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Quantification of urocanic acid isomers in murine skin during development and after irradiation with UVB light. UVB光照射后小鼠皮肤中尿酸异构体的定量测定。
Photo-dermatology Pub Date : 1988-08-01
M Norval, C R McIntyre, T J Simpson, S E Howie, E Bardshiri
{"title":"Quantification of urocanic acid isomers in murine skin during development and after irradiation with UVB light.","authors":"M Norval,&nbsp;C R McIntyre,&nbsp;T J Simpson,&nbsp;S E Howie,&nbsp;E Bardshiri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Urocanic acid has been postulated as the photoreceptor mediator of immunosuppression induced by ultraviolet-B (UVB) irradiation. We have shown previously that transplanted epidermal cells from neonatal mice, irradiated mice or mice skin painted with cis-urocanic acid suppress the immune responses to herpes simplex virus. Dorsal skin from foetal mice at 3 weeks gestation and from neonatal mice within 1 day of birth were assayed for the presence of cis- and trans-urocanic acid and compared with the amounts in the ears of 2, 4, 6 and 8-week old mice. Foetal mice had a low skin urocanic acid content (11.9 ng/mg wet weight), neonatal mice 227 ng/mg, while the other ages had at least 340 ng/mg. Neonatal mice were found to have 11.4% urocanic acid as the cis-isomer, whereas foetal mice had undetectable amounts and all remaining ages had about 4%. Irradiation of 7-week-old mice with 96 mJ/cm2 UVB light resulted in the presence within the ears of 31.1% urocanic acid as the cis-isomer. This level was maintained for at least 16 h, then declined slowly until, after 7 days, 16.2% was in the cis-form. Nonirradiated ears contained 4.7% cis-isomer. It is known that UVB irradiation of mice suppresses the delayed type hypersensitivity response to HSV. The suppression was found to be dependent on the time interval between irradiation and infection with virus; this had to be longer than 5 h and less than 14 days.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13990134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry. 单剂量UVA、UVB和UVC对激光多普勒血流法、光热红外光谱法和蒸发法测量的皮肤血流量、含水量和屏障功能的影响。
Photo-dermatology Pub Date : 1988-08-01
T Frödin, L Molin, M Skogh
{"title":"Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry.","authors":"T Frödin,&nbsp;L Molin,&nbsp;M Skogh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of single doses of ultraviolet (UV) radiation was studied in 6 healthy men of skin Type III. Test areas on the forearm were irradiated with 150 J/cm2 UVA, 0.5 MED, 1 MED, and 3 MED UVB, and 1 MED UVC. Test areas and control areas were followed up for 1 month by clinical assessment, laser-Doppler flowmetry, evaporimetry, and optothermal infrared spectrometry (OTIS). UVA produced immediate erythema; the reaction appeared later with the other wavelength regions. All responses peaked after 12-24 h. The degree of erythema of UV-induced inflammation assessed visually correlated closely with the increase in skin blood flow registered with the laser-Doppler flowmeter. No increase in transepidermal water loss, indicating damage to the epidermal barrier, could be recorded by evaporimetry except on the area irradiated with 3 MED of UVB, where 4 subjects showed a moderate increase after 2 weeks. Changes in water content in the uppermost part of the epidermis, mainly in the stratum corneum, were detected by OTIS. A decrease took place that was most pronounced in the area irradiated with 3 MED UVB. This decrease in the OTIS signal is probably due to a combination of increased thickness and decreased water content of stratum corneum. We believe that these 3 noninvasive methods, especially in combination, are useful in the evaluation of different aspects of UV reactions.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14200678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contact and photocontact allergy to glyceryl para-aminobenzoate. 接触性和光接触性对对氨基苯甲酸甘油过敏。
Photo-dermatology Pub Date : 1988-08-01
M Bruze, B Gruvberger, P Thune
{"title":"Contact and photocontact allergy to glyceryl para-aminobenzoate.","authors":"M Bruze,&nbsp;B Gruvberger,&nbsp;P Thune","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>High-purity glyceryl para-aminobenzoate was produced from a commercial source of the chemical by using a chromatographic technique. Negative test reactions to this purified substance were obtained when it was patch/photopatch-tested on 2 patients with contact and photocontact allergy to a nonpurified batch of glyceryl para-aminobenzoate.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14393647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solar urticaria induced by visible light and inhibited by UVA. 日光性荨麻疹由可见光诱发，UVA抑制。
Photo-dermatology Pub Date : 1988-08-01
V Leenutaphong, R von Kries, E Hölzle, G Plewig
{"title":"Solar urticaria induced by visible light and inhibited by UVA.","authors":"V Leenutaphong,&nbsp;R von Kries,&nbsp;E Hölzle,&nbsp;G Plewig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 17-year-old male with solar urticaria is described. The action spectrum ranged from 400 to 520 nm. Wheals induced by visible light were inhibited by simultaneous or subsequent irradiation of the skin with UVA radiation. UVA irradiation prior to exposure to eliciting wavelengths revealed no inhibitory effect, nor was an inhibitory effect found by pre- or postirradiation of test sites with visible light longer than 530 nm. In vitro activation of the patient's serum by exposure to visible light induced wheal formation at the injection site. The wheal formed by in vitro-activated serum was suppressed only when the serum was exposed to UVA after, but not before irradiation with wavelengths of the action spectrum. This suggests that the inactivation of a photoallergen rather than of its precursor is the mechanism by which UVA exerts an inhibitory effect.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13610794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amiodarone-induced pseudoporphyria. Amiodarone-induced pseudoporphyria。
Photo-dermatology Pub Date : 1988-06-01
A Parodi, M Guarrera, A Rebora
{"title":"Amiodarone-induced pseudoporphyria.","authors":"A Parodi,&nbsp;M Guarrera,&nbsp;A Rebora","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14182882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PUVA therapy for erythropoietic protoporphyria. PUVA治疗红细胞生成性原生卟啉症。
Photo-dermatology Pub Date : 1988-06-01
A M Ros
{"title":"PUVA therapy for erythropoietic protoporphyria.","authors":"A M Ros","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14305537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phototoxic properties of quinine and quinidine: two quinoline methanol isomers. 奎宁和奎尼丁的光毒性:两种喹啉甲醇异构体。
Photo-dermatology Pub Date : 1988-06-01
B Ljunggren, L E Wirestrand
{"title":"Phototoxic properties of quinine and quinidine: two quinoline methanol isomers.","authors":"B Ljunggren,&nbsp;L E Wirestrand","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical photoreactions have been reported for quinine and quinidine after systemic and topical administration. We have investigated the phototoxic properties of these two quinoline methanol isomers in vitro using the Candida albicans inhibition test and photohemolysis, and in vivo with the mouse tail phototoxicity test. Both isomers were phototoxic in the hemolysis model, quinine being the more potent compound. In the Candida test only quinidine was phototoxically active. In the mouse tail model, measuring edema, the phototoxic activity of quinidine was comparatively low, causing a 7.3% wet weight increase of tail tissue at a dose of 150 mg/kg intraperitoneally of drug and 54 J/cm2 of UVA. In spite of its structural similarity to quinidine, quinine was not phototoxic in the mouse. These studies support the assumption, based on clinical data, that quinine photoreactions probably have a non-phototoxic mechanism. For quinidine, however, light-induced reactions based on phototoxicity can not be ruled out, since low-grade phototoxic properties were demonstrated in vivo.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14182881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affective disorders, light and melatonin. 情感性障碍，光线和褪黑素。
Photo-dermatology Pub Date : 1988-06-01
E Souêtre, N E Rosenthal, J P Ortonne
{"title":"Affective disorders, light and melatonin.","authors":"E Souêtre,&nbsp;N E Rosenthal,&nbsp;J P Ortonne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14303730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action spectrum for UV erythema and reproduction of the skin lesions in hydroa vacciniforme. 紫外光红斑的作用谱和痘痘水螅皮肤损伤的再生。
Photo-dermatology Pub Date : 1988-06-01
A Sunohara, N Mizuno, M Sakai, Y Kawabe, S Sakakibara
{"title":"Action spectrum for UV erythema and reproduction of the skin lesions in hydroa vacciniforme.","authors":"A Sunohara,&nbsp;N Mizuno,&nbsp;M Sakai,&nbsp;Y Kawabe,&nbsp;S Sakakibara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Action spectra for UV erythema and reproduction of the skin lesions in 4 patients with hydroa vacciniforme (HV) were studied. Vesicles were successfully reproduced by repeated daily monochromatic irradiations of 330, 340, 350 and 360 nm for 5, 6 or 7 days. The daily doses were equivalent to global solar radiation for 70-190 min. The vesicles produced were identical to those of HV, macroscopically and histologically. Repeated daily exposures to a small dose of UVA produced vesicles, whereas a large but single exposure to UVA failed to do so. Daily exposures to UVB failed to produce the vesicles. The minimal erythema dose (MED) was lower than the minimum limits of the normal persons in the 290-310 nm range.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14305536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of chronic sun exposure on human Langerhans cell densities. 长期日晒对人体朗格汉斯细胞密度的影响。
Photo-dermatology Pub Date : 1988-06-01
J M Czernielewski, I Masouye, A Pisani, J Ferracin, D Auvolat, J P Ortonne
{"title":"Effect of chronic sun exposure on human Langerhans cell densities.","authors":"J M Czernielewski,&nbsp;I Masouye,&nbsp;A Pisani,&nbsp;J Ferracin,&nbsp;D Auvolat,&nbsp;J P Ortonne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study evaluated the Langerhans cell density in chronically sun-exposed skin (hand) and non-exposed skin (buttock) in subjects that were divided into 4 age groups (20-40; 41-60; 61-80; greater than 81 years). Two markers (OKT-6 and anti-HLA-DR) were used to identify the Langerhans cells (LC), and their count was performed either on epidermal sheets (52 individuals) or skin sections (43 individuals). Three major findings result from this study: 1) there are more LC in the non-exposed skin than in the chronically sun-exposed area; 2) there were no age-related changes in LC counts, and 3) LC co-express the T6 and HLA-DR antigens.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14391882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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