B. Brauns, S. Schubert, J. Lehmann, P. Laspe, A. Körner, K. Brockmann, M. Schön, S. Emmert
{"title":"Photosensitive form of trichothiodystrophy associated with a novel mutation in the XPD gene","authors":"B. Brauns, S. Schubert, J. Lehmann, P. Laspe, A. Körner, K. Brockmann, M. Schön, S. Emmert","doi":"10.1111/phpp.12225","DOIUrl":"https://doi.org/10.1111/phpp.12225","url":null,"abstract":"Department of Dermatology, Venereology and Allergology, University Medical Center, Georg August University, G€ ottingen, Germany. Clinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany. DWI – Leibniz Institute for Interactive Materials, Aachen, Germany. Interdisciplinary Pediatric Center for Children with Developmental Disabilities and Severe Chronic Disorders, University Medical Center, Georg August University, G€ ottingen, Germany. Lower Saxony Institute of Occupational Dermatology, University Medical Center G€ ottingen and University of Osnabr€ uck, Osnabr€ uck, Germany.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84822386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disseminated granuloma annulare responding to narrowband UVB phototherapy","authors":"A. Yong, W. Chong, J. Pan","doi":"10.1111/phpp.12223","DOIUrl":"https://doi.org/10.1111/phpp.12223","url":null,"abstract":"To the Editor, Granuloma annulare (GA) is a granulomatous inflammatory, self-limited dermatosis of various clinical forms and unknown etiology. Localized GA is the most common manifestation. On the other hand, disseminated GA (DGA) accounts for approximately 2.8–15% of all cases, typically presenting with numerous erythematous papules and plaques on the trunk and extremities, and it usually proves a challenge to therapy. Psoralen-UVA (PUVA) photochemotherapy and UVA1 phototherapy have been shown to be effective for GA; however, data are scant on the efficacy of narrowband UVB (NBUVB) phototherapy on GA (1). We hereby describe two cases of DGA with excellent response to NBUVB phototherapy.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Grinblat, G. Galimberti, E. Chouela, G. Sanclemente, Miguel Lopez, D. Alcalá, L. Torezan, Gonzalo Pantoja
{"title":"Daylight‐mediated photodynamic therapy for actinic damage in Latin America: consensus recommendations","authors":"B. Grinblat, G. Galimberti, E. Chouela, G. Sanclemente, Miguel Lopez, D. Alcalá, L. Torezan, Gonzalo Pantoja","doi":"10.1111/phpp.12221","DOIUrl":"https://doi.org/10.1111/phpp.12221","url":null,"abstract":"Although conventional photodynamic therapy (c‐PDT) using methyl aminolevulinate cream (MAL) is effective for the treatment of grade I‐II facial and scalp actinic keratosis (AK), it is associated with treatment‐related pain for some patients. Daylight‐mediated PDT (DL‐PDT) has shown similar efficacy to c‐PDT, was nearly painless, and was well tolerated. Overall, DL‐PDT effectively treats AK and offers a simpler and better tolerated treatment option than c‐PDT. This consensus panel provided recommendations on the use of DL‐PDT in Latin America (LATAM) for the treatment of actinic damage associated with few or multiple AKs. The panel was comprised of eight dermatologists from different LATAM countries who have experience using PDT for the treatment of actinic damage. The panel reviewed the relevant literature and provided personal expertise with regard to using DL‐PDT for the treatment of photodamage with or without AK. The recommendations formulated by the expert panel provide evidence‐based guidelines on all aspects of DL‐PDT for the treatment of actinic damage associated with AK in different regions of LATAM. These recommendations provide guidance for dermatologists to ensure maintenance of efficacy and safety of DL‐PDT when treating actinic damage, associated with few or multiple AKs in sun‐exposed skin.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76640822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the thin layer of methyl aminolevulinate used during photodynamic therapy sufficient?","authors":"S. R. Wiegell, C. Lerche, H. Wulf","doi":"10.1111/phpp.12227","DOIUrl":"https://doi.org/10.1111/phpp.12227","url":null,"abstract":"If the recommended 1.0 mm layer of methyl aminolevulinate (MAL) is used during photodynamic therapy (PDT) of large areas with multiple actinic keratoses (AK) huge amounts of cream are needed.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81091006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. García-Rodiño, M. Espasandín‐Arias, I. Vázquez-Osorio, M. Rodríguez-Granados
{"title":"Photosensitivity associated with systemic triflusal therapy","authors":"S. García-Rodiño, M. Espasandín‐Arias, I. Vázquez-Osorio, M. Rodríguez-Granados","doi":"10.1111/phpp.12226","DOIUrl":"https://doi.org/10.1111/phpp.12226","url":null,"abstract":"To the Editor, Triflusal (2-acetyloxy-4-trifluoromethylbenzoic acid) is a fluorinated acetylsalicylic acid analogue used as an antiplatelet drug for prophylaxis of thromboembolic disease. Its main side effects are those concerning the gastrointestinal system. We report a systemic photosensitivity and a solar urticaria in a patient under triflusal therapy. A 72-year-old man, with Fitzpatrick skin phototype II and medical history of hypertension undergoing treatment with olmesartan since 2005, was diagnosed with a carotid stenosis in September 2011; therefore, triflusal (300 mg/12 h) was prescribed. Two years later, he was sent to our Photobiology Unit because of outbreaks of eczematous lesions involving the photoexposed areas of his face, neck and hands (Fig. 1a). Those lesions had appeared 1 month after the introduction of triflusal, and persisted despite the use of topical corticosteroids and oral antihistamines. He was taking no other medication. In order to rule out a systemic photosensitivity, phototesting was performed on the skin of his lower back, using a solar simulator to test UVB and UVA (Xenon arc 16S; Solar Light Co., Philadelphia, PA, USA) and a slide projector to test visible light (GAF 502 Autofocus slide projector lamp). The doses we used were from 3.7 to 24.7 mJ/cm for UVB and from 0.5 to 10 J/cm for UVA. An urticarial reaction was observed 15 min after UVB irradiation (>3.7 mJ/cm) (Fig. 1b) and UVA irradiation (>0.5 J/cm) (Fig. 1c), whereas visible light showed a negative response. These lesions were highly pruritic and cleared after 30 min. Moreover, the minimal erythema dose to UVB (UVB-MED) was 10 mJ/cm (normal value 28 4 mJ/cm, pathologic value <19 mJ/cm) (1) and response to UVA was abnormal (erythema after a single dose of 10 J/cm) (Fig. 1d). He was asked to discontinue triflusal, which was replaced by acetylsalicylic acid (ASA), with a subsequent improvement of his lesions. One week after this switch, the patient was almost asymptomatic, the UVB-MUD had risen to 13.5 mJ/cm and there was no urticarial response to UVA (up to 10 J/cm). A new phototest was performed 2 months later, showing a negative response to UVA and a UVB-MED of 24.7 mJ/cm (an increase above 70% of the previous one). Photopatch tests were also performed with the baseline series of the Spanish Group of Photobiology (MartiTor, Barcelona, Spain) being applied in duplicate to the skin of the upper back, extended with triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB, the triflusal active metabolite) and ASA. All of them were prepared by the hospital pharmacy at 1% in petrolatum and were applied in triplicate to the skin of the upper back. After 2 days, one set was removed and irradiated with 5 J/cm UVA, and the set of triflusal, HTB and ASA was also removed and irradiated with a sub-UVB-MED dose (17.3 mJ/cm). Readings were done immediately, at 30 min, 60 min, days 1, 2 and 3 postirradiation. Immediate reading was negative, whereas a palpable erythemato-e","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81635039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Robert Williams Wood: pioneer of invisible light","authors":"Shruti Sharma, Amit Sharma","doi":"10.1111/phpp.12235","DOIUrl":"https://doi.org/10.1111/phpp.12235","url":null,"abstract":"The Wood's lamp aids in the diagnosis of multiple infectious, inflammatory and neoplastic dermatologic conditions. Although the Wood's lamp has many applications, which have improved both the diagnosis and management of disease, the man credited for its invention is relatively unknown in medicine. Robert Williams Wood, a prominent physicist of the early 20th century, is credited for the invention of the Wood's lamp. Wood was the father of infrared and ultraviolet photography and made significant contributions to other areas in optics and spectroscopy. Wood's work encompassed the formative years of American Physics; he published over 200 original papers over his lifetime. A few years after the invention of the Wood's lamp for ultraviolet photography, physicians in Europe adopted the Wood's lamp for dermatologic applications. Wood's lamp remains popular in clinics globally, given its ease of use and ability to improve diagnostic precision.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89591367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caspase‐5 rescues UVB‐dependent IL‐1β activity in ASC‐deficient epidermal keratinocytes","authors":"E. Hattinger, R. Wolf","doi":"10.1111/phpp.12234","DOIUrl":"https://doi.org/10.1111/phpp.12234","url":null,"abstract":"To the Editor, IL-1b is a potent phlogistic mediator induced in inflammatory skin diseases, which is activated by several environmental triggers (1–3). In epidermal keratinocytes, pro-inflammatory IFN-c regulates proteolytic caspases, which are activated by UVB irradiation to cleave IL-1b (4). Apoptosis-associated speck-like protein containing a CARD (ASC) is an adaptor protein, which is required for activation of UVB-dependent IL-1b release by caspase-1 (2, 5). However, an inducible IL-1b production in ASC-deficient mouse keratinocytes indicates that the cells inherit the capacity for ASC-independent IL-1b activation (6). Inflammatory caspase-5 functions independently of ASC to activate IL-1b (7, 8), and we hypothesized that caspase-5 can rescue an UVB-induced IL-1b production in the absence of ASC. In an experimental model for UVB-triggered inflammation, cultured keratinocytes were UVB-irradiated in the presence of IFN-c to induce an IL-1b release into the supernatant as measured by ELISA. Under these conditions, ASC levels remained unaffected [Fig. 1a; (2)] but when ASC was simultaneously suppressed by siRNA interference (Fig. 1b), IL-1b was induced and increasingly released by keratinocytes (Fig. 1c,d). Data indicated an IL-1b-promoting mechanism independent of ASC, and the regulation of IL-1b-converting caspases","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76358908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editor's Picks","authors":"","doi":"10.1111/phpp.12232","DOIUrl":"https://doi.org/10.1111/phpp.12232","url":null,"abstract":"Titanium dioxide and zinc oxide sunscreens have generally been thought to protect by physically blocking and scattering UV radiation. Cole C. et al. measured transmission and reflectance and found that the average range of reflection for titanium dioxide and zinc oxide was only 4–5%, providing minimal protection via this mechanism (see article in this issue on page 5–10: Metal oxide sunscreens protect skin by absorption, not by reflection or scattering). Contrary to popular belief, these sunscreen filters work similar to organic ‘chemical’ soluble filters and absorb UV rays acting as semiconductors with clearly defined band gap energy. They reflect and scatter radiation only in the visible wavelengths at photon energy above this semiconductor band gap energy. This mechanism of protection does not alter the usefulness of these filters, but understanding it will help in the development of more efficient sunscreen products.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77111606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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