Pharmaciana Pub Date : 2024-01-29 DOI: 10.12928/pharmaciana.v13i3.27253

D. Perwitasari, Faridah Baroroh, Andriana Sari, Putri Rachma Novitasari, Nurul Kodriati, Ratu Matahari, Barkah Djaka Purwanto

{"title":"Interprofessional education applied in first-year and third-year health students: cross-sectional study","authors":"D. Perwitasari, Faridah Baroroh, Andriana Sari, Putri Rachma Novitasari, Nurul Kodriati, Ratu Matahari, Barkah Djaka Purwanto","doi":"10.12928/pharmaciana.v13i3.27253","DOIUrl":"https://doi.org/10.12928/pharmaciana.v13i3.27253","url":null,"abstract":"Health professions work together to provide the best service in health care facilities by collaborating with patients, families, worker and the community. Interprofessional education (IPE) were practice of collaboration between two or more students from different health profession programs . The purpose of study was to compare IPE results from first and third year batches. The two batches included 345 first-year students and 460 third-year students, from three different health disciplines, including medicine, pharmacy, and public health. These students met for four weeks to increase interprofessional collaboration, improve communication skills, foster respect and increase knowledge of the various roles each discipline, especially case management, conflict management and team work. Before IPE program, the students were given pre-questionnaire to assess their prior understanding of IPE. Each group of first-year students presented the outcomes of their discussions in the fourth week, while the third-year students created a poster about the subject and presented it in the second week. The students complete the program and post-questionnaire after their presentation. The International Collaborative Competencies Attainment Survey served the development the IPE questionnaire (ICCAS). The result of pre-IPE domains’ score revealed substantial disparities in the team work domain, with third-year students score was lower than the first students, whereas first-year students had the highest score in the most of IPE categories, unless collaboration and conflict management (p>0.05). The post-IPE domains’ score showed significant differences in all of the domains. Most of the IPE domains had higher score in first year students, excluding communication and team work.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":"151 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors 生姜和百里香精油化合物对冠状病毒-2 受体的硅学研究

Pharmaciana Pub Date : 2024-01-25 DOI: 10.12928/pharmaciana.v13i3.26964

Caroline Caroline, Martha Ervina, Muhammad Rizki Fadhil Pratama, Maria Anabella Jessica

{"title":"In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors","authors":"Caroline Caroline, Martha Ervina, Muhammad Rizki Fadhil Pratama, Maria Anabella Jessica","doi":"10.12928/pharmaciana.v13i3.26964","DOIUrl":"https://doi.org/10.12928/pharmaciana.v13i3.26964","url":null,"abstract":"Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an in silico study was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The research aim to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The moleculer docking method was carried out, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6. As comparisons, remdesivir and favipiravir were used. The three components with the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the ADMETlab 2.0. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3CL protease and spike glycoprotein receptors. The results of the in silico study and ADMET prediction test showed that of the three most potent compounds, α-farnesen was the most potent and safe to use .","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach 利用分子对接方法研究欧当归变种对 HeLa 细胞的细胞毒性以及通过 jak2/stat3 和刺猬途径预测抗增殖活性

Pharmaciana Pub Date : 2024-01-05 DOI: 10.12928/pharmaciana.v13i3.27482

Siti Rofida, L. H. Nurani, Dwi Utami, Citra Ariani Edityaningrum

{"title":"Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach","authors":"Siti Rofida, L. H. Nurani, Dwi Utami, Citra Ariani Edityaningrum","doi":"10.12928/pharmaciana.v13i3.27482","DOIUrl":"https://doi.org/10.12928/pharmaciana.v13i3.27482","url":null,"abstract":"Cervical cancer is one of the second-leading causes of death in women. The discovery of cancer drug candidates continues to be carried out due to the resistance that occurs in cervical cancer therapy. Plant metabolite compounds are one of the sources used to explore new drug candidates. Red ginger rhizome is a candidate plant that has anti-cervical cancer activity. This study aims to determine the cytotoxicity of an ethanol extract of red ginger rhizomes on the growth of HeLa cancer cells and predict anti-proliferative activity via the JAK2/STAT3 and hedgehog pathways. The sample (red ginger rhizome simplicia) was extracted by remaceration using 75% ethanol. The MTT assay method was used to test the cytotoxicity and anti-proliferation of metabolite compounds. The docking molecular study was performed by using Autodock 4.2.6.6.5 software. The receptors used in the JAK2, STAT3, and SMO pathways were obtained from the Protein Data Bank with the codes 6VGL, 6NUQ, and 5L7I, respectively. The ethanol extract produced a thick yellowish-brown extract with an aromatic smell and spicy taste, with an extract yield of 18.63% w/w. The 75% ethanol extract of red ginger rhizomes had cytotoxic activity in HeLa cancer with an IC 50 of 104.22 ± 6.18 µg/mL and an IC 50 of cisplatin of 38.61 ± 3.66 µg/mL. Prediction of antiproliferative activity via the JAK2 pathway showed a binding energy and Ki value of -7.47 kcal/mol, -7.48 kcal/mol, and 3.33 µM, 3.27 µM, as shown by alpha-cedrol and beta-eudesmol compounds. The highest inhibition on the STAT3 and SMO pathways was shown by the beta compound eudesmol, with binding energy and Ki values of -6.05 kcal/mol, -7.57 kcal/mol, and 36.48 µM, respectively; 2.81 µM. (provide relevance and implication)","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma 小分子VEGFR抑制剂治疗肾细胞癌的比较

Pharmaciana Pub Date : 2023-08-03 DOI: 10.12928/pharmaciana.v13i2.24638

Jie Tan, Aadya Jaipuria, R. Priefer

引用次数: 0

Validity and reliability of the world health organisation-five well being index (WHO-5) questionnaire in early detection of depression during Covid-19 pandemic in Yogyakarta 世界卫生组织第五健康指数(WHO-5)问卷在日惹市Covid-19大流行期间早期发现抑郁症的效度和信度

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.24319

Mutmainnah Siradjuddin, D. Perwitasari, Lalu Muhammad Irham, H. Dania, Tetie Herlina

引用次数: 0

Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli 木瓜花乙醇提取物对四环素类抗生素对大肠杆菌的时间杀伤作用

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.24711

Anugraheni Anugraheni, C. S. Rini

引用次数: 0

Antibacterial activities of Elaeocarpus ganitrus Roxb. leaves from Kebumen against Escherichia coli and Shigella flexneri 树菖蒲的抑菌活性。对大肠杆菌和福氏志贺氏菌的抗性

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.19219

Naelaz Zukhruf Wakhidatul Kiromah, Laeli Fitriyati, Sinta Wahyu Septiani

引用次数: 0

Fibrotic effect of monoculture, conditioned media and coculture of fibroblast NIH3T3 cells on collagen secretion and mRNA TGF-beta expressions 单培养、条件培养基和共培养成纤维细胞NIH3T3细胞对胶原分泌和tgf - β mRNA表达的影响

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.25482

R. Awaluddin, D. Nugrahaningsih, Prasetyastuti Prasetyastuti

{"title":"Fibrotic effect of monoculture, conditioned media and coculture of fibroblast NIH3T3 cells on collagen secretion and mRNA TGF-beta expressions","authors":"R. Awaluddin, D. Nugrahaningsih, Prasetyastuti Prasetyastuti","doi":"10.12928/pharmaciana.v13i2.25482","DOIUrl":"https://doi.org/10.12928/pharmaciana.v13i2.25482","url":null,"abstract":"Fibrosis is common profound in diabetes condition, they characterized by accumulation of extracellular matrix in tissue then cause tissue injury. The study aim to investigate effect of monoculture, conditioned media, and coculture fibroblast of NIH3T3 cells (NIH3T3 cells) in LPS-high glucose media (HG-LPS media) conditions on mRNA TGF-β and collagen secretion. The fibroblast NIH3T3 were cultured with various culture type there is mono culture NIH3T3 cells, conditioned media from macrophage RAW264.7 cells culture media, and coculture with RAW264.7 cells (ratio 1:1 and 1:2) in normal media (media containing 4500 µg/mL of glucose) and HG-LPS media (media containing LPS 0.25 µg/mL and D-glucose 5400 µg/mL). Our findings shows that the TGF-β mRNA expression in RAW 264.7 and NIH 3T3 cell coculture media with a culture ratio of 1:1 (Coculture 1:1) were the highest (p<0.05) compared than monoculture of NIH3T3 cells (cultured in normal media or HG-LPS Media), conditioned media from RAW264.7 cells in normal media (CM-M0 Media), and the RAW 264.7 and NIH 3T3 co-culture cells with 1:2 cultured ratio in HG-LPS Media (Coculture 1:2). On other hand, the the relative ratio of collagen secretion on Coculture 1:1 were the highest compared to CM-M0 media (p<0.05). Our study conclude that RAW 264.7 and NIH 3T3 coculture cells with a (1:1) cultured ratio in LPS and high glucose media (Coculture 1:1) is appropriate for diabetic fibrosis in vitro models.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47168901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Measurement of quality parameters of Snakehead Fish (Channa striata) simplicia from sungai Itik village, West Kalimantan 西加里曼丹sungai Itik村简单黑鱼质量参数的测定

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.23856

Wintari Taurina, Mohamad Andrie

{"title":"Measurement of quality parameters of Snakehead Fish (Channa striata) simplicia from sungai Itik village, West Kalimantan","authors":"Wintari Taurina, Mohamad Andrie","doi":"10.12928/pharmaciana.v13i2.23856","DOIUrl":"https://doi.org/10.12928/pharmaciana.v13i2.23856","url":null,"abstract":"Snakehead fish ( Channa striata ) is one of the natural ingredients that have the potential to heal wounds quickly. Snakehead fish extract ointment with a combination of kelulut honey, clove oil, golden sea cucumber extract, and green betel extract can accelerate wound healing. Standardization is a process carried out to ensure the stability, safety, quality, and efficacy of the natural ingredients used. This study aims to standardize simplicia (fish fillet) raw materials used for the manufacture of snakehead fish extract herbal ointment. The method used follows the Indonesian National Standard, samples were sent to LPPT UGM and Baristand Pontianak. The results of the simplicia (fish fillet) test for snakehead fish were 81.6% water content, 0.813% total ash content, 0.02% acid-insoluble ash content, 19.3% protein, 2.93% total fat, 0.01% iron mg/kg, zinc 0.002 mg/kg, and calcium 817 mg/kg and the alkaloid and tannin quality tests were negative. the results of the simplicia test (fish fillet) for snakehead fish E. coli 3 AMP/gr, ALT 3.2 x 104 colonies/g, and the Salmonella test also met the requirements. The results of characterization tests with various methods and parameters that have been carried out show that the simplicia (fish fillet) of snakehead fish ( Channa striata ) has good quality and quality to be processed into extracts.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46923750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of adverse effects of extrapyramidal syndrome use of combination of antipsychotics antidepressants in outpatient schizophrenia patients in RSUP Fatmawati for the period 2016-2020 2016-2020年RSUP Fatmawati门诊精神分裂症患者锥体外系综合征联合使用抗精神病药物和抗抑郁药的不良反应研究

Pharmaciana Pub Date : 2023-07-26 DOI: 10.12928/pharmaciana.v13i2.23280

Ema Nillafita Putri Kusuma, Emy Oktaviani, Windi Astutie Harahap

引用次数: 0

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