Photo-dermatology最新文献_第10页

Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin. 紫外线辐射对接触致敏剂免疫的局部影响。1 .紫外光照射皮肤应用TNCB下调接触性超敏反应。

Photo-dermatology Pub Date : 1988-06-01

P D Cruz, J Nixon-Fulton, R E Tigelaar, P R Bergstresser

{"title":"Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin.","authors":"P D Cruz, J Nixon-Fulton, R E Tigelaar, P R Bergstresser","doi":"","DOIUrl":"","url":null,"abstract":"Exposure of mouse skin to UV radiation in doses comparable to those commonly received by humans has been shown to diminish the capacity of irradiated skin to mediate the induction of contact hypersensitivity to dinitrofluorobenzene (DNFB). In other studies, contact sensitization reactions to the structurally related hapten, trinitrochlorobenzene (TNCB), have been used to test the immunogenic properties of haptenated subpopulations of epidermal cells. To extend the applicability of TNCB to experiments that examine UVB modulation of immunization by epidermal cells, we examined the sensitivity of TNCB-induced contact hypersensitivity to low doses of UVB radiation. Abdominal skin of C3H mice was exposed to daily doses of 660 J/m2 broad-band UV radiation for 4 successive days. Immediately following the final exposure, 7% TNCB was applied to irradiated or non-irradiated skin of designated mice. After 5 days, mice were ear-challenged with 2% TNCB, and incremental ear-swelling responses were measured. Mice sensitized with TNCB through irradiated skin exhibited significantly diminished responses compared with UVB-treated mice sensitized through non-irradiated skin. We also found that mice initially sensitized with TNCB through irradiated skin but subsequently painted with oxazolone on normal skin developed full responses to ear-challenge with oxazolone. In contrast, mice sensitized initially with TNCB through irradiated skin failed to fully immunize even after TNCB was repainted on normal skin at a later date. We conclude that low-dose UVB radiation interrupts the induction of contact hypersensitivity to TNCB, leading to hapten-specific nonresponsiveness rather than hypersensitivity, and that this capacity to prevent successful immunization with TNCB is limited to the site of irradiation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"5 3","pages":"126-32"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14305535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneocyte changes after acute UV irradiation and chronic solar exposure. 急性紫外线照射和慢性太阳照射后角膜细胞的变化。

Photo-dermatology Pub Date : 1988-06-01

P Corcuff, J L Leveque

{"title":"Corneocyte changes after acute UV irradiation and chronic solar exposure.","authors":"P Corcuff, J L Leveque","doi":"","DOIUrl":"","url":null,"abstract":"The effects of UV irradiation on the human stratum corneum (SC) were studied under both artificial and natural conditions. Artificial UV exposure was performed with a solar simulator. Single doses of radiation from 1 to 3 MED were delivered on the backs of volunteers and the measurements were recorded for a period of one month. Corneocytes were harvested from the skin surface by using a \"turbine-machine\". Their count and projected area were measured by image analysis. The evolution of corneocyte counts showed 3 steps: 1) a background level of desquamation until the 8th day; 2) a sharp increase from day 9 to day 11; and 3) a plateau until the 20th day. No evolution of the corneocyte size occurred at 1 MED, but a decrease was recorded at day 20 for 2 MED and earlier for 3 MED. Natural sun exposure was investigated in 2 different experiments: on a population living in a sunny coastline and on professional racing cyclists. In these natural conditions, the response of the SC to UV led to an increase in corneocyte count associated with a decreased size. Even though natural environment involves both weather and sun influences, results showed similar SC responses. In case of acute irradiation, the skin recovers its initial state one month later, but in the natural environment, it maintains altered features as long as the UV irradiation occurs.","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"5 3","pages":"110-5"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14303732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentration of trimethylpsoralen in blood and skin after oral administration. 口服三甲基补骨脂素后血液及皮肤的浓度变化。

Photo-dermatology Pub Date : 1988-06-01

A M Ros, G Wennersten, I Wallin, H Ehrsson

引用次数: 0

Delayed sensorineural deafness and skin carcinogenesis in a Japanese xeroderma pigmentosum group D patient. 迟发性感音神经性耳聋与皮肤癌变一例日本色素性干皮病D组患者。