Pharmaciana最新文献_第9页

Topical anti-inflammatory effect of Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves extract Ekor Naga叶提取物的局部抗炎作用

Pharmaciana Pub Date : 2021-10-23 DOI: 10.12928/pharmaciana.v11i3.17617

Bernike Anatasya, Fathnur Sanik, M. Muhaimin

{"title":"Topical anti-inflammatory effect of Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves extract","authors":"Bernike Anatasya, Fathnur Sanik, M. Muhaimin","doi":"10.12928/pharmaciana.v11i3.17617","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i3.17617","url":null,"abstract":"Ekor Naga ( Rhaphidophora pinnata (L.f) Schott) leaves are leaves that contain secondary metabolites which can be developed into medicine. Ekor Naga leaves have secondary metabolite compounds of flavonoids, alkaloids, triterpenoid saponins, steroids, tannins, and phenols. This metabolite compound is the basis for testing the anti-inflammatory effect of Ekor Naga leaves extract using topical methods. The purpose of this study was to determine the anti-inflammatory effect of the ethanol extract of Ekor Naga leaves by a topical method. This study used five treatment groups with five mice in each treatment. This research tested the anti-inflammatory activity of Ekor Naga leaves extract by using the combination of 2 methods; namely the method of forming airbags and the formation of artificial edema using the induction of 2% carrageenan solution with the observation parameters being the measurement of exudate volume and differentiation of the number of leukocyte cells observed under a microscope. The results showed that the Ekor Naga leaves extract had an anti-inflammatory effect. The best inflammatory effect is a concentration of 10%, followed by a concentration of 5% and 2.5%.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43425620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cost-effectiveness analysis of antiemetics therapy in breast cancer patients with moderate emetogenic chemotherapy in Prof. Dr. Margono Soekarjo Hospital, Indonesia 印度尼西亚Margono Soekarjo教授博士医院癌症中度致吐化疗患者止吐治疗的成本-效果分析

Pharmaciana Pub Date : 2021-10-23 DOI: 10.12928/pharmaciana.v11i3.17650

Ida Dzikriyani, D. Setiawan

{"title":"Cost-effectiveness analysis of antiemetics therapy in breast cancer patients with moderate emetogenic chemotherapy in Prof. Dr. Margono Soekarjo Hospital, Indonesia","authors":"Ida Dzikriyani, D. Setiawan","doi":"10.12928/pharmaciana.v11i3.17650","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i3.17650","url":null,"abstract":"Chemotherapy-induced nausea and vomiting (CINV) significantly reduce the life quality of cancer patients. A 5-HT3 receptor antagonist, corticosteroid, and H2-blocker have been used to control moderate nausea and vomit in cancer patients. The exploration of the cost-effectiveness of several antiemetic combinations in breast cancer patients in Prof. Dr. Margono Soekardjo Hospital, Purwokerto, Indonesia was the aim of this research. Seventy-four Breast cancer patients who have prescribed moderate-emetogenic chemotherapy during the year 2017-1019 were included in this research. There were fifteen patients treated with the combination of ondansetron and dexamethasone (OD). Fourteen patients were treated with the combination of ondansetron and ranitidine (OR). Thirty-five patients were treated using ondansetron, dexamethasone, and ranitidine (ODR) combination. The effectiveness was represented by the absence of acute nausea and vomiting after receiving chemotherapy. The ODR combinations showed the highest effectivity on diminishing nausea and vomiting among breast cancer patients (0.400), followed by the OD combination (0.267) and the OR combination (0.214). However, the ODR combination generates the highest cost (4.6 million rupiahs) compared to other antiemetics combinations. Compared to the combination of ondansetron and dexamethasone, the combination of ODR provides higher ICER (ICER of 13 Million Rupiahs per case prevented) than the combination of OR (ICER of 8.5 million Rupiahs per case prevented). In conclusion, the combination of ondansetron, dexamethasone, and ranitidine generates the highest cost. It also provides the highest effectiveness in preventing nausea and vomiting.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42123655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo Moewardi医院2型糖尿病患者SNP rs1799854 ABCC8基因与血糖水平的鉴定

Pharmaciana Pub Date : 2021-10-23 DOI: 10.12928/pharmaciana.v11i3.19100

Mardiana Puji Lestari, I. N. Faridah, R. Maliza, Melinda Widianingrum, D. Perwitasari

{"title":"Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo","authors":"Mardiana Puji Lestari, I. N. Faridah, R. Maliza, Melinda Widianingrum, D. Perwitasari","doi":"10.12928/pharmaciana.v11i3.19100","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i3.19100","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by high blood glucose levels due to impaired insulin secretion or insulin resistance. Polymorphisms in the ABCC8 gene rs1799854 are widely found to have an association with T2DM, where the ABCC8 gene encodes the SUR1 protein from the K-ATP channel that plays a role in insulin secretion in cells β pancreas. Mutations in the ABCC8 gene can cause potassium channels and insulin secretions problems that possibly decrease the effectiveness of the drug. Polymorphisms in some populations have been reported, but similar research on Solo's population has never been conducted. The purpose of this study is to identify the genotype of the ABCC8 gene in rs1799854 and the therapeutic outcome of blood glucose levels in T2DM patients. This research is cross-sectional research conducted prospectively at Moewardi Hospital Surakarta, Solo. Blood samples were collected from 10 T2DM patients who received sulfonylurea monotherapy taken through veins for genotype examination by DNA isolation, PCR amplification, and sequencing. Parameters of fasting blood glucose (FBG), 2-hour postprandial blood glucose, and HbA1c are measured as therapeutic outcomes . We found the dominant results in a mutant homozygote (TT) 40%; while wild type (CC); and a mutant heterozygote (CT) was 30%. Single Nucleotide Polymorphisms (SNP) of ABCC8 gene rs1799854, found in T2DM patients at Moewardi Hospital Surakarta, Solo, who received sulfonylurea therapy.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45040301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs 析因设计优化壳聚糖与HPMC复合布洛芬透皮贴剂

Pharmaciana Pub Date : 2021-10-23 DOI: 10.12928/pharmaciana.v11i3.19935

S. Shiyan, Misirti Maulidia Anis Marketama, Galih Pratiwi

{"title":"Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs","authors":"S. Shiyan, Misirti Maulidia Anis Marketama, Galih Pratiwi","doi":"10.12928/pharmaciana.v11i3.19935","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i3.19935","url":null,"abstract":"Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix system. Therefore, this study optimizes chitosan and HPMC as polymers using a factorial design approach. The parameters tested included weight uniformity, patch thickness, swelling index, in vitro release rate, folding resistance, ibuprofen uniformity, surface pH, and moisture content. The interactions between the components were evaluated using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR). The optimum concentration of chitosan was 0.5% and HPMC 6% with CV values for weight uniformity of 0.003 ± 1.202%; humidity 0.543 ± 5.595%; swelling index 4.611 ± 23,657%; thickness 0.052 ± 2.428%; surface pH 5; durability is less than 300 times and the uniformity of ibuprofen levels is 1.52 ± 2.99%. The design approach using the FFD2 2 obtained an effective and efficient mathematical-statistical model to determine the optimal polymer combination in the formula. As an additional instrument in design evaluation, the chemometric approach is constructive in modeling and optimization.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49322178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The effectiveness and cost of lansoprazole and pantoprazole for stress ulcer prophylaxis in intensive care unit 兰索拉唑和泮托拉唑在重症监护病房预防应激性溃疡的效果和成本

Pharmaciana Pub Date : 2021-10-23 DOI: 10.12928/pharmaciana.v11i3.19617

Mega Octavia, Z. Ikawati, T. Andayani

{"title":"The effectiveness and cost of lansoprazole and pantoprazole for stress ulcer prophylaxis in intensive care unit","authors":"Mega Octavia, Z. Ikawati, T. Andayani","doi":"10.12928/pharmaciana.v11i3.19617","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i3.19617","url":null,"abstract":"The incidence of bleeding is increased in high risk patients with critical conditions in Intensive Care Unit (ICU). Appropriate prophylaxis medicine is necessary to reduce the incidence of stress ulcer bleeding during hospitalization in ICU which further can minimize the cost of patient care in the ICU. Currently, lansoprazole and pantoprazole are used as a stress ulcers prophylaxis. Nevertheless, there has not been sufficient evidence proving their effectiveness. This study was aimed to compare the effectiveness and cost between iv lansoprazole and iv pantoprazole as a stress ulcer prophylaxis in ICU. In this retrospective observational study, the data were obtained from medical records of all patients admitted to ICU in a District Hospital in Yogyakarta from January 2014 until December 2016. Effectiveness of therapy were obtained from objective data in the medical record by looking at the incidence of major (clinically signiﬁcant) and minor (overt gastrointestinal) bleeding. Chi-square analysis was performed to analyze the difference of bleeding incidence. The average cost was presented as Expected Monetary Value (EMV), which consisted of the cost of prophylaxis and treatment of bleeding. The difference in average cost was analyzed using independent t-test. A total of 119 patients were included in this study. There were 62 patients in the lansoprazole group and 47 patients in the pantoprazole group. Forty eight patients (77.4%) from lansoprazole group and 35 patients (61.4%) from pantoprazole group did not experience any GI bleeding. There was no statistical difference in the incidence of GI bleeding between the two groups (CI 95%, P-value = 0.057). The EMV of lansoprazole group was higher than pantoprazole group IDR 645.122.57 and IDR 511.629.39 respectively. In conclusion, there was no significant difference regarding the effectiveness between iv lansoprazole and iv pantoprazole as stress ulcer prophylaxis. Costs for the prophylaxis of stress ulcers is lower on the use of pantoprazole compared to lansoprazole.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45558397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narcissism, activity on Facebook, and conspicuous consumption among young adults. 年轻人的自恋、Facebook活动和炫耀性消费

IF 1

Pharmaciana Pub Date : 2021-10-14 eCollection Date: 2022-01-01 DOI: 10.5114/cipp.2021.108751

Małgorzata Niesiobędzka, Karol Konaszewski

{"title":"Narcissism, activity on Facebook, and conspicuous consumption among young adults.","authors":"Małgorzata Niesiobędzka, Karol Konaszewski","doi":"10.5114/cipp.2021.108751","DOIUrl":"10.5114/cipp.2021.108751","url":null,"abstract":"Background: The purpose of the study was to explore relationships between narcissistic strategies, self-oriented activity on Facebook, and conspicuous consumption.Participants and procedure: The sample consisted of 323 young Polish adults. Participants completed the Conspicuous Consumption Scale (CCS), the Narcissistic Admiration and Rivalry Questionnaire (NARQ), and questions regarding Facebook use.Results: Empirical support was found for the assumption that conspicuous consumption was predicted by narcissistic rivalry. Although the direct impact of narcissistic admiration on conspicuous consumption was non-significant, this strategy influenced status consumption through self-verified behaviours on social media, the strongest predictor of conspicuous consumption.Conclusions: This shows that narcissistic rivalry directly affects the propensity to conspicuous consumption and narcissistic admiration is related to self-verified activity on Facebook. The involvement of Facebook usage in this manner increases the acquisition and display of expensive, glamorous products as external signals of status.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":"6 1","pages":"21-31"},"PeriodicalIF":1.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88376791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization 黑孜然籽油SNEDDS的制备及其表征

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.18230

Rodhia Ulfa, Dwi Utami, Iis Wahyuningsih

{"title":"Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization","authors":"Rodhia Ulfa, Dwi Utami, Iis Wahyuningsih","doi":"10.12928/pharmaciana.v11i2.18230","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.18230","url":null,"abstract":"Black cumin seed oil (MBJH) ( Nigella sativa L .) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. The liquid SNEDDS (Self-nanoemulsifying drug delivery system) of MBJH as an alternative formulation. However, the disadvantage of liquid-SNEDDS of MJBH was the interaction between the active ingredients with soft gelatin capsules. Hence, this study proposed to develop solid-SNEDDS as a new formulation of MBJH. Solid-SNEDDS of MBJH was prepared from liquid-SEDDS of MBJH by adsorption to solid carrier method, consisting of aerosil and crospovidone as the adsorbent. The characterization of S-SNEDDS was determined by emulsification time and percent transmittance. Micromeritics properties of S-SNEDDS such as the angle of repose, bulk and tap density parameter, compressibility index, and Hausner ratio were measured before and after stored in stress condition (40 C ± 2 C and relative humidity of 75% ± 5% for 14 days). The result showed S-SNEDDS of MBJH with aerosil absorbent had better S-SNEDDS performance in both characteristics and micromeritics properties under stress conditions than crospovidone absorbent. In conclusion, the s-SNEDDS of black cumin oil by solid aerosil carrier method is promising for future research development of S-SNEDDS dosage form.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47315271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Phyllanthus niruri by FTIR Spectroscopy with Chemometrics 化学计量学-傅里叶红外光谱鉴别法

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.15954

K. Kartini, Devi Hardianti, M. A. Hadiyat

{"title":"Identification of Phyllanthus niruri by FTIR Spectroscopy with Chemometrics","authors":"K. Kartini, Devi Hardianti, M. A. Hadiyat","doi":"10.12928/pharmaciana.v11i2.15954","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.15954","url":null,"abstract":"Phyllanthus niruri (Indonesian: meniran) is a crude drug used in scientific jamu for hyperuricemia, mild hypertension, osteoarthritis, hemorrhoids, and hypercholesterolemia. This plant contains various bioactive compounds such as flavonoids, terpenes, coumarins, lignans, tannins, saponins, alkaloids, etc. Phyllanthus niruri is a wild plant growing in the tropics and sub-tropics of Asia, America, and China. This herb grows well from the lowlands to the highlands, such as bushes, terrain, yards, roadsides, gardens, and rivers. The levels of active compounds in a plant can vary depending on many factors, such as growing location, temperature, humidity, rainfall, and others. This research aimed to evaluate and differentiate P. niruri herbs according to their geographical location using FTIR fingerprint coupled with chemometrics, Principal Component Analysis (PCA) and Cluster Analysis (CA). The results of this study showed that 14 samples of P. niruri are classified into two groups. The first group consists of P. niruri powder originating from Tawangmangu, Kediri, Surabaya, Bangkalan, Gresik, Mojokerto, Kertosono, Krian, Blitar, Nganjuk, unknown 1, unknown 2, and unknown 3, whereas the second group consists of only one sample from Pasuruan. In conclusion, FTIR fingerprint analyzed with chemometrics is adequate to differentiate the powder of P. niruri collected from different locations. FTIR fingerprints combined with chemometrics can be further considered as a method in the quality control process of P. niruri .","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42776645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

CYP2A6*4 allele gene high frequency associated with low-density lipoprotein cholesterol (LDL-C) among Javanese Indonesian smokers 爪哇-印尼吸烟者CYP2A6*4等位基因与低密度脂蛋白胆固醇（LDL-C）相关的高频率基因

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20744

P. A. Prasojo, Christine Patramurti

{"title":"CYP2A6*4 allele gene high frequency associated with low-density lipoprotein cholesterol (LDL-C) among Javanese Indonesian smokers","authors":"P. A. Prasojo, Christine Patramurti","doi":"10.12928/pharmaciana.v11i2.20744","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20744","url":null,"abstract":"The CYP2A6 gene, which codes the CYP2A6 enzyme, has known to have ahigh polymorphism. This polymorphism could decrease, increase, or eliminate the CYP2A6 enzyme activity. CYP2A6*4 , an inactive allele, decreased the CYP2A6 enzyme activity. One of the CYP2A6 enzyme-specific substrates is nicotine. This inactive allele could decrease nicotine metabolism that causes high nicotine levels in the blood. In addition, it caused the increasing levels of Low-Density Lipoprotein Cholesterol (LDL-C) by expanding the lipolysis process. The purpose of this research was to evaluate the effect of the CYP2A6*4 allele gene on LDL-C levels. Respondents in this study were 31 male Javanese smokers. This research is an analytic observational study with a cross-sectional design. Polymerase chain reaction (PCR) methods use to identification the CYP2A6*4 allele gene. This study shows that a high-frequency CYP2A6*4 alleles gene among the subject was detected, with an allele frequency is 93.55%. Furthermore, this CYP2A6*4 allele gene did not impact LDL-C levels, with the Odd Ratio value was 1.636 (P-Value = 0.737). In conclusion, the CYP2A6*4 allele gene does not significantly affect the LDL-C levels in Javanese Indonesian smokers.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49391920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark 紫荆树皮富含酚类成分抗氧化酚含量相关性研究

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20674

R. Muharini, I. Lestari, M. Masriani

{"title":"Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark","authors":"R. Muharini, I. Lestari, M. Masriani","doi":"10.12928/pharmaciana.v11i2.20674","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20674","url":null,"abstract":"D illenia suffruticosa is one of the tropical medicinal plants that has been used traditionally for treating several tropical diseases. However, phytochemical and pharmacological investigations of D. suffruticosa wood bark have not been well-investigated. This research aimed to investigate the correlation between antioxidant properties and total phenolic content of phenolics rich extract and fractions from D . suffruticosa wood bark. The phytochemical investigation revealed the existence of phenolics and alkaloids in methanolic crude wood bark extract and all fractions. Meanwhile, the presence of flavonoids was shown in chloroform and methanol fractions. The highest total phenolic content was demonstrated by methanol fraction with 254.34 ± 16.86 mg GAE/g extract. Meanwhile, the highest total flavonoid content was interestingly displayed in chloroform fraction with 15.33 ± 0.26 mg RE/g extract. The crude extract and methanol fraction had a profound antioxidant activity with IC 50 values of less than 15.63 ppm and 8.83 ppm, respectively. A strong correlation was shown between the antioxidant activity and total phenolic contents through correlation analysis. Thus, the D. suffruticosa wood bark could be considered a potential natural source of antioxidants.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47097724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0