Wavelength dependence for DNA synthesis inhibition in hairless mouse epidermis.

Photo-dermatology Pub Date : 1988-04-01
K Kaidbey
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Abstract

Exposure of mammalian skin to ultraviolet radiation (UVR) results in a transient inhibition of scheduled DNA synthesis. The wavelength dependence for this response was investigated in the epidermis of albino hairless mice. Groups of animals were exposed to narrow wavebands of UVR (HPBW 6.6 nm) from a monochromator in the 260-335 nm range. A dose-dependent inhibition of DNA synthesis was observed following exposure to all test wavebands except that centered at 335 nm. An action spectrum constructed from dose-response regression lines showed peak effectiveness at 290 nm. This spectrum bears a close resemblance to published action spectra for the induction of pyrimidine dimers in vivo, suggesting that DNA is the primary chromophore for both events. The DNA synthesis inhibition spectrum bears little resemblance to a published therapeutic action spectrum for the clearing of psoriasis.

无毛小鼠表皮DNA合成抑制的波长依赖性。
哺乳动物皮肤暴露于紫外线辐射(UVR)会导致预定DNA合成的短暂抑制。在白化病无毛小鼠表皮中研究了这种反应的波长依赖性。各组动物暴露于260-335 nm范围内单色器的窄波段UVR (HPBW 6.6 nm)。暴露于除335 nm外的所有测试波段后,观察到DNA合成的剂量依赖性抑制。由剂量-反应回归线构建的作用谱在290 nm处达到有效峰。该光谱与已发表的在体内诱导嘧啶二聚体的作用光谱非常相似,表明DNA是这两个事件的主要发色团。DNA合成抑制谱与已发表的银屑病清除治疗作用谱几乎没有相似之处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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