紫外线诱导的无毛小鼠增生引起的表皮透射变化:作用谱的初步近似。

Photo-dermatology Pub Date : 1988-04-01
H J Sterenborg, J C van der Leun
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引用次数: 0

摘要

通过测量每日暴露于紫外线照射下的无毛小鼠表皮的光透射率,研究了紫外线诱导的表皮增生。研究了Philips TUV 40W和Philips TL01 40W两种不同辐射源的辐射效应,前者主要发射254 nm的辐射,而前者发射312 nm左右的窄带辐射。两种灯都使用了许多组动物,每组动物每天接受不同的剂量。在两种灯的实验中,增生似乎完全由累积剂量决定,而与给予的日剂量无关。这意味着日剂量与第一次照射后所经过的时间之间存在相互关系。此外,传播率随时间和日剂量的变化表现出非常典型的行为。一个简单的数学模型被用来描述这些变化。在之前的研究中,我们使用这个模型来描述西屋FS40太阳灯的类似实验结果。本实验和以往实验的综合数据用于计算紫外线诱导增生的作用谱的第一个近似。此外,我们计算了3种辐照源对紫外线诱导的抗紫外线耐受性增加的剂量-反应关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Change in epidermal transmission due to UV-induced hyperplasia in hairless mice: a first approximation of the action spectrum.

UV-induced epidermal hyperplasia was investigated by measuring the optical transmission of the epidermis of hairless mice exposed daily to ultraviolet radiation. The effects of 2 different radiation sources were investigated: Philips TUV 40W, emitting mainly 254 nm radiation, and Philips TL01 40W, emitting radiation in a narrow band around 312 nm. With both lamps a number of groups of animals were used, each receiving a different daily dose. In the experiments with both types of lamps, hyperplasia appeared to be fully determined by the accumulated dose, irrespective of the daily dose administered. This implies reciprocity between the daily dose and the time elapsed since the first exposure. Moreover, the change of transmission with time and daily dose showed very characteristic behaviour. A simple mathematical model was used to describe these changes. In a previous study we used this model to describe the results of a similar experiment with Westinghouse FS40 sunlamps. The combined data from the present and the previous experiments were used to calculate a first approximation of the action spectrum for UV-induced hyperplasia. In addition, we calculated the dose-response relationship for UV-induced increase in tolerance against ultraviolet radiation for the 3 irradiation sources.

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