Legal regulation in veterinary medicine最新文献

{"title":"Legislative changes in the State Pharmacopoeia of the Russian Federation in the last two editions (XIV and XV editions)","authors":"O. S. Popova","doi":"10.52419/issn2782-6252.2023.3","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3","url":null,"abstract":"A pharmacopoeia is a country's regulatory requirement that sets standards and mandatory requirements for the quality of drugs, starting materials used for drug development, and various pharmaceutical formulations or preparations. The requirements and recommendations set out in it are mandatory for all organizations in the country involved in the production, storage, sale and use of medicines. For violation of the rules recorded in the document, a legal entity or individual faces criminal liability. The article provides a brief analysis of the Russian Federation State Fund over the past 5 years. The State Pharmacopoeia of the Russian Federation XIV and XV editions, as well as the general pharmacopoeial monographs and pharmacopoeial monographs included in them, were analyzed. Taking into account the fact of harmonization of pharmacopoeias, the international pharmacopoeia was also analyzed. Of the 313 General Pharmacopoeial Articles (GPM) that are included in the State Pharmacopoeia of the XV edition, 102 GPM are being introduced into domestic pharmacopoeial practice for the first time. Of the 564 pharmacopoeial monographs (PS), which are approved as part of the main part of the State Pharmacopoeia of the XV edition, 253 PH are being introduced into domestic pharmacopoeial practice for the first time. The pharmaceutical substances included in the XV edition of the State Pharmacopoeia of the Russian Federation mainly establish requirements for the quality of pharmaceutical substances of chemical, synthetic and mineral origin. Pharmacopoeias make it possible to optimize the interaction between manufacturers and regulatory authorities: to facilitate the preparation and assessment of submitted documents and to increase the uniformity of decisions made during regulation. This can save time and resources for manufacturers and regulators.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"2018 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135890056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reasons for the disqualification of horses from equestrian distance running competitions, depending on the length of the distance","authors":"V. A. Guseva, M. A. Ladanova","doi":"10.52419/issn2782-6252.2023.3.94","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.94","url":null,"abstract":"Equestrian distance running is a non-Olympic sport, but it continues to gain popularity in Russia. The rules for conducting competitions and allowing animals to start are strictly regulated by the Equestrian Federation of Russia (FKSR) and the International Federation (FEI). However, veterinary aspects are taken into account very superficially in the regulations, which requires the introduction of in-depth scientific knowledge about injury prevention, diagnosis and treatment of horses participating in endurance competitions. The article provides information about the reasons for the disqualification of horses that participate in endurance competitions. In total, 120 animals were examined at major competitions in Russia and the Netherlands. The result of the conducted research has shown that most often horses are disqualified due to lameness and the symptom complex of colic, and in isolated cases, at long distances from 120 km, myoglobinuria is detected in horses, which is a very dangerous condition for the life and health of animals. Myoglobinuria in our studies was detected mainly in the hot season. There are also literature data that indicate that the results of equestrian distance running competitions are influenced by climate, weather conditions, and soil quality. At competitions, depending on the level of training and qualification, horses run distances from 40 to 160 km in 1 day. It is obvious that the body of animals is subjected to huge loads and in preparation for each distance it is necessary to develop the most optimal approaches in training, feeding and rehabilitation. It is known that when passing a distance of 160 km, horses, as a rule, lose weight. In this regard, it was decided to identify the most common reasons for the disqualification of horses from competitions, depending on the distance covered.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of terrestrial gastropods food products","authors":"A. S. Khishov, S. P. Yatsentyuk, O. E. Ivanova","doi":"10.52419/issn2782-6252.2023.3.151","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.151","url":null,"abstract":"The development of the terrestrial gastropods rearing, including the grape snail, in Russian Federation for the purpose of producing food products, and possibly exporting these products to traditionally consuming the molluscs in the European region, presuppose the appropriate regulatory framework development, incl. regulating the obtained food products safety. In order to provide a scientific justification for the introduced regulations, scientific information was collected on the food risks in terrestrial gastropods, which are traditionally consumed by humans. The specificity of this terrestrial invertebrates group leads to the formation of a safety indicators list that need to be monitored, which is not found in other groups, including those that are unique for the Russian Federation, primarily microbiological and parasitological. On the other hand, some of the risk factors for the consumption of terrestrial gastropods (the content of toxic elements, persistent organic pollutants and foodborne pathogens) are associated with the conditions of their keeping and feeding. According to the results of the study, the most common risk factors were recommended for inclusion in regulations.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring breed diversity and incidence of diseases in the dog population of the shelter ANO “Help to Homeless Dogs”","authors":"P. I. Ukolov, S. N. Anisiforov","doi":"10.52419/issn2782-6252.2023.3.147","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.147","url":null,"abstract":"Large industrial centers and cities are faced with the need to regulate the number of domestic animals, including the reduction of stray dogs. Monitoring the reasons for dogs entering shelters, studying their breed; balance of the most significant diseases as possible sources of replenishment of shelters. The return of lost dogs is an integral part of the task of finding them in a shelter and at the same time it is a complete comprehensive examination and prevention of the spread of diseases in urban areas. Husky dogs are quite difficult to keep in apartments; when deciding to have such a pet, the choice must be objectively responsible. Treatment of the premises of the quarantine zone showed the high effectiveness of the drugs Monclavit-1 and Creolin for the prevention of infectious and parasitic diseases of dogs.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of comprehensive diagnostics of feline uveal melanoma","authors":"V. V. Gulyaeva, A. A. Nikitina, V. A. Trushkin, V. N. Gaponova, P. A. Polistovskaya","doi":"10.52419/issn2782-6252.2023.3.96","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.96","url":null,"abstract":"According to available statistics, melanocytic neoplasia is the most common form of ocular tumor in cats, accounting for 67% of cases in an analysis of 2614 cases of primary ocular neoplasia. Feline diffuse iris melanoma (FDIM) is by far the most common form of melanocytic neoplasia of the eye. The purpose of the study was to conduct a comprehensive diagnosis of eye diseases and identify the features of the course of iris melanoma in cats. Study cats with iris hyperpigmentation underwent a complete ophthalmological examination - slit-lamp biomicroscopy, gonioscopy and indirect ophthalmoscopy. As a result of the research, it was found that 5 animals had hyperpigmented lesions, which look like flat brown spots on the surface of the iris. These precursor lesions are considered benign and are known as iris melanosis. In 10 animals, thickening of the iris, dyscoria, decreased pupil mobility, and dispersion of pigment in the anterior chamber were additionally detected; in 2 of them, involvement of the iridocorneal angle in the pathological process was observed, in 4 - secondary glaucoma, due to tumor infiltration of the iridocorneal angle. According to the results of computed tomography, 3 cats had metastases in the liver. During our studies, one cat underwent an iris biopsy to differentiate melanoma from pleomorphic lymphoma. In the remaining cases, a biopsy was not performed, since 9 patients with obvious pathological changes required enucleation, and in 5 patients monitoring of the pathological process over time was prescribed. Cats presenting for evaluation of hyperpigmented iris lesions should undergo a complete clinical and ophthalmologic examination, including gonioscopy.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"875 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of pulmonary edema of small pets","authors":"E. A. Levenskikh, C. A. Sidorova, O. A. Dragich, M. V. Shchipakin","doi":"10.52419/issn2782-6252.2023.3.83","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.83","url":null,"abstract":"The respiratory system provides the body with oxygen, which is necessary for the vital activity of organs, tissues and cells of the animal. Respiratory diseases are widespread and therefore improving the methods of diagnosis and prevention of lung pathologies is important for veterinary medicine. Pulmonary edema is a life-threatening condition of the animal and requires immediate assistance. There are various types and causes of edema, however, knowing the symptoms, it is possible to carry out the necessary diagnostics, therefore, the study of the mechanism of development and types of pulmonary edema using radiological diagnostic methods is relevant. The research work was carried out on the basis of the veterinary clinic of LLC \"Ringa\", the object of the study were dogs and cats with clinical manifestations of respiratory failure, the main diagnostic method was digital radiography. Based on the conducted studies, cardiogenic and non–cardiogenic pulmonary edema was identified, the mechanism of development of which has differences: cardiogenic pulmonary edema manifests itself against the background of heart defects, cardiosclerosis, arterial hypertension; non-cardiogenic – due to impaired capillary permeability and the release of the liquid part of the blood into the interstitial tissue, and then into the alveoli. X-ray diagnostics allows you to differentiate the pathology of the lungs at the initial stages of its development, since a long process of diagnostic measures can have negative consequences on the animal, and the finished radiograph has high-quality detail of the picture in high resolution with specific changes in the lungs with edema, which ensures the exclusion of other pathologies that can also lead to respiratory failure (neoplasms, pulmonary fibrosis , etc.), and that contributes to the provision of rapid appropriate actions in emergency situations to eliminate this condition and the appointment of specific therapeutic and preventive measures, allowing you to reduce the time in diagnosis, to help the patient, increasing the chances of a favorable outcome.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"244 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Padevyj toxidrome – causes and prevention: a brief review","authors":"A. F. Kuznetsov, K. A. Rozhkov, V. V. Achilov, A. A. Pechenkina","doi":"10.52419/issn2782-6252.2023.3.134","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.134","url":null,"abstract":"Diseases of honey bees, like other social insects, have many features, are much more complicated and require a special approach in their treatment and prevention. The article presents materials on the effective prevention of the padevyj toxidrome of honey bees, the main methods of solving the problem are formulated and practical recommendations are given. The authors present the characteristics of honey of different origin used for forage purposes, give an idea of its quality and effect on the body of honey bees during the wintering period. Based on the analysis of scientific data, the authors conclude that the prospects for further research on the prevention of padevyj toxidrome as an integral part of the organization and planning of wintering honey bees with the improvement of beekeeping technology. The materials given in the article can be used both in scientific activity and in practical beekeeping.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"875 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of body weight gain in laboratory animals with different routes of administration of Lcarnitine","authors":"L. I. Sabirzyanova, A. M. Lunegov, G. V. Konovalova, V. V. Tokar","doi":"10.52419/issn2782-6252.2023.3.125","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.125","url":null,"abstract":"In recent years, several studies have been published that suggest that L-carnitine supplementation may affect weight in some animal species and humans, and may also affect the body composition of growing animals. Currently, only a few results are available on the effects of L-carnitine on weight loss and body composition in animals. Therefore, the purpose of this study was to find out whether injections of L-carnitine can influence the dynamics of the weight of laboratory animals. Toxicity studies were conducted on outbred rats in October 2021 in the vivarium of the St. Petersburg State University of Veterinary Medicine. The study involved females weighing 190-210 grams, purchased from the Federal State Unitary Enterprise “Nursery of Laboratory Animals “RAPPOLOVO”. When studying subchronic toxicity after subcutaneous and intramuscular administration, L-carnitine was administered at 2 dose levels. Doses were determined based on the results of the acute toxicity experiment: 1/5 and 1/10 of the maximum tolerated dose. The first experimental group (n=10) received the drug intramuscularly at a dose of 0.08 mg/kg (1/5 of 2000 mg/kg). The second experimental group (n=10) received the drug intramuscularly at a dose of 0.04 mg/kg (1/10 of 2000 mg/kg). The third experimental group received subcutaneous L -carnitine at a dose of 0.08 mg/kg (1/5 of 2000 mg/kg), the fourth experimental group received subcutaneous L-carnitine at a dose of 1/10 of the maximum tolerated (2000 mg/kg body weight). Group 5 was the control group (n=10) and received sodium chloride 0.09% intramuscularly at a dose of 1/5 of 2000 mg/kg, group 6 was the control group and received sodium chloride 0.09% subcutaneously at a dose of 1/5 of 2000 mg /kg. As a result of studies of subchronic toxicity on laboratory animals of the drug L-carnitine for veterinary use with subcutaneous and intramuscular administration, it was established that a dosage of 1/5 of the maximum tolerated, and a dosage of 1/10 of the maximum tolerated, does not cause changes in the dynamics of body weight animals.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic studies for medicinal plant raw materials","authors":"O. S. Popova","doi":"10.52419/issn2782-6252.2023.3.122","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.122","url":null,"abstract":"Every year, medicinal plant raw materials are increasingly found in the production of medicines. Despite a number of positive properties of plants and raw materials obtained from them, there are also negative aspects of the introduction of native (natural) drugs. For example, biological active substances, their quantity and activity, depend on the season of the year and the climatic conditions of the region. These factors are highly variable, and correlations of biologically active substances with weather are difficult to predict. Thus, only with the help of modern analytical instruments and validated methods can it be possible to create statistically reliable algorithms for searching for biologically active substances. The polythematic abstract and bibliographic database has been analyzed. The main attention was paid to such scientometric databases as: Web of Science Core Collection, Medline, PubMed, RSCI, as well as data from the eLIBRARY.ru portal over the past 10 years. An assessment was made of the statistical data and publication activity of the authors regarding the request for metabolomics of medicinal plant raw materials in medicine and veterinary medicine. Metabolomic studies of medicinal plants aim to provide a complete and accurate study of all small molecule metabolites and complement other omics technologies such as genomics, transcriptomics and proteomics. Based on the literature reviewed, it can be concluded that there are two main approaches to collecting metabolomic data: targeted and untargeted analysis. Targeted and untargeted metabolomics analyzes are similar in sample collection, preparation, and chromatographic conditions (stationary phase and mobile phase). However, targeted metabolomics studies mainly focus on multiple metabolites from the same or different pathways.","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birch bud colloid ointment, production technology and therapeutic activity","authors":"N. H. Huseynov","doi":"10.52419/issn2782-6252.2023.3.108","DOIUrl":"https://doi.org/10.52419/issn2782-6252.2023.3.108","url":null,"abstract":"The successful reproduction of the herd and the growth of livestock productivity is largely hampered by morbidity, i.e.: surgical diseases (bruises, abscesses, bursitis, arthritis, myositis, stretching and rupture of muscles, tendon-ligamentous apparatus, synovial and mucous bags, etc.), breast diseases (injuries, bruises, hematomas, mastitis, etc.). These diseases are still widespread and account for more than 40% of the total number of non-communicable diseases. They cause great economic damage to livestock farms, due to a significant decrease in the productivity of sick animals, the expenditure of material resources for their treatment, premature culling, and often the death of sick animals. Positive results in the fight against this kind of diseases (common characteristic signs of which are – swelling, tension, swelling, soreness with elevated local temperature and functional disorders) that distinguish them into one large group of dangerous diseases can be obtained not only by implementing a complex of general zootechnical and veterinary measures that need to be carried out systematically, on a daily basis, but also by providing drugs with analgesic and anti-inflammatory properties (in combination). The article presents some results of the technology of preparation and therapeutic activity, birch bud colloid ointment, obtained by dispersing birch buds in the laboratory of analytical chemistry and chemical colloids of the Moscow State Medical University, which was insisted on alcohol, mixed into the ointment base and used as stable emulsion ointments. Ointment is a soft dosage form consisting of medicinal substances and a base, intended for application to the skin, wounds or mucous membranes, that is, for external use [2,3].","PeriodicalId":200544,"journal":{"name":"Legal regulation in veterinary medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}