Photodermatology最新文献

{"title":"Daylight photodynamic therapy with methylene blue in plane warts: a randomized double‐blind placebo‐controlled study","authors":"G. Fathy, M. Asaad, Haval Mohamad Rasheed","doi":"10.1111/phpp.12291","DOIUrl":"https://doi.org/10.1111/phpp.12291","url":null,"abstract":"Conventional photodynamic therapy is associated with inconveniently long clinic visits and discomfort during therapy. Daylight‐photodynamic therapy (DL‐PDT) is an effective treatment, nearly pain free and more convenient for both the clinics and patients. There are no published studies of methylene blue (MB) as a photosensitizer (PS) used in DL‐PDT.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72951726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does imiquimod pretreatment optimize 308‐nm excimer laser (UVB) therapy in psoriasis patients?","authors":"Joselin D Tacastacas, P. Oyetakin‐White, D. Soler, A. Young, S. Groft, K. Honda, K. Cooper, T. McCormick","doi":"10.1111/phpp.12299","DOIUrl":"https://doi.org/10.1111/phpp.12299","url":null,"abstract":"Psoriasis continues to be a debilitating skin disease affecting 1–3% of the United States population. Although the effectiveness of several current biologic therapies have described this pathology as a IL‐23, TNF‐a and Th17‐mediated disease, less invasive approaches are still in use and in need of refinement. One of these is the usage of narrow band‐UVB (NB‐UVB) therapy to deplete specifically intra‐epidermal CD3+, CD4+ and CD8+ cells to clear psoriatic plaques.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87619828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodermatology and Photomedicine: Meeting Calendar","authors":"","doi":"10.1111/phpp.12323","DOIUrl":"https://doi.org/10.1111/phpp.12323","url":null,"abstract":"","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85309644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review","authors":"Neha Kumar, C. Warren","doi":"10.1111/phpp.12296","DOIUrl":"https://doi.org/10.1111/phpp.12296","url":null,"abstract":"Photodynamic therapy (PDT), using topical aminolevulinic acid (ALA), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and in situ squamous cell carcinoma. While there is a wide range of neoplastic and non‐neoplastic skin diseases for which ALA‐PDT is used in adults, there is a knowledge gap when it comes to its use in children. This review highlights what is currently known regarding the use and efficacy of this therapy in the pediatric population. A PubMed search was conducted to identify studies including pediatric patients undergoing monotherapy PDT with topical aminolevulinate (published 2005–2016). Twenty pediatric articles were identified. ALA‐PDT has been used successfully in children to reduce the number and size of basal cell tumors, inflammatory acne lesions, plantar warts, and linear porokeratoses. ALA‐PDT may be an attractive alternative to surgery for children with basal cell nevus syndrome, or to conventional destructive and/or topical methods used for plantar warts or linear porokeratoses. PDT can be considered for inflammatory acne when topical treatments have failed and systemic medications are not an option. Pain associated with treatment and insurance coverage may be a barrier to use.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80255093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodermatology and Photomedicine: Meeting Calendar","authors":"","doi":"10.1111/phpp.12307","DOIUrl":"https://doi.org/10.1111/phpp.12307","url":null,"abstract":"","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"55 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79589235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predicting pain and effect of oral analgesia in topical photodynamic therapy","authors":"R. Hambly, N. Mansoor, C. Quinlan, Z. Shah, P. Lenane, N. Ralph, F. Moloney","doi":"10.1111/phpp.12301","DOIUrl":"https://doi.org/10.1111/phpp.12301","url":null,"abstract":"To The Editor, Topical photodynamic therapy (PDT) is highly efficacious for the treatment of actinic keratosis (AK), Bowen’s disease (BD) and superficial basal cell carcinoma (sBCC), and efficacious in thin nodular BCCs (nBCC) (1). It is generally well tolerated, with pain or discomfort being a known side effect (1). Pain is typically described as a burning or stinging sensation of varying intensity. Prior studies looking at factors which influence pain during PDT have shown conflicting results (2–5). The aim of our study was to identify any patient or treatment factors associated with higher levels of pain during PDT and to assess the effect of pretreatment analgesia. Treatment is standardised in our centre and documented in a standard treatment proforma. Patients receive one treatment per course for AK and two treatments per course, one week apart, for BD and BCC. Methyl aminolevulinate (MAL–Metvix Photocure ASA, Oslo, Norway) is used as a photosensitising agent. Wood’s lamp fluorescence (WLF) is used to assess absorption of the photosensitiser (excellent/good/poor). The Aktilite (Photocure ASA) (LED red light, 630 nm, 37J/cm) or Waldmann 1200L (Waldmann Medizintechnik, Villingen-Schwenningen, Germany) (filtered halogen lamp, non-coherent red light, 570–730 nm, 50J/cm) light-source is used. Patients complete a visual analogue pain scale (VAPS) to grade their pain during and after treatment. The highest pain score experienced during treatment is documented (range 0–100). Patients who are unable to complete a VAPS, for example, due to eyesight difficulty, are asked to grade their pain on a similar scale. Patients are offered oral analgesia 30 min pretreatment, and type of analgesia taken is documented. A fan and cooling water spray are provided during treatment. Following ethics approval, retrospective chart review was completed. Data were compiled in Microsoft Excel and analysed using SPSS (IBM SPSS Statistics for Macintosh, Version 22.0. Armonk, NY: IBM Corp.). All AK, BD and BCC treated between 2009 and mid-2015 were included in analysis. Complete data sets were available on all patients. Pearson’s chi-square, independent samples t-test and one-way ANOVA were used to obtain Pvalues, unless otherwise stated. Odds ratio (OR) and 95% confidence intervals (CI) were calculated using binary logistic regression. For the purpose of binary logistic regression, a dichotomous pain response was defined by dividing the VAPS into two groups at the median 40 (1–40 and 41–100). In total, 200 cases of AK, BD and BCC, in 109 patients were analysed. The average age was 74.6 years (Standard Deviation [SD] 9.55 range 33–96). The femaleto male-percentage split was 61 : 39. Sixty nine per cent of lesions were located on the limbs, 17% on the trunk and 14% on the head/neck. Fifty four per cent of lesions were BD, 24% BCC and 22% AK.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88347858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar urticaria with a wide action spectrum from UVB to visible light complicated with UVA‐induced polymorphous light eruption","authors":"I. Kishimoto, N. Uetsu, H. Tanimura, H. Fujii, H. Okamoto","doi":"10.1111/phpp.12300","DOIUrl":"https://doi.org/10.1111/phpp.12300","url":null,"abstract":"To the Editor, Solar urticaria and polymorphous light eruption (PLE) are acquired idiopathic photosensitivity disorders, but each phenomenon is extremely different; one is an immediate reaction, and one is a delayed-type reaction. Phototesting is necessary not only for the diagnosis of these photosensitivity disorders but also for the determination of the action spectrum so that the patient can try to avoid the triggering wavelengths in ordinary life. Solar urticaria is unique in that the particular spectra that inhibit or enhance the reactions by action spectra are present in some cases. In contrast, with PLE, phototesting is difficult, because a single or even repeated exposure of ultraviolet light or visible light sometimes fails to provoke the reaction. Here, we report a case of solar urticaria complicated with PLE. Solar urticaria with an action spectrum ranging from UVB to visible light was diagnosed by clinical presentation, phototesting and intradermal injections of photo-irradiated autologous serum. PLE induced by UVA was diagnosed by clinical presentation and phototesting. A 60-year-old man experienced erythematous skin eruptions on sun-exposed areas immediately after exposure to sunlight while riding a bicycle. The eruptions disappeared within 1 hour. The next day, he went fishing in the sun and experienced pruritic erythema and swelling on the face and dorsal surface of the hands. The swelling improved within a few hours, but erythema persisted until the following day. He is otherwise healthy and takes no medications. There were no abnormal laboratory findings, including antinuclear antibody and porphyria profiles. Photoprovocation tests were performed with a sunlamp (Philips Ultra Violet-B TL 20W12, Eindhoven, The Netherland) for UVB, a black light (Torex FL 20S, BL-BMR, Tokyo, Japan) for UVA and a slide projector (160W; Cabin Kogyo Co, Tokyo, Japan) for visible light. A single exposure to 3.0 J/cm of UVA (Fig. 1a), 8.7 mJ/cm of UVB (Fig. 1b) or visible light (Fig. 1c) at the target distance of 15 cm for 15 min induced erythema or wheal immediately after exposure. Erythema was observed in a visible light-irradiated area with a Y-50 cut-off filter (Fig. 1d), but not with a Y51 filter (Fig. 1e), indicating that the action spectrum in the visible light wavelengths was shorter than 500 nm. Skin reactions provoked by UVB and visible light faded within 45 min, but those provoked by UVA persisted for 30 h (Fig. 2a–c). Histological examination of the skin reaction 30 h after UVA irradiation revealed spongiosis and dense perivascular mononuclear cell infiltrations (Fig. 2d), compatible to polymorphous light eruption. Inhibitory and augmentation spectra were not observed. Next, the serum of the patient was examined for the presence of chromophore to induce urticaria. An aliquot of serum was exposed in vitro to 1.5 J/cm of UVA, 104 mJ/cm of UVB or 5 min of visible light alone or with an R60 cut-off filter; 0.1 ml of the exposed and","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79258517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of demographic and clinical characteristics of actinic keratosis patients on illness perceptions and readiness to increase sun protection behaviours: an exploratory study","authors":"S. Akarsu, Ozlem Ozbagcivan, T. Ilknur, Fatma Semiz, E. Fetil","doi":"10.1111/phpp.12295","DOIUrl":"https://doi.org/10.1111/phpp.12295","url":null,"abstract":"There are no data comprehensively investigating the key beliefs and sun protection behaviours in patients with actinic keratosis (AK). Our aim was to determine and correlate the AK perceptions and readiness to increase sun protection (RISP) behaviours.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Polypodium leucotomos extract against UVB‐induced damage in a model of reconstructed human epidermis","authors":"P. Torricelli, M. Fini, P. Fanti, E. Dika, M. Milani","doi":"10.1111/phpp.12297","DOIUrl":"https://doi.org/10.1111/phpp.12297","url":null,"abstract":"Polypodium leucotomos (PL) exerts potent antioxidant, photo‐protective, and immune‐modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV‐induced cell damage. No data regarding the photo‐protective action of PL in this model are available.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74073092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of DNA damage in human skin by topical sunscreens","authors":"C. Olsen, L. Wilson, A. Green, N. Biswas, J. Loyalka, D. Whiteman","doi":"10.1111/phpp.12298","DOIUrl":"https://doi.org/10.1111/phpp.12298","url":null,"abstract":"There is strong evidence that topical sunscreens, designed to protect against ultraviolet radiation (UVR)‐induced erythema, decrease the amount of UVR to which the skin is exposed, but their effectiveness in reducing UVR‐induced DNA damage in vivo has not been well quantified.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"94 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83339348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}