, and Mendelian Randomization. 研究姜黄素治疗非小细胞肺癌的潜力：荟萃分析、网络药理学和孟德尔随机化的系统综述。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-09 DOI: 10.1002/ptr.70073

Yonglu Guo, Haohao Xu, Peng Shen, Ruijun Cai

{"title":"Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta-Analysis, Network Pharmacology, and Mendelian Randomization.","authors":"Yonglu Guo, Haohao Xu, Peng Shen, Ruijun Cai","doi":"10.1002/ptr.70073","DOIUrl":"https://doi.org/10.1002/ptr.70073","url":null,"abstract":"To evaluate the efficacy and explore the potential mechanism of curcumin for the treatment and prevention of NSCLC. We searched six databases thoroughly for articles published before December 2024. Stata 15.0 software was applied for systematic review with meta-analysis. We utilized network pharmacology, Mendelian randomization, and molecular docking techniques to investigate the pharmacological properties and potential targets of curcumin in the treatment of NSCLC. Twenty-four studies involving 392 experimental animals were included in this study. Meta-analysis results showed that curcumin significantly reduced tumor volume of mice (p < 0.001) in the NSCLC group compared to the control group. Two hundred twenty-nine curcumin target genes were predicted. 1546 NSCLC-related genes were obtained by taking the intersection of DEGs and genes in the key module of WGCNA. Eight hub genes were identified by protein-protein interaction. The eight hub genes showed significant clinical value and were found to be negatively correlated with the majority of immune cell infiltration. Molecular docking results indicated a good binding affinity between these eight hub genes and curcumin. Mendelian randomization demonstrated a causal relationship between the AURKB level and the increased risk of NSCLC. In this study, the effectiveness of curcumin has been demonstrated in in vivo models of NSCLC by meta-analysis. AURKB has been identified as a high-risk target for NSCLC by network pharmacological analysis and MR for the first time. Our study provides a scientific basis for clinical applications of curcumin in NSCLC.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. 黄酮类化合物和其他植物性酚类物质在减轻糖尿病诱导的大血管并发症中的作用。

IF 6.3 2区医学

Phytotherapy Research Pub Date : 2025-09-04 DOI: 10.1002/ptr.70070

Aminu Mohammed, Nasir Tajuddeen, Ahmed Olatunde, Murtala Bindawa Isah, Babangida Sanusi Katsayal, Gilead Ebiegberi Forcados, Aliyu Muhammad, Md Shahidul Islam, Mohammed Auwal Ibrahim

{"title":"The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.","authors":"Aminu Mohammed, Nasir Tajuddeen, Ahmed Olatunde, Murtala Bindawa Isah, Babangida Sanusi Katsayal, Gilead Ebiegberi Forcados, Aliyu Muhammad, Md Shahidul Islam, Mohammed Auwal Ibrahim","doi":"10.1002/ptr.70070","DOIUrl":"https://doi.org/10.1002/ptr.70070","url":null,"abstract":"Macrovascular complications of diabetes mellitus (DM) are diseases of the peripheral and coronary arteries and the cerebrovascular system. Despite the availability of several conventional antidiabetic drugs, the macrovascular complications associated with DM remain a major health burden, partly because the focus of diabetes management has been glucocentric. Interestingly, phytochemicals, particularly flavonoids and other phenolics, were highly promising in the treatment of diabetes-associated macrovascular complications. Herein, we reviewed the studies that reported the beneficial effects of flavonoids and other phenolics in the treatment of diabetes-associated macrovascular complications. Quercetin, apigenin, luteolin, kaempferol, curcumin, resveratrol, and cinnamaldehyde were well studied and demonstrated profound therapeutic activities in reducing the severity of diabetes-associated macrovascular complications through the activation of Nrf2, P13K/Akt, PPARs, and PKC expressions with the suppression of NF-κB, TGF-β, VCAM, and ICAM. Despite strong potential to manage diabetes-associated macrovascular complications in in vitro and in vivo (animal trials) studies, only two studies were reported on patients with diabetes. Hence, it is recommended that further high-quality and in-depth studies, particularly clinical studies, be conducted to unravel the efficacy and beneficial roles of the aforementioned flavonoids and other phenolics in the management of diabetes-associated macrovascular complications.","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0