Legal regulation in veterinary medicine最新文献

{"title":"Comparative analysis of repellent products for dogs in the conditions of farms of the Ararat valley of Armenia","authors":"B. I. Slobodyanik, S. S. Zykova, A. M. Lunegov, Yu. A. Dubkov","doi":"10.52419/issn2782-6252.2023.3.129","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.129","url":null,"abstract":"The article presents the results of a comparative analysis of the clinical efficacy of repellent agents in various forms in the climatic and natural conditions of the Ararat Valley of the Republic of Armenia, during the period of maximum seasonal and daily activity of blood-sucking diptera insects. In the period from June 14 to June 19, 2023, the repellent effect of the veterinary medicinal product RolfClub 3D (RolfClub 3D), in the form of drops on the withers for dogs, and the repellent collar Francodex against insects was studied. The experiment involved 38 clinically healthy dogs aged 1 to 10 years, of both sexes. During the examination of animals, we did not register any complications in the form of inflammatory processes on the skin and the general condition of the studied animals after the use of the funds. In the recommended doses in dogs, the drug did not cause undesirable side effects, specific toxic effects and effects on the central nervous system. The experiment confirmed the repellent effect of veterinary drugs in the form of drops on the withers of RolfClub 3D and a Francodex insect collar applied to dogs individually, once, during the prevention of bites of diptera flying insects according to the presented doses, rules and application techniques, showed high efficiency of the repellent effect in the conditions of farms of the Ararat Valley for 3 days.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135890064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of rational design of medicinal products for veterinary use","authors":"V. S. Ponamarev","doi":"10.52419/issn2782-6252.2023.3.115","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.115","url":null,"abstract":"One of the ways to significantly influence the success of exploratory studies of new chemical drug candidates is to use the principles of rational drug design, associated both with the development of bioinformation technologies and with the implementation of effective models for predicting the potential biological activity of the substance under study. The main purpose of this article is to review and summarize the main features of the rational design of medicinal products for veterinary use. The search and processing of scientific publications were carried out according to the recommendations of H. Snyder for writing review articles. In English and Russian, thematic publications were searched in bibliographic databases (Elibrary, CyberLeninka, Pubmed, Scopus (Elsevier), Web of Science (Clarivate)) using the keywords: “drug development”, “drag design” , “structurally based drag design” with further highlighting of the most cited ones. Articles published before 2013 were used only if they contained information critical to the topic that was missing in later publications. Rational drug design is the most relevant area of research in the field of drug development. This approach makes it possible to predict in advance the properties of synthesized structures. Using modern computer modeling and data analysis techniques, organic chemists can effectively design molecules with desired pharmacological properties. Rational drug design is an extremely promising area in pharmacological science.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"867 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Selephlan on the morphohistological structure of the liver of the Arbor Acres cross poultry","authors":"M. P. Semenenko, A. A. Abramov, E. P. Dolgov, K. A. Semenenko, E. V. Kuzminova","doi":"10.52419/issn2782-6252.2023.3.154","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.154","url":null,"abstract":"The intensification of growing processes, concentrated feeding and other improvements in technological processes in poultry farms have led to the development of new metabolic pathologies for the industry, previously not widely recorded. The development of these diseases is directly related to excessive stress on the poultry body during intensive rearing. The central organ most susceptible to this type of stress is the liver. Currently, clear signs of hepatopathy are recorded even in poultry farming. As a result, an important offal – the liver – is discarded, the poultry lags behind in growth and development, and the quality of the meat decreases. Therefore, the development of hepatoprotective veterinary drugs for poultry farming is an urgent task. To determine the effectiveness of the new hepatoprotective drug Selephlan in the vivarium conditions of the Federal State Budgetary Scientific Institution “Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine”, an experiment was conducted on two groups of broiler chickens (experimental and control) of the Arbor Acres cross (n=100). The studied drug was given to the experimental group during the growth and finishing periods of rearing (15–40 days) at a dose of 1.0% per unit of feed. The poultry of the control group received complete feed (CF) without additives. In order to determine the state of the hepatobiliary system of poultyr in the end of the experimental period, intravital screening monitoring of the liver condition using ultrasound diagnostics was carried out in the experimental and control groups, followed by slaughter to clarify the identified changes in the liver parenchyma tissue. Based on ultrasound diagnostics and histological studies, it was determined that the drug Selephlan under conditions of intensive fattening allows maintaining the healthy structure and functional activity of the liver of broiler chickens at a physiologically normal level throughout the entire productive period of rearing, which has a beneficial effect on the growth characteristics of meat poultry and the quality of the resulting livestock products.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of anamnestic data and their significance in predicting the course of glaucoma in dogs","authors":"M. A. Kuvshinova, A. V. Goncharova, S. V. Saroyan","doi":"10.52419/issn2782-6252.2023.3.99","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.99","url":null,"abstract":"Glaucoma is a dangerous disease for all animal species, as it is accompanied by intractable pain and progressive loss of vision. It is widely known that the classification of the disease is based on the state of the angle of the anterior chamber of the eye (open-angle and closed-angle), as well as on concomitant factors, such as the condition of the iris, lens. Due to the high incidence of glaucoma in animals, especially in dogs, the scientific article discusses the risk factors for the occurrence and development of glaucoma, as well as the analysis of anamnestic data was also performed. The objects of the study were dogs in the amount of 23 animals of different breeds and sex and age groups. The study was conducted at the Department of Veterinary Surgery of the Federal State Budgetary Educational Academy of Higher Education MSAVM&B - MVA named after K.I. Scriabin, as well as the VC «CUVO&M». All animals underwent an ophthalmological examination using a head magnifying glass and a slit lamp, measurement of intraocular pressure and gonioscopy. A diagnosis of glaucoma was made. Particular attention was paid to the iridocorneal angle, the state of the trabecular meshwork, the position of the iris, the presence of fibrinous or hemorrhagic exudate in the anterior chamber, and the localization of the lens were assessed. To achieve the goal of the study, the severity of the manifestation of the disease and its course were established. When analyzing the data of the anamnesis, it was revealed that dogs of the French bulldog and mestizo breeds were most often ill with glaucoma. The age of the animals most susceptible to this disease was 5-10 years. Based on the data of a comprehensive examination, the type of glaucoma that most often occurred in dogs was established: angle-closure secondary. The risk factors for glaucoma were goniodysgenesis, lens luxation, trauma, arterial hypertension, swelling cataract, fibrinous iridocyclitis, postoperative complication. Patterns were revealed between the form of the disease and the risk factors noted in each clinical case, which makes it possible to predict the course of the disease and the preservation of vision. The analysis of the history data made it possible to establish the most important prognostic factors for the onset of glaucoma in dogs and to determine a number of criteria for identifying the primary goals of the therapeutic approach to glaucoma.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hygiene of keeping calves","authors":"A. E. Belopolsky","doi":"10.52419/issn2782-6252.2023.3.137","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.137","url":null,"abstract":"In the first days of life of calves, the influence of numerous environmental factors most strongly affects the full flow of physiologically important processes. Fluctuations in the parameters of the microclimate in calves leads to a decrease in natural resistance, an increase in the level of colds and intestinal diseases in calves of the prophylactic period. Taking into account the natural and climatic territories and technologies used in farms, it is necessary to develop effective measures to control microclimate parameters in order to prevent diseases of calves of various etiologies. The most critical period in calves is the first few weeks of their life, which is associated with the transition from sterile intrauterine development to contact with environmental factors. Possessing complete information about the requirements of the calf's body to the external environment and for their further successful rearing, it is very important to comply with the normative parameters of the indoor microclimate for this type of animal.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of some detoxification properties of a sorbent based on silicon dioxide","authors":"K. F. Zenkov, N. V. Kuznetsova","doi":"10.52419/issn2782-6252.2023.3.112","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.112","url":null,"abstract":"Veterinary sorption preparations are medicinal substances and substances that absorb gases, solid and liquid substances on their surface by adsorption. The purpose of our research was to study the detoxification properties of a sorbent based on silicon dioxide (ADC) obtained from rice processing industry waste during heavy metal poisoning in rats. Mercury dichloride was used for experimental poisoning with heavy metals. Nonlinear rats from the nursery of the RAMS \"Rappolovo\" were used for the experiment. The live weight of the animals averaged 120 g. 3 groups of animals with 20 rats in each were formed. Group No. 1 received the basic diet, ADC and mercury dichloride, group No. 2 – the basic diet and mercury dichloride in the amount of 25 mg per head. Group No. 3 is a control group, which was fed only the basic diet. The experience lasted 14 days. The results were evaluated by the live weight of animals, clinical blood examination, leukogram examination, pathoanatomic autopsy and massometry of internal organs of rats. In study group No. 1, there was no decrease in the body weight of rats during the 14 days of the experiment, while in study group No. 2, where the sorbent was not used, the body weight of rats decreased by 13.79 g. At the end of the experiment, a pathoanatomical autopsy of the animals was performed. In group No. 1, hemorrhages were observed in the mucous membrane of the stomach and intestines. In group No. 2, hemorrhages in the gastric mucosa, damage to the intestines, gallbladder and kidneys were noted, where serous infiltration of connective tissue, large spotty hemorrhages in the serous and mucous membranes were observed. There were no changes in the stomach, intestines, and kidneys in group No. 3. Based on the data obtained, it can be concluded that there are detoxifying properties of a veterinary sorption preparation based on silicon dioxide obtained from rice husks.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135890061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Nefopam in multimodal analgesia in dogs","authors":"V. V. Payterova, N. V. Kuznetsova, K. F. Zenkov","doi":"10.52419/issn2782-6252.2023.3.118","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.118","url":null,"abstract":"Pain that occurs in a surgical patient in the area of surgical intervention is called surgical pain. Postoperative analgesia is one of the most important components in the system of general intensive care, which creates comfortable living conditions for the surgical patient. In veterinary practice, the central non-opioid analgesic Nefopam has become available, which has a structural affinity for diphenhydramine (Diphenhydramine) and orphenadrine and has both spinal and supraspinal mechanisms of action. The aim of the study is to evaluate the efficacy and safety of Nefopam as part of multimodal analgesia in the postoperative period in dogs. For the study were selected 20 dogs aged 1 to 10 years who underwent radical surgery requiring multicomponent anesthesia. The animals were divided into 2 groups of 10 dogs each. Surgical interventions were performed under conditions of general combined anesthesia according to standard protocols of the clinic using neuroleptics, anesthetics, non-narcotic painkillers. In the postoperative period, a non-opioid centrally acting analgesic, Nefopam, was introduced into the scheme of multimodal analgesia in the animals of the experimental group, and Analgin was administered to the dogs of the control group. The level of pain of the visual analog scale for assessing pain according to VAS. To assess the health status of experimental animals before surgery and on the 3rd and 7th days after it, blood was taken for biochemical and clinical studies. The use of Nefopam in the complex of multimodal analgesia used in the clinic is therapeutically justified and effective. It is this kind of analgesia that makes it possible to fully and safely anesthetize patients after extensive and traumatic operations with minimal consumption of non-opioid and opioid analgesics.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rodents: their impact on human economic activity and health","authors":"V. Yu. Komarov, G. S. Nikitin","doi":"10.52419/issn2782-6252.2023.3.139","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.139","url":null,"abstract":"The purpose of this review was to analyze the impact of rodents on human economic activity and human health, the dangers and harm they pose. The article provides brief information about the migration of rodents and their impact on crop yields and possible crop losses. The harmful effects of these small mammals on the livestock, poultry and beekeeping industries are described. The issue of transmission and reservation of diseases by rodents that pose a danger to humans and their domestic animals is considered. The influence of factors on the distribution and dynamics of rodent populations, and the use of modern methods for monitoring the population of areas of the territory are analyzed. Thus, the use of unmanned aerial vehicles (UAVs) and image processing software makes it possible to detect and analyze clusters of rodent burrows, as well as control more targeted processing. When using rodenticides to control rodents, people still face certain questions and problems in regulating populations and effectively using rodenticides, taking into account the negative impact on the environment.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy of the European Moose heart","authors":"V. A. Khvatov, D. S. Bylinskaya","doi":"10.52419/issn2782-6252.2023.3.158","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.158","url":null,"abstract":"The European elk is an artiodactyl mammal and is a valuable commercial animal. These animals are valued in the leather industry and in commercial hunting for meat. In addition, moose are often kept in nature reserves and zoos and often in private fur farms. At the same time, there is practically no material on the anatomy of the European elk, compared with the same representative of the reindeer family – the reindeer. In this regard, the purpose of our study is to study the structural features of the anatomy of the heart of the European moose and to determine its main sources of vascularization. The material for the study was five corpses of European moose aged three to four years, obtained from private farms in the Leningrad region. The study was carried out by morphometry and fine anatomical dissection, as well as the manufacture of corrosive preparations using latex. Morphometric parameters were measured using a vernier caliper of the brand \"Vorel 15100\" made in Poland, as well as a ruler with a length of 25 cm. Processing of the obtained results was carried out in the \"Excel\" program. According to the results of the study, it was found that the heart of the European moose has a leftventricular type of blood supply, and the area of the subsinuous sulcus in the individuals studied by us is occupied by branches of the left coronary artery. Also, during the study, the main anatomical, topographic and morphometric features of the structure of the external and internal structures of the heart of the European moose were determined.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of probiotic supplements \"Hydrolaktiv\" and \"Multibacterin\" as part of the treatment and prevention regimens of gastrointestinal diseases of calves on the level of protein metabolism","authors":"O. A. Rishko, A. V. Prusakov, A. V. Yashin","doi":"10.52419/issn2782-6252.2023.3.70","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.70","url":null,"abstract":"The aim of the study was to establish the effect of probiotic supplements \"HydroLaktiV\" and \"Multibacterin\" as part of the treatment and prevention regimens of gastrointestinal diseases of calves on the level of protein metabolism. The study was conducted on newborn calves, of which three groups were formed according to the principle of analogues: one control (group 1) and two experimental (group 2 and group 3). Animals of all groups were kept in identical conditions. From the fourth day of life until the age of sixty, calves of all groups, according to the scheme adopted in the experimental farm, were fed kefir prepared with the use of the enzymatic feed additive \"GastroVet\", from the age of ten the animals began to be accustomed to coarse feeds by laying out first-class hay and starter feed (KK-62) in feeders. Additionally, the calves of the second experimental group were added to kefir with a feed additive \"HydroLaktiV\" at a dose of 15.0 g per head twice a day, and the calves of the third experimental group received the biocomplex \"Multibacterin\" at a dose of 1.0 ml per 10.0 kg of body weight twice a day. Blood collection from the studied animals was carried out from the jugular vein 30 minutes before feeding in compliance with the rules of asepsis and antiseptics. Blood serum was used for biochemical studies. The latter were performed on a Clima MC-15 semi-automatic analyzer, taking into account the following indicators: total protein, albumin, α-, β- and γglobulins. It has been established that the use of probiotic feed additives \"HydroLaktiV\" and \"Multibacterin\" as part of the treatment and prevention regimens of gastrointestinal diseases of calves has a positive effect on the normalization of protein metabolism, manifested in the maintenance of homeostasis, restoration of humoral immunity of animals after illness, as well as normalization of digestion and metabolic processes.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}